WO2015118558A3 - Procédé pour la préparation de clofarabine - Google Patents

Procédé pour la préparation de clofarabine Download PDF

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Publication number
WO2015118558A3
WO2015118558A3 PCT/IN2015/000068 IN2015000068W WO2015118558A3 WO 2015118558 A3 WO2015118558 A3 WO 2015118558A3 IN 2015000068 W IN2015000068 W IN 2015000068W WO 2015118558 A3 WO2015118558 A3 WO 2015118558A3
Authority
WO
WIPO (PCT)
Prior art keywords
clofarabine
preparation
relates
present
Prior art date
Application number
PCT/IN2015/000068
Other languages
English (en)
Other versions
WO2015118558A2 (fr
Inventor
Srinivasan Thirumalai Rajan
Muppa Kishore Kumar
Original Assignee
Msn Laboratories Private Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Msn Laboratories Private Limited filed Critical Msn Laboratories Private Limited
Publication of WO2015118558A2 publication Critical patent/WO2015118558A2/fr
Publication of WO2015118558A3 publication Critical patent/WO2015118558A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Saccharide Compounds (AREA)

Abstract

La présente invention concerne un procédé de préparation de clofarabine.
PCT/IN2015/000068 2014-02-04 2015-02-04 Procédé pour la préparation de clofarabine WO2015118558A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN518/CHE/2014 2014-02-04
IN518CH2014 IN2014CH00518A (fr) 2014-02-04 2015-02-04

Publications (2)

Publication Number Publication Date
WO2015118558A2 WO2015118558A2 (fr) 2015-08-13
WO2015118558A3 true WO2015118558A3 (fr) 2015-11-05

Family

ID=53778571

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2015/000068 WO2015118558A2 (fr) 2014-02-04 2015-02-04 Procédé pour la préparation de clofarabine

Country Status (2)

Country Link
IN (1) IN2014CH00518A (fr)
WO (1) WO2015118558A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105601688A (zh) * 2015-12-23 2016-05-25 国药一心制药有限公司 一种氯法拉滨中间体及氯法拉滨的制备方法
CN106397518B (zh) * 2016-10-18 2019-05-17 武汉百科药物开发有限公司 一种氯法拉滨的合成方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6680382B2 (en) * 2001-08-02 2004-01-20 Ilex Products, Inc. Process for preparing purine nucleosides
US6949640B2 (en) * 2000-02-18 2005-09-27 Southern Research Institute Method for synthesizing 2-chloro-9-(2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine
CN101265284A (zh) * 2008-05-07 2008-09-17 深圳万乐药业有限公司 氯法拉滨的合成方法
CN101555267A (zh) * 2008-04-09 2009-10-14 杭州容立医药科技有限公司 一种核苷酸类似物克罗拉滨的合成方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6949640B2 (en) * 2000-02-18 2005-09-27 Southern Research Institute Method for synthesizing 2-chloro-9-(2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine
US6680382B2 (en) * 2001-08-02 2004-01-20 Ilex Products, Inc. Process for preparing purine nucleosides
CN101555267A (zh) * 2008-04-09 2009-10-14 杭州容立医药科技有限公司 一种核苷酸类似物克罗拉滨的合成方法
CN101265284A (zh) * 2008-05-07 2008-09-17 深圳万乐药业有限公司 氯法拉滨的合成方法

Also Published As

Publication number Publication date
IN2014CH00518A (fr) 2015-08-07
WO2015118558A2 (fr) 2015-08-13

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