WO2013175499A3 - Forme polymorphe du 5-(4-[4-(5-cyano-1h-indol-3-yl)butyl]pipérazin-1-yl)benzofurane-2-carboxamide - Google Patents

Forme polymorphe du 5-(4-[4-(5-cyano-1h-indol-3-yl)butyl]pipérazin-1-yl)benzofurane-2-carboxamide Download PDF

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Publication number
WO2013175499A3
WO2013175499A3 PCT/IN2013/000262 IN2013000262W WO2013175499A3 WO 2013175499 A3 WO2013175499 A3 WO 2013175499A3 IN 2013000262 W IN2013000262 W IN 2013000262W WO 2013175499 A3 WO2013175499 A3 WO 2013175499A3
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WO
WIPO (PCT)
Prior art keywords
benzofuran
carboxamide
piperazin
indol
cyano
Prior art date
Application number
PCT/IN2013/000262
Other languages
English (en)
Other versions
WO2013175499A2 (fr
Inventor
Shriprakash Dhar DWIVEDI
Ramesh Chandra SINGH
Rajendra Gokalbhai CHAVDA
Original Assignee
Cadila Healthcare Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cadila Healthcare Limited filed Critical Cadila Healthcare Limited
Publication of WO2013175499A2 publication Critical patent/WO2013175499A2/fr
Publication of WO2013175499A3 publication Critical patent/WO2013175499A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention porte sur un procédé pour la préparation de 5-(4-[4-(5-cyano-1H-indol-3-yl)butyl]pipérazin-1-yl)benzofurane-2-carboxamide de formule (1) ou de son sel pharmaceutiquement acceptable ou de solvates ou d'hydrates de ceux-ci. En particulier, la présente invention porte sur un nouveau composé intermédiaire, 5-(pipérazin-1-yl 4-substitué)benzofurane-2-carboxamide de formule (X). La présente invention porte en outre sur une forme à l'état solide du 5-(4-[4-(5-cyano-1H-indol-3-yl)butyl]pipérazin-1-yl)benzofurane-2-carboxamide de formule (1) et sur un procédé pour sa préparation.
PCT/IN2013/000262 2012-04-20 2013-04-22 Forme polymorphe du 5-(4-[4-(5-cyano-1h-indol-3-yl)butyl]pipérazin-1-yl)benzofurane-2-carboxamide WO2013175499A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1260MU2012 2012-04-20
IN1260/MUM/2012 2012-04-20

Publications (2)

Publication Number Publication Date
WO2013175499A2 WO2013175499A2 (fr) 2013-11-28
WO2013175499A3 true WO2013175499A3 (fr) 2014-10-23

Family

ID=49036619

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2013/000262 WO2013175499A2 (fr) 2012-04-20 2013-04-22 Forme polymorphe du 5-(4-[4-(5-cyano-1h-indol-3-yl)butyl]pipérazin-1-yl)benzofurane-2-carboxamide

Country Status (1)

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WO (1) WO2013175499A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013185209A1 (fr) 2012-06-13 2013-12-19 Apotex Technologies Inc. Formes de vilazodone et procédés de préparation associés
US9533949B2 (en) 2012-09-12 2017-01-03 Apotex Pharmachem Inc. Processes for the preparation of 3-alkyl indoles
WO2014061004A2 (fr) * 2012-10-19 2014-04-24 Ranbaxy Laboratories Limited Procédé pour la préparation de vilazodone ou de sel pharmaceutiquement acceptable de celui-ci
US20140179713A1 (en) * 2012-11-05 2014-06-26 Cadila Healthcare Limited Polymorphic form of 5-(4-[4-(5-cyano-1h-indol-3-yl) butyl] piperazin-1-yl) benzofuran-2-carboxamide and process for preparing thereof
CN104926804B (zh) * 2015-06-04 2019-01-25 天津渤海职业技术学院 一类具有抗肿瘤作用的化合物、其制备方法和用途
CN105541811A (zh) * 2016-01-08 2016-05-04 万特制药(海南)有限公司 一种抗抑郁药物维拉佐酮的精制方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0738722A1 (fr) * 1995-04-20 1996-10-23 MERCK PATENT GmbH Dérivés d'acides 5-amino-benzofuran-2-carboxyliques
CN102267985A (zh) * 2011-06-15 2011-12-07 上海医药工业研究院 维拉佐酮或其盐酸盐的制备方法
WO2013114338A1 (fr) * 2012-02-01 2013-08-08 Ranbaxy Laboratories Limited Procédé pour la préparation de vilazodone ou de ses sels pharmaceutiquement acceptables

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0738722A1 (fr) * 1995-04-20 1996-10-23 MERCK PATENT GmbH Dérivés d'acides 5-amino-benzofuran-2-carboxyliques
CN102267985A (zh) * 2011-06-15 2011-12-07 上海医药工业研究院 维拉佐酮或其盐酸盐的制备方法
WO2013114338A1 (fr) * 2012-02-01 2013-08-08 Ranbaxy Laboratories Limited Procédé pour la préparation de vilazodone ou de ses sels pharmaceutiquement acceptables

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HEINRICH T ET AL: "Synthesis and Structure-Activity Relationship in a Class of Indolebutylpiperazines as Dual 5-HT1A Receptor Agonists and Serotonin Reuptake Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 47, no. 19, 1 January 2004 (2004-01-01), pages 4684 - 4692, XP002388367, ISSN: 0022-2623, DOI: 10.1021/JM040793Q *

Also Published As

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WO2013175499A2 (fr) 2013-11-28

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