WO2015070865A1 - Système de thérapie à particules - Google Patents

Système de thérapie à particules Download PDF

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Publication number
WO2015070865A1
WO2015070865A1 PCT/DK2013/050380 DK2013050380W WO2015070865A1 WO 2015070865 A1 WO2015070865 A1 WO 2015070865A1 DK 2013050380 W DK2013050380 W DK 2013050380W WO 2015070865 A1 WO2015070865 A1 WO 2015070865A1
Authority
WO
WIPO (PCT)
Prior art keywords
particle therapy
therapy system
gantry
synchrotron
particle
Prior art date
Application number
PCT/DK2013/050380
Other languages
English (en)
Inventor
Lars Kruse
Original Assignee
Danfysik A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Danfysik A/S filed Critical Danfysik A/S
Priority to PCT/DK2013/050380 priority Critical patent/WO2015070865A1/fr
Priority to EP14801990.4A priority patent/EP3068489A1/fr
Priority to PCT/EP2014/074649 priority patent/WO2015071430A1/fr
Publication of WO2015070865A1 publication Critical patent/WO2015070865A1/fr

Links

Classifications

    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H13/00—Magnetic resonance accelerators; Cyclotrons
    • H05H13/04—Synchrotrons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1077—Beam delivery systems
    • A61N5/1081—Rotating beam systems with a specific mechanical construction, e.g. gantries
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H7/00—Details of devices of the types covered by groups H05H9/00, H05H11/00, H05H13/00
    • H05H7/04—Magnet systems, e.g. undulators, wigglers; Energisation thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N2005/1085—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy characterised by the type of particles applied to the patient
    • A61N2005/1087—Ions; Protons
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H7/00—Details of devices of the types covered by groups H05H9/00, H05H11/00, H05H13/00
    • H05H7/04—Magnet systems, e.g. undulators, wigglers; Energisation thereof
    • H05H2007/048—Magnet systems, e.g. undulators, wigglers; Energisation thereof for modifying beam trajectory, e.g. gantry systems

Definitions

  • the present invention relates to a particle therapy system, use of a particle therapy system and a configuration and layout of a particle therapy system.
  • particle therapy is one of modern cancer therapies that use beams of protons or heavier ions.
  • Treatment of cancer by irradiation of tumours with ions shows benefits over irradiation with photons because favourable energy deposition of the ions in the Bragg peak.
  • particle therapy is proton therapy techniques which are based on the use of proton beams, therapeutic beams of relatively low current (of the order of some Nano amperes) are used, with energies in the range 60 to 250 MeV.
  • therapeutic beams with lower currents and higher energies are required compared to the ones for the protons.
  • the required energies are between 1.500 and 5.000 MeV (i.e. 120 and 450 MeV/u) and currents of a fraction of Nano ampere.
  • an improved, and in particular more compact, particle treatment system would be more cost efficient and advantageous.
  • One object of the present invention is to provide a compact and versatile particle therapy system. It is a further object of the present invention to provide an alternative to the prior art.
  • a particle therapy system for cancer therapy comprising an synchrotron based accelerator mounted on a rotatable gantry, the synchrotron based accelerator configured for receiving a low energy pre-accelerated beam from an injector and accelerate the low energy pre-accelerated beam to an accelerated beam, the synchrotron based accelerator comprising a synchrotron that energizes the beam to a desired energy level, wherein the desired energy level is defined within a target energy level interval and may be changed during use of the system, and a beam transport line directing the accelerated beam in a desired direction inside the gantry.
  • the particle therapy system uses a proton or a charged particle beam such as carbon, which is accelerated by an accelerator.
  • the particle therapy system includes an accelerator, a beam transport system and an irradiation device.
  • the accelerator such as a synchrotron is adapted to accelerate a beam emitted by an ion source to a level close to the speed of light.
  • the beam transport system is adapted to transport the beam extracted from the accelerator.
  • the irradiation device is adapted to irradiate an affected area of a patient with the beam in accordance with the location and shape of the affected area or volume.
  • the proposed particle therapy system simply said, comprises a synchrotron based accelerator that is axially mounted on a rotatable gantry.
  • the accelerator is composed of, at least, an injector, that provides a low energy pre-accelerated beam to be injected into a synchrotron.
  • a synchrotron that accelerates the beam to a requested (not fixed) energy, and further; a beam transport line formed so as to direct the beam to the patient.
  • the system renders all the benefits of a synchrotron beam available in a configuration that allows irradiation of a tumor from many directions in a single, compact system. Still further the system may be built at a reduced cost when compared to the prior art particle therapy apparatus
  • One benefit of a beam from a synchrotron over other accelerator types are at least that the beam is accelerated to a desired energy level and delivered to the patient, or a treatment volume in the patient, without the use of degraders, as are known from e.g. fixed energy cyclotrons.
  • This again has the positive effect that a pencil beam with a small spot sizes at the patient can be achieved without collimators and that the beam can be actively scanned over a tumor, in contrast to passive scanning, where the beam is sent through a system of scattering material, collimators and compensators, and thus preserve the high beam quality in terms of small and well defined spot size and low energy spread.
  • the invention is particularly, but not exclusively, advantageous for obtaining a compact, versatile particle therapy system which allows an entire, or at least the main part of, particle therapy system to be located in a single room.
  • a second aspect of the present invention relates to use of a particle therapy system.
  • the particle therapy system may include any or all features mentioned in relates to the first aspect of the present invention.
  • the particle therapy system is further operated in accordance with a treatment plan.
  • the treatment plan may be established using a treatment planning system which receives the relevant inputs e.g. regarding tumour position, tumour size and shape.
  • the treatment plan includes at least dose rates and dose timings as well as target positions.
  • a third aspect relates to a method of operating a particle therapy system according to the present invention, in accordance with a treatment plan for directing particles to a tumour location in a patient.
  • first, second and third aspects of the present invention may each be combined with any of the other aspects and include any features mentioned in relation to any of the other aspects.
  • FIGS. 1 and 2 are schematic illustrations of a particle therapy system. DETAILED DESCRIPTION OF AN EMBODIMENT
  • FIG. 1 schematically illustrates perspective view of a particle therapy system 10 for cancer therapy.
  • the particle therapy system 10 comprises a rotatable gantry 12. On the rotatable gantry 10 an synchrotron-based accelerator 14 is mounted.
  • the synchrotron based accelerator 14 is configured for receiving a low energy pre-accelerated beam from an injector 15 and accelerate the low energy pre-accelerated beam to an accelerated beam.
  • the synchrotron based accelerator 14 comprises a synchrotron that energizes the beam to a desired energy level, wherein the desired energy level is defined within a target energy level interval and may be changed during use of the system. This energy level may be set via an input device such as a keyboard or dial.
  • a scheme may be defined including timing and positioning of the beam direction. The scheme may be defined by using a therapy planning system.
  • the particle therapy system 10 may then be operated according to the scheme.
  • the particle therapy system 10 further comprises a beam transport line 16 directing the accelerated beam in a desired direction inside the gantry.
  • the particle therapy system 10 makes all the benefits of a synchrotron beam available in a configuration that allows irradiation of a tumor from many directions in a compact system.
  • the rotating beam delivery system is capable of delivering beam to the target from multiple irradiation directions.
  • the target i.e. the tumor
  • the fixed position of the tumor is aimed to be at the crossing of the rotation axis of the gantry and the central treatment beam axis. This crossing point is called iso-center and gantries of this type capable of delivering beams from various directions to the iso-center are called iso-centric gantries.
  • the gantry 12 is rotatable 360 degrees, and is stoppable at any angular position.
  • the beam may be directed to a patient 20 fixated on a robotic table 22 so as to position the tumor at the above mentioned fixed position.
  • the robotic table 22 may be used for changing the patient position relative to the iso center in all 3 dimensions in the gantry 20 opening.
  • the benefits of a beam from a synchrotron over other accelerator types are that the beam is accelerated to a desired energy and delivered to the patient without the use of degraders, as are known from e.g. cyclotrons.
  • the system illustrated in Figure 1 is intended to deliver a proton beam.
  • the injector could be an ECR ion source and an RFQ with output energy of 2-3 MeV providing a proton beam of up to 20 mA.
  • the length of such an injector could be as small as a few meters.
  • the beam is injected into the synchrotron using single- or multi turn injection, resulting in a coasting beam with lOE+10 - lOE+11 particles.
  • the synchrotron accelerates the beam to the final energy in the range of 80 MeV - 250 MeV.
  • the beam will be extracted slowly over seconds and guided to the patient.
  • Such a system 10 could be fitted into a single room.
  • the synchrotron based accelerator 14 may be mounted on the gantry to form a continuous ring having an outlet to the beam transport line.
  • the synchrotron based accelerator may be wrapped around the gantry in a helical geometry.
  • injection line and/or the extraction lines may be wrapped around gantry.
  • the injection and extraction to the synchrotron may be perpendicular to or angled to the plane of the synchrotron.
  • the gantry beam delivery system comprises devices for shaping the beam to match the target, such as pencil beam or passive scattering.
  • the extraction beam line may comprise scanning magnets, which in combination with the synchrotrons energy variation capability, allows the target volume to be scanned and treated by an intensity modulated pencil beam.
  • the beam emittance can for example be limited to 7.5 Pi mm mrad in both X and Y.
  • a beam profile monitor can be installed, not illustrated in Figure 1.
  • a pair of slits in X and Y as means for reducing the divergence of the beam, other means could be used.
  • apertures or collimators with various diameters which may be positioned in the beam line.
  • the particle therapy system 10 is operated in accordance with a treatment plan for directing particle to a tumour location in a patient.
  • This treatment plan may be established by a treatment planning system where information such as tumor type and/or size is used to determine beam strength and direction relative to the patient, this may be translated into angular information positioning the output of the particle therapy system. Depth conformity in the target volume is obtained by adequate control of the beam energy. In this way, a particle radiation dose can be delivered to the entire 3D target volume by e.g. raster scanning technique.
  • the treatment plan may include a desired beam energy, position and dose to treat the target volume.
  • Figure 2 is a schematic side view of the particle therapy system 10.
  • the robotic table 22 may be used to position the patient along the z-axis and/or the y-axis as well as the x-axis.

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  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Plasma & Fusion (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Radiation-Therapy Devices (AREA)

Abstract

La présente invention concerne un système de thérapie à particules pour une thérapie de cancer ayant une portique rotative. La présente invention concerne en outre l'utilisation d'un système de thérapie à particules pour une thérapie à particules selon un plan de traitement. La présente invention concerne en outre l'utilisation d'un système de thérapie à particules, le système de thérapie à particules étant placé dans une pièce unique, et un procédé de fonctionnement d'un système de thérapie à particules.
PCT/DK2013/050380 2013-11-14 2013-11-14 Système de thérapie à particules WO2015070865A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
PCT/DK2013/050380 WO2015070865A1 (fr) 2013-11-14 2013-11-14 Système de thérapie à particules
EP14801990.4A EP3068489A1 (fr) 2013-11-14 2014-11-14 Système de thérapie à particules
PCT/EP2014/074649 WO2015071430A1 (fr) 2013-11-14 2014-11-14 Système de thérapie à particules

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/DK2013/050380 WO2015070865A1 (fr) 2013-11-14 2013-11-14 Système de thérapie à particules

Publications (1)

Publication Number Publication Date
WO2015070865A1 true WO2015070865A1 (fr) 2015-05-21

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PCT/EP2014/074649 WO2015071430A1 (fr) 2013-11-14 2014-11-14 Système de thérapie à particules

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EP (1) EP3068489A1 (fr)
WO (2) WO2015070865A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017212290A1 (fr) * 2016-06-10 2017-12-14 Lancaster University Business Enterprises Limited Système de libération pour thérapie par particules
WO2021002043A1 (fr) * 2019-07-01 2021-01-07 株式会社日立製作所 Système de traitement par faisceau de particules

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110799242B (zh) * 2017-05-03 2022-08-30 通用医疗公司 用于无台架式粒子治疗的系统
WO2019123452A1 (fr) * 2017-12-21 2019-06-27 P-Cure, Ltd. Système et procédé de traitement par irradiation
JP2021041005A (ja) * 2019-09-12 2021-03-18 株式会社日立製作所 粒子線照射システム及び粒子線照射施設

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4112306A (en) * 1976-12-06 1978-09-05 Varian Associates, Inc. Neutron irradiation therapy machine
JPH05188200A (ja) * 1991-12-27 1993-07-30 Ishikawajima Harima Heavy Ind Co Ltd シンクロトロン
JP2001346893A (ja) * 2000-06-06 2001-12-18 Ishikawajima Harima Heavy Ind Co Ltd 放射線治療装置
WO2009070173A1 (fr) * 2007-11-30 2009-06-04 Still River Systems Incorporated Portique intérieur
US8153990B2 (en) 2008-05-20 2012-04-10 Hitachi, Ltd. Particle beam therapy system
US8405056B2 (en) 2006-12-28 2013-03-26 Fondazione per Adroterapia Oncologica—TERA Ion acceleration system for medical and/or other applications
EP2637181A1 (fr) * 2012-03-06 2013-09-11 Tesla Engineering Limited Cryostats à orientations multiples

Family Cites Families (3)

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Publication number Priority date Publication date Assignee Title
US4705955A (en) * 1985-04-02 1987-11-10 Curt Mileikowsky Radiation therapy for cancer patients
DE4411171A1 (de) * 1994-03-30 1995-10-05 Siemens Ag Vorrichtung zur Bereitstellung eines Strahls aus geladenen Teilchen, der eine Achse auf einer diese schneidenden Zielgeraden anfliegt, sowie ihre Verwendung
ES2730108T3 (es) * 2005-11-18 2019-11-08 Mevion Medical Systems Inc Radioterapia de partículas cargadas

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4112306A (en) * 1976-12-06 1978-09-05 Varian Associates, Inc. Neutron irradiation therapy machine
JPH05188200A (ja) * 1991-12-27 1993-07-30 Ishikawajima Harima Heavy Ind Co Ltd シンクロトロン
JP2001346893A (ja) * 2000-06-06 2001-12-18 Ishikawajima Harima Heavy Ind Co Ltd 放射線治療装置
US8405056B2 (en) 2006-12-28 2013-03-26 Fondazione per Adroterapia Oncologica—TERA Ion acceleration system for medical and/or other applications
WO2009070173A1 (fr) * 2007-11-30 2009-06-04 Still River Systems Incorporated Portique intérieur
US8153990B2 (en) 2008-05-20 2012-04-10 Hitachi, Ltd. Particle beam therapy system
EP2637181A1 (fr) * 2012-03-06 2013-09-11 Tesla Engineering Limited Cryostats à orientations multiples

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017212290A1 (fr) * 2016-06-10 2017-12-14 Lancaster University Business Enterprises Limited Système de libération pour thérapie par particules
WO2021002043A1 (fr) * 2019-07-01 2021-01-07 株式会社日立製作所 Système de traitement par faisceau de particules
JP2021007645A (ja) * 2019-07-01 2021-01-28 株式会社日立製作所 粒子線治療システム
JP7319846B2 (ja) 2019-07-01 2023-08-02 株式会社日立製作所 粒子線治療システム

Also Published As

Publication number Publication date
EP3068489A1 (fr) 2016-09-21
WO2015071430A1 (fr) 2015-05-21

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