WO2014049612A3 - Procédés et polymorphes de 5-[4-[4-(5-cyano-1h-indol-3-yl) butyl]-1-pipérazinyl]-2-benzofuran carboxamide et ses sels - Google Patents

Procédés et polymorphes de 5-[4-[4-(5-cyano-1h-indol-3-yl) butyl]-1-pipérazinyl]-2-benzofuran carboxamide et ses sels Download PDF

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Publication number
WO2014049612A3
WO2014049612A3 PCT/IN2013/000580 IN2013000580W WO2014049612A3 WO 2014049612 A3 WO2014049612 A3 WO 2014049612A3 IN 2013000580 W IN2013000580 W IN 2013000580W WO 2014049612 A3 WO2014049612 A3 WO 2014049612A3
Authority
WO
WIPO (PCT)
Prior art keywords
indol
piperazinyl
cyano
butyl
polymorphs
Prior art date
Application number
PCT/IN2013/000580
Other languages
English (en)
Other versions
WO2014049612A2 (fr
Inventor
Srinivasan Thirumalai Rajan
Sajja Eswaraiah
Sunkara VISHNUVARDHAN
Original Assignee
Msn Laboratories Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Msn Laboratories Limited filed Critical Msn Laboratories Limited
Priority to EP13842370.2A priority Critical patent/EP2900658A4/fr
Publication of WO2014049612A2 publication Critical patent/WO2014049612A2/fr
Publication of WO2014049612A3 publication Critical patent/WO2014049612A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention concerne un procédé perfectionné pour la préparation de médicament antidépresseur, c'est-à-dire d'un composé chlorhydrate de 5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]-1-pipérazinyl]-2-benzofuran carboxamide répondant à la formule la représentée par la formule développée suivante : (Ia) T
PCT/IN2013/000580 2012-09-27 2013-09-26 Procédés et polymorphes de 5-[4-[4-(5-cyano-1h-indol-3-yl) butyl]-1-pipérazinyl]-2-benzofuran carboxamide et ses sels WO2014049612A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP13842370.2A EP2900658A4 (fr) 2012-09-27 2013-09-26 Procédés et polymorphes de 5-[4-[4-(5-cyano-1h-indol-3-yl) butyl]-1-pipérazinyl]-2-benzofuran carboxamide et ses sels

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
IN4014/CHE/2012 2012-09-27
IN4014CH2012 2012-09-27
IN4629/CHE/2012 2012-11-06
IN4629CH2012 2012-11-06
IN5296/CHE/2012 2012-12-18
IN5296CH2012 2012-12-18

Publications (2)

Publication Number Publication Date
WO2014049612A2 WO2014049612A2 (fr) 2014-04-03
WO2014049612A3 true WO2014049612A3 (fr) 2014-05-22

Family

ID=50389086

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2013/000580 WO2014049612A2 (fr) 2012-09-27 2013-09-26 Procédés et polymorphes de 5-[4-[4-(5-cyano-1h-indol-3-yl) butyl]-1-pipérazinyl]-2-benzofuran carboxamide et ses sels

Country Status (2)

Country Link
EP (1) EP2900658A4 (fr)
WO (1) WO2014049612A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9533949B2 (en) 2012-09-12 2017-01-03 Apotex Pharmachem Inc. Processes for the preparation of 3-alkyl indoles
WO2016128987A1 (fr) * 2015-02-13 2016-08-18 Harman Finochem Limited Procédé de préparation de la base libre 2-benzofurancarboxamide, 5-[4-[4-(5-cyano-1h-indol-3-yl)butyl]-1-pipérazinyle], et de son sel chlorhydrate
CN105541811A (zh) * 2016-01-08 2016-05-04 万特制药(海南)有限公司 一种抗抑郁药物维拉佐酮的精制方法
CN106518853A (zh) * 2016-09-22 2017-03-22 北京万全德众医药生物技术有限公司 一种盐酸维拉佐酮杂质的制备方法
WO2023173182A1 (fr) * 2022-03-16 2023-09-21 Eurofarma Laboratórios S.A. Sel de docusate de vilazodone, procédé d'obtention, composition pharmaceutique et utilisation

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002102794A2 (fr) * 2001-06-19 2002-12-27 Merck Patent Gmbh Formes polymorphes de chlorhydrate de 1-'4-(5-cyanoindol-3-yl)butyl-4-(2-carbamoylbenzofuran-5-yl)piperazine
CN102219783A (zh) * 2011-05-05 2011-10-19 天津市汉康医药生物技术有限公司 盐酸维拉佐酮及其组合物
CN102617558A (zh) * 2012-03-26 2012-08-01 上海泛凯生物医药科技有限公司 一种维拉佐酮的制备方法
CN102977083A (zh) * 2012-12-17 2013-03-20 南京海纳医药科技有限公司 1-[4-(5-氰基吲哚-3-基)丁基]-4-(2-氨甲酰-苯并呋喃-5-基)-哌嗪盐酸盐的新晶型xⅶ及其制备方法
WO2013078361A1 (fr) * 2011-11-23 2013-05-30 Assia Chemical Industries Ltd. Formes à l'état solide de vilazodone et de chlorhydrate de vilazodone

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013156935A1 (fr) * 2012-04-16 2013-10-24 Ranbaxy Laboratories Limited Procédé de préparation de cristaux de chlorhydrate de vilazodone

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002102794A2 (fr) * 2001-06-19 2002-12-27 Merck Patent Gmbh Formes polymorphes de chlorhydrate de 1-'4-(5-cyanoindol-3-yl)butyl-4-(2-carbamoylbenzofuran-5-yl)piperazine
CN102219783A (zh) * 2011-05-05 2011-10-19 天津市汉康医药生物技术有限公司 盐酸维拉佐酮及其组合物
WO2013078361A1 (fr) * 2011-11-23 2013-05-30 Assia Chemical Industries Ltd. Formes à l'état solide de vilazodone et de chlorhydrate de vilazodone
CN102617558A (zh) * 2012-03-26 2012-08-01 上海泛凯生物医药科技有限公司 一种维拉佐酮的制备方法
CN102977083A (zh) * 2012-12-17 2013-03-20 南京海纳医药科技有限公司 1-[4-(5-氰基吲哚-3-基)丁基]-4-(2-氨甲酰-苯并呋喃-5-基)-哌嗪盐酸盐的新晶型xⅶ及其制备方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2900658A4 *

Also Published As

Publication number Publication date
EP2900658A4 (fr) 2016-07-13
WO2014049612A2 (fr) 2014-04-03
EP2900658A2 (fr) 2015-08-05

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