WO2015037752A1 - Tête de traitement à ondes ultrasonores focalisées à haute intensité ayant une caractéristique d'étanchéité améliorée - Google Patents

Tête de traitement à ondes ultrasonores focalisées à haute intensité ayant une caractéristique d'étanchéité améliorée Download PDF

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Publication number
WO2015037752A1
WO2015037752A1 PCT/KR2013/008248 KR2013008248W WO2015037752A1 WO 2015037752 A1 WO2015037752 A1 WO 2015037752A1 KR 2013008248 W KR2013008248 W KR 2013008248W WO 2015037752 A1 WO2015037752 A1 WO 2015037752A1
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WO
WIPO (PCT)
Prior art keywords
membrane
imaging transducer
circumferential surface
housing
high intensity
Prior art date
Application number
PCT/KR2013/008248
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English (en)
Korean (ko)
Inventor
박경모
손건호
Original Assignee
알피니언메디칼시스템 주식회사
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Priority to KR1020167001121A priority Critical patent/KR101808835B1/ko
Priority to PCT/KR2013/008248 priority patent/WO2015037752A1/fr
Priority to CN201380079563.8A priority patent/CN105530994B/zh
Publication of WO2015037752A1 publication Critical patent/WO2015037752A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N7/02—Localised ultrasound hyperthermia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/225—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves
    • A61B17/2251—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves characterised by coupling elements between the apparatus, e.g. shock wave apparatus or locating means, and the patient, e.g. details of bags, pressure control of bag on patient
    • A61B2017/2253—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves characterised by coupling elements between the apparatus, e.g. shock wave apparatus or locating means, and the patient, e.g. details of bags, pressure control of bag on patient using a coupling gel or liquid

Definitions

  • the present invention relates to a high-intensity focused ultrasound therapy head used to treat high heat generated at the focal point when high-intensity ultrasound energy is collected in one place.
  • High-Intensity Focused Ultrasound is a procedure that burns and removes lesion tissue in the body by using high heat of 65-100 degrees centigrade at the focus when high-intensity ultrasound energy is collected in one place.
  • HIFU High-Intensity Focused Ultrasound
  • Ultrasound itself is harmless to the human body and heat is generated only at the focal point where the ultrasound is concentrated, so the lesions in the body can be treated non-invasive.
  • High-intensity focused ultrasound therapy is available for pancreatic cancer, uterine fibroids, liver cancer, etc., and active research is being conducted on prostate cancer, endometrial cancer, kidney cancer, breast cancer, soft tissue tumors, and bone tumors.
  • the high intensity focused ultrasound therapy head has a high intensity focused ultrasound transducer at its end.
  • the high intensity focused ultrasound transducer is configured to emit high intensity focused ultrasound.
  • the ultrasonic radiating surface of the high intensity focused ultrasound transducer is covered by a membrane.
  • the ultrasonic delivery medium is filled in the space formed between the ultrasonic radiating surface and the membrane.
  • degassed water is used as the ultrasonic delivery medium.
  • the high intensity focused ultrasound treatment head may be provided with an imaging transducer for obtaining a diagnostic image. The imaging transducer is fitted to the high intensity focused ultrasound transducer so that the lower portion penetrates the high intensity focused ultrasound transducer and is located in the space between the ultrasound radiation plane and the membrane.
  • the high intensity focused ultrasound treatment head is positioned above the patient and emits high intensity focused ultrasound through the ultrasonic radiating surface of the high intensity focused ultrasound transducer while keeping the membrane in close contact with the patient's skin.
  • the high intensity focused ultrasound is then delivered to the lesion site of the patient via water between the ultrasonic radiating surface and the membrane.
  • the membrane portion is sealed to the edge portion of the high-intensity focused ultrasound transducer by a sealing mechanism, so that the water filled between the membrane and the ultrasonic radiation surface does not leak.
  • a sealing mechanism so that the water filled between the membrane and the ultrasonic radiation surface does not leak.
  • the imaging transducer may be rotated to acquire a diagnostic image while being fitted to the high intensity focused ultrasound transducer.
  • the combined portion of the imaging transducer and the high intensity focused ultrasound transducer needs to be sealed to prevent leakage of water and to allow the imaging transducer to rotate smoothly.
  • An object of the present invention is to provide a high-intensity ultrasound treatment head that can increase the effect of preventing the leakage of the ultrasound delivery medium.
  • the high intensity focused ultrasound treatment head for achieving the above object includes a high intensity focused ultrasound transducer, a housing, a membrane, and a seal for the membrane.
  • the high intensity focused ultrasound transducer has an ultrasonic radiation plane located at the bottom.
  • the housing receives a high intensity focused ultrasound transducer in the lower opening such that the ultrasonic radiating surface is exposed.
  • the membrane is formed to surround the lower opening of the housing and the outer circumferential surface to form an accommodating space for accommodating the ultrasonic transmission medium between the ultrasonic radiating surface and the close contact with the outer circumferential surface of the housing.
  • the seal for the membrane is located toward the outer peripheral face of the housing to seal between the membrane and the housing.
  • the high intensity focused ultrasound treatment head includes a high intensity focused ultrasound transducer, a membrane, an imaging transducer, a partition, and a seal for the imaging transducer.
  • the high intensity focused ultrasound transducer has an ultrasonic radiation plane located at the bottom.
  • the imaging transducer is formed to surround the ultrasonic radiation surface to form an accommodation space for accommodating the ultrasonic transmission medium between the ultrasonic radiation surface.
  • the imaging transducer is inserted through the insertion hole of the high intensity focused ultrasound transducer and placed in the receiving space.
  • the septum extends upwardly from the periphery of the insertion hole to surround the outer peripheral face of the imaging transducer.
  • the seal for the imaging transducer is located toward the outer peripheral face of the imaging transducer to seal between the imaging transducer and the septum.
  • the effect of preventing leakage of the ultrasound delivery medium can be enhanced.
  • stability may be increased during high-intensity focused ultrasound therapy.
  • the present invention it is possible to smoothly rotate the imaging transducer while increasing the sealing effect of the imaging transducer.
  • assembling or disassembling the sealing site is simple, so that the user's convenience can be enhanced.
  • FIG. 1 is a cross-sectional view of the high intensity focused ultrasound treatment head according to an embodiment of the present invention.
  • FIG. 2 is a cross-sectional view showing a state before the ultrasonic delivery medium is filled in the receiving space in FIG.
  • FIG. 3 is an enlarged cross-sectional view of a region A in FIG. 1.
  • FIG. 4 is an exploded perspective view illustrating the housing and the membrane disassembled in FIG. 3.
  • FIG. 5 is an enlarged perspective view of region C in FIG. 4.
  • FIG. 6 is a cross-sectional view of a housing and a membrane part having a seal for a membrane according to another example.
  • FIG. 7 is a cross-sectional view illustrating a state in which a state is sealed between the housing and the membrane by the first sealing protrusions and the second sealing protrusions in FIG. 6.
  • FIG. 8 is an enlarged cross-sectional view of region B in FIG. 1.
  • FIG. 9 is an exploded perspective view of the imaging transducer and the sealant in FIG. 8.
  • 1 is a cross-sectional view of the high intensity focused ultrasound treatment head according to an embodiment of the present invention.
  • 2 is a cross-sectional view showing a state before the ultrasonic delivery medium is filled in the receiving space in FIG.
  • the high intensity focused ultrasound treatment head 100 includes a high intensity focused ultrasound transducer 110, a housing 120, a membrane 130, and a seal 140 for the membrane. .
  • the high intensity focused ultrasound transducer 110 radiates high intensity focused ultrasound for patient treatment.
  • the high intensity focused ultrasound transducer 110 may have an ultrasonic radiating surface 110a at a lower end thereof.
  • the high intensity focused ultrasound transducer 110 may include an ultrasound generator 111 and an ultrasound radiation frame 116.
  • the ultrasonic wave generator 111 may be mounted on the ultrasonic radiation frame 116.
  • the ultrasonic wave generator 111 may be electrically connected to the driving circuit board by wiring or the like.
  • the ultrasonic wave generator 111 may include a piezoelectric element. When the piezoelectric element receives a voltage by the driving circuit board, the piezoelectric element resonates to generate ultrasonic waves.
  • the piezoelectric element may be made of a piezoelectric ceramic such as lead zirconate titanate (PZT), a single crystal, a composite piezoelectric composite of these materials and a polymer material.
  • the ultrasonic wave generator 111 may include an acoustic matching layer positioned on one side of the piezoelectric element so as to appropriately set resonance characteristics.
  • the ultrasonic generator 111 may be configured in various forms in a range capable of generating high intensity ultrasonic waves, and is not limited thereto.
  • the ultrasonic radiation frame 116 focuses and radiates high intensity ultrasonic waves generated from the ultrasonic generator 111.
  • the ultrasonic radiation frame 116 may have a predetermined thickness and may have a shape in which the central portion is convex upward.
  • the lower surface of the ultrasonic radiation frame 116 corresponds to the ultrasonic radiation surface 110a.
  • the housing 120 receives the high intensity focused ultrasound transducer 110 in the lower opening so that the ultrasonic radiating surface 110a is exposed.
  • the housing 120 may have a cylindrical shape having an inner space and an open lower side thereof.
  • the lower opening of the housing 120 may be closed by the edge of the ultrasonic radiation frame 116 is coupled to the periphery.
  • the membrane 130 is formed to surround the lower opening of the housing 120 and the outer circumferential surface to form an accommodation space 131 for accommodating the ultrasonic transfer medium 101 between the membrane 130 and the ultrasonic radiation surface 110a.
  • the membrane 130 may have a cylindrical hollow shape and have an upper side open.
  • the membrane 130 may be fitted to surround the lower opening and the outer circumferential surface of the housing 120 from the lower side of the housing 120.
  • Ultrasonic delivery medium 101 may be made of degassed water and the like.
  • the membrane 130 is in close contact with the outer circumferential surface of the housing 120.
  • the membrane 130 has a shape as shown in FIG. 2 in a state in which the ultrasonic delivery medium 101 is not received in the receiving space 131. In this state, when the ultrasonic delivery medium 101 is filled in the receiving space 131 in a set amount, the membrane 130 has a hemispherical shape in which a portion surrounding the lower opening of the housing 120 is shown in FIG. 1. It can be modified.
  • the membrane 130 may be made of a material having an acoustic impedance similar to that of the ultrasonic transmission medium 101, less ultrasonic transmission loss, and excellent elasticity.
  • the membrane 130 may be made of a material such as ethylene propylene (EPDM) rubber, latex rubber, silicone rubber, or the like.
  • the membrane 130 may have a portion surrounding the outer circumferential surface of the housing 120 thicker than a portion surrounding the lower opening of the housing 120. Accordingly, the membrane 130 may maintain a more rigid shape in a state in which the outer circumferential surface of the housing 120 is wrapped.
  • the membrane seal 140 is located toward the outer circumferential surface of the housing 120 to seal between the membrane 130 and the housing 120. Accordingly, the ultrasonic transfer medium 101 filled between the membrane 130 and the ultrasonic radiation surface 110a may not leak through the coupling portion of the membrane 130 and the housing 120.
  • the membrane 130 extends to cover the outer circumferential surface of the housing 120 from a portion surrounding the lower opening of the housing 120 to cover the ultrasonic radiating surface 110a and the outer circumferential surface of the housing 120.
  • a portion surrounding the seal is sealed to the housing 120 by the membrane sealing portion 140. Accordingly, when the lower portion of the membrane 130 is pressed to apply pressure to the ultrasonic transfer medium 101, the pressure may be distributed to the circumferential portion of the membrane 130, so that the sealing effect may be enhanced.
  • the ultrasonic transfer medium leaked from the edge of the ultrasonic radiation surface (110a) to the sealing portion located on the outer peripheral surface side of the housing 120
  • the distance traveled can be long. Therefore, even when excessive pressure is applied to the ultrasound delivery medium 101 in the process of bringing the membrane 130 into close contact with the patient's skin during the high intensity focused ultrasound therapy, the ultrasound delivery medium is coupled through the combined portion of the membrane 130 and the housing 120. The effect of preventing 101 from leaking can be increased.
  • the membrane sealing part 140 may include at least two first sealing protrusions 141.
  • the first sealing protrusions 141 may protrude along the circumferential direction from the outer circumferential surface of the housing 120 and may be spaced apart from each other up and down.
  • the membrane 130 has a portion corresponding to the first sealing protrusions 141 in the form of the first sealing protrusions 141. While being deformed to fit the first sealing protrusions (141) is forcibly fitted. Accordingly, the membrane 130 and the housing 120 may be double sealed at the outer circumferential surface of the housing 120.
  • the first sealing protrusions 141 may be formed in a form in which the protruding length gradually increases toward the upper side. Accordingly, the effect of preventing leakage of the ultrasonic delivery medium 101 may be increased.
  • the membrane 130 may increase the portions to be caught with the first sealing protrusions 141, thereby preventing the membrane 130 from falling out from being coupled to the housing 120.
  • the first sealing protrusion 141 is illustrated as two, three or more of course may be possible.
  • the membrane sealing part 140 may further include at least one second sealing protrusion 142. As shown in FIGS. 4 and 5, the second sealing protrusion 142 protrudes along the circumferential direction from the inner circumferential surface of the membrane 130. The second sealing protrusion 142 is disposed between the first sealing protrusions 141.
  • the second sealing protrusion 142 When the inner circumferential surface of the membrane 130 is in close contact with the outer circumferential surface of the housing 120, as shown in FIG. 3, the second sealing protrusion 142 is deformed to be pressed against the outer circumferential surface of the housing 120. do. Accordingly, the second sealing protrusion 142 is disposed between the first sealing protrusions 141 to seal the membrane 130 and the housing 120 once more, and thus, the membrane 130 and the housing 120. ) Can be sealed in triplicate. Thus, the effect of sealing between the membrane 130 and the housing 120 may be higher.
  • the second sealing protrusion 142 is illustrated as having a shape having a substantially semi-circular cross section, the second sealing protrusion 142 may be formed in various shapes without being limited thereto. In addition, two or more second sealing protrusions 142 may be provided.
  • the membrane 130 may be sealed and fixed between the membrane 130 and the housing 120 through the process of fitting the membrane 130 from the lower side of the housing 120. It can increase the convenience.
  • first sealing protrusions 241 may protrude along the circumferential direction from the inner circumferential surface of the membrane 130 and may be spaced apart from each other up and down.
  • first sealing protrusions 241 When the inner circumferential surface of the membrane 130 is in close contact with the outer circumferential surface of the housing 120, the first sealing protrusions 241 are deformed to compress the outer circumferential surface of the housing 120.
  • the first sealing protrusions 241 may be formed in a form in which the protruding length gradually increases toward the upper side.
  • the at least one second sealing protrusion 242 protrudes along the circumferential direction from the outer circumferential surface of the housing 120.
  • the second sealing protrusion 242 is disposed between the first sealing protrusions 241.
  • the membrane 130 has a portion corresponding to the second sealing protrusion 242 in the form of the second sealing protrusion 242.
  • the second sealing protrusion 242 is pressed by being deformed to fit. Accordingly, the gap between the membrane 130 and the housing 120 may be sealed.
  • the sealing portion for the membrane may be formed in various forms, of course.
  • the high intensity focused ultrasound treatment head 100 may include an imaging transducer 150.
  • the high intensity focused ultrasound treatment head 100 may include a seal 160 for an imaging transducer.
  • the imaging transducer 150 is for acquiring a diagnostic image of the subject.
  • the operator may perform high intensity focused ultrasound therapy while checking the diagnostic image acquired by the imaging transducer 150.
  • the imaging transducer 150 may be configured to transmit the ultrasonic signal to the subject and receive the ultrasonic signal reflected from the subject.
  • the imaging transducer 150 may be configured by embedding a piezoelectric element or the like in a cylindrical casing. Ultrasound may be transmitted and received through the lower surface of the imaging transducer 150.
  • the imaging transducer 150 may be inserted through the insertion hole 117 of the high intensity focused ultrasound transducer 110 and positioned in the accommodation space. Insertion hole 117 may be formed in the central portion of the ultrasonic radiation frame 116.
  • a partition wall 126 may be provided to support the imaging transducer 150. The partition wall 126 extends upward from the periphery of the insertion hole 117 to surround the imaging transducer 150 in the housing 120.
  • the imaging transducer 150 may acquire a diagnostic image while rotating as necessary in a state of being coupled to the ultrasonic radiation frame 116. In this case, the imaging transducer 150 may be rotated by the guide of the partition wall 126.
  • the ultrasonic radiation frame 116 may include a flange portion 118 formed to protrude along the upper opening periphery of the insertion hole 117.
  • the partition 126 may have a lower portion fixed and sealed to the flange portion 118 by an adhesive or the like.
  • the partition wall 126 may be formed to be integral with the flange portion 118.
  • the flange portion 118 may be provided with a supply port for supplying the ultrasonic transfer medium to the accommodation space 131, and a discharge port for discharging the ultrasonic transfer medium from the accommodation space 131.
  • the seal 160 for the imaging transducer is positioned toward the outer circumferential surface of the imaging transducer 150 to seal between the imaging transducer 150 and the partition 126.
  • the seal 160 for the imaging transducer may include at least two or more mounting grooves 161.
  • the mounting grooves 161 are each formed concave along the circumferential direction from the outer circumferential surface of the imaging transducer 150.
  • the seating grooves 161 are spaced apart from each other up and down.
  • the seals 166 are respectively seated in the mounting grooves 161 to seal between the imaging transducer 150 and the partition wall 126. With the imaging transducer 150 fitted in the partition 126, the seals 166 are deformed to be compressed into the mounting grooves 161, respectively. At this time, each inner circumferential surface of the sealing materials 166 is in close contact with the outer circumferential surface of the imaging transducer 150, and each outer circumferential surface of the sealing materials 166 is in close contact with the inner circumferential surface of the partition wall 126.
  • the double sealing may be performed between the producer 150 and the partition wall 126.
  • the sealing members 166 may be made of a material such as rubber having elasticity.
  • Each sealant 166 has two line contact portions spaced up and down on an inner circumferential face toward the imaging transducer 150 and two line contact portions spaced up and down on an outer circumferential face toward the partition 126. It may be made in the form having.
  • each of the seals 166 may be formed in a rectangular ring shape which is recessed in a circumferential direction on the inner circumferential surface facing the imaging transducer 150 and the outer circumferential surface facing the partition wall 126.
  • the seating grooves 161 may be formed as rectangular grooves, respectively.
  • each sealant 166 has an effect of quadruple sealing between the imaging transducer 150 and the partition wall 126 by four line contact portions, and the adhesion force by the four line contact portions. By dispersing the rotation of the imaging transducer 150 can be smooth.
  • the seal 160 for the imaging transducer may include at least one pressure reducing groove 162.
  • the pressure reducing groove 162 is formed concave along the circumferential direction from the outer circumferential surface of the imaging transducer 150.
  • the pressure reducing groove 162 is disposed between the seating grooves 161. Therefore, even if a very strong pressure is applied to the membrane 130 so that the ultrasonic delivery medium 101 passes through the sealing material 166 located below the pressure reducing groove 162 and leaks a little, ultrasonic pressure is applied to the pressure reducing groove 162. Since the transfer medium 101 may be sufficiently stored, the pressure applied to the sealing material 166 located above the pressure reducing groove 162 may be reduced. Therefore, the sealing effect between the imaging transducer 150 and the partition wall 126 may be maximized.
  • the pressure reducing groove 162 is illustrated as a rectangular groove, it can be made of grooves of various shapes in the range of the above-described function.
  • the pressure reducing groove 162 may be two or more.
  • At least two or more mounting grooves 161 may be formed concavely along the circumferential direction from the inner circumferential surface of the partition wall 126 to seat the sealing members 166.
  • the at least one pressure reducing groove 162 may be formed concave along the circumferential direction from the inner circumferential surface of the partition 126.
  • the high intensity focused ultrasound treatment head 100 may further include a clamp.
  • the clamp may be positioned to correspond to the membrane seal 140 on the outer circumferential surface of the membrane 130 to tighten the membrane 130. Accordingly, the sealing effect may be further enhanced by increasing the adhesion of the first sealing protrusions 141 to the membrane 130 and the adhesion of the second sealing protrusions 142 to the housing 120. In addition, the effect of preventing the membrane 130 from falling downward from the housing 120 may be further increased.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Surgical Instruments (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)

Abstract

La présente invention concerne une tête de traitement à ondes ultrasonores focalisées à haute intensité ayant une caractéristique d'étanchéité améliorée qui comprend : un transducteur d'ondes ultrasonores focalisées à haute intensité ; un boîtier ; une membrane ; et une partie d'étanchéité pour la membrane. Le transducteur d'ondes ultrasonores focalisées à haute intensité a une surface de rayonnement d'ondes ultrasonores située à l'extrémité inférieure de celui-ci. Le boîtier reçoit le transducteur d'ondes ultrasonores focalisées à haute intensité au niveau de l'ouverture inférieure de celui-ci pour exposer la surface de rayonnement d'ondes ultrasonores. La membrane a un espace de réception qui est formé de manière à entourer l'ouverture inférieure et une surface périphérique externe du boîtier pour recevoir un milieu de transfert d'ondes ultrasonores entre la surface de rayonnement d'ondes ultrasonores et la membrane, et est en contact étroit avec la surface périphérique externe du boîtier. La partie d'étanchéité de la membrane est située sur la surface périphérique externe du boîtier pour sceller un espace entre la membrane et le boîtier.
PCT/KR2013/008248 2013-09-12 2013-09-12 Tête de traitement à ondes ultrasonores focalisées à haute intensité ayant une caractéristique d'étanchéité améliorée WO2015037752A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
KR1020167001121A KR101808835B1 (ko) 2013-09-12 2013-09-12 개선된 밀봉 특성을 갖는 고강도 집속 초음파 치료헤드
PCT/KR2013/008248 WO2015037752A1 (fr) 2013-09-12 2013-09-12 Tête de traitement à ondes ultrasonores focalisées à haute intensité ayant une caractéristique d'étanchéité améliorée
CN201380079563.8A CN105530994B (zh) 2013-09-12 2013-09-12 具有改善的密封特性的高强度聚焦超声波治疗头

Applications Claiming Priority (1)

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PCT/KR2013/008248 WO2015037752A1 (fr) 2013-09-12 2013-09-12 Tête de traitement à ondes ultrasonores focalisées à haute intensité ayant une caractéristique d'étanchéité améliorée

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WO2015037752A1 true WO2015037752A1 (fr) 2015-03-19

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CN107569786A (zh) * 2017-10-20 2018-01-12 中国计量大学 应用于临床治疗的新型超声探头
US11890136B2 (en) * 2018-08-22 2024-02-06 Philips Image Guided Therapy Corporation Fluid barrier for intraluminal ultrasound imaging and associated devices, systems, and methods
KR102414954B1 (ko) * 2021-11-30 2022-07-01 주식회사 모세메디 초음파 와류에너지 투입장치
KR20230126533A (ko) * 2022-02-23 2023-08-30 주식회사 제이시스메디칼 프로브 교체형 고강도 집속 초음파 발생 장치

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KR101808835B1 (ko) 2017-12-13
KR20160025556A (ko) 2016-03-08
CN105530994B (zh) 2018-11-20

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