WO2015005630A1 - Composition capable d'inhiber la sécrétion de tslp et de soulager des maladies allergiques - Google Patents

Composition capable d'inhiber la sécrétion de tslp et de soulager des maladies allergiques Download PDF

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Publication number
WO2015005630A1
WO2015005630A1 PCT/KR2014/006081 KR2014006081W WO2015005630A1 WO 2015005630 A1 WO2015005630 A1 WO 2015005630A1 KR 2014006081 W KR2014006081 W KR 2014006081W WO 2015005630 A1 WO2015005630 A1 WO 2015005630A1
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WO
WIPO (PCT)
Prior art keywords
allergic
formula
tslp
compound represented
composition
Prior art date
Application number
PCT/KR2014/006081
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English (en)
Korean (ko)
Inventor
김윤선
이상화
Original Assignee
주식회사 엘지생활건강
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 주식회사 엘지생활건강 filed Critical 주식회사 엘지생활건강
Priority to CN201480038831.6A priority Critical patent/CN105377248A/zh
Publication of WO2015005630A1 publication Critical patent/WO2015005630A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients

Definitions

  • the inventors of the present invention have been studying a substance capable of improving the imbalance, which is a fundamental cause of the imbalance, by inhibiting the overexpression of TSLP secretion by the compound represented by the following formula (1) to regulate the immune response.
  • the present invention was completed by confirming that it effectively alleviates allergic diseases such as atopic dermatitis, asthma, allergic rhinitis, allergic conjunctivitis, allergic dermatitis, allergic contact dermatitis, gallbladder or food allergy.
  • Allergic diseases of the present invention include atopic dermatitis, asthma, allergic rhinitis, allergic conjunctivitis, allergic dermatitis, allergic contact dermatitis This includes contact dermatitis, hives or food allergy.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Nutrition Science (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Emergency Medicine (AREA)
  • Mycology (AREA)
  • Birds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne une composition pharmaceutique, une composition cosmétique, ou un aliment fonctionnel bénéfique pour la santé, qui sont capables de soulager efficacement des maladies allergiques par inhibition de la sécrétion de lymphopoïétine stromale thymique (TSLP) et inhibition de TSLP, et qui comprennent, en tant que substance active, un composé représenté par la formule chimique 1 de la présente invention ou un sel pharmaceutiquement acceptable. En conséquence, la composition a un excellent effet pour inhiber la sécrétion de TSLP, qui est un facteur de réaction immunitaire, et est donc supérieur pour soulager des maladies allergiques causées par un déséquilibre dans le système immunitaire.
PCT/KR2014/006081 2013-07-09 2014-07-08 Composition capable d'inhiber la sécrétion de tslp et de soulager des maladies allergiques WO2015005630A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201480038831.6A CN105377248A (zh) 2013-07-09 2014-07-08 具有tslp分泌抑制性能及过敏性疾病改善性能的组合物

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20130080273A KR101486147B1 (ko) 2013-07-09 2013-07-09 Tslp 분비 저해능 및 이에 의한 알러지성 질환의 개선능을 가지는 조성물
KR10-2013-0080273 2013-07-09

Publications (1)

Publication Number Publication Date
WO2015005630A1 true WO2015005630A1 (fr) 2015-01-15

Family

ID=52280246

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2014/006081 WO2015005630A1 (fr) 2013-07-09 2014-07-08 Composition capable d'inhiber la sécrétion de tslp et de soulager des maladies allergiques

Country Status (3)

Country Link
KR (1) KR101486147B1 (fr)
CN (1) CN105377248A (fr)
WO (1) WO2015005630A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3065372A1 (fr) * 2017-04-21 2018-10-26 Jean Noel Thorel Composition comprenant de la carboxy methyl naringenine chalcone pour le traitement du prurit et de la dermatite atopique

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101843248B1 (ko) 2015-03-17 2018-03-29 고려대학교 세종산학협력단 흉선 기질 림프단백질 매개 신호전달을 제어하는 펩타이드 유도체 및 이를 포함하는 알러지 및 천식 질환 예방 및 치료용 약학 조성물
WO2016148437A1 (fr) * 2015-03-17 2016-09-22 고려대학교 산학협력단 Dérivé peptidique pour réguler la signalisation médiée par des protéines lymphoïdes du stroma thymique, et composition pharmaceutique pour prévenir et traiter les maladies allergiques et asthmatiques comprenant celui-ci
TWI743047B (zh) * 2015-08-17 2021-10-21 安成生物科技股份有限公司 使用雙醋瑞因或其類似物抑制asc表現、nlrp3表現、以及/或nlrp3發炎體複合物的形成之方法
KR101839721B1 (ko) * 2017-01-06 2018-03-16 고려대학교 세종산학협력단 바이칼레인을 유효성분으로 포함하는 천식 또는 아토피 등의 알러지성 질환의 예방 또는 치료용 약학 조성물
WO2018151442A1 (fr) * 2017-02-17 2018-08-23 서강대학교 산학협력단 Composition permettant de soulager, de prévenir ou de traiter une atopie
KR102561257B1 (ko) * 2018-10-10 2023-07-31 서울대학교병원 Tslp 분비 억제능을 갖는 우스닉산 유도체 및 이를 함유하는 알러지성 질환의 예방 또는 치료용 조성물

Citations (4)

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WO2008056156A1 (fr) * 2006-11-10 2008-05-15 Sosei R & D Ltd. Sels d'acides dihydroxyanthraquinone carboxyliques et leur utilisation thérapeutique
KR20080043800A (ko) * 2005-08-10 2008-05-19 소세이 리서치 앤드 디벨롭먼트 리미티드 디히드록시안트라퀴논 및 그의 용도
KR20110085517A (ko) * 2010-01-20 2011-07-27 영남대학교 산학협력단 안트라퀴논 유도체를 유효성분으로 함유하는 알레르기성 질환 예방 및 치료용 약학조성물
JP2011252153A (ja) * 2004-02-26 2011-12-15 Lab Medidom Sa レインを含むヒアルロン酸のエステル、その製造方法、およびそれを含んでなる組成物

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CN101301284B (zh) * 2008-05-21 2010-11-17 广州艾格生物科技有限公司 大黄酸或其盐在制备治疗慢性肾炎或慢性肾功能衰竭药物中的应用

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011252153A (ja) * 2004-02-26 2011-12-15 Lab Medidom Sa レインを含むヒアルロン酸のエステル、その製造方法、およびそれを含んでなる組成物
KR20080043800A (ko) * 2005-08-10 2008-05-19 소세이 리서치 앤드 디벨롭먼트 리미티드 디히드록시안트라퀴논 및 그의 용도
WO2008056156A1 (fr) * 2006-11-10 2008-05-15 Sosei R & D Ltd. Sels d'acides dihydroxyanthraquinone carboxyliques et leur utilisation thérapeutique
KR20110085517A (ko) * 2010-01-20 2011-07-27 영남대학교 산학협력단 안트라퀴논 유도체를 유효성분으로 함유하는 알레르기성 질환 예방 및 치료용 약학조성물

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SINGH, BALJINDER ET AL.: "The hydroalcoholic extract of Cassia alata (Linn.) leaves and its major compound rhein exhibits antiallergic activity via mast cell stabilization and lipoxygenase inhibition.", JOURNAL OF ETHNOPHARMACOLOGY, vol. 141, 2012, pages 469 - 473 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3065372A1 (fr) * 2017-04-21 2018-10-26 Jean Noel Thorel Composition comprenant de la carboxy methyl naringenine chalcone pour le traitement du prurit et de la dermatite atopique

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Publication number Publication date
KR101486147B1 (ko) 2015-01-23
CN105377248A (zh) 2016-03-02
KR20150006639A (ko) 2015-01-19

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