WO2015007922A1 - Pansements et pastilles à l'aloe vera pour blessures et ulcères - Google Patents

Pansements et pastilles à l'aloe vera pour blessures et ulcères Download PDF

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Publication number
WO2015007922A1
WO2015007922A1 PCT/ES2013/070514 ES2013070514W WO2015007922A1 WO 2015007922 A1 WO2015007922 A1 WO 2015007922A1 ES 2013070514 W ES2013070514 W ES 2013070514W WO 2015007922 A1 WO2015007922 A1 WO 2015007922A1
Authority
WO
WIPO (PCT)
Prior art keywords
aloe vera
sheet
wounds
ulcers
polyurethane
Prior art date
Application number
PCT/ES2013/070514
Other languages
English (en)
Spanish (es)
Inventor
Norberto Benito SANTANA RODRÍGUEZ
Original Assignee
Santana Rodríguez Norberto Benito
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Santana Rodríguez Norberto Benito filed Critical Santana Rodríguez Norberto Benito
Priority to PCT/ES2013/070514 priority Critical patent/WO2015007922A1/fr
Publication of WO2015007922A1 publication Critical patent/WO2015007922A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/00051—Accessories for dressings
    • A61F13/00063—Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
    • A61F13/01017—
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts

Definitions

  • Wounds are physical injuries of the body that are characterized by the alteration of normal tissue continuity, can cause damage to superficial skin structures and structures underlying the skin. Of different etiologies, surgical, traumatic, by burn, ulcers, infection, etc., may take weeks to heal or even Get infected with important consequences. The wound healing process goes through several complex and distinct phases while overlapping in order to ensure tissue repair. Sometimes problems arise of repair in the form of hypertrophic scars and keloids that cause patient problems
  • Surgical wound infections occur in approximately 1-5% of cases of clean surgery, 5-15% of surgery clean-contaminated, 15-30% of contaminated surgery and up to 30-40% in cases of dirty surgeries, despite a correct antibiotic prophylaxis.
  • a wound surgery that requires healing by second intention because it has infected means a daily commitment from the patient and the media sanitary that can last several weeks or months until the healing is has completed, which implies a high health cost, not well quantified.
  • 75% of all surgical infections Postoperative are due to superficial infections of the surgical site.
  • surgical site infections increase the risk of death about 2-11 times, with 77% of these deaths attributed directly to the infection.
  • new agents are needed to help to reduce wound infections in their different forms, to reduce healing time and complications thereof, since they can cause a deterioration of the patient's quality of life by requiring a additional treatment in the healing of complicated wounds, for prolonging the hospital stay, delay the application of other treatments or even cause his death.
  • Aloe vera is commonly used by topical route in wound healing and dermatology.
  • numerous studies suggest that Aloe vera, in one or more of its constituents, promote wound healing due to its antioxidant activity and anti-inflammatory and for its analgesic and antimicrobial effect on wounds acute or chronic Herpes is a common viral infection that occurs in Herpes simplex or Zoster form. It produces pruritic vesicular lesions and Highly contagious and recurrent painful that break leading to scab formation ulcerations becoming sometimes disabling.
  • Acyclovir or famciclovir-based treatments are used indiscriminately in the treatment of common herpes simplex when it should be reserved to treat the possible complications of herpes such as encephalitis and thus avoid Resistance of the virus to these drugs due to its misuse.
  • the properties Aloe vera described and its proven antiviral effect make it ideal for Topical treatment of this problem.
  • the objective of the present invention is to provide dressings and patches with Aloe vera for the treatment of a wide variety of wounds
  • Document GB 0128152 describes a multilayer dressing for wounds comprising: a liquid permeable topsheet that has a surface that rests on the wound and a posterior surface, said sheet upper adapts to block or restrict the passage of liquid from the posterior surface towards the surface that rests on the wound; and a layer of hydrogel coated or bonded to the back surface of the topsheet.
  • the dressing also contains an absorbent layer separated from the hydrogel layer, located on the opposite side of the hydrogel layer from the top sheet.
  • Suitable polymers to form the backing sheet include polyurethanes and polyalkoxyalkylacrylates and methacrylates such as which are described in GB-A-1280631.
  • the term 'hydrogel' refers to generally to materials that interact with the low wound fluid physiological conditions to maintain a high humidity level in the wound surface.
  • the hydrogel layer may contain one or more emollients, alternatively or additionally to the macromolecules forming gel.
  • Emollients are used to soften the surface of the skin and to Increase the degree of hydration. Emollients act either by blocking the loss of water from the outer layer of the skin, or improving water binding To the skin.
  • Preferred emollients include Soft White Paraffin, Paraffin Soft Yellow, liquid paraffin, Urea Creams, Lanolin, Sodium Pyrrolidoncarboxylate (PCA Na), evening primrose extract (gamma acid linolenic), Soybean Oil, Tea Tree Oil, coconut Oil, Oil Almond, Chamomile Extract, Cod Liver Oil, Peanut Oil, Emu Oil, Aloe Vera, Sunflower Oil, avocado Oil, Oil Jojoba, Cocoamida, and mixtures thereof.
  • PCA Na Sodium Pyrrolidoncarboxylate
  • Soybean Oil Tea Tree Oil, coconut Oil, Oil Almond, Chamomile Extract, Cod Liver Oil, Peanut Oil, Emu Oil, Aloe Vera, Sunflower Oil, avocado Oil, Oil Jojoba, Cocoamida, and mixtures thereof.
  • the present invention of dressings with Aloe Vera differs from the multilayer dressing mentioned in GB 0128152 in that it is a dressing (Figure 1) that has no hydrogel, is sterile and is consisting of one or two sheets, preferably a top sheet of polyurethane or other liquid impervious or semipermeable materials such as those described in GB-A-1280631, and a lower sheet of silicone or polyurethane, multi-perforated, adhesive and hypoallergenic in Skin contact. Said bottom sheet contains an adhesive except in the area of the same that is in direct contact with the wound. In the central zone of the dressing, between the two sheets a fabric gauze, polyurethane or Other absorbent material.
  • Said space between both sheets contains Aloe Vera over the entire length of the dressing, the Aloe vera concentration being higher in the central area where it spreads directly to the wound and to the areas perilesional through the perforations of the adhesive sheet with two intentions, the first exercise its beneficial biological properties on the wound mentioned above and the second decrease lesions by healthy perilesional skin irritation such as erythema, vesicles and so common ulceration observed in clinical practice due to the effect of dressings.
  • the dressing consists of a silicone sheet, polyurethane or other waterproof, hypoallergenic material, containing adhesive on the surface of it in contact with the skin, so that Aloe vera It is included in the entire length of the sheet, which presents in the area central a fabric gauze, polyurethane or other absorbent material impregnated in Aloe Vera.
  • the sheet is adhesive except in the area of it that is in direct contact with the wound.
  • Aloe vera therefore, is spread all over the dressing and not only in the hydrogel described in GB 0128152, and its function is not only to block the loss of water from the outer layer of the skin to maintain a relative degree of humidity, or improve the binding of water to the skin as described in the use of emollients of GB-A-1280631, but preferably, prevention and treatment of infections, decreased pain and improvement of wound healing, as well as reduction of maceration, itching and irritations of the perilesional skin that can produce dressings in the treatment of surgical, traumatic wounds, by Burn or herpes
  • the sections of the two-sheet dressing where the top sheet is observed Waterproof (LS) and silicone bottom sheet (LI), adhesive and multi-perforated, in the species between both Aloe Vera (AV) is located in all its extension and in the central area of the gauze or other absorbent material (MA).
  • Figure 2 by way of example, they are shown sterile rectangular dressings of different sizes in length and width composed of a polyurethane top sheet and a bottom sheet of 0.5 to 1 mm thick silicone, transparent, adhesive (on the margin indicated around the gauze), multi-perforated and hypoallergenic containing between both Aloe vera in all its extension with a central zone composed by a sterile absorbent gauze of 2mm thickness of different sizes in length and width.
  • the dressing form in crescent, 5cm wide and 12cm long, of the same characteristics that the dressing of figure 2, with a gauze of 2cm wide and 9 cm long with an adhesive margin of 1.5cm, indicated in surgical wounds cervical or transverse laparotomy.
  • silicone and polyurethane in their different forms of presentation has proven mechanical effects of grip on wounds that confer the property of reducing hypertrophic scars and keloids that have an important impact aesthetics about the people who suffer them depending on the affected areas. Both are considered complications of wound remodeling and when are important can cause problems of lack of elasticity in limbs lower or thorax with limitations of movement and decreased vital respiratory capacity.
  • the present invention also provides patches. constituted by sterile sheets of silicone or polyurethane with Aloe vera, of preferably, composed of a silicone or polyurethane top sheet or other waterproof materials, transparent or not, and other bottom sheet of silicone or polyurethane, transparent, multi-perforated and hypoallergenic that Contains adhesive throughout its length, so that Aloe Vera is distributed homogeneously between the two sheets. Or patches consisting of a Only waterproof, transparent, multi-perforated silicone sheet hypoallergenic that contains adhesive throughout its length and is impregnated Aloe vera throughout its surface.
  • the main functions of these sheets are the prevention and treatment of complications arising from the scarring (hypertrophic scar and keloids) and decreased Dysesthesias in the treatment of surgical, traumatic wounds, for burn or herpes, as well as reducing maceration, itching and skin irritations that produce patches in general and that require usually the temporary suspension of the patch.
  • a section of sterile silicone patches composed of two sheets where the waterproof top sheet (LS) and the bottom sheet of silicone, adhesive and multi-perforated (LI), the space between the two is located Aloe Vera (AV).
  • patches are shown in Figure 5 Sterile rectangular silicone of different sizes in length and width consisting of a waterproof 0-5-1mm silicone top sheet and a 0.5-1 mm thick silicone bottom sheet, transparent, adhesive, multi-perforated and hypoallergenic that contain both Aloe vera in all its extension.
  • figure 6 by way of example, the form is shown of the sterile silicone crescent patch, 1.5cm wide and 10cm long, of the same characteristics as the sheet of figure 5, indicated by preference in cervical surgical wounds or transverse laparotomy.
  • dressings and sheets are covered on its adhesive face by a sheet of protective paper that is removed at the time of placement, protecting the sheet that contacts the skin of contamination and are deposited in a container that prevents microbiological contamination

Abstract

La présente invention concerne la conception de pansements et de pastilles à teneur élevée en aloe vera qui combinent l'efficacité des propriétés mécaniques de la silicone ou du polyuréthane aux propriétés biologiques de l'aloe vera pour traiter et prévenir les infections, diminuer la douleur et les complications engendrées par la cicatrisation des plaies chirurgicales, traumatiques, causées par une brûlure, par l'herpès et la cicatrisation des ulcères.
PCT/ES2013/070514 2013-07-16 2013-07-16 Pansements et pastilles à l'aloe vera pour blessures et ulcères WO2015007922A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/ES2013/070514 WO2015007922A1 (fr) 2013-07-16 2013-07-16 Pansements et pastilles à l'aloe vera pour blessures et ulcères

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/ES2013/070514 WO2015007922A1 (fr) 2013-07-16 2013-07-16 Pansements et pastilles à l'aloe vera pour blessures et ulcères

Publications (1)

Publication Number Publication Date
WO2015007922A1 true WO2015007922A1 (fr) 2015-01-22

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107890582A (zh) * 2017-11-27 2018-04-10 刘名倬 一种硅凝胶联合中药组方治瘢痕敷料的制备方法
CN110393634A (zh) * 2019-06-28 2019-11-01 孙秀梅 一种用于治疗动静脉穿刺术后皮下损伤的治疗膜

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004060359A1 (fr) * 2002-12-31 2004-07-22 Ossur Hf Pansement pour blessure
WO2007096924A2 (fr) * 2006-02-20 2007-08-30 Maiello, Adolfo Extraction, préparation et utilisation de principes actifs de l'aloès pour la réalisation de dispositifs d'automédication tels que des gazes, des pansements, des bas, des bandes élastiques et des semelles orthopédiques à libération contrôlée d'aloès
GB2462678A (en) * 2008-08-21 2010-02-24 Univ Bolton Wound treatment
CN103055107A (zh) * 2013-02-06 2013-04-24 贺军 一种芦荟伤口贴及其制备方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004060359A1 (fr) * 2002-12-31 2004-07-22 Ossur Hf Pansement pour blessure
WO2007096924A2 (fr) * 2006-02-20 2007-08-30 Maiello, Adolfo Extraction, préparation et utilisation de principes actifs de l'aloès pour la réalisation de dispositifs d'automédication tels que des gazes, des pansements, des bas, des bandes élastiques et des semelles orthopédiques à libération contrôlée d'aloès
GB2462678A (en) * 2008-08-21 2010-02-24 Univ Bolton Wound treatment
CN103055107A (zh) * 2013-02-06 2013-04-24 贺军 一种芦荟伤口贴及其制备方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Derwent World Patents Index; AN 2013-P86062 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107890582A (zh) * 2017-11-27 2018-04-10 刘名倬 一种硅凝胶联合中药组方治瘢痕敷料的制备方法
CN110393634A (zh) * 2019-06-28 2019-11-01 孙秀梅 一种用于治疗动静脉穿刺术后皮下损伤的治疗膜

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