WO2015005630A1 - Composition capable d'inhiber la sécrétion de tslp et de soulager des maladies allergiques - Google Patents
Composition capable d'inhiber la sécrétion de tslp et de soulager des maladies allergiques Download PDFInfo
- Publication number
- WO2015005630A1 WO2015005630A1 PCT/KR2014/006081 KR2014006081W WO2015005630A1 WO 2015005630 A1 WO2015005630 A1 WO 2015005630A1 KR 2014006081 W KR2014006081 W KR 2014006081W WO 2015005630 A1 WO2015005630 A1 WO 2015005630A1
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- WIPO (PCT)
- Prior art keywords
- allergic
- formula
- tslp
- compound represented
- composition
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
Definitions
- the inventors of the present invention have been studying a substance capable of improving the imbalance, which is a fundamental cause of the imbalance, by inhibiting the overexpression of TSLP secretion by the compound represented by the following formula (1) to regulate the immune response.
- the present invention was completed by confirming that it effectively alleviates allergic diseases such as atopic dermatitis, asthma, allergic rhinitis, allergic conjunctivitis, allergic dermatitis, allergic contact dermatitis, gallbladder or food allergy.
- Allergic diseases of the present invention include atopic dermatitis, asthma, allergic rhinitis, allergic conjunctivitis, allergic dermatitis, allergic contact dermatitis This includes contact dermatitis, hives or food allergy.
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Emergency Medicine (AREA)
- Birds (AREA)
- Food Science & Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La présente invention concerne une composition pharmaceutique, une composition cosmétique, ou un aliment fonctionnel bénéfique pour la santé, qui sont capables de soulager efficacement des maladies allergiques par inhibition de la sécrétion de lymphopoïétine stromale thymique (TSLP) et inhibition de TSLP, et qui comprennent, en tant que substance active, un composé représenté par la formule chimique 1 de la présente invention ou un sel pharmaceutiquement acceptable. En conséquence, la composition a un excellent effet pour inhiber la sécrétion de TSLP, qui est un facteur de réaction immunitaire, et est donc supérieur pour soulager des maladies allergiques causées par un déséquilibre dans le système immunitaire.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201480038831.6A CN105377248A (zh) | 2013-07-09 | 2014-07-08 | 具有tslp分泌抑制性能及过敏性疾病改善性能的组合物 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20130080273A KR101486147B1 (ko) | 2013-07-09 | 2013-07-09 | Tslp 분비 저해능 및 이에 의한 알러지성 질환의 개선능을 가지는 조성물 |
KR10-2013-0080273 | 2013-07-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2015005630A1 true WO2015005630A1 (fr) | 2015-01-15 |
Family
ID=52280246
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/KR2014/006081 WO2015005630A1 (fr) | 2013-07-09 | 2014-07-08 | Composition capable d'inhiber la sécrétion de tslp et de soulager des maladies allergiques |
Country Status (3)
Country | Link |
---|---|
KR (1) | KR101486147B1 (fr) |
CN (1) | CN105377248A (fr) |
WO (1) | WO2015005630A1 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR3065372A1 (fr) * | 2017-04-21 | 2018-10-26 | Jean Noel Thorel | Composition comprenant de la carboxy methyl naringenine chalcone pour le traitement du prurit et de la dermatite atopique |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101843248B1 (ko) | 2015-03-17 | 2018-03-29 | 고려대학교 세종산학협력단 | 흉선 기질 림프단백질 매개 신호전달을 제어하는 펩타이드 유도체 및 이를 포함하는 알러지 및 천식 질환 예방 및 치료용 약학 조성물 |
WO2016148437A1 (fr) * | 2015-03-17 | 2016-09-22 | 고려대학교 산학협력단 | Dérivé peptidique pour réguler la signalisation médiée par des protéines lymphoïdes du stroma thymique, et composition pharmaceutique pour prévenir et traiter les maladies allergiques et asthmatiques comprenant celui-ci |
CN108349867B (zh) * | 2015-08-17 | 2021-03-09 | 安成生物科技股份有限公司 | 用于抑制asc的表达、nlrp3的表达和/或nlrp3炎性复合体的形成的双醋瑞因或其类似物 |
KR101839721B1 (ko) * | 2017-01-06 | 2018-03-16 | 고려대학교 세종산학협력단 | 바이칼레인을 유효성분으로 포함하는 천식 또는 아토피 등의 알러지성 질환의 예방 또는 치료용 약학 조성물 |
WO2018151442A1 (fr) * | 2017-02-17 | 2018-08-23 | 서강대학교 산학협력단 | Composition permettant de soulager, de prévenir ou de traiter une atopie |
KR102561257B1 (ko) * | 2018-10-10 | 2023-07-31 | 서울대학교병원 | Tslp 분비 억제능을 갖는 우스닉산 유도체 및 이를 함유하는 알러지성 질환의 예방 또는 치료용 조성물 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008056156A1 (fr) * | 2006-11-10 | 2008-05-15 | Sosei R & D Ltd. | Sels d'acides dihydroxyanthraquinone carboxyliques et leur utilisation thérapeutique |
KR20080043800A (ko) * | 2005-08-10 | 2008-05-19 | 소세이 리서치 앤드 디벨롭먼트 리미티드 | 디히드록시안트라퀴논 및 그의 용도 |
KR20110085517A (ko) * | 2010-01-20 | 2011-07-27 | 영남대학교 산학협력단 | 안트라퀴논 유도체를 유효성분으로 함유하는 알레르기성 질환 예방 및 치료용 약학조성물 |
JP2011252153A (ja) * | 2004-02-26 | 2011-12-15 | Lab Medidom Sa | レインを含むヒアルロン酸のエステル、その製造方法、およびそれを含んでなる組成物 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101301284B (zh) * | 2008-05-21 | 2010-11-17 | 广州艾格生物科技有限公司 | 大黄酸或其盐在制备治疗慢性肾炎或慢性肾功能衰竭药物中的应用 |
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2013
- 2013-07-09 KR KR20130080273A patent/KR101486147B1/ko active IP Right Grant
-
2014
- 2014-07-08 CN CN201480038831.6A patent/CN105377248A/zh active Pending
- 2014-07-08 WO PCT/KR2014/006081 patent/WO2015005630A1/fr active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2011252153A (ja) * | 2004-02-26 | 2011-12-15 | Lab Medidom Sa | レインを含むヒアルロン酸のエステル、その製造方法、およびそれを含んでなる組成物 |
KR20080043800A (ko) * | 2005-08-10 | 2008-05-19 | 소세이 리서치 앤드 디벨롭먼트 리미티드 | 디히드록시안트라퀴논 및 그의 용도 |
WO2008056156A1 (fr) * | 2006-11-10 | 2008-05-15 | Sosei R & D Ltd. | Sels d'acides dihydroxyanthraquinone carboxyliques et leur utilisation thérapeutique |
KR20110085517A (ko) * | 2010-01-20 | 2011-07-27 | 영남대학교 산학협력단 | 안트라퀴논 유도체를 유효성분으로 함유하는 알레르기성 질환 예방 및 치료용 약학조성물 |
Non-Patent Citations (1)
Title |
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SINGH, BALJINDER ET AL.: "The hydroalcoholic extract of Cassia alata (Linn.) leaves and its major compound rhein exhibits antiallergic activity via mast cell stabilization and lipoxygenase inhibition.", JOURNAL OF ETHNOPHARMACOLOGY, vol. 141, 2012, pages 469 - 473 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR3065372A1 (fr) * | 2017-04-21 | 2018-10-26 | Jean Noel Thorel | Composition comprenant de la carboxy methyl naringenine chalcone pour le traitement du prurit et de la dermatite atopique |
Also Published As
Publication number | Publication date |
---|---|
CN105377248A (zh) | 2016-03-02 |
KR20150006639A (ko) | 2015-01-19 |
KR101486147B1 (ko) | 2015-01-23 |
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