WO2014126185A1 - Élément de détection de pression, et circuit sanguin et appareil de purification de sang le comprenant - Google Patents

Élément de détection de pression, et circuit sanguin et appareil de purification de sang le comprenant Download PDF

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Publication number
WO2014126185A1
WO2014126185A1 PCT/JP2014/053421 JP2014053421W WO2014126185A1 WO 2014126185 A1 WO2014126185 A1 WO 2014126185A1 JP 2014053421 W JP2014053421 W JP 2014053421W WO 2014126185 A1 WO2014126185 A1 WO 2014126185A1
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Prior art keywords
liquid
blood
pressure
chamber
liquid chamber
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PCT/JP2014/053421
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English (en)
Japanese (ja)
Inventor
真也 竹内
松本　宏
三喜子 池田
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東レ株式会社
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Priority to JP2014508210A priority Critical patent/JPWO2014126185A1/ja
Publication of WO2014126185A1 publication Critical patent/WO2014126185A1/fr

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01L—MEASURING FORCE, STRESS, TORQUE, WORK, MECHANICAL POWER, MECHANICAL EFFICIENCY, OR FLUID PRESSURE
    • G01L19/00—Details of, or accessories for, apparatus for measuring steady or quasi-steady pressure of a fluent medium insofar as such details or accessories are not special to particular types of pressure gauges
    • G01L19/0007—Fluidic connecting means
    • G01L19/0023—Fluidic connecting means for flowthrough systems having a flexible pressure transmitting element
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3639—Blood pressure control, pressure transducers specially adapted therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3639—Blood pressure control, pressure transducers specially adapted therefor
    • A61M1/3641—Pressure isolators

Definitions

  • the present invention relates to a pressure detector and a blood circuit and a blood purification apparatus provided with the pressure detector.
  • Extracorporeal circulation therapy is a treatment method in which blood is removed from a patient's body, blood is treated outside the body using a blood purification device, and the treated blood is returned to the body to purify the blood.
  • a pressure detector that measures the pressure is disposed in the extracorporeal circuit.
  • the following two examples are generally used as pressure detectors arranged in the extracorporeal circuit (Patent Documents 1 and 2).
  • Patent Document 1 a casing (pressure detection) whose interior is separated into a blood chamber and an air chamber by a diaphragm (a membrane deformed by the pressure in the body fluid circulation circuit), which is a flexible sheet, so that blood does not come into contact with air.
  • a pressure measuring device having a body is disclosed.
  • the casing at least a part of the diaphragm is deformed by the pressure of blood filling the blood chamber, and the pressure in the extracorporeal circuit is measured by measuring the deformation amount of the diaphragm.
  • Patent Document 2 paying attention to coagulation associated with the retention of blood, the arrangement of a liquid outlet and a liquid inlet, which are flow paths for introducing liquid into a casing (pressure detector), is used, and the liquid outlet is a liquid inlet.
  • a pressure sensor is disclosed that is arranged at a position that is at least 1/2 turn and less than 1 turn away from the center.
  • the liquid outlet is arranged at a position separated from the liquid inlet by a half or more and less than one round, so that the liquid introduced into the casing flows in along the inner periphery of the side surface of the liquid chamber.
  • circulation is generated, and retention due to rapid expansion of the flow path is eliminated to suppress blood coagulation.
  • the present invention provides a pressure detector that measures the pressure in the extracorporeal circuit without contact between blood and air, and suppresses the retention of blood by improving the flow of blood inside the pressure detector.
  • An object of the present invention is to provide a pressure detector having a novel structure that further suppresses coagulation.
  • the present invention provides the following pressure detectors (1) to (5), the blood circuit (7), and the blood purification device (8).
  • a pressure detecting body for measuring a pressure in an extracorporeal circuit for performing extracorporeal processing of blood having a deformed surface deformed by the pressure in the extracorporeal circuit, a liquid inlet and a liquid outlet.
  • a chamber member having a liquid chamber for allowing the blood to flow in and out, a liquid inlet joint for connecting the liquid inlet and the extracorporeal circulation circuit with a pipe, the liquid outlet and the extracorporeal circuit.
  • a liquid outlet joint for communicating with a pipe, and the flow path inside the liquid inlet joint and the liquid outlet joint extends in a frustum shape toward the liquid chamber.
  • Circuit pressure detector (2) The pressure detector for the extracorporeal circuit according to (1), wherein the liquid chamber has a cylindrical shape, and the liquid inlet and the liquid outlet are arranged on a cylindrical side surface of the liquid chamber. .
  • a blood circuit comprising the extracorporeal circuit pressure detector according to any one of (1) to (6) and an extracorporeal circuit.
  • a blood purification apparatus comprising the blood circuit according to (7).
  • the blood flowing from the extracorporeal circuit into the liquid chamber constituting the chamber member passes through the liquid inlet joint spreading in a frustum shape toward the liquid chamber. Therefore, the blood stay can be suppressed regardless of the blood viscosity and the treatment flow rate, and as a result, blood coagulation can be suppressed.
  • FIG. 1 It is a schematic diagram which shows the embodiment of the pressure detection body of this invention from a side surface. It is a schematic diagram which shows the embodiment of the pressure detection body of this invention from the upper surface. It is a schematic diagram which shows another embodiment of the pressure detection body of this invention. It is a schematic diagram which shows the embodiment of the blood circuit which has a pressure detection body of this invention. It is a schematic diagram which shows the embodiment of the blood purification apparatus which has a pressure detection body of this invention. It is the schematic diagram which shows the component of the pressure detection body of this invention used for Example 1 from the upper surface. It is a figure which shows each flow state of (a) before flowing ink, and after flowing ink (b) with respect to the pressure detection body of this invention used for Example 1.
  • FIG. 1 It is a schematic diagram which shows the component of the conventional pressure detection body used for the comparative example 1 from the upper surface. It is a figure which shows the confirmation result of each flow state of (a) before flowing ink, and after flowing ink (b) with respect to the conventional pressure detection body used for the comparative example 1.
  • FIG. It is a schematic diagram which shows the component of the pressure detection body used for the comparative example 2 from the upper surface.
  • the pressure detector for the extracorporeal circuit is a pressure detector for measuring the pressure in the extracorporeal circuit for performing extracorporeal processing of blood.
  • the deformed surface deformed by the pressure in the extracorporeal circuit and the liquid flow A chamber member having an inlet and a liquid outlet and having a liquid chamber for allowing the blood to flow in and out; a liquid inlet joint for connecting the liquid inlet and the extracorporeal circuit through a pipe; and the liquid A liquid outlet joint for connecting the outlet and the extracorporeal circuit with a pipe, and the flow path inside the liquid inlet joint and the liquid outlet joint is conical toward the liquid chamber. It features a trapezoidal shape.
  • Extracorporeal circuit is a tubular channel through which blood extracted from the human body circulates.
  • the “deformation surface” is a partial surface constituting the chamber member that is at least partially deformed by the pressure in the extracorporeal circuit.
  • the “liquid inlet” is an inlet through which blood flows into the liquid chamber in the chamber member, and the “liquid outlet” is an outlet through which blood is discharged from the liquid chamber within the chamber member.
  • the “liquid inlet joint” is a flow path that connects the extracorporeal circuit and the liquid inlet, and the “liquid outlet joint” is a flow path that connects the extracorporeal circuit and the liquid outlet.
  • FIG. 1 and 2 are schematic views showing an embodiment of the pressure detector for the extracorporeal circuit.
  • a pressure detection body 1 is connected to an extracorporeal circuit 2 and has a deformed surface 8 deformed by the pressure in the extracorporeal circuit, a liquid inlet 3 and a liquid outlet 4, and allows blood to flow in and out.
  • a chamber member 9 including a liquid chamber 5 to be discharged and an air chamber 7 adjacent to the liquid chamber 5 and disposed so as to sandwich the deformation surface 8 is provided.
  • the air chamber 7 is connected to the pressure measuring device 6.
  • the diameter of the liquid inlet in the circumferential direction of the liquid chamber is the diameter 24 in the circumferential direction of the liquid inlet.
  • the shapes of the liquid inlet joint 10 and the liquid outlet joint 11 are the liquid inlet 3, the liquid outlet 4, and the liquid chamber. It is preferable that the shape is a smooth connection.
  • the specific shape can be appropriately designed according to the flow velocity and viscosity of the liquid, but the flow paths inside the liquid inlet joint 10 and the liquid outlet joint 11 are frustum-shaped toward the liquid chamber 5 side. More preferably, it is configured to spread.
  • the means for measuring the pressure is that the deformation surface 8 arranged so as to sandwich the liquid chamber 5 and the air chamber 7 is deformed by the pressure of blood flowing in the liquid chamber 5 and indirectly detects the deformation amount.
  • the pressure in the extracorporeal circuit 2 is measured. Specifically, in the air chamber 7 which is an airtight space between the deformation surface 8 and the pressure measuring device 6, a pressure change accompanying the deformation of the deformation surface 8 is generated in the air chamber 7, and the pressure change Is measured using the pressure measuring device 6 to indirectly measure the pressure in the extracorporeal circuit 2.
  • a method of measuring the pressure in the extracorporeal circuit 2 by directly measuring the deformation amount of the deformation surface 8 with a load sensor, a strain gauge or the like may be used.
  • the pressure measuring method is not particularly limited as long as it can correctly measure the pressure in the extracorporeal circuit, and is not particularly limited.
  • the liquid chamber 5 has a cylindrical shape, but the shape of the liquid chamber 5 is not limited, and may be a polygonal column such as a hexagonal column. Further, there is no particular problem even if the arbitrary cross-sectional shape of the liquid chamber 5 parallel to the deformation surface 8 and the deformation surface 8 have different shapes and sizes. However, in order to form a smooth flow without generating blood stagnation, the liquid chamber 5 has a cylindrical shape and the deformation surface 8 is a circular film having the same radius as the liquid chamber 5. Preferably there is.
  • the side surface of the liquid chamber 5 is linear as viewed from the cross section, but there is no problem even if it is inclined at an arbitrary angle.
  • the liquid chamber side corners 12, 13, and 14 which are corners inside the liquid chamber 5 are perpendicular, but the corners may be rounded.
  • the inner corner of the liquid chamber 5 is preferably rounded to some extent.
  • the shape of the deformation surface 8 is a flat plate-like film, but there is no problem even if it has a corrugated shape as seen from the cross section. Further, the deformation surface 8 does not necessarily have to be a portion where the entire surface is deformed, and the area and shape of the deformation portion of the deformation surface 8 can be any ratio or shape as long as the pressure can be measured correctly. There is no particular limitation.
  • the flow paths of the liquid inlet joint 10 and the liquid outlet joint 11 having a truncated cone shape flow in parallel to the deformation surface 8 toward the liquid inlet 3 and the liquid outlet 4.
  • an angle with respect to the deformation surface 8 may be provided.
  • the liquid inlet joint 10 and the liquid outlet joint 11 that are frustum-shaped have the blood within an angle range of 0 to 30 degrees with respect to the deformation surface 8. It is preferably arranged so as to flow into the chamber member 9, more preferably within a range of 0 to 15 degrees, most preferably parallel.
  • the liquid inlet 3 and the liquid outlet 4 are provided at intermediate positions with respect to the height direction of the side surface of the liquid chamber 5, but the position of the liquid inlet is the height of the side surface. It may deviate from an intermediate position with respect to the direction. Further, the positions of the liquid inlet 3 and the liquid outlet 4 may be shifted from the same axis on the side of the liquid chamber 5 with respect to the height direction of the side of the liquid chamber 5. However, in order to form a smoother liquid flow, the liquid inlet 3 and the liquid outlet 4 are preferably in an intermediate position with respect to the height direction of the side surface of the liquid chamber 5. The positions of the liquid inlet 3 and the liquid outlet 4 are preferably on the same axis on the side surface of the liquid chamber 5 with respect to the height direction of the chamber 5.
  • the liquid inlet joint 10 for connecting the liquid inlet 3 and the extracorporeal circuit 2 with a pipe has a flow path in the shape of a frustum in the direction of the liquid chamber 5. It has spread.
  • the portion where the liquid inlet joint 10 and the liquid chamber 5 are connected that is, the diameter 24 in the circumferential direction of the liquid inlet 3 is preferably wider than that of the extracorporeal circuit 2.
  • De 4 Af / Wp (Formula 1)
  • De is an internal circulation circuit inner diameter
  • Af is a cross-sectional area at an arbitrary position of the liquid inlet joint
  • Wp is a cross-sectional circumference at an arbitrary position of the liquid inlet joint.
  • the liquid inlet 3 is constituted by a connection surface between the liquid inlet joint 10 and the liquid chamber 5, and the connection surface, that is, the diameter 24 in the circumferential direction of the liquid inlet 3 satisfies the relationship of Equation 1. I just need it. However, in order to form a smoother and smoother flow in the liquid chamber 5, the diameter 24 in the circumferential direction of the liquid inlet 3 is 13.9% or more of the circumferential length of the liquid chamber 5. It is preferable. On the other hand, when the diameter 24 in the circumferential direction of the liquid inlet 3 is 50% or more with respect to the circumferential length of the liquid chamber 5, the fluid inlet joint 10 cannot have a frustum shape. That is, the diameter 24 in the circumferential direction of the liquid inlet 3 is most preferably in the range of 13.9% to 50% of the circumferential length of the liquid chamber 5.
  • the liquid inlet 3 and the liquid outlet 4 are installed at opposite positions with the chamber member 9 in between, but may be shifted from the opposite positions.
  • the opposite position is most preferable.
  • the facing position means that the liquid chamber 5 has a symmetrical relationship with the center of the liquid chamber 5 as an axis.
  • the liquid inlet 3 and the liquid outlet 4 have the same shape, but the liquid outlet 4 has a smaller installation area with the liquid chamber 5 than the liquid inlet 3.
  • the effect of the invention is not reduced.
  • the fluid inlet 3 and the liquid outlet 4 have the same shape in order to form a liquid flow that is smoother and more uniform in terms of formability of the pressure detector 1 and prevention of incorrect attachment of the extracorporeal circuit 2. Most preferably.
  • the material of the liquid chamber 5 and the air chamber 7 is not particularly limited as being hard or soft.
  • the liquid chamber 5 is affected by environmental factors such as liquid temperature and temperature, and external force that deforms the liquid chamber 5 and the air chamber 7. If the shape of the air chamber 7 changes, it becomes difficult to correctly measure the pressure in the extracorporeal circuit 2. Therefore, the material of the liquid chamber 5 and the air chamber 7 is preferably hard, and moreover, a material having biocompatibility is preferable in order to directly or indirectly touch the patient's blood.
  • vinyl chloride, polycarbonate, polypropylene, polyethylene, polyurethane and the like can be mentioned, and any of them can be suitably used.
  • the manufacturing method is not particularly limited, and examples thereof include injection molding, blow molding, and molding by cutting.
  • the material of the deformable surface 8 is hard, the amount of deformation due to pressure becomes small, and it becomes difficult to accurately measure the pressure in the extracorporeal circuit 2, so that it is a soft material that deforms flexibly with respect to the pressure. It is preferable that Furthermore, a material having biocompatibility is preferable because it directly or indirectly contacts the patient's blood.
  • a material having biocompatibility is preferable because it directly or indirectly contacts the patient's blood.
  • polyvinyl chloride, silicone resin, styrene thermoplastic elastomer, styrene thermoplastic elastomer compound, etc. can be used, but not limited to this, any material having biocompatibility is suitable. Can be used.
  • the material of the extracorporeal circuit 2 may be any material such as synthetic resin, metal and glass, but a synthetic resin, particularly a thermoplastic resin is preferable from the viewpoint of manufacturing cost, workability and operability.
  • a synthetic resin particularly a thermoplastic resin is preferable from the viewpoint of manufacturing cost, workability and operability.
  • the thermoplastic resin include polyolefin resins, polyamide resins, polyester resins, polyurethane resins, fluorine resins, silicon resins, ABS resins, polyvinyl chloride, polycarbonate, polystyrene, polyacrylate, Polyacetal or the like can be used.
  • the soft material is preferable because it is strong against bending and cracking and has excellent flexibility during operation, and soft vinyl chloride is particularly preferable from the viewpoint of assembly.
  • the material of the liquid inlet joint 10 and the liquid outlet joint 11 is not particularly hard or soft, and any of synthetic resin, metal, glass, etc. may be used, but in order to directly or indirectly touch the patient's blood, A material having biocompatibility is preferred. Moreover, it is preferable that it is the same material as the liquid chamber 5 and the air chamber 7 from a viewpoint of manufacturing cost, workability, and assemblability. For example, vinyl chloride, polycarbonate, polypropylene, polyethylene, polyurethane, or the like can be used. Moreover, the manufacturing method is not particularly limited, and specifically, injection molding, blow molding, molding by cutting, or the like can be used. Further, the extracorporeal circuit 2, the liquid inlet joint 10 and the liquid outlet joint 11 may be integrally molded.
  • the joining method of the liquid chamber 5, the air chamber 7, the deformed surface 8, the liquid inlet joint 10, the liquid outlet joint 11 and the extracorporeal circulation circuit 2 is not particularly limited. Joining and adhesion can be mentioned. For example, in hot melt bonding, high frequency welding, induction heating welding, ultrasonic welding, friction welding, spin welding, hot plate welding, hot wire welding and the like can be mentioned, and in bonding, cyanoacrylate, epoxy, polyurethane, Examples include adhesion using a synthetic rubber type, an ultraviolet curable type, a modified acrylic resin, a hot melt type, and the like.
  • bonding of a hard material and a soft material can include a mechanical seal that seals a soft material by pressing the hard material, and a hot-melt bonding or bonding as described above. .
  • Such a pressure detector 1 may be used as it is after being molded and joined, but it is sterilized and used particularly in medical applications for extracorporeal circulation therapy.
  • the sterilization method may be in accordance with a normal medical device sterilization method, and may be sterilized by a chemical solution, gas, radiation, high-pressure steam, heating or the like.
  • the size of the liquid chamber 5 is preferably about 1 to 10 cm 3 in volume, more preferably about 1 to 5 cm 3 , and most preferably 1 to 3 cm 3 .
  • the size of the air chamber 7 is preferably 0.2 to 1.0 cm 3 in volume, more preferably 0.3 to 0.8 cm 3 .
  • the blood circuit of the present invention is characterized by comprising the above-mentioned pressure detecting body for extracorporeal circuit and the extracorporeal circuit.
  • FIG. 15 As an embodiment of the above blood circuit, a blood circuit 15 having a pressure detector 1 and an extracorporeal circuit 2 is shown in FIG.
  • the blood circuit 15 has a configuration in which the pressure detector 1, the drip chamber 16, and the like are connected by the extracorporeal circuit 2.
  • the term “continuous” means that each of them is simply connected, or the pressure detector 1, the drip chamber 16, and the extracorporeal circulation at a predetermined position with respect to the substrate 17 made of a hard or soft material.
  • the circuit 2 or the like may be attached.
  • substrate 17 it is preferable that it is a hard material from a viewpoint of attaching / detaching to the blood purification apparatus, and attaching / detaching the pressure detection body 1, the extracorporeal circulation circuit 2, etc.
  • FIG. Specifically, ABS resin, polypropylene, nylon, polyvinyl chloride, polycarbonate, polyethersulfone, polyethylene terephthalate, or the like can be used.
  • the blood purification apparatus of the present invention is characterized by comprising the above-described blood circuit.
  • a blood purification device 18 having a blood circuit 15 is shown in FIG.
  • the blood purification apparatus 18 has a configuration in which an operation panel 19, a module holder 20, a blood pump 21, a chemical liquid holder 22, and the like are arranged at predetermined positions, and a blood circuit 15, a blood purification module 23, and the like are installed therein. Are connected to each other.
  • the blood purification device 18 is used for blood purification therapy after setting according to the blood purification module 23 to be used.
  • Example 1 The flow state of the liquid was confirmed by the following methods 1) to 5) using the pressure detector having the configuration shown in FIG. 1)
  • the first liquid to be circulated as simulated blood to the extracorporeal circuit and pressure detector is an xanthan gum aqueous solution (concentration 750 mg / L), and the solution is fed at a flow rate of 30 ml / min using a feed pump, and is extracorporeally circulated.
  • the circuit and pressure detector were filled.
  • an appropriate amount of ink was poured from the extracorporeal circuit on the liquid inlet side of the pressure detector while the liquid feed pump was still running (30 ml / min).
  • the flow state of the ink in the liquid chamber in the pressure detector was visually confirmed.
  • a soft polyvinyl chloride tube having an inner diameter of about 3.0 mm was connected to the liquid inlet and the liquid outlet, and the liquid feed pump was installed on the extracorporeal circuit on the liquid inlet side.
  • the volume of the blood chamber of the pressure detection body is approximately 2.3 cm 3
  • the flow path connecting the extracorporeal circuit and the liquid chamber is a frustum shape
  • the diameter A in the circumferential direction of the liquid inlet is
  • the pressure detection body was 33.3% with respect to the circumference, and the liquid inlet and the liquid outlet were arranged at opposite positions with the chamber member interposed therebetween.
  • the pressure detector of this example is for the purpose of confirming the flow state of the liquid chamber, and pressure measurement is not performed, so only the liquid chamber was made of polycarbonate.
  • Comparative Example 1 On the other hand, as Comparative Example 1, the flow state was confirmed by the following method using a pressure detector having the configuration shown in FIG.
  • the liquid chamber has the same dimensions as in the first embodiment, and the extracorporeal circulation circuit having an inner diameter of about 3.0 mm is directly connected to the liquid inlet and the liquid outlet, and as shown in FIG. The outlets are arranged in the vicinity.
  • the pressure detector of this comparative example was intended to confirm the flow state of the liquid chamber, and no pressure measurement was performed. Therefore, only the liquid chamber was made of polycarbonate.
  • the liquid chamber with a liquid inlet joint and a liquid outlet joint that communicate with the blood circulation circuit and the liquid chamber in the shape of a frustum. As a result, the coagulation of blood is suppressed.
  • Example 2 Next, the effect of changing the diameter A in the circumferential direction of the liquid chamber at the liquid inlet shown in FIG. 6 was confirmed.
  • the flow velocity distribution of the liquid chamber was compared using the result obtained by computer simulation.
  • the standard deviation in the flow velocity distribution in the liquid chamber for each example is shown in Table 1.
  • the computer simulation was performed using fluid analysis software “STAR-CD” manufactured by IDAJ.
  • This simulation model since pressure evaluation is not performed, only the liquid chamber is modeled, and the diameter A in the circumferential direction of the liquid chamber at the liquid inlet is 8.3% of the circumferential length of the liquid chamber.
  • the model was configured to flow from the liquid inlet to the liquid chamber at a flow rate of 30 ml / min and to discharge from the liquid outlet.
  • Example 3 Next, the effect was confirmed by setting the diameter A in the circumferential direction of the liquid chamber at the liquid inlet to 16.7% of the circumferential length of the liquid chamber. As a result of the simulation, as shown in Table 1, the standard deviation in the flow velocity distribution in the liquid chamber was 0.003468 (m / s).
  • Example 4 Next, the effect was confirmed by setting the diameter A in the circumferential direction of the liquid chamber at the liquid inlet to 25% of the circumferential length of the liquid chamber. As a result of the simulation, as shown in Table 1, the standard deviation in the flow velocity distribution of the liquid chamber was 0.002608 (m / s).
  • Comparative Example 2 On the other hand, as Comparative Example 2, the flow state was confirmed by the following method using a pressure detector having the configuration shown in FIG.
  • the liquid chamber has the same dimensions as the first embodiment, and an extracorporeal circuit having an inner diameter of about 3.0 mm is directly connected to the liquid inlet and the liquid outlet without passing through the frustum-shaped liquid inlet joint and the liquid outlet joint.
  • the liquid inlet and the liquid outlet are arranged to face each other across the liquid chamber.
  • the flow velocity distribution in the liquid chamber was confirmed as a model in which this was introduced into the liquid chamber from the liquid inlet and discharged from the liquid outlet by the same method as in Examples 2-4.
  • the diameter A in the circumferential direction of the liquid chamber at the liquid inlet is 13.9% to 50% of the circumferential length of the liquid chamber, blood retention is improved without causing a short path.
  • the blood flow disturbance can be reduced by suppressing the standard deviation of the flow velocity distribution, and blood coagulation can be further suppressed.
  • the pressure detector of the present invention and the blood circuit and blood purification apparatus provided with the pressure detector can suppress the coagulation of blood more than conventional pressure detectors. Therefore, the pressure in the extracorporeal circuit can be measured safely and can be usefully used for extracorporeal circulation treatment.

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  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • External Artificial Organs (AREA)
  • Measuring Fluid Pressure (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)

Abstract

La présente invention vise à proposer un élément de détection de pression ayant une nouvelle structure, ledit élément de détection de pression mesurant la pression à l'intérieur d'un circuit de circulation extracorporelle sans entrer en contact avec le sang ou l'air, la coagulation du sang étant mieux supprimée en réduisant au minimum la rétention de sang suite à l'amélioration du débit sanguin à l'intérieur de l'élément de détection de pression ; et un circuit sanguin et un appareil de purification de sang comprenant l'élément de détection de pression. La présente invention concerne un élément de détection de pression pour un circuit de circulation extracorporelle pour mesurer la pression à l'intérieur d'un circuit de circulation extracorporelle, qui exécute un traitement extracorporel de sang et comprend : un élément de chambre ayant une chambre de fluide qui a une surface de déformation déformée par la pression à l'intérieur du circuit de circulation extracorporelle, une entrée de fluide et une sortie de fluide, et qui permet au sang d'entrer et de sortir ; un joint d'entrée de fluide pour relier l'entrée de fluide au circuit de circulation extracorporelle ; et un joint de sortie de fluide pour relier la sortie de fluide au circuit de circulation extracorporelle. Des passages d'écoulement à l'intérieur du joint d'entrée de fluide et du joint de sortie de fluide s'élargissent sous forme de cône vers la chambre de fluide.
PCT/JP2014/053421 2013-02-15 2014-02-14 Élément de détection de pression, et circuit sanguin et appareil de purification de sang le comprenant WO2014126185A1 (fr)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016077406A (ja) * 2014-10-14 2016-05-16 ニプロ株式会社 圧力測定部を有する血液回路
JP2017038803A (ja) * 2015-08-20 2017-02-23 ニプロ株式会社 圧力測定部を有する血液回路

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JP2007222490A (ja) * 2006-02-24 2007-09-06 Jms Co Ltd 回路内圧センサ用検出ユニット、回路内圧センサ
JP2008051663A (ja) * 2006-08-24 2008-03-06 Asahi Kasei Kuraray Medical Co Ltd 圧力センサ
JP2011212174A (ja) * 2010-03-31 2011-10-27 Toray Medical Co Ltd 血液浄化装置

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JP2007222490A (ja) * 2006-02-24 2007-09-06 Jms Co Ltd 回路内圧センサ用検出ユニット、回路内圧センサ
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Publication number Priority date Publication date Assignee Title
JP2016077406A (ja) * 2014-10-14 2016-05-16 ニプロ株式会社 圧力測定部を有する血液回路
JP2017038803A (ja) * 2015-08-20 2017-02-23 ニプロ株式会社 圧力測定部を有する血液回路

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