WO2015078216A1 - Procédé de traitement d'infections fongiques, compositions fongicides et leur utilisation - Google Patents

Procédé de traitement d'infections fongiques, compositions fongicides et leur utilisation Download PDF

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Publication number
WO2015078216A1
WO2015078216A1 PCT/CN2014/086107 CN2014086107W WO2015078216A1 WO 2015078216 A1 WO2015078216 A1 WO 2015078216A1 CN 2014086107 W CN2014086107 W CN 2014086107W WO 2015078216 A1 WO2015078216 A1 WO 2015078216A1
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carbendazim
thiophanate
methyl
component
composition
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PCT/CN2014/086107
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English (en)
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James Timothy BRISTOW
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Rotam Agrochem International Company Limited
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Priority to CN201480065350.4A priority Critical patent/CN105792655A/zh
Publication of WO2015078216A1 publication Critical patent/WO2015078216A1/fr

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647—Triazoles; Hydrogenated triazoles
    • A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Definitions

  • the present invention relates to a method of preventing and/or treating fungal infestations in plants and plant parts comprising (1) preparing a fungicidal composition comprising a component (A) at least one triazoles and a component (B) at least one benzimidazoles; and (2) applying the fungicidal composition on the plants or plant parts or on a locus at specific growth stages of the plants or plant parts.
  • Anthracnose of soybean is caused by the fungus Colletotrichum truncatum, which is a common species associated with Anthracnose.
  • Colletotrichum truncatum which is a common species associated with Anthracnose.
  • Colletotrichum species have also been identified to be involved. According to estimates, a reduction of yield is around 50%.
  • Ramulose of cotton is caused by Colletotrichum gossypii var. cephalosporioides.
  • the reduction of fiber production can reach up to 80% if this disease occurs in the early growth period of cotton. (Mansuêmia Alves Couto de Oliveira et al. , “Inheritance of resistance to Colletotrichum gossypii var. cephalosporioides in cotton, ” Crop Breeding and Applied Biotechnology, 2010, 10: 65-73)
  • Septoria tritici blotch of wheat is caused by Mycosphaerella graminicola (anamorph: Septoria tritici) .
  • the reduction of yield caused by this disease can range from 30% to 50%.
  • Triazoles can be employed for preventing and treating fungal infestations. Triazoles are effective in controlling fungal infestations by inhibiting one specific enzyme, C14-demethylase, which plays a role in sterol production. Sterols, such as ergosterol, are needed for membrane structure and function, making them essential for the development of functional cell walls by the fungi. Therefore, these fungicides result in abnormal fungal growth and eventually death.
  • triazoles examples include azaconazole, bitertanol, bromuconazole, cyproconazole, diclobutrazol, difenoconazole, diniconazole, diniconazole-M, epoxiconazole, etaconazole, fenbuconazole, fluquinconazole, flusilazole, flutriafol, furconazole, furconazole-cis, hexaconazole, imibenconazole, ipconazole, metconazole, myclobutanil, penconazole, propiconazole, prothioconazole, quinconazole, simeconazole, tebuconazole, tetraconazole, triadimefon, triadimenol, triticonazole, uniconazole and uniconazole-P.
  • Benzimidazoles can be also employed for preventing and treating fungal infestations.
  • Benzimidazoles are a class of systemic fungicides exhibiting both protective and curative actions. Benzimidazoles are absorbed through the leaves and roots of the plant, with translocation principally acropetally, and function by inhibition of the beta-tubulin assembly. Examples of benzimidazoles include albendazole, benomyl, carbendazim, chlorfenazole, cypendazole, debacarb, fuberidazole, mecarbinzid, rabenzazole, thiabendazole and thiophanate-methyl.
  • fungicidal composition comprising a component (A) at least one triazole and a component (B) at least one benzimidazole on the plants, plant parts or a locus, particularly on cotton, soybean and wheat, at specific growth stages, particularly at late vegetative stage, an excellent performance in preventing and treating fungal infestations may be observed.
  • the present invention relates to a method of preventing and/or treating fungal infestations in plants and plant parts comprising (1) preparing a fungicidal composition comprising a component (A) at least one triazole and a component (B) at least one benzimidazole; and (2) applying the fungicidal composition on the plants or plant parts or on a locus at specific growth stages of the plants or plant parts; .
  • soybean growth stages are determined according to a commonly used method as shown in Table A. (McWilliams, D. A. ; Berglund, D. R. ; Endres, G. J., Soybean Growth and Management Quick Guide NDSU Agriculture 2004, A-1174. )
  • Vegetative stage VE Emergence VC Cotyledon stage V1 First unrolled trifoliate V2 Second unrolled trifoliate V3 Third unrolled trifoliate V4 Forth unrolled trifoliate V5 Fifth unrolled trifoliate V6 Flowering will soon start V (n) Vegetative stage, with n leaves 2.
  • Reproductive stage R1 Beginning bloom, first flower R2 Full bloom, flower in top 2 nodes R3 Beginning pod, 3/16 inches pod in top 4 nodes R4 Full pod, 3/4inches pod in top 4 nodes R5 1/8inches seed in top 4 nodes R6 Full size seed in top 4 nodes R7 Beginning maturity, one mature pod R8 Full maturity, 95% of pods on the plant are mature R (n) Reproductive stage
  • the wheat growth stages are determined according to Zadok scale as shown in Table B (Zadoks J.C.; Chang, T.T.; Konzak, C.F. A Decimal Code for the Growth Stages of Cereals Weed Research 1974, 14, 415-421.)
  • the cotton growth stages are determined according to the following scale (Table C):
  • Plant refers to all plant and plant populations such as desired and undesired wild plants or crop plants.
  • Plant parts refers to all parts and organs of plants, such as shoot, leaves, needles, stalks, stems, fruit bodies, fruits, seeds, roots, tubers and rhizomes.
  • Harvested materials, and vegetative and generative propagation materials for example, cutting, tubers, meristem tissue, rhizomes, offsets, seeds, single and multiple plant cells and any other plant tissues, are also included.
  • Locus refers to the place on which the plants are growing, the place on which the plant propagation materials of the plants are sown or the place on which the plant propagation materials of the plants will be sown.
  • At least one designates a number of the respective compounds of 1, 2, 3, 4, 5, 6, 7, 8, 9 or more, preferably 1, 2, or 3.
  • a method of preventing and/or treating fungal infestations caused by fungi of a plant comprising:
  • fungicidal composition comprising a component (A) at least one triazole and a component (B) at least one benzimidazole;
  • the at least one triazole may be selected from azaconazole, bitertanol, bromuconazole, cyproconazole, diclobutrazol, difenoconazole, diniconazole, diniconazole-M, epoxiconazole, etaconazole, fenbuconazole, fluquinconazole, flusilazole, flutriafol, furconazole, furconazole-cis, hexaconazole, imibenconazole, ipconazole, metconazole, myclobutanil, penconazole, propiconazole, prothioconazole, quinconazole, simeconazole, tebuconazole, tetraconazole, triadimefon, triadimenol, triticonazole, uniconazole, uniconazole-Pand/or any combination of 2, 3, 4 or more thereof.
  • the at least one benzimidazole may be selected from albendazole, benomyl, carbendazim, chlorfenazole, cypendazole, debacarb, fuberidazole, mecarbinzid, rabenzazole, thiabendazole, thiophanate-methyl and/or any combination of 2, 3, 4 or more thereof.
  • the components (A) and (B) of the fungicidal composition are:
  • the component (A) is tebuconazole and the component (B) is carbendazim.
  • Suitable plants include cereals, such as wheat, barley, rye, oats, rice, maize, sorghum, millet and manioc; beet, such as sugar beet and fodder beet; fruit, such as pomes, stone fruit and soft fruit, such as apples, pears, plums, peaches, almonds, cherries, or berries, for example, strawberries, raspberries and blackberries; leguminous plants, such as beans, lentils, peas and soybeans; oil plants, such as rape, mustard, poppy, olives, sunflowers, coconut, castor oil plants, cocoa beans and groundnuts; cucurbitaceae, such as marrows, cucumbers and melons; fibrous plants, such as cotton, flax, hemp and jute; citrus fruit, such as oranges, lemons, grapefruit and mandarins; vegetables, such as
  • the components (A) and (B) may be applied in any desired sequence, any combination, consecutively or simultaneously.
  • the method is effected by applying to the plant, plant parts or on a locus a composition as hereinbefore defined.
  • the components (A) and (B) may be applied simultaneously. They may be applied as a composition containing the components (A) and (B), in which the components (A) and (B) can be obtained from a separate formulation source and mixed together (known as a tank-mix, ready-to-apply, spray broth, or slurry), optionally with other pesticides, or the components (A) and (B) can be obtained as a single formulation mixture source (known as a pre-mix, concentrate, formulated compound (or product) ) , and optionally mixed together with other pesticides.
  • a separate formulation source known as a tank-mix, ready-to-apply, spray broth, or slurry
  • other pesticides or the components (A) and (B) can be obtained as a single formulation mixture source (known as a pre-mix, concentrate, formulated compound (or product) ) , and optionally mixed together with other pesticides.
  • the present invention also relates to a composition
  • a composition comprising components (A) and (B), as active ingredients, and optionally other pesticides, and optionally one or more customary formulation auxiliaries; which may be in the form of a tank-mix or pre-mix composition.
  • a tank-mix formulation comprises of from 0.1 to 20% by weight, preferably 0.1 to 18%, especially 0.1 to 15%, or 1 to 15%, or 5 to 15% of the components (A) and (B), and of from 99.9 to 80%, preferably 99.9 to 82%, especially 99.9 to 85%, of one or more solid or liquid auxiliaries (including, for example, a solvent such as water), where the auxiliaries can be surfactant in an amount of from 0 to 20%, preferably 0.1 to 18%, especially 0.1 to 15%, or 1 to 15%, or 5 to 15% based on the tank-mix formulation.
  • auxiliaries including, for example, a solvent such as water
  • a pre-mix formulation comprises of from 0.1 to 99.9% by weight, especially 1 to 95%, preferably 5 to 95%, or 10 to 95%, or 20 to 95%, or 30 to 95%, or 40 to 95%, or 50 to 95% the components (A) and (B), and the remainder, e. g. 99.9 to 0.1%, especially 99 to 5%, of a solid or liquid adjuvant (including, for example, a solvent such as water), where the auxiliaries can be a surfactant in an amount of 0 to 50%, especially 0.5 to 40%, based on the pre-mix formulation.
  • a solid or liquid adjuvant including, for example, a solvent such as water
  • the rates of application (use) of the composition of the present invention vary, for example, according to type of use, type of crop, the specific active ingredient in the combination, type of plants, but is such that the active ingredients in the combination is an effective amount to provide the desired action (such as disease or pest control) .
  • the application rate of the composition for a given set of conditions can readily be determined by trials.
  • the composition of the present invention may be applied of from 0.01 kg to 3 kg per hectare (kg/ha), e. g. 0.02 kg/ha, or 0.04 kg/ha or 0.05 kg/ha, or 0.1 kg/ha or 0.2 kg/ha, or 0.4 kg/ha, 0.6 kg/ha, 0.7 kg/ha, 0.8 kg/ha, 0.9 kg/ha, 1.0 kg/ha, 1.1 kg/ha, 1.2 kg/ha, 1.3 kg/ha, 1.4 kg/ha, 0.6 L/ha, 0.7 L/ha, 0.8 L/ha, 0.9 L/ha, 1.0 L/ha, 1.1 L/ha, 1.2 L/ha, 1.3 L/ha or 1.4 L/ha of the composition.
  • suitable application rates may be 40-400 g/ha of the component (A) and 40-600 g/ha of the component (B) ; or may be 200-250 g/ha of the component (A) and 120-600 g/ha of the component (B) ; or may be 100-200 g/ha of the component (A) and 100-200 g/ha of the component (B) ; or may be 100-150 g/ha of the component (A) and 100-150 g/ha of the component (B) ; or may be 150-200 g/ha of the component (A) and 150-200 g/ha of the component (B) .
  • the composition comprises the component (A) tebuconazole and the component (B) carbendazim
  • typical application rates for prevention and treatment may be 80-200 g/ha, preferably 100-200 g/ha or 100-150 g/ha or 150 to 200 g/ha of tebuconazole, and 80-200 g/ha, preferably 100-200 g/ha or 100-150 g/ha or 150 to 200 g/ha carbendazim.
  • a total amount of the component (A) and the component (B) is 5% to 90%, preferably 10% to 80%, 15% to 60%, or 20% to 40% by weight of the fungicidal composition.
  • the fungicidal component (A) triazoles may be present in the fungicidal composition of the present invention in any suitable amount, and is generally present in an amount of from 5% to 50% by weight of the composition, preferably from 10% to 40% or 10% to 25% by weight of the composition. In certain embodiments, the component (A) is 12.5% by weight of the composition.
  • the fungicidal component (B) benzimidazoles may be present in the fungicidal composition of the present invention in any suitable amount, and is generally present in an amount of from 5% and 50% by weight of the composition, preferably from 10% to 40% or 10% to 25% by weight of the composition. In some embodiments, the component (B) is 12.5% by weight of the composition.
  • the components (A) and (B) may be present in the composition or applied in any amounts relative to each other.
  • the weight ratio of any two of the components (A) and (B) in the composition independently is preferably in the range of from 25: 1 to 1: 25, 20: 1 to 1: 20, or 15: 1 to 1: 15, more preferably 10: 1 to 1: 10, 5: 1 to 1: 5, 2.5: 1 to 1: 2.5 or 1: 1.
  • the fungicidal composition of the present invention may contain or be mixed with other pesticides, such as other fungicides, insecticides and nematicides.
  • the components (A) and (B), and any other pesticides may be applied and used in pure form, for example, in a specific particle size, or preferably together with one or more auxiliaries, as is customary in formulation technology.
  • auxiliaries employed in the composition will depend upon the type of formulation and/or the manner in which the formulation is to be applied by the end user. Formulations incorporating the composition of the present invention are described hereinafter. Suitable auxiliaries which may be comprised in the composition according to the invention are all customary formulation adjuvants or components, such as extender, carriers, solvents, surfactants, stabilizers, anti-foaming agents, anti-freezing agents, preservatives, antioxidants, colorants, thickeners, solid adherents and inert fillers. Such auxiliaries are known in the art and are commercially available. Their use in the formulation of the compositions of the present invention will be apparent to the person skilled in the art.
  • the fungicidal composition may further comprise one or more inert fillers.
  • inert fillers are known in the art and available commercially. Suitable fillers include, for example, natural ground minerals, such as kaolin, alumina, talc, chalk, quartz, attapulgite, montmorillonite, and diatomaceous earth, or synthetic ground minerals, such as highly dispersed silicic acid, aluminum oxide, silicates, and calcium phosphates and calcium hydrogen phosphates.
  • Suitable inert fillers for granules include, for example, crushed and fractionated natural minerals, such as calcite, marble, pumice, sepiolite, and dolomite, or synthetic granules of inorganic and organic ground materials, as well as granules of organic material, such as sawdust, coconut husks, corn cobs, and tobacco stalks.
  • the fungicidal composition optionally includes one or more surfactants which are preferably non-ionic, cationic and/or anionic in nature and surfactant mixtures which have good emulsifying, dispersing and wetting properties, depending on the nature of the components to be formulated.
  • surfactants are known in the art and are commercially available.
  • non-ionic surfactants are polyoxyethylated (POE) sorbitan esters such as POE (20) sorbitan trioleate and polyoxyethylated (POE) sorbitol esters such as POE (40) sorbitol hexaoleate.
  • POE (20) sorbitan trioleate is commercially available under the tradenames ATLAS TM G1086 and CIRRASOL TM G1086 marketed by UniqEMA.
  • Combination of a POE sorbitan ester with a POE sorbitol ester allows optimizing the HLB (hydrophilic-lipophilic balance) value of the surfactant to obtain the highest quality emulsion (smallest suspended droplets) when the composition is added to water.
  • High quality of emulsions typically leads to optimal fungicidal performance.
  • Suitable cationic surfactants include quaternary ammonium salts carrying, as N-substituent, at least one C 8 -C 22 alkyl radical and, as a further substituent, unsubstituted or halogenated lower alkyl, benzyl or hydroxyl-lower alkyl radicals.
  • the salts are preferably in the form of halide, methyl sulfate or ethyl sulfate.
  • Examples of such cationic surfactants are stearyltrimethylammonium chloride and benzyl bis (2-chloroethyl) ethylammonium bromide.
  • Suitable anionic surfactants can be both so-called water-soluble soaps and water-soluble synthetic surface-active compounds.
  • Soaps which may be used are the alkali metal, alkaline earth metal or substituted or unsubstituted ammonium salts of higher fatty acid (C 10 -C 22 ), for example, the sodium or potassium salt of oleic or stearic acid, or of natural fatty acid mixtures.
  • the surfactant can be an emulsifier, dispersant or wetting agent of ionic or nonionic type.
  • examples which may be used are salts of polyacrylic acids, salts of lignosulphonic acid, salts of phenylsulphonic or naphthalenesulphonic acids, polycondensates of ethylene oxide with fatty alcohols or with fatty acids or with fatty amines, substituted phenols, especially alkylphenols, sulphosuccinic ester salts, taurine derivatives, especially alkyltaurates, or phosphoric esters of polyethoxylated phenols or alcohols.
  • the presence of at least one surfactant is generally required when the components and/or the inert carrier and/or auxiliary/adjuvant are insoluble in water and the vehicle for the final application of the composition is water.
  • the fungicidal composition optionally further comprises one or more polymeric stabilizer.
  • the suitable polymeric stabilizers that may be used in the present invention include, but are not limited to, polypropylene, polyisobutylene, polyisoprene, copolymers of monoolefins and diolefins, polyacrylates, polystyrene, polyvinyl acetate, polyurethanes or polyamides. Suitable stabilizers are known in the art and commercially available.
  • surfactants and polymeric stabilizers mentioned above are generally believed to impart stability to the composition, in turn allowing the composition to be formulated, stored, transported and applied.
  • Suitable anti-foams include all substances which can normally be used for this purpose in agrochemical compositions. Suitable anti-foams are known in the art and are available commercially. Particularly preferred anti-foams are mixtures of polydimethylsiloxanes and perfluroalkylphosphonic acids, such as the silicone anti-foams available from GE or Compton.
  • Suitable organic solvents are selected from all customary organic solvents which thoroughly dissolve the components employed. Again, suitable organic solvents for the components (A) and (B) are known in the art. The following may be mentioned as being preferred: N-methyl pyrrolidone, N-octyl pyrrolidone, cyclohexyl-1-pyrrolidone; or SOLVESSO TM 200, a mixture of paraffinic, isoparaffinic, cycloparaffinic and aromatic hydrocarbons. Suitable solvents are commercially available.
  • Suitable preservatives include all substances which can normally be used for this purpose in agrochemical compositions of this type and again are well known in the art. Suitable examples that may be mentioned include tolylfluanid, such as (from Bayer AG) and benzisothiazolinone, such as (from Bayer AG) .
  • Suitable antioxidants are all substances which can normally be used for this purpose in agrochemical compositions, as is known in the art. Preference is given to butylated hydroxytoluene.
  • Suitable thickeners include all substances which can normally be used for this purpose in agrochemical compositions.
  • thickeners are known in the art and available commercially.
  • the fungicidal composition may further comprise one or more solid adherents.
  • adherents are known in the art and available commercially. They include organic adhesives, including tackifiers, such as celluloses of substituted celluloses, natural and synthetic polymers in the form of powders, granules, or lattices, and inorganic adhesives such as gypsum, silica, or cement.
  • composition according to the invention may also comprise water.
  • the fungicidal composition may be provided in the form of several different formulations, for examples, water-soluble concentrate (SL), an emulsifiable concentrate (EC), an emulsion (EW), a micro-emulsion (ME), a suspension concentrate (SC), an oil-based suspension concentrate (OD), a flowable suspension (FS), a water-dispersible granule (WG), water-soluble granule (SG), water-dispersible powder (WP), water soluble powder (SP), a granule (GR), an encapsulated granule (CG), a fine granule (FG), a macrogranule (GG), an aqueous suspo-emulsion (SE) , capsule suspension (CS) and a microgranule (MG) .
  • the formulation of the fungicidal composition is in the form of suspension concentrates (SC) .
  • either straight (that is undiluted) or diluted with a suitable solvent, especially water, plants, plant parts and loci can be treated and protected against fungicidal infections, for example, by fungi, by spraying, pouring or immersing.
  • the fungicidal composition according to the present invention is applied on the plants and/or plant parts at specific growth stages. Growth stage begins when the majority (50% or more) of the plants in a field are at or beyond that stage.
  • the fungicidal composition may be applied at the vegetative stages of a plant. Vegetative stages can be characterized, among others, by the following properties of the plants:
  • the fungicidal composition is applied at the late vegetative stages of the plant. Vegetative stages of various plant will be apparent to person skilled in the art.
  • the fungicidal composition may be applied in the vegetative stages of V1 to V6 of the plant, preferably in the vegetative stages of V2 to V6 of the plant or in the vegetative stages of V3 to V6 of the plant or in the vegetative stages of V4 to V6 of the plant, or in the vegetative stages of V5 to V6 of the plant.
  • the fungicidal composition may thus be applied in any one or more of the vegetative stages V1, V2, V3, V4, V5 or V6 of the plant.
  • the fungicidal composition may be applied in the vegetative stage of plants.
  • the fungicidal composition may be applied at the late vegetative stage of plants.
  • the fungicidal composition may be applied in the vegetative stage of soybean.
  • the fungicidal composition may be in any of the vegetative stages of V1 to V6, V2 to V6, V3 to V6, V4 to V6, V5 to V6 or at the vegetative stage of V6 of soybean.
  • the fungicidal composition may be applied at the vegetative stages of cotton. In some embodiments, the fungicidal composition may be applied in any of the vegetative stages of V1 to V6, V2 to V6, V3 to V6, V4 to V6, V5 to V6 or at the vegetative stage of V6 of cotton.
  • the fungicidal composition may be applied at the leaf development stage of wheat.
  • the fungicidal composition may be applied from the leaf development stage to the booting stage of wheat.
  • the fungicidal composition may be applied from the tillering stage to the booting stage of wheat and/or from the stem elongation stage to the booting stage of wheat, and/or at the booting stage of wheat.
  • the components (A) and (B) may be applied to the plant, plant part or a locus in any order.
  • fungicidal compositions according to the present invention are effective in preventing and treating fungicidal infections, for example, but not limited to:
  • Colletotrichum gossypii [anamorph] (Anthracnose) ; Ramularia gossypii and Mycosphaerella areola [teleomorph] (Areolate mildew) ; Alternaria macrospora and Alternaria alternata (Leaf spot) ; Colletotrichum gossypii var. cephalosporioides (Ramulose) on cotton;
  • Alternaria spp. Alternaria leaf spot
  • Septoria glycines Brown spot
  • Diaporthe phaseolorum Pod and stem blight
  • Microsphaera diffusa Puldery mildew
  • Cercospora kikuchii Purple seed stain
  • Phakopsora pachyrhizi Rust, asian rust
  • Sclerophthora macrospora Downy mildew
  • Tapesia yallundae Ramulispora herpotrichoides [anamorph]
  • Tapesia acuformis Ramulispora acuformis [anamorph]
  • Puccinia triticina Puccinia tritici-duri (brown rust)
  • the fungal infestations are selected from powdery mildew, asian soybean rust, anthracnose, ramulose and septoria tritici blotch.
  • the fungi are selected from Colletotrichum gossypii var. cephalosporioides, Phakopsora pachyrhizi and Septoria tritici.
  • this invention also provides a method of controlling fungal infestations in plants or plant parts, in particular wheat, soybean and cotton, especially the control of powdery mildew, asian soybean rust, anthracnose, ramulose and septoria tritici blotch.
  • a water-dispersible power was prepared having the following composition:
  • a water-soluble concentrates was prepared having the following composition:
  • An aqueous suspension concentrate was prepared having the following composition:
  • Difenoconazole 50g Carbendazim 500g Propylene glycol 100g Tristyrylphenol ethoxylates 50g Sodium lignosulfonate 100g
  • Carboxymethylcellulose 10g Silicone oil (in the form of a 75% emulsion in water) 10g Water Balance to 1L
  • the finely ground difenoconazole and carbendazim were intimately mixed with the auxiliaries, giving a suspension concentrate from which suspensions of any desired dilution could be obtained by dilution with water.
  • a suspension of difenoconazole, carbendazim and auxiliaries was wet milled with a bead-mill to achieve a stable formulation and with the appropriate treatment characteristics.
  • a suspo-emulsion was prepared having the following composition:
  • Epoxiconazole EC phase was prepared by mixing epoxiconazole with SOLVESSO TM 200 and 80.
  • a dispersion of particles of carbendazim in a continuous water phase was prepared by mixing carbendazim, a dispersant and a required amount of water through finely milled using a horizontal agitating bead mill.
  • the oil phase was added to the continuous water phase under agitation, followed with suitable thickener and antifreezing agent to get the desired formulation.
  • An aqueous suspension concentrate was prepared having the following composition:
  • An oil-based suspension concentrate was prepared having the following composition:
  • the finely ground hexaconazole and carbendazim were intimately mixed with the auxiliaries, giving an oil-based suspension concentrate from which suspensions of any desired dilution could be obtained by dilution with water.
  • a suspo-emulsion was prepared having the following composition:
  • Prothioconazole EC phase was prepared by mixing prothioconazole with SOLVESSO TM 200 and 80.
  • a dispersion of particles of carbendazim in a continuous water phase was prepared by mixing carbendazim, a dispersant and a required amount of water through finely milled using a horizontal agitating bead mill.
  • the oil phase was added to the continuous water phase under agitation, followed with suitable thickener and antifreezing agent to get the desired formulation.
  • An aqueous suspension concentrate was prepared having the following composition:
  • tebuconazole and carbendazim were intimately mixed with the auxiliaries, giving a suspension concentrate from which suspensions of any desired dilution could be obtained by dilution with water.
  • a suspension of tebuconazole and carbendazim and auxiliaries was wet milled with a bead-mill to achieve a stable formulation with the appropriate treatment characteristics.
  • An aqueous suspension concentrate was prepared having the following composition:
  • bitertanol and thiophanate-methyl were intimately mixed with the auxiliaries, giving a suspension concentrate from which suspensions of any desired dilution could be obtained by dilution with water.
  • auxiliaries including water
  • a suspo-emulsion was prepared having the following composition:
  • Cyproconazole EC phase was prepared by mixing prothioconazole with SOLVESSO TM 200 and 80.
  • a dispersion of particles of thiophanate-methyl in a continuous water phase was prepared by mixing thiophanate-methyl, a dispersant and a required amount of water through finely milled using a horizontal agitating bead mill.
  • the oil phase was added to the continuous water phase under agitation, followed with suitable thickener and antifreezing agent to get the desired formulation.
  • a suspo-emulsion was prepared having the following composition:
  • Difenoconazole was mixed with N-methyl pyrrolidone and the emulsifiers OR/36 and polymeric stabilizer polyurethanes to get an oil phase.
  • the finely ground thiophanate-methyl were intimately mixed with the other auxiliaries (including water), giving a water phase.
  • a suspension of thiophanate-methyl and auxiliaries (including water) was wet milled with a bead-mill to achieve a water phase.
  • the oil phase was added to water phase under continuous agitation for an optimum amount of time.
  • An aqueous suspension concentrate was prepared having the following composition:
  • An oil-based suspension concentrate was prepared having the following composition:
  • the finely ground flutriafol and thiophanate-methyl were intimately mixed with the auxiliaries, giving an oil-based suspension concentrate from which suspensions of any desired dilution could be obtained by dilution with water.
  • An aqueous suspension concentrate was prepared having the following composition:
  • hexaconazole and thiophanate-methyl were intimately mixed with the auxiliaries, giving a suspension concentrate from which suspensions of any desired dilution could be obtained by dilution with water.
  • a suspension of hexaconazole, thiophanate-methyl and auxiliaries was wet milled with a bead-mill to achieve a stable formulation and with the appropriate treatment characteristics.
  • a water-dispersible granule was prepared having the following composition:
  • Prothioconazole, thiophanate-methyl, surfactant and carrier were mixed and ground through superfine mill, then granulated by paste extruding.
  • An aqueous suspension concentrate was prepared having the following composition:
  • tebuconazole and thiophanate-methyl were intimately mixed with the auxiliaries, giving a suspension concentrate from which suspensions of any desired dilution could be obtained by dilution with water.
  • a suspension of tebuconazole, thiophanate-methyl and auxiliaries was wet milled with a bead-mill to achieve a stable formulation and with the appropriate treatment characteristics.
  • Cotton plants were sprayed with a conidial suspension of Colletotrichum gossypii var. cephalosporioides, and incubated at 20 °C and 100 % relative atmospheric humidity for 48 hours. Then they were sprayed with Formulations Examples set out above at different vegetative stages. The application rate was 1 kg/ha or 1 L/ha. After staying in a greenhouse at 15 °C and 80 % relative atmospheric humidity for 15 days, severity was assessed.
  • the process to prepare Control 2 was the same as the Example 1, but without the addition of bitertanol.
  • the process to prepare Control 3 was the same as the Example 8,but without the addition of carbendazim.
  • the process to prepare Control 4 was the same as the Example 13, but without the addition of thiophanate-methyl.
  • the process to prepare Control 5 was the same as the Example 8, but without the addition of tebuconazole.
  • the process to prepare Control 6 was the same as the Example 13, but without the addition of flutriafol.
  • Example 1 500+250 V1-V2 50%
  • Example 1 500+250 V3-V4 50%
  • Example 1 500+250 V5-V6 40%
  • Example 8 125+125 V1-V2 20%
  • Example 8 125+125 V3-V4 10%
  • Example 8 125+125 V4-V5 5%
  • Example 8 125+125 V5-V6 10%
  • Example 13 125+30 V1-V2 70%
  • Example 13 125+30 V3-V4 70%
  • Example 13 125+30 V5-V6 60% Control 1 0+0 V1-V2 100% Control 1 0+0 V3-V4 100% Control 1 0+0 V4-V5 100% Control 1 0+0 V5-V6 100% Control 2 500+0 V1-V2 75% Control 2 500+0 V3-V4 75% Control 2 500+0 V4-V5 70% Control 2 500+0 V5-V6 70% Control 3 125+0 V1-V
  • Control 5 0+125 V5-V6 30% Control 6 0+30 V1-V2 85% Control 6 0+30 V3-V4 80% Control 6 0+30 V4-V5 85% Control 6 0+30 V5-V6 85%
  • Soybean plants were sprayed with a conidial suspension of Phakopsora pachyrhizi, and incubated at 20 °C and 100 % relative atmospheric humidity for 48 hours. Then they were sprayed with Formulations Examples set out above at different vegetative stages. The application rate was 1 kg/ha or 1 L/ha. After staying in a greenhouse at 15 °C and 80 % relative atmospheric humidity for 15 days, severity was assessed.
  • the process to prepare Control 2 was the same as the Example 5, but without the addition of fluriafol.
  • the process to prepare Control 3 was the same as the Example 8, but without the addition of carbendazim.
  • the process to prepare Control 4 was the same as the Example 12, but without the addition of thiophanate-methyl.
  • the process to prepare Control 5 was the same as the Example 8, but without the addition of tebuconazole.
  • the process to prepare Control 6 was the same as the Example 12, but without the addition of epoxiconazole.
  • Wheat plants were sprayed with a conidial suspension of Septoria tritici, and incubated at 20 °C and 100 % relative atmospheric humidity for 48 hours. Then they were sprayed with Formulations Examples set out above at different growth stages. The application rate was 1 kg/ha or 1 L/ha. After staying in a greenhouse at 15 °C and 80 % relative atmospheric humidity for 15 days, severity was assessed.
  • Control 2 was the same as the Example 8, but without the addition of carbendazim.
  • the process to prepare Control 3 was the same as the Example 11, but without the addition of thiophanate-methyl.
  • the process to prepare Control 4 was the same as the Example 8, but without the addition of tebuconazole.
  • the process to prepare Control 5 was the same as the Example 11, but without the addition of difenoconazole.
  • Young soybean plants were sprayed with a conidial suspension of Phakopsora pachyrhizi, and incubated at 20 °C and 100 % relative atmospheric humidity for 48 hours.
  • One set of the plants were sprayed with different application rates of a composition comprising tebuconazole and carbendazim after three days.
  • Another set of the plants were sprayed with different application rates of composition comprising tebuconazole and carbendazim after five days. All the plants were stayed in a greenhouse at 15 °C and 80 % relative atmospheric humidity. Severity of the plants were examined after 7 days of application.

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  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

L'invention concerne un procédé de prévention et de traitement des infestations fongiques d'une plante par application d'une composition fongicide, comprenant un composant (A) au moins un triazole et un composant (B) au moins un benzimidazole, sur des plantes ou parties de plantes ou sur un locus à des étapes de croissance spécifiques des plantes ou parties de plantes.
PCT/CN2014/086107 2013-11-28 2014-09-09 Procédé de traitement d'infections fongiques, compositions fongicides et leur utilisation WO2015078216A1 (fr)

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BR102013030596A BR102013030596A2 (pt) 2013-11-28 2013-11-28 método de tratamento de infecções fungicidas, composições fungicidas e seu uso
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CN105325465A (zh) * 2015-12-08 2016-02-17 济南舜昊生物科技有限公司 用于防治菜豆白粉病的微乳剂
CN105325462A (zh) * 2015-12-08 2016-02-17 济南舜昊生物科技有限公司 用于菜豆的杀菌剂
CN105410035A (zh) * 2015-12-08 2016-03-23 济南舜昊生物科技有限公司 含有氟硅唑的复配制剂
CN106234393A (zh) * 2016-07-18 2016-12-21 河北上瑞化工有限公司 一种含己唑醇和多菌灵的农药悬浮剂及其制备方法
WO2016204160A1 (fr) * 2015-06-15 2016-12-22 石原産業株式会社 Composition et procédé de lutte contre les maladies du soja
CN109105384A (zh) * 2018-10-22 2019-01-01 贵州道元生物技术有限公司 一种防治梨树黑心病的复配杀菌组合物

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CN109042702A (zh) * 2018-09-21 2018-12-21 贵州道元生物技术有限公司 一种防治水稻纹枯病的丙硫唑和苯醚甲环唑的杀菌组合物及其用途
CN108887280A (zh) * 2018-09-21 2018-11-27 贵州道元生物技术有限公司 一种防治小麦条锈病的丙硫唑和粉唑醇的杀菌组合物及其用途

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WO2016204160A1 (fr) * 2015-06-15 2016-12-22 石原産業株式会社 Composition et procédé de lutte contre les maladies du soja
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CN105325465A (zh) * 2015-12-08 2016-02-17 济南舜昊生物科技有限公司 用于防治菜豆白粉病的微乳剂
CN105325462A (zh) * 2015-12-08 2016-02-17 济南舜昊生物科技有限公司 用于菜豆的杀菌剂
CN105410035A (zh) * 2015-12-08 2016-03-23 济南舜昊生物科技有限公司 含有氟硅唑的复配制剂
CN106234393A (zh) * 2016-07-18 2016-12-21 河北上瑞化工有限公司 一种含己唑醇和多菌灵的农药悬浮剂及其制备方法
CN109105384A (zh) * 2018-10-22 2019-01-01 贵州道元生物技术有限公司 一种防治梨树黑心病的复配杀菌组合物

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AR098242A1 (es) 2016-05-18

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