EP2900658A4 - Processes and polymorphs of 5-[4-[4-(5-cyano-1h-indol-3-yl) butyl]-1-piperazinyl]-2-benzofuran carboxamide and its salts - Google Patents

Processes and polymorphs of 5-[4-[4-(5-cyano-1h-indol-3-yl) butyl]-1-piperazinyl]-2-benzofuran carboxamide and its salts

Info

Publication number
EP2900658A4
EP2900658A4 EP13842370.2A EP13842370A EP2900658A4 EP 2900658 A4 EP2900658 A4 EP 2900658A4 EP 13842370 A EP13842370 A EP 13842370A EP 2900658 A4 EP2900658 A4 EP 2900658A4
Authority
EP
European Patent Office
Prior art keywords
polymorphs
indol
piperazinyl
cyano
butyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP13842370.2A
Other languages
German (de)
French (fr)
Other versions
EP2900658A2 (en
Inventor
Rajan Srinivasan Thirumalai
Sajja Eswaraiah
Sunkara Vishnuvardhan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MSN Laboratories Pvt Ltd
Original Assignee
MSN Laboratories Pvt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MSN Laboratories Pvt Ltd filed Critical MSN Laboratories Pvt Ltd
Publication of EP2900658A2 publication Critical patent/EP2900658A2/en
Publication of EP2900658A4 publication Critical patent/EP2900658A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
EP13842370.2A 2012-09-27 2013-09-26 Processes and polymorphs of 5-[4-[4-(5-cyano-1h-indol-3-yl) butyl]-1-piperazinyl]-2-benzofuran carboxamide and its salts Withdrawn EP2900658A4 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN4014CH2012 2012-09-27
IN4629CH2012 2012-11-06
IN5296CH2012 2012-12-18
PCT/IN2013/000580 WO2014049612A2 (en) 2012-09-27 2013-09-26 Processes and polymorphs of 5-[4-[4-(5-cyano-1h-indol-3-yl) butyl]-1-piperazinyl]-2-benzofuran carboxamide and its salts

Publications (2)

Publication Number Publication Date
EP2900658A2 EP2900658A2 (en) 2015-08-05
EP2900658A4 true EP2900658A4 (en) 2016-07-13

Family

ID=50389086

Family Applications (1)

Application Number Title Priority Date Filing Date
EP13842370.2A Withdrawn EP2900658A4 (en) 2012-09-27 2013-09-26 Processes and polymorphs of 5-[4-[4-(5-cyano-1h-indol-3-yl) butyl]-1-piperazinyl]-2-benzofuran carboxamide and its salts

Country Status (2)

Country Link
EP (1) EP2900658A4 (en)
WO (1) WO2014049612A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9533949B2 (en) 2012-09-12 2017-01-03 Apotex Pharmachem Inc. Processes for the preparation of 3-alkyl indoles
WO2016128987A1 (en) * 2015-02-13 2016-08-18 Harman Finochem Limited A process for preparation of 2-benzofurancarboxamide, 5-[4-[4-(5cyano-1h-indol-3-yl)butyl]-1-piperazinyl] free base and its hydrochloride salt
CN105541811A (en) * 2016-01-08 2016-05-04 万特制药(海南)有限公司 Refining method for antidepressant drug vilazodone
CN106518853A (en) * 2016-09-22 2017-03-22 北京万全德众医药生物技术有限公司 Preparation method of vilazodone hydrochloride impurities
WO2023173182A1 (en) * 2022-03-16 2023-09-21 Eurofarma Laboratórios S.A. Vilazodone docusate salt, production process, pharmaceutical composition and use

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002102794A2 (en) * 2001-06-19 2002-12-27 Merck Patent Gmbh Polymorphic forms of 1-'4-(5-cyanoindol-3-yl)butyl-4-(2-carbamoylbenzofuran-5-yl)piperazine hydrochloride
CN102219783A (en) * 2011-05-05 2011-10-19 天津市汉康医药生物技术有限公司 Vilazodone hydrochloride and composition thereof
WO2013156935A1 (en) * 2012-04-16 2013-10-24 Ranbaxy Laboratories Limited Process for the preparation of crystalline vilazodone hydrochloride

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2854649A1 (en) * 2011-11-23 2013-05-30 Assia Chemical Industries Ltd. Solid state forms of vilazodone and vilazodone hydrochloride
CN102617558A (en) * 2012-03-26 2012-08-01 上海泛凯生物医药科技有限公司 Preparation method of vilazodone
CN102977083A (en) * 2012-12-17 2013-03-20 南京海纳医药科技有限公司 New crystal form XVII of 1-(4-(5-cyanoindole-3-yl) butyl)-4-(2-carbamyl-benzofuran-5-yl)-piperazine hydrochloride and preparation method of new crystal form XVII

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002102794A2 (en) * 2001-06-19 2002-12-27 Merck Patent Gmbh Polymorphic forms of 1-'4-(5-cyanoindol-3-yl)butyl-4-(2-carbamoylbenzofuran-5-yl)piperazine hydrochloride
CN102219783A (en) * 2011-05-05 2011-10-19 天津市汉康医药生物技术有限公司 Vilazodone hydrochloride and composition thereof
WO2013156935A1 (en) * 2012-04-16 2013-10-24 Ranbaxy Laboratories Limited Process for the preparation of crystalline vilazodone hydrochloride

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CAIRA: "Crystalline Polymorphism of Organic Compounds", TOPICS IN CURRENT CHEMISTRY, SPRINGER, BERLIN, DE, vol. 198, 1 January 1998 (1998-01-01), pages 163 - 208, XP008166276, ISSN: 0340-1022 *
DATABASE WPI Week 201232, Derwent World Patents Index; AN 2011-P35968 [32], XP002754050 *

Also Published As

Publication number Publication date
WO2014049612A2 (en) 2014-04-03
EP2900658A2 (en) 2015-08-05
WO2014049612A3 (en) 2014-05-22

Similar Documents

Publication Publication Date Title
SMT201700052B (en) 2- (AZAINDOL-2-IL) BENZIMIDAZOLS AS PAD4 INHIBITORS
HK1223795A1 (en) Gene expression biomarkers of laquinimod responsiveness
IL239025B (en) Fxr agonist for treatment of pulmonary disease
ZA201602640B (en) Heteroaryl compounds as btk inhibitors and uses thereof
HK1208026A1 (en) Heteroaryl inhibitors of pde4 pde4
HK1215023A1 (en) Heterocyclic glutaminase inhibitors
IL236031A (en) Processes to produce certain 2-(pyridin-3-yl)thiazoles
EP2819045A4 (en) Device for provision of personal genome information environment, method for provision of personal genome information environment, and program
EP2938341A4 (en) Heterocyclic compounds and methods of use thereof
EP2931284A4 (en) Bace inhibitors of iminothiadiazine dioxides
EP2827849A4 (en) Treatment of pulmonary hypertension with leukotriene inhibitors
IL272301B (en) Benzamide and nicotinamide compounds and methods of using same
SG11201404144PA (en) 4-(benzoimidazol-2-yl)-thiazole compounds and related aza derivatives
EP2900658A4 (en) Processes and polymorphs of 5-[4-[4-(5-cyano-1h-indol-3-yl) butyl]-1-piperazinyl]-2-benzofuran carboxamide and its salts
EP2866893A4 (en) Heterocyclic guanidine f1f0-atpase inhibitors
HK1206739A1 (en) 3,4-disubstituted 1 h-pyrazole and 4,5-disubstituted thiazole inhibitors of syk 34- 1h- 45- syk
HK1212975A1 (en) Thiazole derivatives as inhibitors of brutons tyrosine kinase
IL236030A (en) Processes to produce certain 2-(pyridin-3-yl) thiazoles
IL232170A0 (en) Heterocyclic carboxamides useful as inhibitors of phosphodiesterase type 10a
IL235935A0 (en) Substituted picolinamide kinase inhibitors

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20150424

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

DAX Request for extension of the european patent (deleted)
RIC1 Information provided on ipc code assigned before grant

Ipc: C07D 209/10 20060101ALI20160212BHEP

Ipc: C07D 405/12 20060101AFI20160212BHEP

Ipc: A61K 31/496 20060101ALI20160212BHEP

A4 Supplementary search report drawn up and despatched

Effective date: 20160610

RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 31/496 20060101ALI20160606BHEP

Ipc: C07D 209/10 20060101ALI20160606BHEP

Ipc: C07D 405/12 20060101AFI20160606BHEP

17Q First examination report despatched

Effective date: 20170508

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20170919