WO2015032694A1 - Système d'automatisation de laboratoire et procédé de désinfection - Google Patents

Système d'automatisation de laboratoire et procédé de désinfection Download PDF

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Publication number
WO2015032694A1
WO2015032694A1 PCT/EP2014/068340 EP2014068340W WO2015032694A1 WO 2015032694 A1 WO2015032694 A1 WO 2015032694A1 EP 2014068340 W EP2014068340 W EP 2014068340W WO 2015032694 A1 WO2015032694 A1 WO 2015032694A1
Authority
WO
WIPO (PCT)
Prior art keywords
automation system
laboratory automation
compartment
operating element
opening
Prior art date
Application number
PCT/EP2014/068340
Other languages
German (de)
English (en)
Inventor
Fabian FERHATI
Original Assignee
Roche Diagnostics Gmbh
F. Hoffmann-La Roche Ag
Roche Diagnostics Operations, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics Gmbh, F. Hoffmann-La Roche Ag, Roche Diagnostics Operations, Inc. filed Critical Roche Diagnostics Gmbh
Publication of WO2015032694A1 publication Critical patent/WO2015032694A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/08—Radiation
    • A61L2/10—Ultraviolet radiation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L13/00—Cleaning or rinsing apparatus
    • B01L13/02—Cleaning or rinsing apparatus for receptacle or instruments
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/08—Ergonomic or safety aspects of handling devices
    • B01L2200/082—Handling hazardous material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00178—Special arrangements of analysers
    • G01N2035/00306—Housings, cabinets, control panels (details)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor

Definitions

  • the invention relates to a laboratory automation system, comprising: a housing and a control element for operator control of the laboratory automation system.
  • Such laboratory automation systems may be used, for example, for handling and processing medical samples contained in sample tubes.
  • the medical samples are usually body fluids.
  • the control element is used for operator control of the laboratory automation system.
  • Such an operating element can have, for example, a monitor and a keyboard.
  • Such input devices are usually relatively bulky. They also consume space when they are not needed at the moment. Usually they stand out over the rest of the laboratory automation system and thus pose a risk of injury to working people. Furthermore, dust, germs, droplets or other undesirable foreign bodies can settle on such input devices, which is particularly disturbing in the medical environment. If such input devices are used by different people, there is still a risk of transmission of diseases.
  • the invention relates to a method for disinfecting or sterilizing an operating element of a laboratory automation system. Generic methods are performed for example by spraying the control with disinfectants and are therefore expensive. A sufficiently frequent application is not guaranteed.
  • the invention relates to a laboratory automation system, comprising: a housing and a control element for operator control of the laboratory automation system.
  • a compartment for receiving the operating element and an opening assigned to the compartment are formed in the housing.
  • the opening is associated with closing means, wherein the closing means have an open state in which the operating element can be introduced through the opening in the compartment, and wherein the closing means further comprises a closed state in which the opening is closed.
  • the housing may be similar to a laboratory automation system according to the prior art. Such devices often have expansions of one to several meters in all dimensions.
  • control element can be, for example, the combination of a screen with a keyboard.
  • other input devices may also be present, for example a computer mouse, a touchpad, a touchscreen, a trackball or a pointing device.
  • the operating element can also be made removable, for example as a handheld device.
  • the compartment for receiving the operating element may be designed such that it is completely enclosed or closed when the closing means is in its closed state. Thus, a complete shielding of the compartment to the environment of the laboratory automation system can be achieved. This avoids, for example, the contamination of elements stored in the compartment, such as the operating element, by processes taking place in the environment of the laboratory automation system.
  • the opening may be formed on any sides of the housing. However, it is preferably formed on a front side of the housing, so that, for example, the operating element can be simply pulled out or pushed inwards. It will be described in more detail below how the laboratory automation system can be designed for this purpose.
  • the closing means may for example be designed to be manually operable. However, for example, they can also be designed to be electrically operable, in particular they can be designed with be provided an electrically operated sliding or folding mechanism.
  • the closing means may comprise a flat piece of material which closes the opening in the closed state. In the closed state, it can be provided, in particular, that the opening through the closing means is light-tight, radiation-tight, gas-tight, fluid-tight, impermeable to other influences or a combination thereof. In particular, it is preferred if the opening is closed by the closing means at least light-tight and fluid-tight when the closing means are in the closed state.
  • disinfectants or sterilizing agents are provided in the compartment. These serve, in particular, for disinfection or sterilization of the operating element.
  • the control element can be disinfected during a time in which it is not used. This can effectively prevent the transmission of diseases, for example between different users.
  • the disinfectant or sterilizing agent is a system for spraying the operating element or other components located in the housing with a disinfectant or sterilizing liquid, for example alcohol.
  • the disinfectants or sterilizing agents may have at least one ultraviolet radiation (UV) source.
  • UV ultraviolet radiation
  • the UV source can be designed in such a way that, during operation, it emits UV-C radiation having a wavelength between 240 nm and 270 nm at least temporarily.
  • a wavelength spectrum has proved to be particularly advantageous for the purposes of disinfection. These are in particular those radiation areas which have a reliable killing or neutralizing effect on pathogens such as bacteria or viruses.
  • the UV source can be configured as a UV light-emitting diode or as an arrangement with a plurality of UV light-emitting diodes. This is a reliable and energy-saving source of UV radiation.
  • the laboratory automation system may include activating means which activate the disinfectant, preferably immediately after the closure means have entered the closed state, and at least during such period of time that a germicidal UV-C dose is delivered.
  • activating agent can be achieved be that a disinfection of the operating element begins immediately after the closing of the opening by the closing means. This prevents that the disinfection fails, for example, due to forgotten activation of the disinfectant.
  • a disinfected state of the control element is made as quickly as possible in this way, so that it can be used quickly again.
  • a germicidal UV-C dose can be determined for each germ species to be killed, depending on the wavelength or wavelength spectrum used. It is a combination of irradiation time and irradiation intensity. A low radiation intensity can be compensated, for example, by a longer irradiation time. Preferably, a germicidal UV-C dose is delivered, which is sufficient to reliably kill all known pathogens.
  • the disinfectants can act directly on the control. This can be achieved, for example, by the control element being irradiated directly by the UV source, for example an arrangement of UV light-emitting diodes.
  • the disinfectants can act on the operating element on the whole side, so that an all-round disinfecting effect is achieved. For example, if the disinfectants are designed as nozzles which spray a liquid disinfectant, they can be arranged such that they spray directly on the control element located in the housing.
  • the laboratory automation system can also have an air circulation device, wherein disinfectants act on air circulated by the air circulation device.
  • This can be achieved, for example, by aspirating air from the interior of the housing and feeding it into an air circulation channel in which the air is irradiated with UV radiation.
  • a UV source in this case is arranged to emit the UV radiation into the air circulation channel.
  • This can be a direct exposure of UV radiation to the input element or other components located in the housing can be avoided. This can be advantageous, for example, if the UV radiation would have a negative effect, for example bleaching or thermal damage to the operating element or other components.
  • the laboratory automation system may comprise a number of extendable drawers adapted to receive samples, the disinfectants being adapted to act on samples contained in the drawers.
  • Such an effect on samples in the drawers may alternatively or in addition to the effect on a control panel. ment be provided.
  • the drawers can be equipped with samples from outside the housing in order to disinfect them. The next time the disinfecting agents are activated, for example because the operating element is introduced through the opening into the interior of the housing and is to be disinfected, these samples are also disinfected. This saves work steps and energy.
  • the disinfectant or sterilization agent can be arranged to be movable on a rail.
  • the disinfectants can be adapted to different current requirements. For example, an altered operating element or another arrangement as well as any necessary disinfection of samples located in drawers can be taken into account.
  • the laboratory automation system may include a slide-in device for linearly feeding and removing the control element into and out of the compartment.
  • a slide-in device can be designed, for example, as an arrangement of linearly displaceable rails. This allows a particularly simple design and ease of use.
  • the operating element can be pulled out linearly by a user through the opening and can likewise be inserted again through the opening into the compartment.
  • the laboratory automation system may include a ball joint for pivoting the operating member, particularly in a state where the operating member is outside the compartment.
  • a ball joint may for example be mounted inside the housing, wherein an aforementioned insertion device may be pivotally mounted on the ball joint.
  • the ball joint may for example also be mounted between two elements of a slide-in device or at the end of a slide-in device.
  • a three-dimensional adjustability of the operating element when it is outside the housing can be achieved.
  • different requirements for example different body sizes of operating or differently desired operating positions, can advantageously be taken into account.
  • the operating element has at least one monitor and a keyboard, wherein the keyboard is attachable to a back of the monitor in a storage state and by means of hinges and / or rails in a working state the monitor can be spent.
  • the keyboard can simply be moved to a working position.
  • At least one support surface for placing objects can be formed on the input device. On such a support surface objects can be placed, which are moved in and out with the control and thus can also be disinfected within the housing. This allows an increase in the functionality for disinfecting. For example, devices that are to be used outside of the laboratory automation system and subjected to rapid disinfection can simply be placed on such a support surface and disinfected within the compartment.
  • the invention further relates to a method for disinfecting or sterilizing an operating element of a laboratory automation system, the method comprising the steps of retracting the operating element into a compartment of the laboratory automation system, closing an opening associated with the compartment, and activating disinfectants or sterilizing agents in the compartment ,
  • FIG. 2 shows the laboratory automation system of FIG. 1 in a different state.
  • FIG. 2 shows the laboratory automation system of FIG. 1 in a different state.
  • FIG. 3 shows the laboratory automation system of FIG. 1 in yet another state
  • FIG. 6 is a schematic view of a UV-based disinfectant
  • Fig. 7 is a schematic view of another UV-based disinfectant. Detailed description of the embodiments
  • Fig. 1 shows a laboratory automation system 10.
  • the laboratory automation system 10 has a housing 1 1, which encloses the laboratory automation system 10.
  • the housing 1 1 is movably mounted on rollers.
  • a receiving area 12 is formed, which provides a flat bearing surface.
  • a sample holder with samples 13 are placed so that they are available for handling and / or analysis by the laboratory automation system 10. These are typically medical samples in the form of liquids contained in respective tubes.
  • the laboratory automation system 10 further has an opening 14 in the housing 1 1, which is closed in the state shown in Fig. 1 by closing means in the form of a flap 15.
  • the laboratory automation system 10 has a drawer 18, of which in the state shown in Fig. 1, only an outer surface and a control knob can be seen. In other words, the drawer 18 is fully retracted in the state shown in Fig. 1.
  • Fig. 2 shows the laboratory automation system 10 of Fig. 1 in a different state.
  • the flap 15 is opened. This is done by the flap 15 is folded out on an elongated hinge 16.
  • the flap 15 is designed in a known manner such that it opens when you press lightly against the flap 15 with a finger or with one hand at a marked location.
  • a sensor for detecting the state of the flap 15 is integrated.
  • the hinge 16 can serve as an activating means for activating disinfectants or sterilizing agents described below, in particular such that the disinfectants are activated when the flap 15 is closed.
  • the flap 15 is open in the state shown in FIG. 2, it is possible to look through the opening 14.
  • a disposed within the housing 1 1 compartment 13 is visible, which is accessible through the opening 14.
  • This compartment 13 is used inter alia for receiving a control element 20th
  • the operating element 20 is completely contained in the compartment 13 and thus within the housing 1 1. This is a condition in which the operating element 20 is stored and - as will be shown later - can be disinfected. It will be described below how the operating element 20 can be used to operate the laboratory automation system 10.
  • the operating element 20 has a screen 22 and a keyboard 24.
  • the keyboard 24 is folded up so that it extends with its longitudinal direction along the monitor 22.
  • the drawer 18 is pulled out.
  • 18 items can be placed in the drawer, which should be disinfected within the housing 1 1.
  • FIG. 3 shows the laboratory automation system 10 in yet another state.
  • the drawer 18 is retracted again.
  • the operating element 20 has moved out of the compartment 13 in the state shown in FIG. 3.
  • the monitor 22 and the keyboard 24 are outside the housing 1 1.
  • the keyboard 24 is further folded down, so that a conventional computer workstation is created. This can be used to control the laboratory automation system 10.
  • the operating element 20 is supported by an arm 26, which in turn is connected to a ball joint 27.
  • the ball joint 27 is connected to a slide-in device 30, wherein the insertion device 30 serves to pull the ball joint 27 with the arm 26 and the control element 20 from the tray 13 and push it back into this if necessary. It will be explained in more detail below how this is done.
  • Fig. 4 shows the control element 20 and the components located thereon to the insertion device 30 in greater detail. It can be seen again that the keyboard 24 is folded down so that it forms a normal VDU workstation together with the monitor 22.
  • the arm or leg 26 is presently arranged such that it forms an extension of the insertion device 30.
  • the insertion device 30 has an outer rail 32 and an inner rail 34.
  • the inner rail 34 is connected to the ball joint 27.
  • the ball joint 27 can be used to three-dimensionally adjust the position of the operating element 20. Thus, for example, different heights or lateral orientations can be adjusted.
  • Fig. 5 shows three possible embodiments of a UV source.
  • FIG. 5 a shows a round lamp field 40 with a plurality of smaller UV lamps 41.
  • Such UV lamps 41 may, for example, be light-emitting diodes (LEDs) or ordinary, for example fluorescent-based, UV lamps.
  • Fig. 5b shows another embodiment of a UV lamp 42.
  • two U-shaped tubes 43 are arranged on the UV lamp 42, which are designed as conventional, fluorescent UV lamps.
  • Fig. 5c shows a lamp bar 44, which has a plurality of individual, smaller lamps 45. These are preferably light emitting diodes (LEDs).
  • LEDs light emitting diodes
  • FIG. 6 shows schematically disinfectants 50 in relation to the input unit 20 and the drawer 18.
  • the disinfectants 50 have a UV lamp 52 and a rail 54.
  • the UV lamp 52 can be moved electrically along the rail 54. This allows the positioning of the UV lamp 52 at different locations within the housing 11.
  • the operating element 20 is here in the same state in which it is located in FIG. 1, namely in a storage state within the compartment 13 in the housing 11. As shown, the control element 20 is in this state immediately below the rail 54, which is achieved so that the UV lamp 52 can be passed over the control element 20. This allows irradiation of the control element 20 from all sides, by the UV lamp 52 is driven to all sides of the control element 20 and accordingly For a long time it is lit to deliver a UV-C dose germicidal the pathogens to be removed.
  • the UV lamp 52 can be arranged above the drawer 18. With appropriate radiation in this position, the UV radiation from the lamp 52 directly reaches the interior of the drawer 18 and there fulfills a disinfecting effect.
  • Fig. 7 shows an alternative embodiment of disinfectants 50.
  • two fixed strips of lamps 52 are arranged, which are mounted opposite one another.
  • the two strips of lamps 52 are attached directly to the housing 1 1.
  • the monitor 22 Adjacent to the two strips of lamps 52, the monitor 22 is arranged, which can be disinfected in this way from at least one side. If the monitor 22 is also to be disinfected from other sides or should the keyboard 24 also be disinfected, additional lamps 52 may be provided within the housing 11 or the control element 20 with the monitor 22 and the keyboard 24 may be rotated within the compartment 13 ,

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  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)

Abstract

L'invention concerne un système d'automatisation de laboratoire et un procédé associé. Selon l'invention, un élément de commande du système d'automatisation de laboratoire est monté dans un compartiment et de préférence également désinfecté ou stérilisé.
PCT/EP2014/068340 2013-09-04 2014-08-29 Système d'automatisation de laboratoire et procédé de désinfection WO2015032694A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102013217687 2013-09-04
DE102013217687.2 2013-09-04

Publications (1)

Publication Number Publication Date
WO2015032694A1 true WO2015032694A1 (fr) 2015-03-12

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PCT/EP2014/068340 WO2015032694A1 (fr) 2013-09-04 2014-08-29 Système d'automatisation de laboratoire et procédé de désinfection

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020148322A1 (fr) * 2019-01-17 2020-07-23 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Dispositif comportant une zone de niveau de protection pour détecter directement ou indirectement au moins une substance biologique ou au moins une substance dans au moins un échantillon qui peut contenir une substance biologique
DE202020104659U1 (de) 2020-08-11 2021-11-15 seiwo Technik GmbH Desinfektionsmöbel

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5536084A (en) * 1994-05-09 1996-07-16 Grandview Hospital And Medical Center Mobile nursing unit and system therefor
GB2422807A (en) * 2005-02-04 2006-08-09 David Miller Method and apparatus for automatic sterilisation and auditing of computer keyboards and associated peripherals
WO2007136906A2 (fr) * 2006-05-17 2007-11-29 Andrew Ross stÉrilisation UV de fomites d'interface utilisateur
US20080067417A1 (en) * 2006-06-26 2008-03-20 Microsoft Corporation Self-sterilizing input device
WO2009123813A1 (fr) * 2008-03-03 2009-10-08 Vioguard Corporation Dispositif de traitement par ultraviolets
US20100086964A1 (en) * 2008-10-06 2010-04-08 Leica Biosystems Nussloch Gmbh Apparatus and method for identifying at least one specimen slide

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5536084A (en) * 1994-05-09 1996-07-16 Grandview Hospital And Medical Center Mobile nursing unit and system therefor
GB2422807A (en) * 2005-02-04 2006-08-09 David Miller Method and apparatus for automatic sterilisation and auditing of computer keyboards and associated peripherals
WO2007136906A2 (fr) * 2006-05-17 2007-11-29 Andrew Ross stÉrilisation UV de fomites d'interface utilisateur
US20080067417A1 (en) * 2006-06-26 2008-03-20 Microsoft Corporation Self-sterilizing input device
WO2009123813A1 (fr) * 2008-03-03 2009-10-08 Vioguard Corporation Dispositif de traitement par ultraviolets
US20100086964A1 (en) * 2008-10-06 2010-04-08 Leica Biosystems Nussloch Gmbh Apparatus and method for identifying at least one specimen slide

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020148322A1 (fr) * 2019-01-17 2020-07-23 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Dispositif comportant une zone de niveau de protection pour détecter directement ou indirectement au moins une substance biologique ou au moins une substance dans au moins un échantillon qui peut contenir une substance biologique
DE202020104659U1 (de) 2020-08-11 2021-11-15 seiwo Technik GmbH Desinfektionsmöbel

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