WO2014171183A1

WO2014171183A1 - Medical tubular body

Info

Publication number: WO2014171183A1
Application number: PCT/JP2014/054562
Authority: WO
Inventors: 雄起向井
Original assignee: 株式会社カネカ
Priority date: 2013-04-16
Filing date: 2014-02-25
Publication date: 2014-10-23

Abstract

The purpose of the present invention is to provide a medical tubular body which has excellent visibility under X-ray fluoroscopy, excellent insertability into a catheter, and excellent slidability inside of the catheter, which can contract to become even smaller, and which, in a contracted state, suppresses contact between markers and the tubular body, or between adjacent markers. This medical tubular body is manufactured provided with an expandable tubular body and at least two markers (121, 122) formed on at least one end of the tubular body, wherein the two markers (121, 122) have mutually different positions in the axial direction when the tubular body is contracted.

Description

Medical tubular body

The present invention relates to a medical tubular body that can be expanded in diameter, and is used, for example, to treat a lesion where a blood vessel or other in-vivo lumen is narrowed or occluded. More specifically, the present invention relates to a medical tubular body typified by a stent placed in a lesioned part of a living body lumen, or a medical tubular body used for removing a thrombus generated in a lesioned part.

A medical tubular body typified by a stent is generally a medical instrument for treating various diseases caused by stenosis or occlusion of a blood vessel or other living body lumen. The medical tubular body includes a lesion that is expanded from the inside, such as a stenosis or occlusion, and is placed in the lesion to maintain the inner diameter of the lumen, or a thrombus that has developed in or around the lesion. Examples include those that are removed from the entangled body and restored to the luminal inner diameter at the lesion.

The medical tubular body is used in the body, but once the medical tubular body is inserted into the body, its position cannot be visually confirmed. Therefore, usually, a marker including a radiopaque material is provided at a predetermined position of the medical tubular body, and the treatment is performed while confirming the exact position of the marker under fluoroscopy.

The marker visibility is required to be improved in terms of accurate transport to the lesion (delivery) and alignment of the exact extended range (working range) in the expanded state.

For example, FIG. 14 of Patent Document 1 describes an intravascular medical instrument (medical tubular body) that can be inserted into a small-diameter delivery system by making the marker shape longer in the axial direction and shorter in the radial direction. ing.

Patent Document 2 describes a medical tubular body in which markers having a predetermined distance are arranged around the end of the tubular body for the purpose of facilitating the determination of the direction of the medical tubular body. Yes.

JP 2003-334256 A Special table 2003-527925 gazette

However, in the medical tubular body of Patent Document 1 and Patent Document 2, in order to further improve the marker visibility, insertability into the catheter, slidability within the catheter, There is a limit according to the characteristics of the configuration. The method of simply increasing the size of the marker or increasing the number of markers in order to improve the visibility of the marker is an obstacle to insertion of the tubular body into the catheter and sliding of the tubular body within the catheter. . This is because when the diameter of the tubular body is reduced, the marker comes into contact with a strut, which is a column that forms a part of the tubular body, or an adjacent marker, and the outer diameter of the tubular body cannot be sufficiently reduced even when the diameter is reduced.

The present invention has excellent visibility under fluoroscopy, insertion into a catheter, and slidability within a catheter, and can suppress contact between a marker and a tubular body or adjacent markers in a reduced diameter state. An object of the present invention is to provide a medical tubular body that can be reduced in diameter.

The present inventor has made various studies on the shape and arrangement of the markers in order to solve the above problems. As the medical tubular body is reduced in diameter, each marker formed at the end of the tubular body gathers toward the central axis of the tubular body. In the present study, the present inventor did not make the marker small because the markers gathered in one place do not contact with each other in this way, but utilized the axial dimension of the tubular body to place the marker in a different place. The present invention was completed by thinking that it could not be escaped.

That is, the medical tubular body of the present invention that has solved the above-described problem has a tubular body that can be expanded in diameter, and at least two markers formed at at least one end of the tubular body. The markers have different axial positions when the tubular body is reduced in diameter. Thus, since the two markers have different axial positions, they do not contact each other.

In the medical tubular body, it is preferable that the tubular body includes a plurality of struts having different lengths, and the marker is formed at an end of each strut. If struts having different lengths are used, markers can be easily formed at different positions in the axial direction of the tubular body.

In the above-described medical tubular body, an embodiment in which the tubular body has a mesh structure and the mesh units are arranged in a spiral shape can be preferably implemented.

In the medical tubular body, it is desirable that the two markers do not contact each other when the tubular body is reduced in diameter.

In the medical tubular body, when the diameter of the tubular body is reduced, it is desirable that members (hereinafter referred to as “housing”) that are non-deformable portions included in the tubular body do not contact each other. .

In the medical tubular body, it is preferable that the marker is formed inside the tubular body. With such a configuration, even if the diameter of the tubular body contracts, the gap inside the tubular body is effectively used and the marker is stored in the gap. Therefore, even if the markers do not contact each other or the marker and the tubular body, or even if they contact each other, the degree of contact is reduced as compared with the conventional case. As a result, the diameter of the tubular body when contracted can be made smaller than before.

In the medical tubular body, it is preferable that the marker is formed on a flat portion on the inner surface of the tubular body. When the inner surface of the tubular body is a flat surface, it is easy to increase the contact area between the inner surface of the tubular body and the marker, so that the tubular body and the marker can be more firmly fixed.

In the medical tubular body, the marker is preferably welded to the inner surface of the tubular body. It is possible to provide a medical tubular body with reduced risk of marker dropping.

In the medical tubular body, the marker is preferably sized to be accommodated in an inner space when the tubular body is reduced in diameter.

In the medical tubular body, it is preferable that a gap is formed between one end of the marker and the tubular body when the diameter of the tubular body is reduced. Since the tubular body does not necessarily have a reduced diameter as designed, it may be advantageous to reduce the diameter of the tubular body by leaving some gaps.

In the above-described medical tubular body, the marker can preferably be implemented such that the axial length of the tubular body is longer than the radial length of the tubular body. Even when the marker is arranged using the inner space of the tubular body, the inner space of the tubular body is naturally limited, so that the marker volume can be increased by forming it longer in the axial direction of the tubular body.

In the medical tubular body, it is preferable that the marker housing has an opening, and the marker is embedded in the opening.

In the medical tubular body, it is preferable that the markers are spaced apart from each other more than the length of the marker housing in the axial direction of the tubular body.

In the medical tubular body, the marker is preferably columnar.

In the medical tubular body, it is preferable that the end of the tubular body has a shape obtained by obliquely cutting a cylinder.

In the present invention, since the positions of the two markers formed at the end of the medical tubular body are different in the axial direction of the tubular body, the two markers do not contact each other even when the tubular body contracts. Therefore, it is possible to reduce the diameter of the medical tubular body smaller than before while maintaining the volume per marker.

FIG. 1 is a development view of the medical tubular body according to the first embodiment of the present invention. FIG. 2 is an enlarged view of an end of the medical tubular body according to the first embodiment of the present invention. FIG. 3 is an end perspective view of the medical tubular body (when the diameter is reduced) according to the first embodiment of the present invention. FIG. 4 is a development view of the medical tubular body according to the second embodiment of the present invention. FIG. 5 is a development view of the medical tubular body according to the third embodiment of the present invention. FIG. 6A is an end perspective view of the medical tubular body according to the third embodiment (during diameter expansion), and FIG. 6B is a medical tubular body according to the third embodiment (expanded diameter). It is the figure which looked at time from the axial direction. FIG. 7A is an end perspective view of the medical tubular body according to the third embodiment (when the diameter is reduced), and FIG. 7B is a medical tubular body according to the third embodiment (the diameter is reduced). It is the figure which looked at time from the axial direction. FIG. 8 is a development view of the medical tubular body according to the fourth embodiment of the present invention. FIG. 9A is an end perspective view of the medical tubular body according to the fourth embodiment (when the diameter is expanded), and FIG. 9B is a medical tubular body according to the fourth embodiment (the diameter is expanded). It is the figure which looked at time from the axial direction. FIG. 10A is an end perspective view of the medical tubular body according to the fourth embodiment (when the diameter is reduced), and FIG. 10B is a medical tubular body according to the fourth embodiment (the diameter is reduced). It is the figure which looked at time from the axial direction.

The medical tubular body of the present invention has a tubular body that can be expanded, and at least two markers formed on at least one end of the tubular body, and the two markers are contractions of the tubular body. The positions in the axial direction at the time of diameter are different from each other. In this way, the two markers have different axial positions, and the markers do not come into contact with each other even when the diameter of the tubular body is reduced, so that the diameter of the medical tubular body can be further reduced. The positional relationship in the axial direction of the marker may change depending on the expansion / contraction of the tubular body. In the present invention, the fact that the axial positions of the two markers are different from each other is based on the structure of the tubular body when the diameter is reduced. It is not intended to be based on the axial position at the time of diameter expansion.
“Different positions in the axial direction of the tubular body” means that “positions separated by at least one marker length in the axial direction of the tubular body so that the markers do not contact each other”. Can understand. In the present specification, a configuration in which a marker is removed from a medical tubular body is referred to as a “tubular body”.

(1) Use of medical tubular body The medical tubular body is used in a living body lumen. For example, it is placed in a lesioned part of a living body lumen to maintain or expand the diameter of the living body lumen. And a peripheral protection device such as a peripheral protection filter, a thrombectomy device for removing a thrombus formed in a lumen in a living body, and the like.

(2) Classification of medical tubular bodies For medical tubular bodies, for example, (i) a coiled type made of a single linear metal or polymer material, and (ii) a metal tube cut out with a laser or the like (Iii) a type in which linear portions are welded and assembled, and (iv) a type in which a plurality of linear metals are woven.

The medical tubular body is used by being attached to a catheter (delivery system: delivery device) or the like having a portion where the medical tubular body is placed for delivery (delivery) to a lesioned part. From the viewpoint of an expansion mechanism, the medical tubular body is (i) a balloon that mounts (mounts) a medical tubular body on the outer surface of the balloon and transports it to the lesioned area, and expands the medical tubular body with the balloon at the lesioned area. It can be classified into an expandable type and (ii) a self-expandable type that expands itself by removing the member that suppresses expansion at the lesioned part by transporting to the lesioned part with a catheter having a member that suppresses expansion.

The medical tubular body is reduced in a direction perpendicular to the longitudinal axis of the tubular body (that is, the radial direction of the tubular body) in a state where the medical tubular body is installed in a delivery system composed of a balloon, a catheter, or the like, and the longitudinal axis direction. In other words, by extending, the diameter is reduced to a cylindrical shape that is longer than the expanded state. In the self-expanding type, since it is not necessary to provide a balloon inside, the diameter of the reduced diameter state can be reduced as compared with the balloon expansion type.

(3) Tubular body A tubular body is a structure which can be expanded in diameter, for example comprised by mesh structures, such as a mesh. In the present invention, being able to expand the diameter means that the tube can be expanded in a direction perpendicular to the major axis (radial direction) of the tubular body, and can be contracted (reduced diameter) from the expanded state. To do. The tubular body is formed, for example, from a pattern of interconnected structural elements that expand and contract in the circumferential and axial directions. The tubular body in the present invention can be applied in any pattern and is therefore not limited to any particular stent shape or structural element pattern.

(4) Marker Once the medical tubular body is placed in the body, its position cannot be confirmed visually. Therefore, a marker including a radiopaque material is provided at a predetermined position of the medical tubular body so that the medical tubular body can be observed under X-ray fluoroscopy. The marker does not need to completely block X-rays, and may have an X-ray transmittance that can detect the presence of the marker under fluoroscopy.

This application claims the benefit of priority based on Japanese Patent Application No. 2013-86134 filed on April 16, 2013. The entire contents of the above Japanese Patent Application No. 2013-86134 are incorporated herein by reference.

(Embodiment 1)
Hereinafter, the medical tubular body according to the first embodiment of the present invention will be described with reference to the drawings. FIG. 1 is a development view of the medical tubular body according to the first embodiment of the present invention. The medical tubular body 100 has a distal end 101 and a proximal end 102, and has a metal mesh portion 111 between the distal end 101 and the proximal end 102. The metal mesh portion 111 is configured by a combination of continuous cells 112. The metal mesh portion 111 is bent into a tubular shape with the longitudinal direction as the central axis, and the two long sides of the metal mesh portion 111 are joined to form a tubular body.

The medical tubular body 100 according to the first embodiment of the present invention has a marker housing 161 at the distal end 101 or the proximal end 102, a marker 121 fixed to the marker housing 161, and other markers 122 to 124. is doing. The marker housing 161 will be described later with reference to FIG.

FIG. 2 is an enlarged view of the vicinity of the marker 121 of the medical tubular body 100 according to the first embodiment of the present invention. In FIG. 2, a marker housing 161 having an opening at the distal end 101 is provided, and a marker 121 is embedded in the opening. The material of the marker housing 161 is preferably the same material as that of the metal mesh portion 111 in terms of strength and corrosion resistance, and preferably has an integral structure with the metal mesh portion 111.

FIG. 3 is a perspective view of the end portion (distal end 101) of the medical tubular body (when the diameter is reduced) 100 according to the first embodiment of the present invention. Due to the reduced diameter of the medical tubular body 100, the markers 122 to 124 are very close to the vicinity of the axis of the medical tubular body 100. However, since the markers 121 to 124 in the present embodiment have different axial positions when the tubular body is reduced in diameter, the markers 121 to 124 are in contact with each other even when the tubular body is reduced in diameter. The diameter of the medical tubular body 100 can be made smaller than before. The form of fixing the markers 121 to 124 is not particularly limited. However, as shown in FIGS. 1 to 3, when the marker housing 161 is larger than the marker 121, the marker in the axial direction of the tubular body is used. It is desirable that the markers 121 to 124 be separated from each other by a length longer than the length of the housing 161.

The material used for the metal mesh portion 111 is not particularly limited as long as it is a material that can withstand a strong load at the time of deformation or indwelling, such as expansion or contraction, but is stainless steel for medical use. 316L stainless steel, tantalum, Co—Cr (cobalt chromium) alloy, Ni—Ti (nickel-titanium) alloy and the like can be preferably used. In particular, a nickel-titanium alloy can be preferably used because it has shape memory characteristics and elastic characteristics and is excellent in workability. Of the nickel-titanium alloys, an alloy containing about 50% by mass to about 60% by mass of nickel can be preferably used.

The metal mesh portion 111 may include a biodegradable material such as a biodegradable polymer or metal. Alternatively, the biodegradable material may be a composite of at least two biodegradable polymers and / or metals.

As a method for producing the metal mesh portion 111, a laser processing method, an electric discharge processing method, a mechanical cutting method, an etching method, or the like can be suitably used. In the present invention, in particular, a method of cutting a tubular material into a pattern of the cells 112 by a laser processing method and forming a mesh shape can be preferably used.

The material constituting the marker 121 is not particularly limited as long as it is a material having higher radiopacity than the constituent material of the medical tubular body 100. A metal material is preferable from the viewpoint of workability such as an influence on a living body or a difficulty in deformation when attached to the marker housing 161. In particular, platinum, palladium, and tantalum are preferable because they have excellent biological compatibility with the human body. In particular, when a nickel-titanium alloy is used as the material of the marker housing 161, tantalum is preferable because it has a small difference in electrochemical potential and is difficult to corrode.

The size of the tubular body is not particularly limited, but in Embodiment 1, the outer diameter of the tubular body is, for example, about 0.36 to 0.46 mm when the diameter is reduced, and is about 4.0 to 4.5 mm when the diameter is expanded, for example. . The marker has a thickness of about 0.05 to 0.10 mm and an outer diameter of about 0.1 to 0.3 mm, for example.

(Embodiment 2)
Hereinafter, the medical tubular body according to the second embodiment of the present invention will be described with reference to the drawings. FIG. 4 is a development view of the medical tubular body according to the second embodiment of the present invention. The medical tubular body 100 has a distal end 101 and a proximal end 102, and has a metal mesh portion 111 between the distal end 101 and the proximal end 102. The metal mesh portion 111 is configured by a combination of cells 112 that are continuous in the spiral direction. The medical tubular body 100 according to the second embodiment of the present invention basically has the same configuration as that of the medical tubular body 100 according to the first embodiment of the present invention. The same reference numerals are given and description thereof is omitted.

The medical tubular body 100 according to the second embodiment of the present invention is different from the medical tubular body 100 according to the first embodiment in that the length of the support columns 151 to 154 is different in the first embodiment. Whereas the positions of the markers 121 to 124 in the body axial direction are different, in the second embodiment, as shown in FIG. 4, the cells 112 are made continuous in the spiral direction to form the metal mesh portion 111. Thus, the positions of the markers 121 to 124 in the axial direction of the tubular body are different. In the method of the first embodiment, when the struts 151 to 154 are formed very long, the strut may be deformed in the living body lumen. However, in the present embodiment, the end of the tubular body is configured obliquely (that is, shaped like the tip of an injection needle) due to the configuration of the metal mesh portion 111 itself, so that the long support as in the first embodiment This is advantageous in that the rigidity of the end of the tubular body is maintained.

In the first and second embodiments, the markers 121 to 124 are aligned in a straight line with a certain angle with respect to the axial direction of the medical tubular body 100. 1 and 4 are developed views, but the markers 121 to 124 can be seen in a straight line even when the metal mesh portion 111 is bent to form a tubular shape and the medical tubular body 100 is observed from the side. This is because the end of the tubular body has a shape obtained by obliquely cutting the cylinder (that is, a shape like the tip of an injection needle). As the diameter of the tubular body shrinks, the angle between the straight line in which the markers 121 to 124 are arranged and the axial direction of the tubular body becomes smaller. When the contraction of the tubular body is completed, as shown in FIG. 3, the straight line in which the markers 121 to 124 are arranged becomes substantially parallel to the axis of the tubular body. By utilizing such movement of the marker, the expansion and contraction of the tubular body can be performed from the angle formed by the straight line in which the markers 121 to 124 are arranged and the axis of the tubular body. You can know the degree.

(Embodiment 3)
Hereinafter, the medical tubular body according to the third embodiment of the present invention will be described with reference to the drawings. FIG. 5 is a development view of the medical tubular body according to the third embodiment of the present invention. The medical tubular body 100 has a distal end 101 and a proximal end 102, and has a metal mesh portion 111 between the distal end 101 and the proximal end 102. Since the medical tubular body 100 according to the third embodiment of the present invention has the same configuration as the medical tubular body 100 according to the second embodiment of the present invention, the same reference numerals are given to the same configurations. The description is omitted.

The medical tubular body 100 according to the third embodiment of the present invention is different from the medical tubular body 100 according to the second embodiment in that the marker 121 and the like are embedded in the marker housing 161 in the second embodiment. However, in the third embodiment, the marker 121 and the like are formed on the marker housing 131 and on the inner surface of the tubular body.

The method for attaching each of the markers 121 to 124 to the marker housing is not particularly limited as long as it is a method that does not drop off during the transportation of the medical tubular body 100 or the indwelling operation in the lesioned part. As the method, for example, welding, brazing, caulking, and the like can be mentioned. This is because, in the case of welding, a material different from a marker material such as a marker housing or a solder is not used. On the other hand, in the case of brazing, a material different from the marker housing or the marker material is used, and in the case of caulking, it is difficult to obtain the smoothness of the outer surface in the radial direction of the marker housing. When the marker is attached by welding, the inner surface of the marker housing is preferably flat, and is preferably oval, square, or rectangular because a linear length corresponding to the diameter of the welding spot is required.

The diameter of the welding spot is preferably 80% or less of the short side of the fixed surface of the marker, more preferably 70% or less, and still more preferably 60%, from the viewpoint of not adversely affecting the fluoroscopic image. The following. On the other hand, from the viewpoint of maintaining the attachment strength of the marker, the diameter of the welding spot is preferably 20% or more of the short side of the fixed surface of the marker, more preferably 30% or more, and even more preferably 40% or more. And Specifically, the diameter of the welding spot is preferably about 40 μm to 100 μm, more preferably about 50 μm to 90 μm.

FIG. 6A is a perspective view of the vicinity of the distal end 101 of the medical tubular body according to the third embodiment (when the diameter is expanded), and FIG. 6B is a view of the distal end 101 viewed from the axial direction. FIG. 7A is a perspective view of the vicinity of the distal end 101 of the medical tubular body according to the third embodiment (when the diameter is reduced), and FIG. 7B is a view of the distal end 101 seen from the axial direction. It is a figure. As can be seen from FIGS. 6 and 7, since the markers 121 to 124 are formed at different positions in the axial direction of the tubular body as in the first and second embodiments, the markers 121 to 124 when the diameter of the tubular body is reduced. Are accommodated in the internal space of the tubular body without interfering with each other.

Furthermore, as can be seen from FIG. 7, the marker of the medical tubular body 100 according to the present embodiment is formed inside the tubular body capable of expanding the diameter. ˜124 fit in the void inside the tubular body. Therefore, even if a marker and a tubular body do not contact each other or contact, the degree of contact is reduced more than before.

7B, the markers 121 to 124 have some gaps on the side opposite to the side fixed to the marker housings 131 to 134, and the diameter of the markers 121 to 124 is reduced. It may not be perfectly aligned with the axial direction of the tubular body. Of course, it is ideal that the markers 121 to 124 are perfectly aligned in that a marker having a large volume can be arranged by making the best use of the voids in the tubular body. However, since the tubular body does not necessarily have a reduced diameter as designed, leaving some clearance may be advantageous for reducing the diameter of the tubular body. Therefore, it is also a preferable aspect to employ a configuration in which the markers 121 to 124 are not arranged in a straight line when the diameter of the tubular body is reduced.

(Embodiment 4)
Hereinafter, the medical tubular body according to the fourth embodiment of the present invention will be described with reference to the drawings. FIG. 8 is a development view of the medical tubular body according to the fourth embodiment of the present invention. FIG. 9A is a perspective view of the vicinity of the distal end 101 of the medical tubular body according to the fourth embodiment (when expanded in diameter), and FIG. 9B shows the distal end 101 viewed from the axial direction. FIG. FIG. 10A is a perspective view of the vicinity of the distal end 101 of the medical tubular body according to the fourth embodiment (when the diameter is reduced), and FIG. 10B is a view of the distal end 101 seen from the axial direction. It is a figure.

The medical tubular body 100 according to the fourth embodiment of the present invention has substantially the same configuration as the medical tubular body 100 according to the third embodiment of the present invention. 124 is formed in a columnar shape, but the fourth embodiment is different in that the markers 121 to 124 are formed in a prismatic shape. If the markers 121 to 124 are prismatic shapes, the contact surface with the marker housings 131 to 134 is large, which is advantageous in terms of fixing strength.

As mentioned above, although the medical tubular body concerning embodiment of this invention was demonstrated using the specific example, this invention is not restrict | limited by the said embodiment, In the range which can adapt to the meaning of the said and the postscript. Of course, it is possible to carry out with modifications, and they are all included in the technical scope of the present invention.

The medical tubular body of the present invention can be suitably used for various medical tubular bodies such as drug-coated stents and biodegradable stents in addition to those exemplified.

DESCRIPTION OF SYMBOLS 100 Medical tubular body 101 Distal end 102 Proximal end 111 Metal mesh part 112 Cell 121,122,123,124 Marker 131,132,133,134 Marker housing 141 Inner side surface of marker housing 151,152,153,154 161 Marker housing

Claims

The tubular body has a diameter-expandable tubular body and at least two markers formed on at least one end of the tubular body, and the two markers have an axial position when the diameter of the tubular body is reduced. A medical tubular body characterized by being different.
The medical tubular body according to claim 1, wherein the tubular body includes a plurality of struts having different lengths, and the marker is formed at an end of each strut.
The medical tubular body according to claim 1 or 2, wherein the tubular body has a mesh structure, and the mesh units are arranged in a spiral shape.
The medical tubular body according to any one of claims 1 to 3, wherein the two markers do not contact each other when the diameter of the tubular body is reduced.
The member according to any one of claims 1 to 4, wherein members (hereinafter referred to as "housings") that are non-deformable portions constituting a part of the tubular body and do not contact each other when the diameter of the tubular body is reduced. A medical tubular body according to claim 1.
The medical tubular body according to any one of claims 1 to 5, wherein the marker is formed inside the tubular body.
The medical tubular body according to any one of claims 1 to 6, wherein the marker is formed on a flat portion of an inner surface of the tubular body.
The medical tubular body according to any one of claims 1 to 7, wherein the marker is welded to an inner surface of the tubular body.
The medical tubular body according to any one of claims 1 to 8, wherein the marker is sized to be accommodated in an inner space when the diameter of the tubular body is reduced.
The medical tubular body according to any one of claims 6 to 9, wherein a gap is formed between one end of the marker and the tubular body when the tubular body is reduced in diameter.
The medical tubular body according to any one of claims 1 to 10, wherein the marker is longer in the axial length of the tubular body than in the radial direction of the tubular body.
The medical tubular body according to any one of claims 1 to 11, wherein the marker housing has an opening, and the marker is embedded in the opening.
The medical tubular body according to any one of claims 1 to 12, wherein the markers are spaced apart from each other beyond the length of the marker housing in the axial direction of the tubular body.
The medical tubular body according to any one of claims 1 to 13, wherein the marker is columnar.
The medical tubular body according to any one of claims 1 to 14, wherein an end of the tubular body has a shape obtained by obliquely cutting a cylinder.