WO2014132270A3 - Procédé de préparation de monochlorydrate d'acétamide 2- (2-aminothiazol -4-yl)-n- [4- (2- {[ (2r) -2-hydroxy -2-phényl-éthyl] amino} éthyl) phényl], de ses intermédiaires et polymorphe de celui-ci - Google Patents

Procédé de préparation de monochlorydrate d'acétamide 2- (2-aminothiazol -4-yl)-n- [4- (2- {[ (2r) -2-hydroxy -2-phényl-éthyl] amino} éthyl) phényl], de ses intermédiaires et polymorphe de celui-ci Download PDF

Info

Publication number
WO2014132270A3
WO2014132270A3 PCT/IN2014/000129 IN2014000129W WO2014132270A3 WO 2014132270 A3 WO2014132270 A3 WO 2014132270A3 IN 2014000129 W IN2014000129 W IN 2014000129W WO 2014132270 A3 WO2014132270 A3 WO 2014132270A3
Authority
WO
WIPO (PCT)
Prior art keywords
phenyl
ethyl
aminothiazol
polymorph
intermediates
Prior art date
Application number
PCT/IN2014/000129
Other languages
English (en)
Other versions
WO2014132270A2 (fr
Inventor
Srinivasan Thirumalai Rajan
Sajja Eswaraiah
Suraparaju Raghuram
Original Assignee
Msn Laboratories Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Msn Laboratories Limited filed Critical Msn Laboratories Limited
Publication of WO2014132270A2 publication Critical patent/WO2014132270A2/fr
Publication of WO2014132270A3 publication Critical patent/WO2014132270A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/40—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne un procédé de préparation du composé monochlorhydrate d'acétamide 2- (2-aminothiazol -4-yl)-N- [4- (2- {[ (2R) -2-hydroxy -2-phényléthyl] amino} éthyl)phényl] de formule-la, de ses intermédiaires et polymorphe de celui-ci. [insérer la Formule ici]
PCT/IN2014/000129 2013-02-27 2014-02-26 Procédé de préparation de monochlorydrate d'acétamide 2- (2-aminothiazol -4-yl)-n- [4- (2- {[ (2r) -2-hydroxy -2-phényl-éthyl] amino} éthyl) phényl], de ses intermédiaires et polymorphe de celui-ci WO2014132270A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN868CH2013 2013-02-27
IN868/CHE/2013 2013-02-27

Publications (2)

Publication Number Publication Date
WO2014132270A2 WO2014132270A2 (fr) 2014-09-04
WO2014132270A3 true WO2014132270A3 (fr) 2014-12-24

Family

ID=51428918

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2014/000129 WO2014132270A2 (fr) 2013-02-27 2014-02-26 Procédé de préparation de monochlorydrate d'acétamide 2- (2-aminothiazol -4-yl)-n- [4- (2- {[ (2r) -2-hydroxy -2-phényl-éthyl] amino} éthyl) phényl], de ses intermédiaires et polymorphe de celui-ci

Country Status (1)

Country Link
WO (1) WO2014132270A2 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015040605A1 (fr) * 2013-09-23 2015-03-26 Ranbaxy Laboratories Limited Forme cristalline de mirabegron
CN104230840A (zh) * 2014-09-05 2014-12-24 安徽联创药物化学有限公司 米拉贝隆的合成方法
WO2016049749A1 (fr) * 2014-10-01 2016-04-07 Apotex Inc. Formes solides du mirabégron
CN105111165B (zh) * 2015-09-14 2017-10-31 保定博洋生物科技有限公司 一种米拉贝隆的制备方法
HUP1600051A2 (en) * 2016-02-01 2017-08-28 Egyt Gyogyszervegyeszeti Gyar Mirabegron cocrystals
HU231124B1 (hu) * 2016-02-10 2020-12-28 Egis Gyógyszergyár Zrt. Eljárás morfológiailag egységes mirabegron és mirabegron monohidroklorid előállítására
CN106278909B (zh) * 2016-08-12 2022-07-15 浙江华海药业股份有限公司 一种米拉贝隆中间体的后处理方法
CZ2017461A3 (cs) 2017-08-09 2019-02-20 Saneca Pharmaceuticals A.S. Způsob přípravy 4-nitrofenylethylamidu kyseliny mandlové ze 4-nitrobenzylkyanidu
CN109456277B (zh) * 2018-10-29 2022-04-22 安徽省庆云医药股份有限公司 一种米拉贝隆的制备方法
CN109651290B (zh) * 2018-10-31 2022-04-01 安徽省庆云医药股份有限公司 一种米拉贝隆的制备方法
KR102350458B1 (ko) * 2019-12-11 2022-01-12 주식회사 다산제약 (r)-2-((4-아미노페네틸)아미노)-1-페닐에탄올의 신규한 제조방법
CN111205151B (zh) * 2020-02-29 2021-03-05 深圳市祥根生物科技有限公司 一种布洛芬杂质i的环保制备方法
CN111440126B (zh) * 2020-04-03 2023-11-28 湖南复瑞生物医药技术有限责任公司 一种米拉贝隆的制备方法
CN113816864B (zh) * 2020-06-18 2024-03-29 南京正大天晴制药有限公司 一种(r)-2-羟基-n-[2-(4-氨基苯基)乙基]-2-苯乙胺的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1440969A1 (fr) * 2001-10-30 2004-07-28 Yamanouchi Pharmaceutical Co. Ltd. Cristal a forme alpha ou beta d'un derive acetanilinide
EP1559427A1 (fr) * 2002-11-07 2005-08-03 Yamanouchi Pharmaceutical Co. Ltd. Remede pour vessie hyperactive comprenant un derive anilide de l'acide acetique en tant qu'ingredient actif

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1440969A1 (fr) * 2001-10-30 2004-07-28 Yamanouchi Pharmaceutical Co. Ltd. Cristal a forme alpha ou beta d'un derive acetanilinide
EP1559427A1 (fr) * 2002-11-07 2005-08-03 Yamanouchi Pharmaceutical Co. Ltd. Remede pour vessie hyperactive comprenant un derive anilide de l'acide acetique en tant qu'ingredient actif

Also Published As

Publication number Publication date
WO2014132270A2 (fr) 2014-09-04

Similar Documents

Publication Publication Date Title
WO2014132270A3 (fr) Procédé de préparation de monochlorydrate d'acétamide 2- (2-aminothiazol -4-yl)-n- [4- (2- {[ (2r) -2-hydroxy -2-phényl-éthyl] amino} éthyl) phényl], de ses intermédiaires et polymorphe de celui-ci
HK1217487A1 (zh) 用於治療成癮的作為乙醛脫氫酶- 抑制劑的 -氧基- -二氫-吡啶- -基 -芐基 -苯甲酰胺衍生物
IL230152A (en) METHOD FOR PREPARING n- [5- (aminosulfonyl) -4-methyl-3,1-thiazole-2-ram] n -methyl- 2 - [4 - (2-pyridinyl) phenyl] Acetamide and its monohydrate-saturated salt
JO3318B1 (ar) مثبطات bace
WO2013150545A8 (fr) Procédés de préparation de dérivés de benzimidazole et de sels de ceux-ci
IL234742A0 (en) Salts of 5-[(2,21)]4]-2})-2-(r-difluoro-2-phenylethoxy)phenyl]ethyl}amino)-1-hydroxyethyl]-8-hydroxyquinoline-2(1h)- potency
UA114325C2 (uk) Феноксіетилпіперидинові сполуки
MX2019007629A (es) Proceso para la preparacion de un derivado de 2-piridiletilcarboxamida.
ZA201503246B (en) N-(2-(cyclic amine)ethyl)benzamide derivatives as p2x7 inhibitors
WO2015068175A3 (fr) Procédé perfectionné de préparation de pazopanib ou d'un sel de qualité pharmaceutique de celui-ci
WO2014049612A3 (fr) Procédés et polymorphes de 5-[4-[4-(5-cyano-1h-indol-3-yl) butyl]-1-pipérazinyl]-2-benzofuran carboxamide et ses sels
BR112014030126A2 (pt) processos para produzir certos 2-(piridino-3-il)tiazóis
PH12017502010A1 (en) Process for the preparation of 2-{4-[2-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}sulfanyl)-3,5-dicyano-6-(pyrrolidin-1-yl)pyridin-4-yl]phenoxy}ethyl-l-alanyl-l-alaninate monohydrochloride
IL235485A (en) Metabolites of (R1 - trans) - 2,3) - 2] - n - Dihydro-4-benzopornyl) cyclopropyl] methyl] propanamide
ZA202000224B (en) 2-[4-(methylaminomethyl)phenyl]-5-fluoro-benzofuran-7-carboxamide hydrochloride polymorph, preparation method therefor and application thereof
WO2013157019A3 (fr) Procédé pour la préparation de dasatinib monohydraté
EP3653602A4 (fr) Composé amide substitué n-(2-(naphth-1-yl substitué)éthyl), sa préparation et ses utilisations
EP3205646A3 (fr) Intermédiaires pour la fabrication de (r)-5-[2- (5,6-diéthylindan-2-ylamino)-1-hydroxyéthyl]-8-hydroxy-(1h)-quinolin-2-one (indacatérol)
BR112013011707A2 (pt) processo para a preparação de derivados de 2,2-difluoroetilamina partindo de n-(2,2-difluoroetil) - prop - 2 - eno - 1 - amina
WO2014203277A3 (fr) Procédé de préparation de chlorhydrate de (1s-2r)-2-(aminométhyl)-n-n'-diéthyl-1-phénylcyclopropanecarboxamide
WO2014125233A3 (fr) Procédé de synthèse de 4-piperidin-4-yl-benzène-1,3-diol et de ses sels et nouveau composé 4-(2,4-dihydroxy-phényl)-4-hydroxy-piperidine-1-carboxylate de tert-butyle
IN2013MU00777A (fr)
WO2014178068A3 (fr) Procédé perfectionné pour la préparation de n-[1-(1-naphtyl)éthyl]-3-[3-(trifluorométhyl)phényl]propan-1-amine et de ses sels pharmaceutiquement acceptables
PE20142313A1 (es) Inhibidores de la peptido desformilasa
HK1218915A1 (zh) 用作半胱氨酸蛋白酶抑制劑的 乙炔基- -氧代-六氫-呋喃並 吡咯- -羰基 -甲基-丁基 -氟- -甲基-哌嗪基 噻唑- -基 -苯甲酰胺的鹽的形式 結晶多晶型物

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 14757737

Country of ref document: EP

Kind code of ref document: A2

122 Ep: pct application non-entry in european phase

Ref document number: 14757737

Country of ref document: EP

Kind code of ref document: A2