WO2015085996A1 - Produits cosmétiques antitranspirants contenant du lysozyme et/ou de l'albumine de sérum bovin et/ou de la protéine de yaourt - Google Patents

Produits cosmétiques antitranspirants contenant du lysozyme et/ou de l'albumine de sérum bovin et/ou de la protéine de yaourt Download PDF

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WO2015085996A1
WO2015085996A1 PCT/DE2014/200270 DE2014200270W WO2015085996A1 WO 2015085996 A1 WO2015085996 A1 WO 2015085996A1 DE 2014200270 W DE2014200270 W DE 2014200270W WO 2015085996 A1 WO2015085996 A1 WO 2015085996A1
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Prior art keywords
aluminum
antiperspirant
weight
antiperspirant cosmetic
cosmetic agent
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PCT/DE2014/200270
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German (de)
English (en)
Inventor
Bernhard Banowski
Melanie Giesen
Stefan Evers
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Henkel Ag & Co. Kgaa
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Publication of WO2015085996A1 publication Critical patent/WO2015085996A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00—Anti-perspirants or body deodorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/26—Aluminium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/342—Alcohols having more than seven atoms in an unbroken chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
    • A61K8/585—Organosilicon compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/66—Enzymes

Definitions

  • Antiperspirant cosmetic products containing lysozyme and / or bovine serum albumin and / or yoghurt protein are used as antiperspirant cosmetic products containing lysozyme and / or bovine serum albumin and / or yoghurt protein.
  • the present invention relates to an antiperspirant cosmetic agent which contains at least one antiperspirant aluminum salt and lysozyme and / or bovine serum albumin (BSA) and / or yoghurt protein and wherein the addition of the lysozyme and / or bovine serum albumin (BSA) and / or Yoghurt protein results in an increase in the closure of the sweat gland (s) and / or in a closure formation of the sweat gland (s).
  • BSA antiperspirant aluminum salt and lysozyme and / or bovine serum albumin
  • the present invention relates to the use of a combination of at least one antiperspirant aluminum salt and lysozyme and / or bovine serum albumin (BSA) and / or yoghurt protein for the reduction and / or prevention of axillary sweat.
  • BSA bovine serum albumin
  • the present invention relates to a non-therapeutic cosmetic method for preventing and / or reducing transpiration of the body, in which the antiperspirant according to the invention is applied to the skin, in particular to the skin of the armpits.
  • the present invention relates to the use of lysozyme and / or bovine serum albumin (BSA) and / or yoghurt protein for enhancing the closure of the sweat gland (s) and / or closure of the sweat gland (s) by aluminum salts.
  • BSA bovine serum albumin
  • washing, cleaning and caring for one's own body is a basic human need, and modern industry is constantly trying to meet these needs of man in a variety of ways.
  • Especially important for daily hygiene is the permanent elimination or at least reduction of body odor and underarm wetness.
  • Numerous specific deodorant or antiperspirant personal care products are known in the art which have been developed for use in body regions having a high density of sweat glands, especially in the underarm area. These are formulated in a wide variety of dosage forms, for example as powder, in stick form, as aerosol spray, pump spray, liquid and gel roll on application, cream, gel and as impregnated flexible substrates (towels).
  • Prior art cosmetic antiperspirants contain at least one antiperspirant salt in addition to at least one oil or fatty substance and one perfume component or perfume.
  • the antiperspirant salts used in antiperspirants reduce the sweat secretion of the body by a temporary narrowing or blockage of the excretory ducts of the sweat glands, so that the amount of sweat can be reduced by about 20 to 60 percent.
  • they have an additional deodorizing effect due to their antimicrobial effect.
  • a disadvantage of the aforementioned activated basic aluminum and aluminum zirconium halides of the prior art is the change in the polymer structure in aqueous solution with increasing storage time and / or when using protic solvents or a limited effect of non-activated, inexpensive aluminum salts, so that a significant reduction in the sweat secretion of the body by the temporary narrowing and / or obstruction of the excretory ducts of the sweat glands can not always be ensured.
  • antiperspirant cosmetic agents which have no significant decrease in antiperspirant activity even during long periods of storage and / or when using high levels of protic solvents. Furthermore, the antiperspirants should be inexpensive to produce.
  • the subject of the present invention is thus an antiperspirant cosmetic containing
  • hydrogel formation of the antiperspirant aluminum salt with lysozyme and / or occurs exclusively at extremely specific pH values Bovine serum albumin (BSA) and / or yogurt protein.
  • the lysozyme used in the context of the present invention can be isolated from animals as well as animal products, plants, fungi, bacteria and bacteriophages. In the context of the present invention, preference is given to using lysozyme which is obtained from egg white.
  • the yoghurt protein used in the present invention is preferably obtained from fermented skimmed milk.
  • albumins which are obtained from animal sources, plants and human sources. In the context of the present invention, these albumins have a comparable effect as bovine serum albumin (BSA).
  • BSA bovine serum albumin
  • antiperspirant is understood according to the invention to reduce or reduce the perspiration of the sweat glands of the body.
  • cosmetic oil in the sense of the present invention is understood as meaning an oil which is suitable for cosmetic use and which is immiscible with water.Furthermore, the cosmetic oil used according to the invention is neither fragrance nor essential oils.
  • fragments in the context of the present invention means substances having a molecular weight of 74 to 300 g / mol, which contain at least one osmophoric group in the molecule and have an odor and / or taste, ie they are able to Osmophore groups are groups covalently bound to the molecular skeleton in the form of hydroxy groups, formyl groups, oxo groups, alkoxycarbonyl groups, nitrile groups, nitro groups, azide groups, etc.
  • fragments within the meaning of present invention even at 20 ° C and 1013 hPa liquid perfume oils, perfumes, or perfume oil ingredients.
  • the term "waxes" in the context of the present invention means substances which are kneadable at 20 ° C. or solid to brittle, have a coarse to fine-crystalline structure and are translucent to opaque, but not vitreous, in color Substances above 25 ° C without decomposition, slightly liquid above the melting point (slightly viscous), have a strong temperature-dependent consistency and solubility and are polishable under light pressure.
  • volatile cosmetic oil refers to cosmetic oils which at 20 ° C and an ambient pressure of 1 .013 hPa a vapor pressure of 2.66 Pa to 40,000 Pa (0.02 to 300 mm Hg), preferably from 10 to 12,000 Pa (0.1 to 90 mm Hg), more preferably from 13 to 3000 Pa (0.1 to 23 mm Hg), in particular from 15 to 500 Pa (0.1 to 4 mm Hg) have.
  • nonvolatile cosmetic oils in the context of the present invention means cosmetic oils which have a vapor pressure of less than 2.66 Pa (0.02 mm Hg) at 20 ° C. and an ambient pressure of 1.103 hPa ,
  • fatty acid as used in the present invention means aliphatic carboxylic acids which have unbranched or branched carbon residues of 4 to 40 carbon atoms also be synthetically produced fatty acids.Furthermore, the fatty acids may be monounsaturated or polyunsaturated.
  • fatty alcohol in the context of the present invention means aliphatic, monohydric, primary alcohols which have unbranched or branched hydrocarbon radicals having 4 to 40 carbon atoms The fatty alcohols used in the context of the invention may also be monounsaturated or polyunsaturated ,
  • wt .-% refers in the present case, unless otherwise stated, on the total weight of the antiperspirant cosmetic agents according to the invention without any optional propellant.
  • the cosmetic oil which is liquid at 20 ° C and 1013 hPa is selected from the group of
  • volatile cyclic silicone oils especially cyclotrisiloxane, cyclotetrasiloxane, cyclopentasiloxane and cyclohexasiloxane, and linear silicone oils having 2 to 10 siloxane units, especially hexamethyldisiloxane, octamethyltrisiloxane, decamethyltetrasiloxane;
  • volatile non-silicone oils especially liquid paraffin oils and isoparaffin oils such as isodecane, isoundecane, isododecane, isotridecane, isotetradecane, isopentadecane, isohexadecane and isoeicosan;
  • nonvolatile silicone oils especially higher molecular weight linear polyalkylsiloxanes
  • nonvolatile non-silicone oils in particular the esters of linear or branched saturated or unsaturated C 2 to C fatty acids having linear or branched saturated or unsaturated C 2 to C 30 fatty acids which may be hydroxylated, C 8 to C 22 fatty alcohol esters of monovalent or polyvalent C 2 to C fatty acids.
  • C7-hydroxycarboxylic acids the triethyl citrates, the branched saturated or unsaturated C6-3o fatty alcohols, the mono-, di- and triglycerides of linear or branched, saturated or unsaturated, optionally hydroxylated Cs-30 fatty acids, the dicarboxylic acid esters of linear or branched C2 -Cio-alkanols, the adducts of ethylene oxide and / or propylene oxide to mono- or polyhydric C3-22 alkanols, which may be esterified, the symmetrical, asymmetrical or cyclic esters of carbonic acid with fatty alcohols, the esters of dimers of unsaturated Ci2-22 Fatty acids with monovalent, linear, branched and cyclic C2 -is-alkanols or C2-6-alkanols, the benzoic acid esters of linear or branched Cs-22-alkanols such as benzoic acid Ci2-is-al
  • volatile silicone oils and volatile non-silicone oils results in a drier skin feel and faster release of the antiperspirant aluminum salt.
  • the cyclic volatile silicone oils which can be used in the context of the invention have a vapor pressure of from 13 to 15 Pa (0.1 mm Hg) at 20 ° C. and an ambient pressure of 1013 hPa.
  • a linear volatile silicone oil and a low molecular weight phenyl trimethicone having a vapor pressure of about 2,000 Pa (15 mm Hg) at 20 ° C and an ambient pressure of 1013 hPa can be used.
  • cyclic volatile silicone oils used in the antiperspirant cosmetic agents according to the invention become.
  • volatile non-silicone oils in the form of Cio-13 isoparaffine mixtures having a vapor pressure of from 10 to 400 Pa (0.08 to 3 mm Hg), preferably from 13 to 100 Pa (0.1 to 0.8 mm Hg) , used at 20 ° C and an ambient pressure of 1 .013 hPa.
  • the volatile C8-Ci6-isoparaffin in a total amount of 1 to 60 wt .-%, preferably from 3 to 45 wt .-%, preferably from 5 to 40 wt .-%, in particular from 8 to 20 wt .-%, based on the total weight of the antiperspirant cosmetic agent is included.
  • antiperspirant cosmetic products with a low proportion of volatile oils - that is, with 0.5 to 15 wt .-%, based on the total weight of the antiperspirant cosmetic agent, on volatile oils - or even without volatile oils to formulate.
  • the antiperspirant cosmetic agents comprise a non-volatile silicone oil and / or a non-volatile non-silicone oil.
  • preferred antiperspirant cosmetic agents contain at least one ester of linear or branched saturated or unsaturated fatty alcohols having 2 to 30 carbon atoms with linear or branched saturated or unsaturated fatty acids having 2 to 30 carbon atoms, which may be hydroxylated, in a total amount of 1 to 30 wt .-%, preferably from 5 to 26 wt .-%, preferably from 9 to 24 wt .-%, in particular from 12 to 17 wt .-%, based on the total weight of the antiperspirant cosmetic agent.
  • non-volatile silicone oils may be linear polyalkylsiloxanes having a kinematic viscosity of from 5 to 2,000 cSt at 25 ° C., in particular linear polydimethylsiloxanes having a kinematic viscosity at 25 ° C. of from 5 to 2,000 cSt, preferably from 10 to 350 cSt, in particular from 50 to 100 cSt.
  • the non-volatile silicone oils mentioned above are under the trade names Dow Corning ® 200 or Xiameter of PMX Dow Corning or Xiameter available.
  • nonvolatile silicone oils are phenyltrimethicones having a kinematic viscosity at 25 ° C. of from 10 to 100 cSt, preferably from 15 to 30 cSt, and also cetyldimethicones.
  • the cosmetic oil which is liquid at 20 ° C. and 1 .013 hPa is present in a total amount of from 1 to 95% by weight, preferably from 10 to 85% by weight, preferably from 20 to 75 Wt .-%, more preferably from 35 to 70 wt .-%, in particular from 50 to 60 wt .-%, based on the total weight of the antiperspirant cosmetic agent contained.
  • the antiperspirant compositions according to the invention less than 0.2 wt .-%, preferably less than 0.1 wt .-%, in particular 0 wt .-% of at 20 ° C and 1.
  • the fragrance is selected from the group of
  • esters in particular benzyl acetate, phenoxyethyl isobutyrate, p-tert-butylcyclohexyl acetate, lactyl acetate, dimethylbenzylcarbinylacetate (DMBCA), phenylethylacetate, benzylacetate, ethylmethylphenylglycinate, allylcyclohexylpropionate, styrallylpropionate, benzylsalicylate, cyclohexylsalicylate, floramate, melusate and jasmecyclate;
  • DMBCA dimethylbenzylcarbinylacetate
  • aldehydes especially linear alkanals of 8 to 18 carbon atoms, citral, citronellal, citronellyloxy-acetaldehyde, cyclamen aldehyde, lilial and bourgeonal;
  • ketones especially ionone, alpha-isomethylionone and methyl cedryl ketone
  • alcohols especially anethole, citronellol, eugenol, geraniol, linalool, phenylethyl alcohol and terpineol;
  • hydrocarbons in particular terpenes such as limonene and pinene; such as
  • mixtures of different fragrances are preferably used, which together produce an appealing scent.
  • Particularly pleasing antiperspirant cosmetic agents according to the invention are obtained when the perfume in a total amount of 0.00001 to 10 wt .-%, preferably from 0.001 to 9 wt .-%, preferably from 0.01 to 8 wt .-%, further preferably from 0.5 to 7 wt .-%, in particular from 1 to 6 wt .-%, based on the total weight of the antiperspirant cosmetic agent is included.
  • the fragrance in a total amount of 0.00001 to 5 wt .-%, preferably 0.001 to 4 wt .-%, preferably 0.01 to 3 wt .-%, more preferably 0 , 1 to 2 wt .-%, in particular 0.2 to 1, 5 wt .-%, based on the total weight of the blowing agent-containing antiperspirant cosmetic agent is included.
  • the wax is selected from the group of
  • esters of saturated monohydric Cs -is alcohols with saturated C 12-18 monocarboxylic acids (iii) esters of saturated monohydric Cs -is alcohols with saturated C 12-18 monocarboxylic acids
  • esters of a saturated monohydric C 16 -C 60 alkanol and a saturated C 8 -C 36 monocarboxylic acid in particular cetyl behenate, stearyl behenate and C 20 -C 40 -alkyl stearate;
  • glycerol triesters of saturated linear C 12 -C 20 carboxylic acids which may be hydroxylated, in particular hydrogenated palm oil, hydrogenated coconut oil, hydrogenated castor oil, glyceryl tribehenate and glyceryl tri-12-hydroxy stearate;
  • animal waxes in particular beeswax, shellac wax and spermaceti;
  • (ix) synthetic waxes in particular montan ester waxes, hydrogenated jojoba waxes and sasol waxes, polyalkylene waxes and polyethylene glycol waxes, C 2o-C4o dialkyl esters of dimer acids, C 30-50 alkyl beeswax and alkyl and alkylaryl esters of dimer fatty acids, paraffin waxes; such as
  • esters of saturated, monohydric C 12-18 alcohols with saturated C 12 -is monocarboxylic acids are stearyl laurate, cetearyl stearate (eg Crodamol® CSS), cetyl palmitate (e.g. Cutina® CP) and myristyl myristate (eg Cetiol® MM).
  • cetearyl stearate eg Crodamol® CSS
  • cetyl palmitate e.g. Cutina® CP
  • myristyl myristate eg Cetiol® MM
  • a C2o-C4o-alkyl stearate is preferably used as the wax component.
  • This ester is known under the name Kester ® K82H or Kesterwachs ® K80H and is sold by Koster Keunen Inc..
  • the wax in a total amount of 0.01 to 50 wt .-%, preferably from 3 to 40 wt .-%, preferably from 5 to 30 wt .-%, in particular from 6 to 25 wt .-%, based on the total weight of the antiperspirant cosmetic agent is included.
  • a particularly good antiperspirant effect is obtained in the context of the present invention, if the antiperspirant aluminum salt in a total amount of 1 to 40 wt .-%, preferably from 3 to 35 wt .-%, preferably from 4 to 32 wt .-%, on preferably from 5 to 28 wt .-%, more preferably from 8 to 25 wt .-%, in particular from 12 to 22 wt .-%, based on the total weight of the antiperspirant cosmetic agent is included.
  • the antiperspirant aluminum salt in a total amount of 0.1 to 20 wt .-%, preferably from 0.5 to 15 wt .-%, preferably from 1 to 12 wt .-%, more preferably from 1, 5 to 10 wt .-%, in particular from 2 to 8 wt .-%, based on the total weight of the blowing agent-containing antiperspirant composition is included.
  • the antiperspirant aluminum salt may be selected from the group of
  • water-soluble astringent inorganic salts of aluminum especially aluminum chlorohydrate, aluminum sesquichlorohydrate, aluminum dichlorohydrate, aluminum hydroxide, potassium aluminum sulfate, aluminum bromohydrate, aluminum chloride, aluminum sulfate;
  • water-soluble astringent organic salts of aluminum in particular aluminum chlorohydrex-propylene glycol, aluminum chlorohydrex-polyethylene glycol, aluminum-propylene glycol complexes, aluminum sesquichlorohydrex-propylene glycol, aluminum sesqui-chlorohydrex-polyethylene glycol, aluminum-propylene glycol-dichlorohydrex, aluminum-poly-ethylene glycol dichlorohydrex, aluminum undecylenoyl collagen amino acid Sodium aluminum lactate, sodium aluminum chlorhydroxactate, aluminum lipoamino acids, aluminum lactate, aluminum chlorohydroxy allantoinate, sodium aluminum chlorohydroxy lactate;
  • water-soluble astringent inorganic aluminum-zirconium salts especially aluminum zirconium trichlorohydrate, aluminum zirconium tetrachlorohydrate, aluminum zirconium pentachlorohydrate, aluminum zirconium octachlorohydrate;
  • water-soluble astringent organic aluminum-zirconium salts in particular aluminum zirconium-propylene glycol complexes, aluminum zirconium trichlorohydrex glycine, aluminum zirconium tetrachlorohydrex glycine, aluminum zirconium pentachlorohydrex glycine, aluminum zirconium octachlorohydrex glycine; such as
  • antiperspirant aluminum salts is understood to mean aluminosilicates and zeolites.
  • water-soluble aluminum salts are those salts which have a solubility of at least 3% by weight at 20 ° C., ie at least 3 dissolve g of the antiperspirant aluminum salt in 97 g of water at 20 ° C.
  • Particularly preferred inorganic aluminum salts are chosen from aluminum chlorohydrate, aluminum chlorohydrate, in particular having the general formula [Al2 (OH) 5 Cl ⁇ 1 -6 H20] n, preferably [Al 2 (OH) 5 Cl ⁇ 2-3 ⁇ 2 ⁇ ] ⁇ , which in non-activated (polymerized) or may be in activated (depolymerized) form, as well as aluminum chlorohydrate having the general formula [Al2 (OH) 4Cl2 ⁇ 1 -6 H20] n, preferably [Al2 (OH) 4Cl2 ⁇ H20 2-3] n that polymerized in non-activated ( ) or in activated (depolymerized) form.
  • the preparation of such antiperspirant aluminum salts is disclosed, for example, in US 3,887,692 A, US 3,904,741 A, US 4,359,456 A, GB 2 048 229 A and GB 1 347 950 A.
  • antiperspirant aluminum salts are selected from so-called "activated” aluminum salts, which are also referred to as "antiperspirant active ingredients” with enhanced activity (English: enhanced activity). Such agents are known in the art and are also commercially available. Their preparation is disclosed, for example, in the publications GB 2 048 229 A, US Pat. Nos. 4,775,528 and 6,010,688.
  • Activated aluminum salts are typically produced by heat-treating a dilute solution of the appropriate salt (e.g., a 10 wt.% Salt solution) to increase its HPLC peak 4-to-peak 3 area ratio. The activated salt can then be dried to a powder, in particular spray-dried. In addition to the spray drying z. B. also suitable for drum drying.
  • Activated aluminum salts typically have a HPLC peak 4-to-peak 3 area ratio of at least 0.4, preferably at least 0.7, especially at least 0.9, with at least 70% of the aluminum attributable to these HPLC peaks.
  • activated aluminum zirconium salts which have a high HPLC peak 5 aluminum content, in particular a peak 5 area of at least 33%, preferably of at least 45%, based on the total area under the peaks 2 to 5, measured by HPLC of a 10 wt .-% aqueous solution of the active ingredient under conditions at which the aluminum species are resolved into at least 4 consecutive peaks (designated peaks 2 to 5).
  • Preferred aluminum-zirconium salts having a high HPLC peak 5-aluminum content also referred to as "E 5 AZCH" are disclosed, for example, in US Pat. Nos. 6,436,381 and 6,649,152.
  • the above-mentioned activated aluminum-zirconium salt may additionally be stabilized with a water-soluble strontium salt and / or with a water-soluble calcium salt, as disclosed, for example, in US Pat. No. 6,923,952A.
  • antiperspirant aluminum salts as nonaqueous solutions or solubilisates of an activated antiperspirant aluminum or aluminum zirconium salt, for example in accordance with US Pat. No. 6,010,688 A.
  • Such aluminum or aluminum zirconium salts are stabilized by the addition of an effective amount of a polyhydric alcohol having 3 to 6 carbon atoms and 3 to 6 hydroxyl groups, preferably propylene glycol, sorbitol and pentaerythritol, against the loss of activation of the salt.
  • complexes of activated aluminum or aluminum zirconium antiperspirant salts with a polyhydric alcohol containing from 20 to 50% by weight, preferably from 20 to 42% by weight, activated antiperspirant aluminum or aluminum zirconium salt and from 2 to 16 Wt .-% molecularly bound water, the remainder to 100 wt .-% is at least one polyhydric alcohol having 3 to 6 carbon atoms and 3 to 6 hydroxyl groups.
  • Propylene glycol, propylene glycol / sorbitol mixtures and propylene glycol / pentaerythritol mixtures are preferred such alcohols.
  • Such inventively preferred complexes of an activated antiperspirant aluminum or aluminum zirconium salt with a polyhydric alcohol are, for. For example, in documents US 5,643,558 A and US 6,245,325.
  • antiperspirant aluminum salts of basic calcium aluminum salts as z.
  • these salts can be obtained by reacting calcium carbonate with aluminum chlorhydroxide or aluminum chloride and aluminum powder or by adding calcium chloride dihydrate to aluminum chlorhydroxide.
  • aluminum-zirconium complexes which are buffered with salts of amino acids, in particular with alkali and Erdalkaliglycinaten, and as such.
  • use As disclosed in the document US 4 017 599 A, use.
  • antiperspirant activated aluminum and aluminum zirconium salts which are preferred according to the invention may also be those described in the following US Pat. Nos. 6,245,325, 6,042,816, 6,245,325, 6,042,816, 6,245,325, US Pat 042 816 A, US 6,245,325, US 6,042,816 A or US Pat. No. 7,105,691 A, aluminum or zirconium salts which are preferably stabilized by amino acids, in particular glycine, hydroxyalkanoic acids, in particular glycolic acid and lactic acid, or betaines.
  • activated aluminum salts are those of the general formula Al 2 (OH) 6- a Xa, where X is Cl, Br, I or NO 3 and "a" is a number from 0.3 to 5, preferably from 0.8 to 2, 5 is in particular from 1 to 2, so that the molar ratio of Al: X 0.9: 1 to 2.1: 1.
  • Such activated antiperspirant aluminum salts are disclosed, for example, in US Pat. No. 6,074,632.
  • Preferred activated aluminum-zirconium salts are those of the general formula ZrO (OH) 2-P BYB, wherein Y is Cl, Br, I, NO3 or SO4, b is a rational number from 0.8 to 2 and p is the valence of Y is such that the Al: Zr molar ratio is from 2 to 10 and the metal: (X + Y) ratio is from 0.73 to 2.1, preferably from 0.9 to 1.5.
  • Such activated antiperspirant aluminum zirconium salts are disclosed, for example, in the aforementioned US Pat. No. 6,074,632.
  • a particularly preferred salt is aluminum-zirconium chlorohydrate (ie, X and Y are Cl) which has an Al: Zr ratio of 2 to 10 and a molar metal: Cl ratio of 0.9 to 2.1.
  • Preferred antiperspirant active compounds are disclosed in US 6,663,854 A and US 2004/0009133 A1.
  • Particularly preferred antiperspirant aluminum salts according to the invention have a molar metal-to-chloride ratio of 1.9 to 2.1.
  • the metal-to-chloride ratio of aluminum sesquichlorohydrates which is also particularly preferred in the invention is from 1.5: 1 to 1.8: 1.
  • Preferred aluminum zirconium tetrachlorohydrates have a molar ratio of Al: Zr of from 2 to 6 and of metal: chloride of from 0.9 to 1 .3, in particular salts having a molar metal to chloride ratio of from 0.9 to 1.1 , preferably from 0.9 to 1.0 are preferred.
  • a particularly effective hydrogel formation between lysozyme and / or bovine serum albumin (BSA) and / or yogurt protein and the antiperspirant aluminum salt is achieved when lysozyme and / or bovine serum albumin (BSA) and / or yoghurt protein in a Total amount of 0.05 to 15 wt .-%, preferably from 0.1 to 10 wt .-%, preferably from 0.3 to 5 wt .-%, more preferably from 0.5 to 7 wt .-%, still more preferably from 0.8 to 5 wt .-%, in particular from 1 to 3 wt .-%, based on the total weight of the antiperspirant cosmetic agent is included.
  • the cosmetic agent lysozyme and / or bovine serum albumin (BSA) and / or yoghurt protein in a total amount of 0.05 to 70 wt .-%, preferably from 0.5 to 60% by weight, preferably from 1 to 50% by weight, more preferably from 3 to 40% by weight, even more preferably from 5 to 35% by weight, especially from 8 to 25 Wt .-%, based on the total weight of the blowing agent-containing antiperspirant cosmetic agent is included.
  • BSA bovine serum albumin
  • the cosmetic agent lysozyme and / or bovine serum albumin (BSA) and / or yoghurt protein in a total amount of 0.05 to 50% by weight, preferably from 0.5 to 45 wt. -%, preferably from 1 to 35 wt .-%, more preferably from 3 to 29 wt .-%, even more preferably from 5 to 27 wt .-%, in particular from 8 to 25 wt .-%, based on the total weight of the blowing agent-containing antiperspirant cosmetic agent.
  • BSA bovine serum albumin
  • the antiperspirant cosmetic agents may contain lysozyme and / or bovine serum albumin (BSA) and / or yoghurt protein in a total amount of 0.05 to 35% by weight, preferably 0.3 to 30 Wt .-%, preferably 0.5 to 25% by weight, more preferably from 0.7 to 15 wt .-%, still more preferably from 1, 0 to 12 wt .-%, in particular from 1, 5 to 10 Wt .-%, based on the total weight of the blowing agent-containing antiperspirant cosmetic agent included.
  • BSA bovine serum albumin
  • the use of the abovementioned amount (s) of lysozyme and / or bovine serum albumin (BSA) and / or yoghurt protein results in significantly increased and extremely pH-selective hydrogel formation with the antiperspirant aluminum salt. In this way, an effective blockage of the excretory ducts of the sweat glands and thus an excellent antiperspirant effect is ensured. Furthermore, the use of the aforementioned amount (s) of lysozyme and / or bovine serum albumin (BSA) and / or yoghurt protein does not result in undesirable premature hydrogel formation in the antiperspirant cosmetic composition or on the skin surface, so that the excellent antiperspirant effect itself is ensured over long storage periods
  • the antiperspirant effect of the antiperspirant cosmetic agents of the invention can be further improved if the antiperspirant cosmetic agent has a weight ratio of the antiperspirant aluminum salt to lysozyme and / or bovine serum albumin (BSA) and / or yoghurt protein of 40: 1 to 19: 1, preferably 30 From 1 to 16: 1, preferably from 20: 1 to 15: 1, more preferably from 10: 1 to 13: 1, even more preferably from 9: 1 to 12: 1, in particular from 8: 1 to 1: 1, having.
  • BSA bovine serum albumin
  • the antiperspirant cosmetic agent has a weight ratio of the antiperspirant aluminum salt to lysozyme and / or bovine serum albumin (BSA) and / or yoghurt protein of 1: 1.5 to 1:50, preferably of 1: 2 to 1: 35, more preferably from 1: 2.5 to 1: 30, even more preferably from 1: 3 to 1: 25, in particular from 1: 3.5 to 1: 20.
  • the above weight ratio refers to the total amount of all antiperspirant aluminum salts and the total amount of lysozyme and / or bovine serum albumin (BSA) and / or yoghurt protein in the antiperspirant cosmetic agent.
  • the weight ratio of the antiperspirant aluminum salt to lysozyme and / or bovine serum albumin (BSA) and / or yoghurt protein is 1, 5: 1.
  • the use of a weight ratio of the antiperspirant aluminum salt leads to lysozyme and / or Bovine serum albumin (BSA) and / or yogurt protein of 10: 1 to antiperspirant cosmetic agents according to the invention, which have an excellent antiperspirant effect.
  • protic solvents in particular in high concentrations or amounts, can be used without the antiperspirant effect of the antiperspirant cosmetic agents according to the invention being adversely affected, so that an extremely flexible formulation of the compositions according to the invention is possible.
  • the antiperspirant cosmetic agent contains no zirconium-containing compounds.
  • zirconium-containing antiperspirant compounds such as zirconium-aluminum mixed salts results in the more cost-effective provision of the antiperspirant cosmetic agents of the invention, since the raw materials for the production of zirconium-containing compounds have higher prices.
  • the antiperspirant cosmetic agent preferably contains free water in a total amount of less than 10% by weight, preferably less than 8% by weight, preferably less than 5% by weight, more preferably less than 3% by weight. even more preferably less than 1% by weight, in particular 0% by weight, based on the total weight of the antiperspirant cosmetic agent.
  • free water is thus understood to mean water which is different from water of crystallization, water of hydration or similar molecularly bound water of the constituents used, in particular the antiperspirant aluminum salts.
  • the blockage of the excretory ducts of the sweat glands can be significantly increased by a hydrogel formation which occurs when at least one antiperspirant aluminum salt is combined with lysozyme and / or bovine serum albumin (BSA) and / or yoghurt protein, if the antiperspirant cosmetic according to the invention Agent free water in an amount of 15 to 96 wt .-%, based on the total weight of the antiperspirant cosmetic agent included.
  • BSA bovine serum albumin
  • the antiperspirant cosmetic agent therefore contains free water in a total amount of 15 to 96 wt .-%, preferably from 25 to 80 wt .-%, preferably from 30 to 70 wt .-%, in particular from 40 to 60 wt .-%, based on the total weight of the antiperspirant cosmetic agent.
  • the antiperspirant cosmetic agents according to the invention are preferably in the form of a suspension of the undissolved antiperspirant aluminum salt in the cosmetic oil which is liquid at 20 ° C. and 1013 hPa.
  • the antiperspirant cosmetic agent is present as a water-in-oil emulsion.
  • This may in particular be a sprayable water-in-oil emulsion, which can be sprayed by means of a propellant.
  • the present invention in the form of a water-in-oil emulsion antiperspirant cosmetic agent lysozyme and / or bovine serum albumin (BSA) and / or yogurt protein in a total amount of 0.05 to 20 wt.
  • BSA bovine serum albumin
  • -% preferably from 0.1 to 15 wt .-%, preferably from 0.3 to 10 wt .-%, more preferably from 0.5 to 7 wt .-%, still more preferably from 0.8 to 5 wt .-%, in particular from 1 to 3 wt .-%, based on the total weight of the antiperspirant cosmetic agent contains.
  • the antiperspirant cosmetic agent is present as an oil-in-water emulsion.
  • the agent according to the invention is preferably sprayed as a propellant-free pump spray or Ouetschspray or applied as a roll-on.
  • the antiperspirant cosmetic agent present in the form of an oil-in-water emulsion comprises lysozyme and / or bovine serum albumin (BSA) and / or yoghurt protein in a total amount of 0.05 to 20% by weight.
  • BSA bovine serum albumin
  • the cosmetic agent lysozyme and / or bovine serum albumin (BSA) and / or yoghurt protein in a total amount of 0.05 to 50 wt .-%, preferably from 0.1 to 45 parts by weight.
  • BSA bovine serum albumin
  • % preferably from 0.3 to 35% by weight, more preferably from 0.5 to 29% by weight, even more preferably from 0.8 to 27% by weight, in particular from 1 to 25% by weight , based on the total weight of the blowing agent-containing antiperspirant cosmetic agent.
  • the antiperspirant cosmetic agent is present as an aqueous, aqueous-alcoholic or aqueous-glycolic solution.
  • an antiperspirant aluminum salt with lysozyme and / or bovine serum albumin (BSA) and / or yoghurt protein Owing to the combination according to the invention of an antiperspirant aluminum salt with lysozyme and / or bovine serum albumin (BSA) and / or yoghurt protein, even protic solvents, such as aqueous solutions, can be used to formulate the antiperspirant cosmetic agents according to the invention without a significant reduction in antiperspirant activity .
  • the addition of lysozyme and / or bovine serum albumin (BSA) and / or yoghurt protein ensures effective closure of the excretory ducts of the sweat glands, even when protic solvents are used, and thus provides excellent antiperspirant activity.
  • the antiperspirant cosmetic agent contains ethanol in a total amount of 1 to 90 wt .-%, preferably from 5 to 70 wt .-%, preferably from 7 to 50 wt .-%, in particular from 10 to 30 Wt .-%, based on the total weight of the antiperspirant cosmetic agent.
  • the antiperspirant cosmetic agent ethanol in a total amount of 10 to 95 wt .-%, preferably from 15 to 90 wt .-%, preferably from 20 to 87 wt .-%, more preferably from 30 to 85 wt .-%, in particular from 40 to 80 wt .-%, based on the total weight of the antiperspirant cosmetic agent contains.
  • the use of lysozyme and / or bovine serum albumin (BSA) and / or yoghurt protein may even use high levels of protic solvents, such as ethanol, without adversely affecting the antiperspirant activity of the antiperspirant cosmetic of the present invention.
  • the antiperspirant cosmetic agent is formulated as a spray application.
  • the spray application is carried out with a spray device which contains a filling of the liquid, viscous-flowable, suspension-shaped or powdered antiperspirant cosmetic agent according to the invention in a container.
  • the filling may be under the pressure of a propellant (compressed gas cans, compressed gas packages, aerosol dispensers), or it may be a mechanically operated pump sprayer without propellant (pump sprays / squeeze bottle).
  • the containers have a removal device, preferably in the form of valves, which allow the removal of the contents as a mist, smoke, foam, powder, paste or liquid jet.
  • Cylindrical vessels made of metal (aluminum, tinplate, volume preferably not more than 1 .000 ml), protected or non-splintering glass or plastic (preferably a maximum of 220 ml) or splintering glass or plastic (volume preferably 50) are used as containers for the spraying devices to 400 ml) in question.
  • Cream, gel, pasty and liquid agents may e.g. be packaged in pump, spray or squeeze dispensers, especially in multi-chamber pump, multi-chamber spray or multi-chamber squeeze dispensers.
  • the packaging for the compositions according to the invention may be opaque, but also transparent or translucent.
  • the antiperspirant cosmetic is preferably formulated as a stick, soft solid, cream, roll-on, dibenzylidenalditol-based gel, loose or compact powder.
  • the wording of the Antiperspirant cosmetic agents according to the invention in a particular dosage form, such as, for example, an antiperspirant roll-on, an antiperspirant stick or an antiperspirant gel preferably conforms to the requirements of the intended use.
  • the antiperspirant cosmetic agents according to the invention can therefore be present in solid, semisolid, liquid, disperse, emulsified, suspended, gelatinous, multiphase or powdery form.
  • the term liquid also includes any types of solid dispersions in liquids.
  • multiphase antiperspirant cosmetic agents are also understood to mean agents which have at least two different phases with a phase separation and in which the phases can be arranged horizontally, ie one above the other, or vertically, ie side by side.
  • the application can be done, for example, with a roller ball applicator.
  • rollers have a ball mounted in a ball bed, which can be moved by movement over a surface.
  • the ball absorbs some of the antiperspirant cosmetic agent according to the invention to be distributed and conveys it to the surface to be treated.
  • the packaging for the compositions according to the invention can, as stated above, be opaque, transparent or translucent.
  • the antiperspirant cosmetic agent is contained on and / or in a disposable substrate selected from the group of wipes, pads and bulbs.
  • a disposable substrate selected from the group of wipes, pads and bulbs.
  • wet wipes ie prefabricated for the user, preferably individually packaged, wet wipes, as they are for. B. from the field of glass cleaning or from the field of wet toilet paper are well known.
  • Such wet wipes which can advantageously also contain preservatives, are impregnated or applied with an antiperspirant cosmetic agent according to the invention and preferably individually packaged. You can z. B. be used as a deodorant cloth, which is particularly interesting for use on the go.
  • Preferred substrate materials are selected from porous sheet-like cloths.
  • wipes can be made of a fibrous or cellular flexible material which has sufficient mechanical stability and softness for application to the skin.
  • wipes include wipes of woven and nonwoven synthetic and natural fibers, felt, paper or foam, such as hydrophilic polyurethane foam.
  • Deodorising or antiperspirant substrates preferred according to the invention can be obtained by impregnation or impregnation or by melting a sweat-inhibiting cosmetic agent according to the invention on a substrate.
  • the antiperspirant cosmetic agents of the present invention may further contain other adjuvants.
  • the antiperspirant cosmetic agents according to the invention preferably contain at least one wide adjuvant selected from the group of (i) emulsifiers and / or surfactants; (ii) thickeners; (iii) chelating agents; (iv) deodorant agents; (v) monohydric and / or polyhydric alcohols and / or polyethylene glycols; (vi) skin-cooling agents; (vii) propellants; (viii) preservatives and (ix) their mixtures.
  • Emulsifiers and surfactants which are preferably suitable according to the invention are selected from anionic, cationic, nonionic, amphoteric, in particular ampholytic and zwitterionic emulsifiers and surfactants.
  • Surfactants are amphiphilic (bifunctional) compounds which consist of at least one hydrophobic and at least one hydrophilic moiety.
  • the hydrophobic moiety is preferably a hydrocarbon chain of 8 to 28 carbon atoms, which may be saturated or unsaturated, linear or branched. Most preferably, this C8-C28 alkyl chain is linear.
  • anionic surfactants surfactants with exclusively anionic charges; they contain z.
  • carboxyl groups sulfonic acid groups or sulfate groups.
  • Particularly preferred anionic surfactants are alkyl sulfates, alkyl ether sulfates, acyl glutamates and Cs-24-carboxylic acids and their salts, the so-called soaps.
  • Cationic surfactants are understood as meaning surfactants with exclusively cationic charges; they contain z.
  • Preferred esterquats are quaternized ester salts of fatty acids with triethanolamine, quaternized ester salts of fatty acids with diethanolalkylamines and quaternized ester salts of fatty acids with 1,2-dihydroxypropyldialkylamines.
  • amphoteric surfactants are subdivided into ampholytic surfactants and zwitterionic surfactants.
  • Ampholytic surfactants are understood as meaning those surface-active compounds which have both acidic (for example -COOH or -SCbH groups) and basic hydrophilic groups (for example amino groups) and thus behave acidic or basic depending on the condition.
  • zwitterionic surfactants the person skilled in the art understands surfactants which are in the same molecule carry both a negative and a positive charge.
  • Examples of preferred zwitterionic surfactants are the betaines, the N-alkyl-N, N-dimethylammonium glycinates, the N-acyl-aminopropyl-N, N-dimethylammoniumglycinate and the 2-alkyl-3-carboxymethyl-3-hydroxyethyl-imidazoline with each 8 to 24 carbon atoms in the alkyl group.
  • ampholytic surfactants are N-alkylglycines, N-alkylaminopropionic acids, N-alkylaminobutyric acids, N-alkyliminodipropionic acids, N-hydroxyethyl-N-alkylamidopropylglycines, N-alkyltaurines, N-alkylsarcosines, 2-alkylaminopropionic acids and alkylaminoacetic acids each having 8 to 24 carbon atoms in the alkyl group
  • compositions of the invention which are formulated as an emulsion, in particular as an oil-in-water emulsion, preferably contain at least one nonionic oil-in-water emulsifier having an HLB value of more than 7 to 20.
  • nonionic oil-in-water emulsifier having an HLB value of more than 7 to 20.
  • L is the weight fraction of the lipophilic groups, that is the fatty alkyl or fatty acyl groups, in the ethylene oxide adducts, expressed in weight percent.
  • a water-in-oil emulsifier having an HLB value of greater than 1.0 and less than or equal to 7.0 is used.
  • Nonionic oil-in-water emulsifiers suitable for the purposes of the present invention and suitable nonionic water-in-oil emulsifiers are described, for example, in German Offenlegungsschrift DE 10 2006 004 957 A1.
  • Substances which are selected from cellulose ethers, especially hydroxyalkylcelluloses, in particular hydroxypropylcellulose, hydroxypropylmethylcellulose, hydroxyethylcellulose, carboxymethylcellulose, cetylhydroxyethylcellulose, hydroxybutylmethylcellulose, methylhydroxyethylcellulose, furthermore xanthan gum, sclerotium gum, succinoglucans, polygalactomannans, are preferably used for thickening the antiperspirant cosmetic agents according to the invention , in particular guar gums and locust bean gum, in particular guar gum and locust bean gum itself and the nonionic hydroxyalkyl guar derivatives and locust bean gum derivatives such as hydroxypropyl guar, carboxymethylhydroxypropyl guar, hydroxypropyl methyl guar, hydroxyethyl guar and carboxymethyl guar, furthermore pectins, agar, carrageenans (Carrageenan), tragacan
  • Particularly preferred thickeners are selected from cellulose ethers, especially from hydroxyalkylcelluloses, in particular from hydroxypropylcellulose, hydroxypropylmethylcellulose, hydroxyethylcellulose, carboxymethylcellulose, cetylhydroxyethylcellulose, hydroxybutylmethylcellulose and methylhydroxyethylcellulose, and also mixtures thereof. Hydroxyethyl cellulose is preferably used as thickener.
  • the antiperspirant cosmetic agents according to the invention may comprise at least one chelating agent selected of ethylenediaminetetraacetic acid (EDTA) and its salts, and of nitrilotriacetic acid (NTA) and mixtures of these substances, in a total amount of from 0.01 to 0.5% by weight, preferably from 0.02 to 0.3% by weight, in particular from 0.05 to 0.1% by weight, based on the total weight of the antiperspirant agent according to the invention.
  • EDTA ethylenediaminetetraacetic acid
  • NTA nitrilotriacetic acid
  • chelating agents which are selected from the group of ⁇ -alaninediacetic acid, cyclodextrin, diethylenetriaminepentamethylenephosphonic acid, sodium, potassium, calcium disodium, ammonium and triethanolamine salts of ethylenediaminetetraacetic acid (EDTA), etidronic acid, hydroxyethylethylenediaminetetraacetic acid ( HEDTA) and its sodium salts, sodium salts of nitrilotriacetic acid (NTA), diethylenetriaminepentaacetic acid, phytic acid, hydroxypropyl cyclodextrin, methylcyclodextrin, aminotrimethylene phosphonate pentasodium, ethylenediamine pentasodium, diethylene pentasodium, pentasodium triphosphate, potassium EDTMP, sodium EDTMP, Natriumdihydroxyethylglycinat, sodium phytate, Natriumpolydimethylglyce
  • Tetrasodiumiminodisuccinate Tetrasodiumiminodisuccinate, trisodium ethylenediamine disuccinate and desferrioxamine.
  • the antiperspirant effect of the antiperspirant cosmetic agents according to the invention can be further increased if at least one deodorant active ingredient in a total amount of 0.0001 to 40 wt .-%, preferably from 0.2 to 20 wt .-%, preferably from 1 to 15 wt .-%, in particular from 1, 5 to 5 wt .-%, based on the total weight of the antiperspirant cosmetic agent according to the invention, is included. If ethanol is used in the compositions according to the invention, this does not apply in the context of the present invention as a deodorant active ingredient, but as a constituent of the carrier.
  • Deodorant agents which are preferred according to the invention are selected from the group of (i) silver salts; (ii) aromatic alcohols, in particular 2-benzylheptan-1-ol and mixtures of 2-benzylheptan-1-ol and phenoxyethanol; (iii) 1,2-alkanediols having 5 to 12 carbon atoms, especially 3- (2-ethylhexyloxy) -1,2-propanediol; (iv) triethyl citrate; (v) agents against exoesterases, in particular against arylsulfatase, lipase, beta-glucuronidase and Cystathione-beta-lyase; (vi) cationic phospholipids; (vii) odor absorbers, especially silicates such as montmorillonite, kaolinite, hit, beidellite, nontronite, saponite, hectorite, bentonite, smectite and talc,
  • Preferred antiperspirant cosmetic agents according to the invention also contain at least one water-soluble polyhydric C 2-9 -alkanol having 2 to 6 hydroxyl groups and / or at least one water-soluble polyethylene glycol having 3 to 50 ethylene oxide units and mixtures thereof. This does not include the abovementioned deodorant active ingredients in the form of 1, 2-alkanediols.
  • Preferred alkanols are selected from 1, 2-propylene glycol, 2-methyl-1, 3-propanediol, glycerol, 1, 2-butylene glycol, 1, 3-butylene glycol, 1, 4-butylene glycol, pentylene glycols such as 1, 2-pentanediol and 1, 5-pentanediol, hexanediols such as 1, 2-hexanediol and 1, 6-hexanediol, hexanetriols such as 1, 2,6-hexanetriol, 1, 2-octanediol, 1, 8-octanediol, dipropylene glycol, tripropylene glycol, diglycerol, triglycerol , Erythritol, sorbitol, cis-1,4-dimethylolcyclohexane, trans-1,4-dimethylolcyclohexane, any mixtures of isomers
  • Suitable water-soluble polyethylene glycols are selected from PEG-3, PEG-4, PEG-6, PEG-7, PEG-8, PEG-9, PEG-10, PEG-12, PEG-14, PEG-16, PEG-18 and PEG-20 and mixtures thereof, with PEG-3 to PEG-8 being preferred.
  • the antiperspirant cosmetic agents further contain at least one skin-cooling agent.
  • Skin-cooling active ingredients suitable according to the invention are, for example, menthol, isopulegol and menthol derivatives, eg. Eg menthyl lactate, menthyl glycolate, menthyl ethyl oxamate, menthyl pyrrolidone carboxylic acid, menthyl methyl ether, menthoxy propane diol, menthone glycerol acetal (9-methyl-6- (1-methylethyl) -1, 4-dioxaspiro (4.5) decane-2-methanol), monomethyl succinate, 2 -Hydroxymethyl-3,5,5-trimethylcyclohexanol and 5-methyl-2- (1-methylethyl) cyclohexyl-N-ethyloxamate.
  • Preferred skin-cooling active ingredients are menthol, isopulegol, menthyl lactate, menthoxypropanediol, menthylpyrrolidonecarboxylic acid and 5-methyl-2- (1-methylethyl) cyclohexyl-N-ethyloxamate, as well as mixtures of these substances, in particular mixtures of menthol and menthyl lactate, menthol, menthol glycolate and menthyl lactate, menthol and menthoxypropanediol or menthol and isopulegol.
  • the antiperspirant cosmetic agents according to the invention contain a propellant.
  • propellants are propane, propene, n-butane, isobutane, isobutene, n-pentane, pentene, isopentane, isopentene, methane, ethane, dimethyl ether, nitrogen, air, oxygen, nitrous oxide, 1, 1, 1, 3-tetrafluoroethane, heptafluoro-n-propane, perfluoroethane, monochlorodifluoromethane, 1, 1 - Difluoroethane, tetrafluoropropenes, both individually and in their mixtures.
  • hydrophilic propellants such as carbon dioxide
  • hydrophilic propellants such as carbon dioxide
  • lipophilic propellant gas eg., Propane / butane
  • propane, n-butane, isobutane and mixtures of these propellants propane, n-butane, isobutane and mixtures of these propellants. It has been found that the use of n-butane as the only propellant gas according to the invention can be particularly preferred.
  • the total amount of the blowing agent is 20 to 95 wt.%, Preferably 30 to 85 wt.%, In particular 40 to 75 wt .-%, each based on the total weight of the antiperspirant, consisting of the inventive antiperspirant cosmetic agent, the blowing agent and optionally further excipients.
  • the total amount of blowing agent 1 to 95 wt .-%, preferably 2 to 85 wt .-%, in particular 3 to 75 wt .-%, .-%, each based on the total weight of Antiperspirant, consisting of the antiperspirant cosmetic agent of the invention and the propellant is.
  • lipophilic thickeners can furthermore be used according to the invention.
  • the at least one antiperspirant aluminum salt is preferably suspended undissolved in at least one cosmetic oil which is liquid at 20 ° C. and 1 .013 hPa.
  • at least one lipophilic thickener may be added to this suspension as a suspending aid.
  • Lipophilic thickeners preferred according to the invention are selected from hydrophobized clay minerals and fumed silicic acids.
  • the antiperspirant cosmetic agents of the present invention may further contain at least one preservative.
  • Preservatives preferred according to the invention are formaldehyde releasers (such as, for example, 1,3-dimethylol-4,4-dimethylhydantoin, INCI name DMDM hydantoin, available, for example, under the trade name Glydant from Lonza), iodopropynyl butyl carbamates, such as 3-iodo-2-propynyl butyl carbamate (e.g., those available under the trade designations Glycacil-L, Glycacil-S from Lonza, and / or Dekaben LMB from Jan Dekker), parabens (ie, p-hydroxybenzoic acid alkyl esters, such as methyl, ethyl , Propyl and / or butylparaben), phenoxyethanol, ethanol, benzoic acid, dibromodicyanobut
  • preservatives which can be used in the context of the present invention are the substances listed in Annex 6 of the Cosmetics Regulation.
  • the preservatives are preferably in a total amount of 0.01 to 10 wt .-%, preferably from 0.1 to 7 wt .-%, preferably from 0.2 to 5 wt .-%, in particular from 0.3 to 2, 0 wt .-%, based on the total weight of the antiperspirant cosmetic agent included.
  • the antiperspirant cosmetic agents according to the invention are characterized in that they are formulated as a water-in-oil emulsion and - based on the total weight of the antiperspirant cosmetic agent according to the invention - at least one antiperspirant aluminum salt in a total amount of 2 to 75 wt. -%, preferably 3 to 70 wt .-%, preferably 4 to 65 wt .-%, more preferably 5 to 55 wt .-%, even more preferably 8 to 40 wt .-%, in particular 10 to 30 wt .-% .
  • BSA bovine serum albumin
  • the lysozyme and / or bovine serum albumin (BSA) and / or yoghurt protein in a total amount of 0.05 to 70 wt .-%, preferably from 0.1 to 60 % By weight, preferably from 0.5 to 50% by weight, more preferably from 1 to 40% by weight, even more preferably from 2 to 30% by weight, in particular from 3 to 25% by weight, based on the total weight of the antiperspirant cosmetic agent.
  • BSA bovine serum albumin
  • the antiperspirant cosmetic agents according to the invention are characterized in that they are formulated as an oil-in-water emulsion and - based on the total weight of the antiperspirant cosmetic agent according to the invention - at least one antiperspirant aluminum salt in a total amount of 2 to 75 wt %, preferably 3 to 70% by weight, preferably 4 to 65% by weight, more preferably 5 to 55% by weight, even more preferably 8 to 40% by weight, in particular 10 to 30% by weight. %
  • BSA bovine serum albumin
  • the lysozyme and / or bovine serum albumin (BSA) and / or yoghurt protein in a total amount of 0.05 to 70 wt .-%, preferably from 0.1 to 60 % By weight, preferably from 0.5 to 50% by weight, more preferably from 1 to 40% by weight, even more preferably from 2 to 30% by weight, in particular from 3 to 25% by weight, based on the total weight of the antiperspirant cosmetic agent.
  • BSA bovine serum albumin
  • a further preferred embodiment of the present invention comprises antiperspirant cosmetic agents according to the invention, which are characterized in that they comprise, based on the total weight of the antiperspirant cosmetic agent according to the invention, at least one antiperspirant aluminum salt in a total amount of 2 to 75% by weight, preferably 3 to 70 wt .-%, preferably 4 to 65 wt .-%, more preferably 5 to 55 wt .-%, even more preferably 8 to 40 wt .-%, in particular 10 to 30 wt .-%,
  • BSA bovine serum albumin
  • the lysozyme and / or bovine serum albumin (BSA) and / or yoghurt protein in a total amount of 0.05 to 70 wt .-%, preferably from 0.1 to 60 % By weight, preferably from 0.5 to 50% by weight, more preferably from 1 to 40% by weight, even more preferably from 2 to 30% by weight, in particular from 3 to 25% by weight, based on the total weight of the antiperspirant cosmetic agent.
  • BSA bovine serum albumin
  • a further preferred embodiment of the present invention comprises antiperspirant cosmetic agents according to the invention, which are characterized in that they comprise, based on the total weight of the antiperspirant cosmetic agent according to the invention, at least one antiperspirant aluminum salt in a total amount of 2 to 75% by weight, preferably 3 to 70 wt .-%, preferably 4 to 65 wt .-%, more preferably 5 to 55 wt .-%, even more preferably 8 to 40 wt .-%, in particular 10 to 30 wt .-%, Lysozyme and / or bovine serum albumin (BSA) and / or yoghurt protein in a total amount of 0.05 to 20 wt.%, Preferably 0.1 to 15 wt.%, Preferably 0.3 to 10 wt. %, more preferably 0.5 to 7 wt .-%, even more preferably 0.8 to 5 wt .-%, in particular 1 to 3 wt .-%,
  • the antiperspirant cosmetic agents according to the invention have a dynamic viscosity in the range from 10 to 5000 mPas, preferably from 100 to 1000 mPas, preferably from 200 to 800 mPas, measured with a Brookfield viscometer, spindle RV 4, 20 s, without Helipath at 20 ° C ambient temperature and 20 ° C sample temperature.
  • the lysozyme and / or bovine serum albumin (BSA) and / or yoghurt protein in a total amount of 0.05 to 70 wt .-%, preferably from 0.1 to 60 % By weight, preferably from 0.5 to 50% by weight, more preferably from 1 to 40% by weight, even more preferably from 2 to 30% by weight, in particular from 3 to 25% by weight, based on the total weight of the antiperspirant cosmetic agent.
  • BSA bovine serum albumin
  • a further preferred embodiment of the present invention comprises antiperspirant cosmetic agents according to the invention, which are characterized in that they comprise, based on the total weight of the antiperspirant cosmetic agent according to the invention, at least one antiperspirant aluminum salt in a total amount of 2 to 75% by weight, preferably 3 to 70 wt .-%, preferably 4 to 65 wt .-%, more preferably 5 to 55 wt .-%, even more preferably 8 to 40 wt .-%, in particular 10 to 30 wt .-%,
  • BSA bovine serum albumin
  • the antiperspirant cosmetic agents according to the invention have a dynamic viscosity in the range of 1 .000 to 800,000 mPas, preferably from 2,000 to 700,000 mPas, preferably from 3,000 to 500,000 mPas, measured with a Brookfield viscometer, spindle RV 4, 20 s "1 , without Helipath, at 20 ° C ambient temperature and 20 ° C sample temperature.
  • the antiperspirant cosmetic agents according to the invention are characterized in that they are formulated as a water-in-oil emulsion and - based on the total weight of the antiperspirant cosmetic agent according to the invention - at least one antiperspirant aluminum salt in a total amount of 2 to 75 wt %, preferably 3 to 70% by weight, preferably 4 to 65% by weight, more preferably 5 to 55% by weight, even more preferably 8 to 40% by weight, in particular 10 to 30% by weight. %
  • BSA bovine serum albumin
  • the lysozyme and / or bovine serum albumin (BSA) and / or yoghurt protein in a total amount of 0.05 to 70 wt .-%, preferably from 0.1 to 60 % By weight, preferably from 0.5 to 50% by weight, more preferably from 1 to 40% by weight, even more preferably from 2 to 30% by weight, in particular from 3 to 25% by weight, based on the total weight of the antiperspirant cosmetic agent.
  • BSA bovine serum albumin
  • the antiperspirant cosmetic agents according to the invention are characterized in that they are formulated as an oil-in-water emulsion and - based on the total weight of the antiperspirant cosmetic agent according to the invention - at least one antiperspirant aluminum salt in a total amount of 2 to 75 wt %, preferably 3 to 70% by weight, preferably 4 to 65% by weight, more preferably 5 to 55% by weight, even more preferably 8 to 40% by weight, in particular 10 to 30% by weight. %
  • BSA bovine serum albumin
  • wt .-% optionally 0.01 to 2 wt .-%, preferably 0.1 to 1 wt .-%, preferably 0.2 to 0.7 wt .-%, in particular 0.3 to 0.5 wt .-% of a hydrogel forming substance
  • the Lysozyme and / or bovine serum albumin (BSA) and / or yoghurt protein in a total amount of 0.05 to 70 wt .-%, preferably from 0.1 to 60 wt .-%, preferably from 0.5 to 50 wt .-%, more preferably from 1 to 40 wt .-%, even more preferably from 2 to 30 wt .-%, in particular from 3 to 25 wt .-%, based on the total weight of the antiperspirant cosmetic agent contained.
  • BSA bovine serum albumin
  • compositions according to the invention can therefore, as kit-of-parts, containing, separated from one another, a) at least one first container containing a cosmetic agent comprising at least one antiperspirant aluminum-containing compound, and
  • a cosmetic agent comprising lysozyme and / or bovine serum albumin (BSA) and / or yoghurt protein, wherein the cosmetic agent less than 0.5 wt .-%, preferably less than 0.2 wt. %, preferably less than 0.05% by weight, more preferably less than 0.005% by weight, in particular 0% by weight, of aluminum-containing compounds,
  • BSA bovine serum albumin
  • aluminum-containing compounds is understood to mean antiperspirant aluminum salts and aluminum-zirconium salts.
  • a second object of the present invention is the use of a combination of at least one substance selected from the group of cosmetic oils which are liquid at 20 ° C. and 1 .013 hPa, fragrances and waxes, at least one antiperspirant aluminum salt in a total amount of 0, 1 to 80% by weight, based on the total weight of the combination, and lysozyme and / or bovine serum albumin (BSA) and / or yoghurt protein, to reduce and / or prevent perspiration.
  • cosmetic oils which are liquid at 20 ° C. and 1 .013 hPa
  • fragrances and waxes at least one antiperspirant aluminum salt in a total amount of 0, 1 to 80% by weight, based on the total weight of the combination
  • BSA bovine serum albumin
  • the term "combination" in the sense of the present invention also comprises a mixture of the at least one substance and the antiperspirant aluminum salt with lysozyme and / or bovine serum albumin (BSA) and / or yoghurt protein.
  • BSA bovine serum albumin
  • a third aspect of the present invention is a non-therapeutic cosmetic method for preventing and / or reducing transpiration of the body, which comprises an antiperspirant cosmetic agent containing at least one selected from the group of cosmetic oils at 20 ° C and 1.013 hPa are liquid, fragrances and growing, at least one antiperspirant aluminum salt in a total amount of 0.1 to 80 wt .-%, based on the total weight of the antiperspirant cosmetic agent, and lysozyme and / or bovine serum albumin (BSA) and / or yoghurt protein, on the skin , in particular on the skin of the armpits, is applied.
  • an antiperspirant cosmetic agent containing at least one selected from the group of cosmetic oils at 20 ° C and 1.013 hPa are liquid, fragrances and growing, at least one antiperspirant aluminum salt in a total amount of 0.1 to 80 wt .-%, based on the total weight of the antiperspirant cosmetic agent, and lyso
  • a cosmetic agent containing an antiperspirant aluminum salt and then an aluminum salt-free cosmetic agent containing lysozyme and / or bovine serum albumin (BSA) and / or yoghurt protein is applied.
  • BSA bovine serum albumin
  • the time between application of the two remedies is from 10 seconds to 24 hours.
  • a fourth object of the present invention is the use of lysozyme and / or bovine serum albumin (BSA) and / or yoghurt protein to enhance the closure of the sweat gland (s) and / or to occlude the sweat gland (s) in combination with aluminum salts.
  • BSA bovine serum albumin
  • Closure of the sweat gland (s) is the formation of a hydrogel and / or precipitate of the at least one antiperspirant aluminum salt and lysozyme and / or bovine serum albumin (BSA) and / or yoghurt protein in the excretory duct of the sweat gland or the excretory ducts of the sweat glands to understand.
  • occlusion is also understood as meaning the support of the formation of a precipitate of the antiperspirant aluminum salt by the addition of lysozyme and / or bovine serum albumin (BSA) and / or yoghurt protein. This occlusion avoids or reduces secretion of sweat from the duct.
  • a beaker 100 ml of demineralized water are introduced and then added 35 ml of a dilution of the solution indicated in Table 1.
  • the solutions from Table 1 are diluted in a beaker to an aluminum salt content of 1, 25 wt .-% and the turbidity of the solution with a Methrom Optrode 6.11 15,000 at a wavelength of 574 nm (greenish yellow) in mV (resolution 0.1 mV ).
  • the pH of the solution in the beaker is adjusted to pH 6.5 to 6.6 by addition of a 2% sodium bicarbonate solution with stirring.
  • the turbidity of the solution is measured again. The higher the turbidity of the solution, the lower the measured value obtained in mV. Each measurement is carried out twice and from this the mean value is formed.
  • the turbidity is a measure of the potential of the mixture for hydrogel formation.
  • E-Ill 312 The addition of the lysozyme, the bovine serum albumin (BSA) and the yoghurt protein to a Aluminiumchlorohydratants leads at a pH of 6.5 to 6.6 in the inventive samples El, E-II and E-III to a significantly higher turbidity or Hydrogel formation as in comparative sample VI.
  • the addition of the lysozyme and / or bovine serum albumin (BSA) and / or the yoghurt protein enhances hydrogel formation and ensures effective closure of the ducts of the sweat glands.
  • Antiperspirant cosmetic agents according to the invention (amounts in% by weight)
  • bovine serum albumin BSA
  • BSA bovine serum albumin
  • Cyclomethicone (at least 95% by weight cyclopentad ad ad ad siloxane) 100 100 100 100 100 100 100 100 100 100 100 100 Antiperspirant cosmetic agents according to the invention in the form of an oil-in-water emulsion (amounts in% by weight)
  • Antiperspirant cosmetic agents according to the invention in the form of microemulsions (in% by weight)
  • a single-layer substrate of 100% viscose having a weight per unit area of 50 g / m 2 was applied to 75 g each of the exemplary emulsions 14 or 15 per square meter or 75 g each of the exemplary compositions 10 and 11, respectively , cut into cloths of suitable size and packed in sachets.
  • Antiperspirant cosmetic agents according to the invention in the form of a water-in-oil emulsion (amounts in% by weight)
  • Antiperspirant cosmetic agents according to the invention (amounts in% by weight)
  • Antiperspirant cosmetic agents according to the invention (amounts in% by weight, based on the total weight of the blowing agent-free composition)
  • Example compositions 26-29 were charged to an aluminum spray can optionally coated with epoxy-phenolic paint in a weight ratio of propellant (butane / propane / isobutane mixture) to suspension of 80:20, 85:15, 60:40 and 90:10, respectively.
  • propellant butane / propane / isobutane mixture
  • Antiperspirant cosmetic agents according to the invention (amounts in% by weight, based on the total weight of the blowing agent-free composition)
  • Example compositions 30-32 were packed into an optionally epoxy-phenolic varnish-sprayed aluminum spray can in a weight ratio of propellant (butane / propane / isobutane mixture) to suspension of 80:20, 85:15, 60:40 and 90:10, respectively.
  • propellant butane / propane / isobutane mixture
  • Antiperspirant cosmetic agents according to the invention in the form of O / W emulsions (amounts in parts by weight)
  • Antiperspirant cosmetic agents according to the invention (amounts in% by weight, based on the total weight of the blowing agent-free composition)
  • Example compositions 36-39 were packed into an optionally epoxy-phenolic lacquer sprayed aluminum spray can in a weight ratio of propellant (butane / propane / isobutane mixture) to suspension of 80:20, 85:15, 60:40 and 90:10, respectively.
  • propellant butane / propane / isobutane mixture
  • Antiperspirant cosmetic compositions according to the invention in the form of W / O emulsions (amounts in% by weight)
  • Lysozyme and / or bovine serum albumin (BSA) 2.50 1.00 3.00 0.500 and / or yoghurt protein
  • Plantar ® 2000 DECYL GLUCOSIDE about 50% AS BASF

Abstract

La présente invention concerne un produit cosmétique antitranspirant, contenant a) au moins une substance choisie dans le groupe constitué par les huiles cosmétiques qui sont à l'état liquide à une température de 20 °C et sous une pression de 1,013 hPa, les parfums et les cires, b) au moins un sel d'aluminium antitranspirant en quantité totale de 0,1 à 80 % en poids, rapportée au poids total du produit cosmétique antitranspirant, et c) du lysozyme et/ou de l'albumine de sérum bovin (ASB) et/ou de la protéine de yaourt, l'ajout de lysozyme et/ou d'albumine de sérum bovin (ASB) et/ou de protéine de yaourt ayant pour effet un blocage efficace des canaux excréteurs des glandes sudoripares.
PCT/DE2014/200270 2013-12-11 2014-06-18 Produits cosmétiques antitranspirants contenant du lysozyme et/ou de l'albumine de sérum bovin et/ou de la protéine de yaourt WO2015085996A1 (fr)

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