WO2015007922A1 - Dressings and plasters with aloe vera for wounds and ulcers - Google Patents
Dressings and plasters with aloe vera for wounds and ulcers Download PDFInfo
- Publication number
- WO2015007922A1 WO2015007922A1 PCT/ES2013/070514 ES2013070514W WO2015007922A1 WO 2015007922 A1 WO2015007922 A1 WO 2015007922A1 ES 2013070514 W ES2013070514 W ES 2013070514W WO 2015007922 A1 WO2015007922 A1 WO 2015007922A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- aloe vera
- sheet
- wounds
- ulcers
- polyurethane
- Prior art date
Links
- 208000027418 Wounds and injury Diseases 0.000 title claims abstract description 32
- 206010052428 Wound Diseases 0.000 title claims abstract description 30
- 235000002961 Aloe barbadensis Nutrition 0.000 title claims abstract description 29
- 235000011399 aloe vera Nutrition 0.000 title claims abstract description 29
- 208000025865 Ulcer Diseases 0.000 title claims abstract description 15
- 231100000397 ulcer Toxicity 0.000 title claims abstract description 13
- 244000186892 Aloe vera Species 0.000 title claims abstract 16
- 229920001296 polysiloxane Polymers 0.000 claims abstract description 22
- 229920002635 polyurethane Polymers 0.000 claims abstract description 20
- 239000004814 polyurethane Substances 0.000 claims abstract description 20
- 238000011282 treatment Methods 0.000 claims abstract description 17
- 230000002265 prevention Effects 0.000 claims abstract description 10
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 claims abstract description 9
- 208000015181 infectious disease Diseases 0.000 claims abstract description 9
- 230000000472 traumatic effect Effects 0.000 claims abstract description 8
- 230000035876 healing Effects 0.000 claims abstract description 7
- 239000000853 adhesive Substances 0.000 claims description 19
- 230000001070 adhesive effect Effects 0.000 claims description 19
- 239000000463 material Substances 0.000 claims description 14
- 230000000774 hypoallergenic effect Effects 0.000 claims description 11
- 230000002745 absorbent Effects 0.000 claims description 7
- 239000002250 absorbent Substances 0.000 claims description 7
- 230000003247 decreasing effect Effects 0.000 claims description 7
- 208000002260 Keloid Diseases 0.000 claims description 6
- 230000001969 hypertrophic effect Effects 0.000 claims description 6
- 210000001117 keloid Anatomy 0.000 claims description 6
- 231100000241 scar Toxicity 0.000 claims description 6
- 230000009467 reduction Effects 0.000 claims description 5
- 230000037390 scarring Effects 0.000 claims description 5
- 208000003251 Pruritus Diseases 0.000 claims description 4
- 239000004744 fabric Substances 0.000 claims description 4
- 230000007803 itching Effects 0.000 claims description 4
- 238000002803 maceration Methods 0.000 claims description 4
- 208000035824 paresthesia Diseases 0.000 claims description 4
- 206010040880 Skin irritation Diseases 0.000 claims description 3
- 208000002847 Surgical Wound Diseases 0.000 claims description 3
- 230000006378 damage Effects 0.000 claims description 3
- 230000006872 improvement Effects 0.000 claims description 3
- 230000036556 skin irritation Effects 0.000 claims description 3
- 231100000475 skin irritation Toxicity 0.000 claims description 3
- 230000002792 vascular Effects 0.000 claims description 3
- 230000000845 anti-microbial effect Effects 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 208000014674 injury Diseases 0.000 claims description 2
- 230000007794 irritation Effects 0.000 claims description 2
- 239000000725 suspension Substances 0.000 claims description 2
- 230000005810 radionecrosis Effects 0.000 claims 2
- 239000003589 local anesthetic agent Substances 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 230000004071 biological effect Effects 0.000 abstract description 2
- 244000144927 Aloe barbadensis Species 0.000 description 13
- 239000000017 hydrogel Substances 0.000 description 7
- 239000003974 emollient agent Substances 0.000 description 5
- 238000001356 surgical procedure Methods 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 230000029663 wound healing Effects 0.000 description 4
- 230000034994 death Effects 0.000 description 3
- 231100000517 death Toxicity 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- -1 Aloe Vera Substances 0.000 description 2
- 208000032544 Cicatrix Diseases 0.000 description 2
- 208000009889 Herpes Simplex Diseases 0.000 description 2
- 208000031650 Surgical Wound Infection Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 238000002350 laparotomy Methods 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 239000012188 paraffin wax Substances 0.000 description 2
- 230000037387 scars Effects 0.000 description 2
- 230000000699 topical effect Effects 0.000 description 2
- 230000036269 ulceration Effects 0.000 description 2
- HBZVNWNSRNTWPS-UHFFFAOYSA-N 6-amino-4-hydroxynaphthalene-2-sulfonic acid Chemical compound C1=C(S(O)(=O)=O)C=C(O)C2=CC(N)=CC=C21 HBZVNWNSRNTWPS-UHFFFAOYSA-N 0.000 description 1
- 235000011437 Amygdalus communis Nutrition 0.000 description 1
- 244000144725 Amygdalus communis Species 0.000 description 1
- 206010011985 Decubitus ulcer Diseases 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 208000007514 Herpes zoster Diseases 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- 235000019483 Peanut oil Nutrition 0.000 description 1
- 235000004433 Simmondsia californica Nutrition 0.000 description 1
- 244000044822 Simmondsia californica Species 0.000 description 1
- 235000019486 Sunflower oil Nutrition 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 206010048038 Wound infection Diseases 0.000 description 1
- 229960004150 aciclovir Drugs 0.000 description 1
- MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 235000020224 almond Nutrition 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000021302 avocado oil Nutrition 0.000 description 1
- 239000008163 avocado oil Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 235000020221 chamomile extract Nutrition 0.000 description 1
- 229940119217 chamomile extract Drugs 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 235000012716 cod liver oil Nutrition 0.000 description 1
- 239000003026 cod liver oil Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000010776 emu oil Substances 0.000 description 1
- 206010014599 encephalitis Diseases 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 229940045761 evening primrose extract Drugs 0.000 description 1
- 235000008524 evening primrose extract Nutrition 0.000 description 1
- 229960004396 famciclovir Drugs 0.000 description 1
- GGXKWVWZWMLJEH-UHFFFAOYSA-N famcyclovir Chemical compound N1=C(N)N=C2N(CCC(COC(=O)C)COC(C)=O)C=NC2=C1 GGXKWVWZWMLJEH-UHFFFAOYSA-N 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 230000005802 health problem Effects 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 150000002734 metacrylic acid derivatives Chemical class 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000011169 microbiological contamination Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000001823 pruritic effect Effects 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 238000007634 remodeling Methods 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 230000018040 scab formation Effects 0.000 description 1
- HYRLWUFWDYFEES-UHFFFAOYSA-M sodium;2-oxopyrrolidine-1-carboxylate Chemical compound [Na+].[O-]C(=O)N1CCCC1=O HYRLWUFWDYFEES-UHFFFAOYSA-M 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000002600 sunflower oil Substances 0.000 description 1
- 239000010677 tea tree oil Substances 0.000 description 1
- 229940111630 tea tree oil Drugs 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/00051—Accessories for dressings
- A61F13/00063—Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/01—Non-adhesive bandages or dressings
- A61F13/01008—Non-adhesive bandages or dressings characterised by the material
- A61F13/01017—Non-adhesive bandages or dressings characterised by the material synthetic, e.g. polymer based
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
Definitions
- Wounds are physical injuries of the body that are characterized by the alteration of normal tissue continuity, can cause damage to superficial skin structures and structures underlying the skin. Of different etiologies, surgical, traumatic, by burn, ulcers, infection, etc., may take weeks to heal or even Get infected with important consequences. The wound healing process goes through several complex and distinct phases while overlapping in order to ensure tissue repair. Sometimes problems arise of repair in the form of hypertrophic scars and keloids that cause patient problems
- Surgical wound infections occur in approximately 1-5% of cases of clean surgery, 5-15% of surgery clean-contaminated, 15-30% of contaminated surgery and up to 30-40% in cases of dirty surgeries, despite a correct antibiotic prophylaxis.
- a wound surgery that requires healing by second intention because it has infected means a daily commitment from the patient and the media sanitary that can last several weeks or months until the healing is has completed, which implies a high health cost, not well quantified.
- 75% of all surgical infections Postoperative are due to superficial infections of the surgical site.
- surgical site infections increase the risk of death about 2-11 times, with 77% of these deaths attributed directly to the infection.
- new agents are needed to help to reduce wound infections in their different forms, to reduce healing time and complications thereof, since they can cause a deterioration of the patient's quality of life by requiring a additional treatment in the healing of complicated wounds, for prolonging the hospital stay, delay the application of other treatments or even cause his death.
- Aloe vera is commonly used by topical route in wound healing and dermatology.
- numerous studies suggest that Aloe vera, in one or more of its constituents, promote wound healing due to its antioxidant activity and anti-inflammatory and for its analgesic and antimicrobial effect on wounds acute or chronic Herpes is a common viral infection that occurs in Herpes simplex or Zoster form. It produces pruritic vesicular lesions and Highly contagious and recurrent painful that break leading to scab formation ulcerations becoming sometimes disabling.
- Acyclovir or famciclovir-based treatments are used indiscriminately in the treatment of common herpes simplex when it should be reserved to treat the possible complications of herpes such as encephalitis and thus avoid Resistance of the virus to these drugs due to its misuse.
- the properties Aloe vera described and its proven antiviral effect make it ideal for Topical treatment of this problem.
- the objective of the present invention is to provide dressings and patches with Aloe vera for the treatment of a wide variety of wounds
- Document GB 0128152 describes a multilayer dressing for wounds comprising: a liquid permeable topsheet that has a surface that rests on the wound and a posterior surface, said sheet upper adapts to block or restrict the passage of liquid from the posterior surface towards the surface that rests on the wound; and a layer of hydrogel coated or bonded to the back surface of the topsheet.
- the dressing also contains an absorbent layer separated from the hydrogel layer, located on the opposite side of the hydrogel layer from the top sheet.
- Suitable polymers to form the backing sheet include polyurethanes and polyalkoxyalkylacrylates and methacrylates such as which are described in GB-A-1280631.
- the term 'hydrogel' refers to generally to materials that interact with the low wound fluid physiological conditions to maintain a high humidity level in the wound surface.
- the hydrogel layer may contain one or more emollients, alternatively or additionally to the macromolecules forming gel.
- Emollients are used to soften the surface of the skin and to Increase the degree of hydration. Emollients act either by blocking the loss of water from the outer layer of the skin, or improving water binding To the skin.
- Preferred emollients include Soft White Paraffin, Paraffin Soft Yellow, liquid paraffin, Urea Creams, Lanolin, Sodium Pyrrolidoncarboxylate (PCA Na), evening primrose extract (gamma acid linolenic), Soybean Oil, Tea Tree Oil, coconut Oil, Oil Almond, Chamomile Extract, Cod Liver Oil, Peanut Oil, Emu Oil, Aloe Vera, Sunflower Oil, avocado Oil, Oil Jojoba, Cocoamida, and mixtures thereof.
- PCA Na Sodium Pyrrolidoncarboxylate
- Soybean Oil Tea Tree Oil, coconut Oil, Oil Almond, Chamomile Extract, Cod Liver Oil, Peanut Oil, Emu Oil, Aloe Vera, Sunflower Oil, avocado Oil, Oil Jojoba, Cocoamida, and mixtures thereof.
- the present invention of dressings with Aloe Vera differs from the multilayer dressing mentioned in GB 0128152 in that it is a dressing (Figure 1) that has no hydrogel, is sterile and is consisting of one or two sheets, preferably a top sheet of polyurethane or other liquid impervious or semipermeable materials such as those described in GB-A-1280631, and a lower sheet of silicone or polyurethane, multi-perforated, adhesive and hypoallergenic in Skin contact. Said bottom sheet contains an adhesive except in the area of the same that is in direct contact with the wound. In the central zone of the dressing, between the two sheets a fabric gauze, polyurethane or Other absorbent material.
- Said space between both sheets contains Aloe Vera over the entire length of the dressing, the Aloe vera concentration being higher in the central area where it spreads directly to the wound and to the areas perilesional through the perforations of the adhesive sheet with two intentions, the first exercise its beneficial biological properties on the wound mentioned above and the second decrease lesions by healthy perilesional skin irritation such as erythema, vesicles and so common ulceration observed in clinical practice due to the effect of dressings.
- the dressing consists of a silicone sheet, polyurethane or other waterproof, hypoallergenic material, containing adhesive on the surface of it in contact with the skin, so that Aloe vera It is included in the entire length of the sheet, which presents in the area central a fabric gauze, polyurethane or other absorbent material impregnated in Aloe Vera.
- the sheet is adhesive except in the area of it that is in direct contact with the wound.
- Aloe vera therefore, is spread all over the dressing and not only in the hydrogel described in GB 0128152, and its function is not only to block the loss of water from the outer layer of the skin to maintain a relative degree of humidity, or improve the binding of water to the skin as described in the use of emollients of GB-A-1280631, but preferably, prevention and treatment of infections, decreased pain and improvement of wound healing, as well as reduction of maceration, itching and irritations of the perilesional skin that can produce dressings in the treatment of surgical, traumatic wounds, by Burn or herpes
- the sections of the two-sheet dressing where the top sheet is observed Waterproof (LS) and silicone bottom sheet (LI), adhesive and multi-perforated, in the species between both Aloe Vera (AV) is located in all its extension and in the central area of the gauze or other absorbent material (MA).
- Figure 2 by way of example, they are shown sterile rectangular dressings of different sizes in length and width composed of a polyurethane top sheet and a bottom sheet of 0.5 to 1 mm thick silicone, transparent, adhesive (on the margin indicated around the gauze), multi-perforated and hypoallergenic containing between both Aloe vera in all its extension with a central zone composed by a sterile absorbent gauze of 2mm thickness of different sizes in length and width.
- the dressing form in crescent, 5cm wide and 12cm long, of the same characteristics that the dressing of figure 2, with a gauze of 2cm wide and 9 cm long with an adhesive margin of 1.5cm, indicated in surgical wounds cervical or transverse laparotomy.
- silicone and polyurethane in their different forms of presentation has proven mechanical effects of grip on wounds that confer the property of reducing hypertrophic scars and keloids that have an important impact aesthetics about the people who suffer them depending on the affected areas. Both are considered complications of wound remodeling and when are important can cause problems of lack of elasticity in limbs lower or thorax with limitations of movement and decreased vital respiratory capacity.
- the present invention also provides patches. constituted by sterile sheets of silicone or polyurethane with Aloe vera, of preferably, composed of a silicone or polyurethane top sheet or other waterproof materials, transparent or not, and other bottom sheet of silicone or polyurethane, transparent, multi-perforated and hypoallergenic that Contains adhesive throughout its length, so that Aloe Vera is distributed homogeneously between the two sheets. Or patches consisting of a Only waterproof, transparent, multi-perforated silicone sheet hypoallergenic that contains adhesive throughout its length and is impregnated Aloe vera throughout its surface.
- the main functions of these sheets are the prevention and treatment of complications arising from the scarring (hypertrophic scar and keloids) and decreased Dysesthesias in the treatment of surgical, traumatic wounds, for burn or herpes, as well as reducing maceration, itching and skin irritations that produce patches in general and that require usually the temporary suspension of the patch.
- a section of sterile silicone patches composed of two sheets where the waterproof top sheet (LS) and the bottom sheet of silicone, adhesive and multi-perforated (LI), the space between the two is located Aloe Vera (AV).
- patches are shown in Figure 5 Sterile rectangular silicone of different sizes in length and width consisting of a waterproof 0-5-1mm silicone top sheet and a 0.5-1 mm thick silicone bottom sheet, transparent, adhesive, multi-perforated and hypoallergenic that contain both Aloe vera in all its extension.
- figure 6 by way of example, the form is shown of the sterile silicone crescent patch, 1.5cm wide and 10cm long, of the same characteristics as the sheet of figure 5, indicated by preference in cervical surgical wounds or transverse laparotomy.
- dressings and sheets are covered on its adhesive face by a sheet of protective paper that is removed at the time of placement, protecting the sheet that contacts the skin of contamination and are deposited in a container that prevents microbiological contamination
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Zoology (AREA)
- Botany (AREA)
- Medicinal Chemistry (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to the design of dressings and plasters with a high aloe vera content, combining the efficiency of the mechanical properties of silicone or polyurethane with the biological properties of aloe vera, for the treatment and prevention of infections, for reducing pain and complications during the healing of surgical and traumatic wounds caused by burns, herpes and ulcers.
Description
Las heridas son lesiones físicas del cuerpo que se
caracterizan por la alteración de la normal continuidad de los tejidos, pueden
causar daño a las estructuras cutáneas superficiales y a las estructuras
subyacentes a la piel. De diferentes etiologías, quirúrgicas, traumáticas, por
quemadura, úlceras, infección, etc, pueden tardar semanas en sanar o incluso
infectarse con consecuencias importantes. El proceso de curación de una herida
pasa por varias fases complejas y distintas a la vez que se solapan con el fin
de asegurar la reparación de tejidos. En ocasiones surgen problemas derivadas
de la reparación en forma de cicatrices hipertróficas y queloides que ocasionan
problemas a los pacientes. Wounds are physical injuries of the body that are
characterized by the alteration of normal tissue continuity, can
cause damage to superficial skin structures and structures
underlying the skin. Of different etiologies, surgical, traumatic, by
burn, ulcers, infection, etc., may take weeks to heal or even
Get infected with important consequences. The wound healing process
goes through several complex and distinct phases while overlapping in order
to ensure tissue repair. Sometimes problems arise
of repair in the form of hypertrophic scars and keloids that cause
patient problems
Cada año se operan en el mundo aproximadamente 230
millones de personas. Las infecciones de las heridas quirúrgicas se producen en
aproximadamente el 1-5% de los casos de cirugía limpia, 5-15% de cirugía
limpia-contaminada, 15-30% de cirugía contaminada y hasta un 30-40% en casos de
cirugías sucias, a pesar de una correcta profilaxis antibiótica. Una herida
quirúrgica que requiere cicatrización por segunda intención porque se ha
infectado supone un compromiso diario por parte del paciente y de los medios
sanitarios que puede durar varias semanas o meses hasta que la cicatrización se
haya completado, lo que implica un alto coste sanitario, no bien cuantificado.
Hay que tener en cuenta que el 75% de todas las infecciones quirúrgicas
postoperatorias son debidas a infecciones superficiales del sitio quirúrgico.
Además, las infecciones del sitio quirúrgico incrementan el riesgo de muerte
unas 2-11 veces, siendo el 77% de estas muertes atribuidas directamente a la
infección. Every year approximately 230 are operated in the world
millions of people. Surgical wound infections occur in
approximately 1-5% of cases of clean surgery, 5-15% of surgery
clean-contaminated, 15-30% of contaminated surgery and up to 30-40% in cases of
dirty surgeries, despite a correct antibiotic prophylaxis. A wound
surgery that requires healing by second intention because it has
infected means a daily commitment from the patient and the media
sanitary that can last several weeks or months until the healing is
has completed, which implies a high health cost, not well quantified.
Keep in mind that 75% of all surgical infections
Postoperative are due to superficial infections of the surgical site.
In addition, surgical site infections increase the risk of death
about 2-11 times, with 77% of these deaths attributed directly to the
infection.
Las úlceras, bien por decúbito, vasculares o por
radioterapia son un problema cotidiano en la práctica clínica de difícil
solución, siendo su prevención y tratamiento precoz las mejores armas. La
morbilidad y al alto coste personal y sanitario que suponen la convierten en un
importante problema sanitario en incremento por le envejecimiento poblacional.
Ulcers, either by decubitus, vascular or by
radiotherapy are a daily problem in difficult clinical practice
solution, its prevention and early treatment being the best weapons. The
morbidity and the high personal and health cost that they imply make it a
major health problem increasing due to population aging.
Por lo tanto, son necesarios nuevos agentes que ayuden
a disminuir las infecciones de las heridas en sus distintas formas, a reducir
el tiempo de cicatrización y las complicaciones de las mismas, ya que pueden
provocar un deterioro de la calidad de vida del paciente por requerir un
tratamiento adicional en la curación de heridas complicadas, por prolongar la
estancia hospitalaria, retrasar la aplicación de otros tratamientos o incluso
provocar su fallecimiento. Therefore, new agents are needed to help
to reduce wound infections in their different forms, to reduce
healing time and complications thereof, since they can
cause a deterioration of the patient's quality of life by requiring a
additional treatment in the healing of complicated wounds, for prolonging the
hospital stay, delay the application of other treatments or even
cause his death.
En este sentido, el Aloe vera comúnmente se usa por
vía tópica en la curación de heridas y en dermatología. De hecho, numerosos
estudios sugieren que el Aloe vera, en uno o más de sus constituyentes,
promueven la cicatrización de heridas por su actividad antioxidante y
anti-inflamatoria y por su efecto analgésico y antimicrobiano sobre heridas
agudas o crónicas. El herpes es una infección viral común que se presenta en
forma de herpes simple o Zoster. Produce lesiones vesiculosas pruriginosas y
dolorosas altamente contagiosas y recurrentes que se rompen dando lugar a
ulceraciones con formación de costras llegando a ser en ocasiones invalidantes.
Los tratamientos a base de aciclovir o famciclovir se usan indiscriminadamente
en el tratamiento del herpes simple común cuando debería reservarse para tratar
las posibles complicaciones del herpes como la encefalitis y evitar así, las
resistencias del virus a estos fármacos por su mal uso. Las propiedades
descritas del Aloe vera y su demostrado efecto antiviral lo hacen ideal para el
tratamiento tópico de este problema. In this sense, Aloe vera is commonly used by
topical route in wound healing and dermatology. In fact numerous
studies suggest that Aloe vera, in one or more of its constituents,
promote wound healing due to its antioxidant activity and
anti-inflammatory and for its analgesic and antimicrobial effect on wounds
acute or chronic Herpes is a common viral infection that occurs in
Herpes simplex or Zoster form. It produces pruritic vesicular lesions and
Highly contagious and recurrent painful that break leading to
scab formation ulcerations becoming sometimes disabling.
Acyclovir or famciclovir-based treatments are used indiscriminately
in the treatment of common herpes simplex when it should be reserved to treat
the possible complications of herpes such as encephalitis and thus avoid
Resistance of the virus to these drugs due to its misuse. The properties
Aloe vera described and its proven antiviral effect make it ideal for
Topical treatment of this problem.
El objetivo de la presente invención es proveer
apósitos y parches con Aloe vera para el tratamiento de una amplia variedad de
heridas. En el documento GB 0128152 se describe un apósito en multicapa para
heridas que comprende: una lámina superior permeable al líquido que tiene una
superficie que apoya sobre la herida y una superficie posterior, dicha lámina
superior se adapta para bloquear o restringir el pasaje del líquido desde la
superficie posterior hacia la superficie que apoya sobre la herida; y una capa de
hidrogel recubierta o unida a la superficie posterior de la lámina superior. De
preferencia, el apósito también contiene una capa absorbente separada de la
capa de hidrogel, ubicada en el lado opuesto de la capa de hidrogel desde la
lámina superior. Los polímeros adecuados para formar la lámina de soporte
incluyen poliuretanos y polialcoxialquilacrilatos y metacrilatos tales como los
que se describen en el documento GB-A-1280631. El término 'hidrogel' se refiere
generalmente a materiales que interactúan con el fluido de la herida bajo
condiciones fisiológicas para mantener un nivel de humedad elevado en la
superficie de la herida. La capa de hidrogel puede contener uno o más
emolientes, alternativa o adicionalmente a las macromoléculas formadoras de
gel. Los emolientes se usan para suavizar la superficie de la piel y para
aumentar el grado de hidratación. Los emolientes actúan ya sea bloqueando la
pérdida de agua desde la capa externa de la piel, o mejorando la unión del agua
a la piel. Los emolientes de preferencia incluyen Parafina Blanca Suave, Parafina
Amarilla Suave, parafina líquida, Cremas de Urea, Lanolina,
Pirrolidoncarboxilato Sódico (PCA Na), extracto de Onagra (ácido gamma
linolénico), Aceite de Soja, Aceite del Árbol de Té, Aceite de Coco, Aceite de
Almendra, Extracto de Camomila, Aceite de Hígado de Bacalao, Aceite de Maní,
Aceite de Emú, Aloe Vera, Aceite de Girasol, Aceite de Aguacate, Aceite de
Jojoba, Cocoamida, y mezclas de los mismos. The objective of the present invention is to provide
dressings and patches with Aloe vera for the treatment of a wide variety of
wounds Document GB 0128152 describes a multilayer dressing for
wounds comprising: a liquid permeable topsheet that has a
surface that rests on the wound and a posterior surface, said sheet
upper adapts to block or restrict the passage of liquid from the
posterior surface towards the surface that rests on the wound; and a layer of
hydrogel coated or bonded to the back surface of the topsheet. From
Preferably, the dressing also contains an absorbent layer separated from the
hydrogel layer, located on the opposite side of the hydrogel layer from the
top sheet. Suitable polymers to form the backing sheet
include polyurethanes and polyalkoxyalkylacrylates and methacrylates such as
which are described in GB-A-1280631. The term 'hydrogel' refers to
generally to materials that interact with the low wound fluid
physiological conditions to maintain a high humidity level in the
wound surface. The hydrogel layer may contain one or more
emollients, alternatively or additionally to the macromolecules forming
gel. Emollients are used to soften the surface of the skin and to
Increase the degree of hydration. Emollients act either by blocking the
loss of water from the outer layer of the skin, or improving water binding
To the skin. Preferred emollients include Soft White Paraffin, Paraffin
Soft Yellow, liquid paraffin, Urea Creams, Lanolin,
Sodium Pyrrolidoncarboxylate (PCA Na), evening primrose extract (gamma acid
linolenic), Soybean Oil, Tea Tree Oil, Coconut Oil, Oil
Almond, Chamomile Extract, Cod Liver Oil, Peanut Oil,
Emu Oil, Aloe Vera, Sunflower Oil, Avocado Oil, Oil
Jojoba, Cocoamida, and mixtures thereof.
La presente invención de apósitos con Aloe vera
difiere del apósito multicapa mencionado en el documento GB 0128152 en que se
trata de un apósito (Figura 1) que no tiene hidrogel, es estéril y está
constituido por una o dos láminas, de preferencia una lámina superior de
poliuretano u otros materiales impermeables a los líquidos o semipermeables
como los que se describen en el documento GB-A-1280631, y una lamina inferior
de silicona o poliuretano, multiperforada, adhesiva e hipoalergénica en
contacto con la piel. Dicha lámina inferior contiene un adhesivo salvo en la
zona de la misma que está en contacto directo con la herida. En la zona central
del apósito, entre las dos láminas se dispone una gasa de tejido, poliuretano u
otro material absorbente. Dicho espacio entre ambas láminas contiene Aloe Vera
en toda la extensión del apósito, siendo la concentración de Aloe vera superior
en la zona central donde difunde directamente hacia la herida y hacia las zonas
perilesionales a través de las perforaciones de la lámina adhesiva con dos
intenciones, la primera ejercer sus propiedades biológicas beneficiosas sobre
la herida anteriormente mencionadas y la segunda disminuir las lesiones por
irritación de la piel sana perilesional tales como eritema, vesículas y
ulceración tan comunes observadas en la práctica clínica por efecto de los
apósitos. O bien, el apósito está constituido por una lámina de silicona,
poliuretano u otro material impermeable, hipoalergénica, que contiene adhesivo
en la superficie de la misma en contacto con la piel, de forma que el Aloe vera
está incluido en toda la extensión de la lámina, que presenta en la zona
central una gasa de tejido, poliuretano u otro material absorbente impregnada
en Aloe vera. La lámina es adhesiva salvo en la zona de la misma que está en
contacto directo con la herida. The present invention of dressings with Aloe Vera
differs from the multilayer dressing mentioned in GB 0128152 in that
it is a dressing (Figure 1) that has no hydrogel, is sterile and is
consisting of one or two sheets, preferably a top sheet of
polyurethane or other liquid impervious or semipermeable materials
such as those described in GB-A-1280631, and a lower sheet
of silicone or polyurethane, multi-perforated, adhesive and hypoallergenic in
Skin contact. Said bottom sheet contains an adhesive except in the
area of the same that is in direct contact with the wound. In the central zone
of the dressing, between the two sheets a fabric gauze, polyurethane or
Other absorbent material. Said space between both sheets contains Aloe Vera
over the entire length of the dressing, the Aloe vera concentration being higher
in the central area where it spreads directly to the wound and to the areas
perilesional through the perforations of the adhesive sheet with two
intentions, the first exercise its beneficial biological properties on
the wound mentioned above and the second decrease lesions by
healthy perilesional skin irritation such as erythema, vesicles and
so common ulceration observed in clinical practice due to the effect of
dressings. Or, the dressing consists of a silicone sheet,
polyurethane or other waterproof, hypoallergenic material, containing adhesive
on the surface of it in contact with the skin, so that Aloe vera
It is included in the entire length of the sheet, which presents in the area
central a fabric gauze, polyurethane or other absorbent material impregnated
in Aloe Vera. The sheet is adhesive except in the area of it that is in
direct contact with the wound.
El Aloe vera, por tanto, está repartido por todo el
apósito y no sólo en el hidrogel descrito en el documento GB 0128152, y su
función no sólo es bloquear la pérdida de agua desde la capa externa de la piel
para mantener un relativo grado de humedad, o mejorar la unión del agua a la
piel como se describe en el uso de emolientes del documento GB-A-1280631, sino
de preferencia, la prevención y tratamiento de infecciones, disminución del
dolor y mejora de la cicatrización de las heridas, así como la reducción de la
maceración, picor e irritaciones de la piel perilesional que pueden producir
los apósitos en el tratamiento de heridas quirúrgicas, traumáticas, por
quemadura o por herpes. Aloe vera, therefore, is spread all over the
dressing and not only in the hydrogel described in GB 0128152, and its
function is not only to block the loss of water from the outer layer of the skin
to maintain a relative degree of humidity, or improve the binding of water to the
skin as described in the use of emollients of GB-A-1280631, but
preferably, prevention and treatment of infections, decreased
pain and improvement of wound healing, as well as reduction of
maceration, itching and irritations of the perilesional skin that can produce
dressings in the treatment of surgical, traumatic wounds, by
Burn or herpes
En la figura 1, a modo de ejemplo, se muestran las
secciones del apósito de dos láminas donde se observa la lámina superior
impermeable (LS) y la lámina inferior (LI) de silicona, adhesiva y
multiperforada, en el especie entre ambas se sitúa el Aloe Vera (AV) en toda su
extensión y en la zona central del mismo la gasa u otro material absorbente
(MA). In figure 1, by way of example, the
sections of the two-sheet dressing where the top sheet is observed
Waterproof (LS) and silicone bottom sheet (LI), adhesive and
multi-perforated, in the species between both Aloe Vera (AV) is located in all its
extension and in the central area of the gauze or other absorbent material
(MA).
En la Figura 2, a modo de ejemplo, se muestran
apósitos estériles de forma rectangular de diferentes tamaños en largo y ancho
compuestos por una lámina superior de poliuretano y una lámina inferior de
silicona de 0,5 a 1 mm de espesor, transparente, adhesiva (en el margen
indicado alrededor de la gasa), multiperforada e hipoalergénica que contienen
entre ambas Aloe vera en toda su extensión con una zona central compuesta por
una gasa estéril absorbente de 2mm de espesor de diferentes tamaños en largo y
ancho. In Figure 2, by way of example, they are shown
sterile rectangular dressings of different sizes in length and width
composed of a polyurethane top sheet and a bottom sheet of
0.5 to 1 mm thick silicone, transparent, adhesive (on the margin
indicated around the gauze), multi-perforated and hypoallergenic containing
between both Aloe vera in all its extension with a central zone composed by
a sterile absorbent gauze of 2mm thickness of different sizes in length and
width.
En la figura 3, a modo de ejemplo, se describe la
forma de apósito en semiluna, de 5cm de ancho y 12 cm de largo, de las mismas
características que el apósito de la figura 2, con una gasa de 2cm de ancho y 9
cm de largo con un margen adhesivo de 1,5cm, indicado en heridas quirúrgicas
cervicales o de laparotomía transversa. In figure 3, by way of example, the
dressing form in crescent, 5cm wide and 12cm long, of the same
characteristics that the dressing of figure 2, with a gauze of 2cm wide and 9
cm long with an adhesive margin of 1.5cm, indicated in surgical wounds
cervical or transverse laparotomy.
Por otro lado, la silicona y el poliuretano en sus
diferentes formas de presentación, tiene demostrados efectos mecánicos de
prensión sobre las heridas que le confieren la propiedad de reducir las
cicatrices hipertróficas y queloides que tienen una importante repercusión
estética sobre las personas que las sufren dependiendo de las zonas afectadas.
Ambas, se consideran complicaciones de la remodelación de las heridas y cuando
son importantes pueden ocasionar problemas de falta de elasticidad en miembros
inferiores o tórax con limitaciones del movimiento y de disminución de la
capacidad vital respiratoria. On the other hand, silicone and polyurethane in their
different forms of presentation, has proven mechanical effects of
grip on wounds that confer the property of reducing
hypertrophic scars and keloids that have an important impact
aesthetics about the people who suffer them depending on the affected areas.
Both are considered complications of wound remodeling and when
are important can cause problems of lack of elasticity in limbs
lower or thorax with limitations of movement and decreased
vital respiratory capacity.
La presente invención también provee parches
constituidos por láminas estériles de silicona o poliuretano con Aloe vera, de
preferencia, compuestos por una lámina superior de silicona o poliuretano u
otros materiales impermeables, transparente o no, y otra lámina inferior de
silicona o poliuretano, transparente, multiperforada e hipoalergénica que
contiene adhesivo en toda su extensión, de forma que el Aloe vera se distribuye
de forma homogénea entre las dos láminas. O bien los parches compuestas por una
sóla lámina de silicona impermeable, transparente, multiperforada,
hipoalergénica que contiene adhesivo en toda su extensión y se halla impregnada
de Aloe vera en toda su superficie. Las principales funciones de estas láminas
son la prevención y tratamiento de las complicaciones derivadas de la
cicatrización (cicatriz hipertrófica y queloides) y la disminución de las
disestesias en el tratamiento de heridas quirúrgicas, traumáticas, por
quemadura o por herpes, así como la reducción de la maceración, picor e
irritaciones de la piel que producir los parches en general y que requieren
habitualmente la suspensión temporal del parche. The present invention also provides patches.
constituted by sterile sheets of silicone or polyurethane with Aloe vera, of
preferably, composed of a silicone or polyurethane top sheet or
other waterproof materials, transparent or not, and other bottom sheet of
silicone or polyurethane, transparent, multi-perforated and hypoallergenic that
Contains adhesive throughout its length, so that Aloe Vera is distributed
homogeneously between the two sheets. Or patches consisting of a
Only waterproof, transparent, multi-perforated silicone sheet
hypoallergenic that contains adhesive throughout its length and is impregnated
Aloe vera throughout its surface. The main functions of these sheets
are the prevention and treatment of complications arising from the
scarring (hypertrophic scar and keloids) and decreased
Dysesthesias in the treatment of surgical, traumatic wounds, for
burn or herpes, as well as reducing maceration, itching and
skin irritations that produce patches in general and that require
usually the temporary suspension of the patch.
En la figura 4, a modo de ejemplo, se muestra una
sección de los parches estériles de silicona compuestos por dos láminas donde
se observa la lámina superior impermeable (LS) y la lámina inferior de
silicona, adhesiva y multiperforada (LI), en el espacio entre ambas se sitúa el
Aloe vera (AV). In figure 4, by way of example, a
section of sterile silicone patches composed of two sheets where
the waterproof top sheet (LS) and the bottom sheet of
silicone, adhesive and multi-perforated (LI), the space between the two is located
Aloe Vera (AV).
En la Figura 5, a modo de ejemplo, se muestran parches
de silicona estériles de forma rectangular de diferentes tamaños en largo y
ancho compuestos por una lámina superior impermeable de silicona de 0-5-1mm y
una lámina inferior de silicona de 0,5-1 mm de espesor, transparente, adhesiva,
multiperforada e hipoalergénica que contienen entre ambas Aloe vera en toda su
extensión. As an example, patches are shown in Figure 5
Sterile rectangular silicone of different sizes in length and
width consisting of a waterproof 0-5-1mm silicone top sheet and
a 0.5-1 mm thick silicone bottom sheet, transparent, adhesive,
multi-perforated and hypoallergenic that contain both Aloe vera in all its
extension.
En la figura 6, a modo de ejemplo, se muestra la forma
del parche estéril de silicona en semiluna, de 1,5cm de ancho y 10 cm de largo,
de las mismas características que la lámina de la figura 5, indicada de
preferencia en heridas quirúrgicas cervicales o de laparotomía transversa. In figure 6, by way of example, the form is shown
of the sterile silicone crescent patch, 1.5cm wide and 10cm long,
of the same characteristics as the sheet of figure 5, indicated by
preference in cervical surgical wounds or transverse laparotomy.
Por último, los apósitos y las láminas están
cubiertos en su cara adhesiva por una lámina de papel protectora que se retira
en el momento de su colocación, protegiendo a lámina que contacta con la piel
de la contaminación y están depositados en un envase que impide la
contaminación microbiológica. Finally, dressings and sheets are
covered on its adhesive face by a sheet of protective paper that is removed
at the time of placement, protecting the sheet that contacts the skin
of contamination and are deposited in a container that prevents
microbiological contamination
Claims (1)
1.-Apósitos con Aloe vera para heridas de diferentes formas
y tamaños, que se caracterizan por ser estériles y estar compuestos por dos
láminas, una lámina superior de poliuretano u otros materiales impermeables o
semipermeables y una lamina inferior de silicona o poliuretano, multiperforada,
transparente, adhesiva e hipoalergénica que se encuentra en contacto con la
piel. El espacio entre ambas láminas contiene Aloe Vera y en la zona central
del apósito existe una gasa de tejido, poliuretano u otro material absorbente.
La concentración de Aloe vera es superior en la zona central del apósito donde
difunde hacia la herida y las zonas perilesionales a través de las
perforaciones de la lámina adhesiva. O bien, el apósito está constituido por
una lámina de silicona, poliuretano u otro material impermeable,
hipoalergénica, que contiene adhesivo en la superficie de la misma en contacto
con la piel, de forma que el Aloe vera está incluido en toda la extensión de la
lámina, que presenta en la zona central una gasa de tejido, poliuretano u otro
material absorbente impregnada en Aloe vera. La lámina es adhesiva salvo en la
zona de la misma que está en contacto directo con la herida.1.-Dressings with Aloe vera for wounds of different forms
and sizes, which are characterized by being sterile and composed of two
sheets, a polyurethane top sheet or other waterproof materials or
semipermeable and a multi-perforated silicone or polyurethane bottom sheet,
transparent, adhesive and hypoallergenic that is in contact with the
skin. The space between both sheets contains Aloe Vera and in the central area
of the dressing there is a gauze of fabric, polyurethane or other absorbent material.
The concentration of Aloe vera is higher in the central area of the dressing where
spreads to the wound and perilesional areas through the
perforations of the adhesive sheet. Or, the dressing consists of
a sheet of silicone, polyurethane or other waterproof material,
hypoallergenic, which contains adhesive on the surface of it in contact
with the skin, so that Aloe vera is included in the full extent of the
sheet, which has a fabric, polyurethane or other gauze in the central area
absorbent material impregnated in Aloe vera. The sheet is adhesive except in the
area of the same that is in direct contact with the wound.
2.-Apósitos para heridas de acuerdo con la reivindicación 1
en forma de semiluna.2. Wound dressings according to claim 1
in the shape of a crescent.
3.-Apósitos, de acuerdo con la reivindicación 1 y 2 para la
prevención y tratamiento de infecciones, disminución del dolor y mejora de la
cicatrización de heridas quirúrgicas, traumáticas, por quemadura o por herpes,
así como, para la reducción de la maceración, picor e irritaciones de la piel
perilesional que pueden producir los apósitos.3. Dressings according to claim 1 and 2 for the
infection prevention and treatment, pain reduction and improvement of
healing of surgical, traumatic, burn or herpes wounds,
as well as for the reduction of maceration, itching and skin irritations
perilesional that dressings can produce.
4.-Apósitos con Aloe vera para úlceras de acuerdo con la
reivindicación 1.4.-Dressings with Aloe vera for ulcers according to the
claim 1.
5.-Apósitos de acuerdo con la reivindicación 4 para
prevención y tratamiento de infecciones, disminución del dolor y mejora de la
cicatrización de las úlceras de cualquier etiología (presión, vasculares o por
radionecrosis, etc).5. Dressings according to claim 4 for
infection prevention and treatment, pain reduction and improvement of
scarring of ulcers of any etiology (pressure, vascular or by
radionecrosis, etc).
6.-Parches con Aloe vera para heridas de diferentes formas
y tamaños que se caracterizan por ser estériles y estar compuestos por una
lámina superior de silicona o poliuretano u otros materiales impermeables o
semipermeables, transparente o no, y otra lámina inferior de silicona o
poliuretano, transparente, multiperforada e hipoalergénica que contiene
adhesivo en toda su extensión, de forma que el Aloe vera se distribuye de forma
homogénea entre las dos láminas. O bien los parches compuestos por una sóla
lámina de silicona impermeable, transparente, multiperforada, hipoalergénica
que contiene adhesivo en toda su extensión y se halla impregnada de Aloe vera
en toda su superficie.6.-Patches with Aloe vera for wounds of different shapes
and sizes that are characterized by being sterile and being composed of a
silicone or polyurethane top sheet or other waterproof materials or
semipermeable, transparent or not, and other silicone bottom sheet or
polyurethane, transparent, multi-perforated and hypoallergenic containing
adhesive throughout its length, so that Aloe vera is distributed so
homogeneous between the two sheets. Or patches consisting of only one
waterproof, transparent, multiperforated, hypoallergenic silicone sheet
which contains adhesive throughout its length and is impregnated with Aloe vera
in all its surface.
7.-Parches con Aloe vera de acuerdo con la reivindicación 6
en forma de semiluna.7.-Patches with Aloe Vera according to claim 6
in the shape of a crescent.
8.-Parches con Aloe vera de acuerdo con la reivindación 6 y
7 para la prevención y tratamiento de complicaciones derivadas de la
cicatrización (cicatriz hipertrófica y queloides) y disminución de las
disestesias de las heridas quirúrgicas, traumáticas, por quemadura y en los
herpes, así como para la reducción de la maceración, picor e irritaciones de la
piel que producir los parches en general y que requieren habitualmente la
suspensión temporal del parche.8.-Patches with Aloe Vera according to claim 6 and
7 for the prevention and treatment of complications arising from
scarring (hypertrophic scar and keloids) and decreased
dysesthesias of surgical, traumatic, burn injuries and in the
herpes, as well as for the reduction of maceration, itching and irritations of the
skin that produce patches in general and usually require
temporary suspension of the patch.
9.-Parches con Aloe vera para úlceras de acuerdo con la
reivindicación 6.9.-Patches with Aloe vera for ulcers according to the
claim 6.
10.-Parches con Aloe vera para úlceras de acuerdo con la
reivindicación 9 para prevención de complicaciones derivadas de la
cicatrización (cicatriz hipertrófica y queloides), disminución de las
disestesias de las úlceras de cualquier etiología (presión, vasculares, por
radionecrosis,etc).10.-Patches with Aloe vera for ulcers according to the
claim 9 for prevention of complications arising from the
scarring (hypertrophic scar and keloids), decreased
Dysesthesias of ulcers of any etiology (pressure, vascular,
radionecrosis, etc).
11.-Envases de tubo y envases presurizados de diferentes
formas y tamaños que contienen Aloe vera con silicona, poliuretano u otro
material hipoalergénico y estéril que se solidifica al entrar en contacto con
el aire sobre la piel formando una lámina que se amolda a la superficie de la
herida para uso en heridas quirúrgicas, traumáticas, por quemadura, úlceras y
herpes.11.-Tube containers and pressurized containers of different
shapes and sizes containing Aloe vera with silicone, polyurethane or other
hypoallergenic and sterile material that solidifies upon contact with
the air over the skin forming a sheet that conforms to the surface of the
wound for use in surgical, traumatic, burn, ulcer and
herpes.
12.-Envases de tubo y envases presurizados de acuerdo con
la reivindicación 11 para la prevención y tratamiento de infecciones,
disminución del dolor, mejora de la cicatrización, prevención y tratamiento de
complicaciones derivadas de la cicatrización (cicatriz hipertrófica y
queloides) y disminución de las disestesias de heridas quirúrgicas, heridas
traumáticas, úlceras de cualquier etiología y herpes.12.-Tube containers and pressurized containers according to
claim 11 for the prevention and treatment of infections,
decreased pain, improved healing, prevention and treatment of
complications arising from scarring (hypertrophic scar and
keloids) and decreased dysesthesias of surgical wounds, wounds
traumatic, ulcers of any etiology and herpes.
13.-Un apósito o parche para heridas y úlceras de acuerdo
con cualquiera de las reivindicaciones precedentes, con una o más capas que
contengan Aloe vera en toda su extensión.13.-A dressing or patch for wounds and ulcers according
with any of the preceding claims, with one or more layers that
contain Aloe vera in its entirety.
14.-Un apósito o parche para heridas y úlceras de acuerdo
con cualquiera de las reivindicaciones precedentes, que contenga Aloe vera en
toda su extensión y además un agente terapéutico activo, un agente
antimicrobiano o anestésico local.14.-A dressing or patch for wounds and ulcers according
with any of the preceding claims, containing Aloe vera in
all its extension and also an active therapeutic agent, an agent
antimicrobial or local anesthetic.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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PCT/ES2013/070514 WO2015007922A1 (en) | 2013-07-16 | 2013-07-16 | Dressings and plasters with aloe vera for wounds and ulcers |
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PCT/ES2013/070514 WO2015007922A1 (en) | 2013-07-16 | 2013-07-16 | Dressings and plasters with aloe vera for wounds and ulcers |
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WO2015007922A1 true WO2015007922A1 (en) | 2015-01-22 |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107890582A (en) * | 2017-11-27 | 2018-04-10 | 刘名倬 | A kind of Silica hydrogel Combined with Chinese Herbal prescription controls the preparation method of scar dressing |
CN110393634A (en) * | 2019-06-28 | 2019-11-01 | 孙秀梅 | It is a kind of for treating the treatment film of the postoperative subcutaneous lesion of artery and vein puncture |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004060359A1 (en) * | 2002-12-31 | 2004-07-22 | Ossur Hf | Wound dressing |
WO2007096924A2 (en) * | 2006-02-20 | 2007-08-30 | Maiello, Adolfo | Extraction, preparation and use of active principles of the aloe plant for producing self-meditaion devices such as controlled-release gauzes, bandages, stockings, elastic bands and arch supports |
GB2462678A (en) * | 2008-08-21 | 2010-02-24 | Univ Bolton | Wound treatment |
CN103055107A (en) * | 2013-02-06 | 2013-04-24 | 贺军 | Aloe wound paste and preparation method thereof |
-
2013
- 2013-07-16 WO PCT/ES2013/070514 patent/WO2015007922A1/en active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004060359A1 (en) * | 2002-12-31 | 2004-07-22 | Ossur Hf | Wound dressing |
WO2007096924A2 (en) * | 2006-02-20 | 2007-08-30 | Maiello, Adolfo | Extraction, preparation and use of active principles of the aloe plant for producing self-meditaion devices such as controlled-release gauzes, bandages, stockings, elastic bands and arch supports |
GB2462678A (en) * | 2008-08-21 | 2010-02-24 | Univ Bolton | Wound treatment |
CN103055107A (en) * | 2013-02-06 | 2013-04-24 | 贺军 | Aloe wound paste and preparation method thereof |
Non-Patent Citations (1)
Title |
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DATABASE WPI Derwent World Patents Index; AN 2013-P86062 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107890582A (en) * | 2017-11-27 | 2018-04-10 | 刘名倬 | A kind of Silica hydrogel Combined with Chinese Herbal prescription controls the preparation method of scar dressing |
CN110393634A (en) * | 2019-06-28 | 2019-11-01 | 孙秀梅 | It is a kind of for treating the treatment film of the postoperative subcutaneous lesion of artery and vein puncture |
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