WO2014119826A1 - Composition cosmétique pour le blanchiment ou l'atténuation de rides comprenant un extrait d'algue en tant que principe actif - Google Patents

Composition cosmétique pour le blanchiment ou l'atténuation de rides comprenant un extrait d'algue en tant que principe actif Download PDF

Info

Publication number
WO2014119826A1
WO2014119826A1 PCT/KR2013/005103 KR2013005103W WO2014119826A1 WO 2014119826 A1 WO2014119826 A1 WO 2014119826A1 KR 2013005103 W KR2013005103 W KR 2013005103W WO 2014119826 A1 WO2014119826 A1 WO 2014119826A1
Authority
WO
WIPO (PCT)
Prior art keywords
seaweed extract
cosmetic composition
whitening
present
extract
Prior art date
Application number
PCT/KR2013/005103
Other languages
English (en)
Korean (ko)
Inventor
한태준
Original Assignee
Han Tae Jun
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Han Tae Jun filed Critical Han Tae Jun
Publication of WO2014119826A1 publication Critical patent/WO2014119826A1/fr

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9706—Algae
    • A61K8/9717—Rhodophycota or Rhodophyta [red algae], e.g. Porphyra
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

Definitions

  • the present invention relates to a cosmetic composition for improving whitening or wrinkles containing a seaweed extract as an active ingredient.
  • pigments affecting skin color include melanin, melanoid, carotene, hemoglobin, and the most important pigment is melanin.
  • Melanin plays an important role in preventing skin damage from ultraviolet rays by absorbing or scattering ultraviolet rays, and also excellent in removing free radical species, but sometimes melanin itself generates free radicals, and catechol in melanin structure Or quinones reduce or oxidize other substances, and melanin itself exhibits the properties of free radicals. Therefore, in order to prevent skin discoloration, it is necessary to suppress melanin production.
  • Melanin is biosynthesized into a brown, eumelanin polymer through a series of oxidation processes beginning with the conversion of tyrosine, an amino acid, to tyrosinase and conversion to dihydroxy phenylalanine.
  • the biosynthesis process of melanin proceeds in the organelle of a special type of brown cells called melanosomes, and through the biosynthesis process, melanosomes including melanin granules migrate around the nuclei of keratinocytes and accumulate.
  • melanin The synthesis of melanin, the number of melanosomes, and the migration to the surrounding keratinocytes are largely genetically influenced, in part, by hormones and ultraviolet rays, and other intracellular regulatory factors such as cytokines, copper, zinc, It is known to be affected by metal ions such as iron and interferon, prostaglandin, histamine and the like.
  • ascorbic acid, hydroquinone, kojic acid, arbutin and some extracts are used as whitening cosmetics because they have inhibitory activity of tyrosinase involved in melanogenesis, but they are degraded due to their low stability in cosmetic formulations or Its use is limited due to problems such as the occurrence of off-flavor, unclear efficacy at the biological level. Therefore, in recent years, researches are being actively conducted to develop skin whitening ingredients derived from natural products which can minimize side effects on the skin.
  • aging of the skin may be divided into stress, disease, environmental factors, wounds, or internal aging that occurs with age, and light aging caused by exposure to light such as ultraviolet rays.
  • Aging of the skin is caused by the destruction of the antioxidant protective film present in the living body by the activated free radicals, thereby oxidizing lipids, proteins, polysaccharides and nucleic acids, which are the major constituents of the skin, and thus destroying skin cells and tissues.
  • collagen, hyaluronic acid, elastin, proteoglycan, and fibronectin which are the connective tissues of the skin, are cleaved, which causes severe excessive inflammatory reaction and skin elasticity. If this becomes more severe, mutations in the DNA can lead to mutations, cancer, and reduced immune function.
  • MMP matrix metalloproteinase
  • Adenosine, retinoic acid, and the like are known to be effective for improving skin wrinkles, but adenosine is ineffective in clinical practice, and retinoic acid can be used in women of childbearing potential, and there is a high risk of irritation such as erythema.
  • Laver is a red algae belonging to the genus (Porphyra) is called haekai or Haitai.
  • the fronds are embedded in a thin and sticky material, and have various colors ranging from dark brown to reddish-pink. The sexual reproduction occurs at the edge.
  • Laver grows in the upper intertidal zones of the southern and northern hemispheres and grows well in nitrogen-rich water, such as areas where sewage drains.
  • the seaweed is harvested, dried and used for food, more than any other sea horse. About 70 kinds of seaweed are known worldwide, but about 10 species are known in Korea. Among them, P. tenera and P. yezoensis are farmed. In addition, P.
  • N-N N-nitrosodimethylamine
  • -N N-nitrosodimethylamine
  • porphyran isolated from seaweed has been studied to regulate the effects of calcium, magnesium and potassium in hyperlipidemic mice, and has been used to treat hemorrhoids and ovulation.
  • the present inventors while studying the whitening or wrinkle improvement using the seaweed extract, confirmed that the seaweed extract shows excellent tyrosinase activity inhibitory activity, melanin synthesis inhibitory ability, collagen synthesis ability and MMP activity inhibition ability, and completed the present invention.
  • the present invention is to provide a cosmetic composition for improving whitening or wrinkles containing the seaweed extract as an active ingredient.
  • the present invention provides a cosmetic composition for whitening or improving wrinkles containing the seaweed extract as an active ingredient.
  • the seaweed extract as an active ingredient in the cosmetic composition of the present invention can be obtained by a conventional extraction method, and commercially available ones can be purchased and used.
  • Conventional extraction methods may include, but are not limited to, ultrasonic extraction, filtration and reflux extraction.
  • the extract was prepared using the method described in the Republic of Korea Patent Publication No. 10-969325 filed by the applicant.
  • the dried steam is added to water, C 1 ⁇ C 4 alcohol or a mixed solvent of water and C 1 ⁇ C 4 alcohol and maintained for 1 to 5 hours in a constant temperature water bath maintained at 30 ⁇ 60 °C to extract the active ingredient do.
  • the C 1 ⁇ C 4 alcohol may be selected from 1 to 100% methanol or 1 to 100% ethanol, preferably 1 to 100% methanol.
  • the extract was filtered and the filtrate was concentrated in vacuo to obtain a seaweed extract in powder form. Seaweed extract in powder form is added to distilled water, filtered to remove impurities, and purified to obtain a seaweed extract.
  • the laver used in the present invention is preferably radiation pattern laver (Porphyra yezoensis), but is not limited thereto.
  • Seaweed extract according to the present invention is excellent in inhibiting tyrosinase activity, melanin synthesis inhibitory ability, collagen synthesis and MMP activity, almost cytotoxic in keratinocytes (HaCaT), human fibroblasts (1064 SK) and skin cancer cells (B16F) It is non-irritant, nonsensitizing, very sensitive (grade I), and does not cause phototoxicity and photosensitization. Therefore, the seaweed extract according to the present invention can be usefully used in the cosmetic composition for whitening or wrinkle improvement.
  • Seaweed extract of the present invention may be included in 0.0001 to 30.0% by weight, more preferably 0.001 to 10.0% by weight, and most preferably 0.01 to 5.0% by weight relative to the total weight of the cosmetic composition.
  • the cosmetic composition according to the present invention contains components conventionally used in cosmetic compositions in addition to the seaweed extract as an active ingredient, and includes, for example, conventional auxiliaries such as antioxidants, stabilizers, solubilizers, vitamins, pigments and flavors, and carriers. Include.
  • conventional auxiliaries such as antioxidants, stabilizers, solubilizers, vitamins, pigments and flavors, and carriers. Include.
  • Cosmetic compositions according to the invention can be prepared in any formulations conventionally prepared in the art, for example solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, cleansing, oils, Powder foundations, emulsion foundations, wax foundations and sprays and the like can be formulated, but is not limited thereto.
  • the cosmetic composition according to the present invention can be prepared in the form of a flexible lotion, nourishing lotion, nourishing cream, massage cream, essence, eye cream, cleansing cream, cleansing foam, cleansing water, pack, spray or powder have.
  • the formulation of the present invention is a paste, cream or gel, animal oils, vegetable oils, waxes, paraffins, starches, trachants, cellulose derivatives, polyethylene glycols, silicones, bentonites, silicas, talc or zinc oxide may be used as carrier components.
  • animal oils, vegetable oils, waxes, paraffins, starches, trachants, cellulose derivatives, polyethylene glycols, silicones, bentonites, silicas, talc or zinc oxide may be used as carrier components.
  • animal oils vegetable oils, waxes, paraffins, starches, trachants, cellulose derivatives, polyethylene glycols, silicones, bentonites, silicas, talc or zinc oxide
  • cellulose derivatives polyethylene glycols
  • silicones bentonites
  • silicas talc or zinc oxide
  • lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used, in particular, in the case of a spray, additionally chlorofluorohydrocarbon, Propellant such as propane / butane or dimethyl ether.
  • a solvent, solubilizing agent or emulsifying agent is used as the carrier component, for example, water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, Fatty acid esters of 1,3-butylglycol oil, glycerol aliphatic esters, polyethylene glycols or sorbitan are used.
  • liquid carrier diluents such as water, ethanol or propylene glycol
  • suspending agents such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, microcrystals Soluble cellulose, aluminum metahydroxy, bentonite, agar or tracant and the like can be used.
  • the formulation of the invention is a cleansing, in particular a surfactant-containing cleansing, it is an aliphatic alcohol sulfate, an aliphatic alcohol ether sulfate, a sulfosuccinic acid monoester, isethionate, an imidazolinium derivative, methyltaurate, sarcosy as a carrier component.
  • Nates, fatty acid amide ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives or ethoxylated glycerol fatty acid esters and the like can be used.
  • Seaweed extract according to the present invention is excellent in inhibiting tyrosinase activity, melanin synthesis inhibitory ability, collagen synthesis and MMP activity, almost cytotoxic in keratinocytes (HaCaT), human fibroblasts (1064 SK) and skin cancer cells (B16F) It is non-irritant, nonsensitizing, very sensitive (grade I), and does not cause phototoxicity and photosensitization.
  • 1 is a diagram showing the effect of the seaweed extract of the present invention on the inhibition of tyrosinase activity.
  • Figure 2 is a diagram showing the effect of the laver extract of the present invention on the inhibition of melanin activity.
  • Figure 3 is a view showing the effect of the extract of the present invention on the cell proliferation of keratinocytes (HaCaT), human fibroblasts (1064 SK), skin cancer cells (B16F).
  • Figure 4 is a diagram showing the collagen synthesis ability of the seaweed extract of the present invention.
  • FIG. 5 is a diagram showing the inhibitory activity of MMPs activity of the seaweed extract of the present invention.
  • the seaweed extract used in the present invention was prepared using the method described in Korean Patent Publication No. 10-969325 to which the applicant has applied for and registered.
  • a constant temperature water bath maintained at 45 ° C after adding 100 g of dried Porphyra yezoensis to a vial, followed by adding 20 ml of 80% by volume aqueous methanol solution (mixed solvent consisting of 80 volumes of methanol and 20 volumes of water).
  • the active ingredient was extracted by maintaining for 3 hours.
  • the contents in the vial were then filtered through filter paper (whatman No. 2) to separate the supernatant from the remaining solids. Extraction was carried out two more times by extraction and filtration from the remaining solid.
  • the separated supernatants were collected, concentrated in vacuo, concentrated and filtered (whatman No. 2), and the remaining solids were extracted twice in the same manner.
  • the extracts thus obtained were collected, concentrated in a vacuum evaporator and dried to give a crude extract (Pophyra extract, PE) in powder form.
  • the crude extract aqueous solution from which impurities are removed is composed of a water-methanol concentration gradient (previously water and then 50 vol% methanol) on a Prep LC system (dual pump (Koto, Japan), auto injector, UV / RI detector, and fraction collector).
  • Aqueous extract) (developing rate of 5ml / min) and then using a UV detector and RI detector to obtain a crude extract fraction absorbing the ultraviolet wavelength of 280 ⁇ 400 nm.
  • the crude extract fraction obtained in (2) was 10ml / min with 0.2% by volume of acetic acid aqueous solution in a hydrophobic cross column (Capcellpak C18 UG120 semi-prepatative column; Shiseido, Japan) protected by UG120 guard column (Shiseido, Japan). It was developed at the rate of and purified first.
  • the first purified extract was purified on a size exclusion column (Ohpak 2002; Shiseido, Japan) with water at a rate of 2.5 mL / min and secondarily purified.
  • the secondary tablet extract was a bright yellow liquid, which was concentrated on a vacuum evaporator and lyophilized to give the tablet extract in powder form.
  • the laver extract of the present invention was confirmed to have excellent tyrosinase activity inhibitory ability.
  • the laver extract of the present invention was confirmed to inhibit melanin synthesis by ⁇ -MSH close to 80% in B16F10 cells. Therefore, it can be seen that the seaweed extract of the present invention is excellent in melanin synthesis inhibitory ability.
  • Example 2 Wrinkle improvement effect of the seaweed extract of the present invention
  • HaCaT keratinocytes
  • human fibroblasts 1064 SK
  • skin cancer cells B16F
  • MMT Thiazolyl Blue Tetrazolium Bromide assay measured cell proliferation of keratinocytes (HaCaT), human fibroblast primary cell line (1064 SK) and skin cancer cells (B16F). That is, the growth of the cells was determined by measuring the purple formazan produced by the reduction of MTT by living cells. After irradiating each cell with UV, the culture medium was again exchanged with DMEM medium containing 10% FBS and antibiotics and incubated for another 8 hours. 10 ⁇ l of MTT (5 mg / mL PBS) solution was then added to each well and incubated for 3 hours. The culture solution containing MTT was removed, 200 ⁇ l of DMSO was added to each well, extracted for 30 minutes, and the absorbance was measured at 560 nm.
  • HaCaT keratinocytes
  • human fibroblast primary cell line 1064 SK
  • B16F skin cancer cells
  • the laver extract of the present invention showed no cytotoxicity in keratinocytes (HaCaT), human fibroblasts (1064 SK), skin cancer cells (B16F).
  • Human fibroblasts (1064 SK) were aliquoted into 500 ⁇ l in 24 well plates at 2 ⁇ 10 5 cells / ml and incubated for 24 hours. After incubation, all of the medium was removed, and the medium (serum extract of Preparation Example 1) was diluted to a concentration (10, 20, 30 ⁇ l) selected through the evaluation of cell proliferation ability and added to each well using a medium containing no serum. After incubation for 48 hours, the medium was collected, and the supernatant was taken by centrifugation for 2000 rpm / 3 minutes. Collagen synthesis capacity was measured using the supernatant by the procollagen type 1 c-peptide ELISA method.
  • the procollagen type 1 c-peptide ELISA method is as follows.
  • 100 ⁇ l of antibody-POD conjugate solution was added to each well of a 96 well plate coated with antibody titer, and 20 ⁇ l of the culture solution and the standard solution diluted to 1/5 were added.
  • the standard solution was prepared by diluting the collagen standard to 0, 10, 20, 40, 80, 160, 320, 640 ng / ml with diluent, respectively. After sealing a plate, it was made to react at 37 degreeC for 3 hours. After the reaction, each well was washed 3-4 times with PBS. 100 ⁇ l of substrate solution was added thereto, followed by reaction at room temperature for 15 minutes. 100 ⁇ l of stop solution (1N H 2 SO 4 or 1N HCl) was added thereto, and the absorbance was measured at 450 nm using an ELISA reader. The amount of collagen measured was corrected after protein quantification.
  • the laver extract of the present invention was confirmed to have excellent collagen synthesis ability.
  • Gelatin zymography was performed using human skin keratinocytes (HaCaT) medium solution obtained to measure the collagen synthesis ability of 2, and the degree of inhibition of activity of MMP2 and MMP9 was confirmed.
  • HaCaT human skin keratinocytes
  • the laver extract of the present invention showed a slight inhibitory activity of about 10% on MMP2 activity in keratinocytes (HaCaT), while inhibiting the activity of MMP9 by about 40%.
  • Example 4 Skin irritation test of seaweed extract of the present invention
  • the test substance was applied to the skin of rabbits for 24 hours, and then mortality, general symptoms, weight change and skin irritation for 72 hours were evaluated.
  • test substance seaweed extract
  • the skin sensitization of the laver extract of the present invention against guinea pigs was evaluated by the Buehler method, and mortality, general symptoms, weight change and post-induced skin response were examined during the test period.
  • the guinea pigs were coated with a seaweed extract and irradiated with UV, followed by mortality, general symptoms, weight change and sensitization of the test animals.
  • the skin reaction was investigated.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

La présente invention concerne une composition cosmétique qui est destinée au blanchiment ou à l'atténuation des rides et qui comprend un extrait d'algue en tant que principe actif. L'extrait d'algue selon la présente invention est doté d'une activité inhibitrice de la tyrosinase, d'une activité inhibitrice de la mélanogenèse, d'une capacité de synthèse du collagène et d'une activité inhibitrice de MMP excellentes, ne présente pratiquement aucune cytotoxicité dans les kératinocytes (HaCaT), les cellules de fibroblastes dermiques (1064 SK) et les cellules de carcinome épidermoïde (B16F) humaines, n'est pas irritant, provoque une très faible sensibilisation (niveau I) et ne présente pas de propriétés phototoxiques ni de propriétés photosensibles. Par conséquent, l'extrait d'algue selon la présente invention se révèle utile pour une composition cosmétique destinée au blanchiment ou à l'atténuation des rides.
PCT/KR2013/005103 2013-01-30 2013-06-11 Composition cosmétique pour le blanchiment ou l'atténuation de rides comprenant un extrait d'algue en tant que principe actif WO2014119826A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2013-0010510 2013-01-30
KR1020130010510A KR20140097865A (ko) 2013-01-30 2013-01-30 김 추출물을 유효성분으로 함유하는 미백 또는 주름 개선용 화장료 조성물

Publications (1)

Publication Number Publication Date
WO2014119826A1 true WO2014119826A1 (fr) 2014-08-07

Family

ID=51262517

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2013/005103 WO2014119826A1 (fr) 2013-01-30 2013-06-11 Composition cosmétique pour le blanchiment ou l'atténuation de rides comprenant un extrait d'algue en tant que principe actif

Country Status (2)

Country Link
KR (1) KR20140097865A (fr)
WO (1) WO2014119826A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20160089911A (ko) 2015-01-20 2016-07-29 주식회사 그린파이오니아 타우린 및 알라닌을 함유하는 김추출물의 제조방법 및 이를 포함하는 화장료 조성물
KR102014283B1 (ko) 2018-04-05 2019-08-26 삼척시 민물김 추출물을 유효성분으로 포함하는 주름 개선용 조성물
KR102054132B1 (ko) 2018-04-05 2019-12-12 삼척시 민물김 추출물을 유효성분으로 포함하는 피부 미백용 조성물
KR102336538B1 (ko) * 2020-06-09 2021-12-08 주식회사 코사이언스 피부 미백 효과를 갖는 천연 복합 추출물을 함유하는 피부 미백용 조성물

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1433463A1 (fr) * 2002-12-26 2004-06-30 Shirako Co., Ltd. Cosmétique contenant de protéines d'algues
KR20040092781A (ko) * 2003-04-29 2004-11-04 학교법인 영남학원 토후박 추출물을 함유하는 미백용 화장료 조성물
US20110262505A1 (en) * 2010-04-22 2011-10-27 Gina Athwal Seaweed-derived cosmetic compositions
KR20120016309A (ko) * 2012-01-17 2012-02-23 이재학 사탕형 제과류 꽃꽂이형 꽃송이 장식 포장재
KR20120056594A (ko) * 2010-11-25 2012-06-04 (주)아모레퍼시픽 모자반 추출물, 청각 추출물 및 참미역 추출물을 함유하는 화장료 조성물

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1433463A1 (fr) * 2002-12-26 2004-06-30 Shirako Co., Ltd. Cosmétique contenant de protéines d'algues
KR20040092781A (ko) * 2003-04-29 2004-11-04 학교법인 영남학원 토후박 추출물을 함유하는 미백용 화장료 조성물
US20110262505A1 (en) * 2010-04-22 2011-10-27 Gina Athwal Seaweed-derived cosmetic compositions
KR20120056594A (ko) * 2010-11-25 2012-06-04 (주)아모레퍼시픽 모자반 추출물, 청각 추출물 및 참미역 추출물을 함유하는 화장료 조성물
KR20120016309A (ko) * 2012-01-17 2012-02-23 이재학 사탕형 제과류 꽃꽂이형 꽃송이 장식 포장재

Also Published As

Publication number Publication date
KR20140097865A (ko) 2014-08-07

Similar Documents

Publication Publication Date Title
KR100823533B1 (ko) 알파 비사볼올을 유효성분으로 포함하는 피부 상태 개선용조성물
KR100862968B1 (ko) 마트린 또는 옥시마트린을 포함하는 피부 주름 개선제
WO2015163528A1 (fr) Composition cosmétique pour le blanchiment de la peau et l'atténuation des rides contenant, pour principes actifs, un extrait de rose blanche et un composé dérivé de la gartanine isolé à partir de celle-ci
WO2015053460A1 (fr) Composition cosmétique contenant un liquide de baies de ginseng à fermentation de pleurotus ferulae
WO2020246766A1 (fr) Composition pour prévenir ou atténuer le vieillissement cutané, contenant un extrait de rhodiola sachalinensis fermenté à l'aide de bovista plumbea
WO2015156439A1 (fr) Composition pour améliorer l'état de la peau, comprenant un extrait d'andrographis paniculata, un andrographolide ou sel correspondant
WO2014119826A1 (fr) Composition cosmétique pour le blanchiment ou l'atténuation de rides comprenant un extrait d'algue en tant que principe actif
WO2022260454A1 (fr) Composition pour le traitement de la dermatite atopique ou le renforcement de la barrière cutanée ou la prévention du vieillissement de la peau, comprenant un extrait de forsythia velutina nakai
WO2013129723A1 (fr) Composition d'amélioration d'états de la peau comprenant de l'hordénine
WO2017200288A1 (fr) Composition pour le blanchiment de la peau, la prévention du vieillissement de la peau ou l'amélioration des rides de la peau, comprenant un extrait médicinal oriental naturel en tant que substance active
WO2012020989A2 (fr) Composition pharmaceutique ou cosmétique contenant de l'acide nicotinique adénine dinucléotide phosphate ou un dérivé de celui-ci
WO2018097388A1 (fr) Composition pour le blanchiment de la peau, l'atténuation des rides, l'antioxydation et la protection contre la lumière ultraviolette, contenant un extrait de graine de jujube comme principe actif
WO2018111042A2 (fr) Composition cosmétique comprenant un extrait de plantes médicinales en tant qu'ingrédient actif
WO2017119535A1 (fr) Composition anti-âge comprenant de la carnosine, peptide de soja, et extrait d'andrographis paniculata
WO2014003224A1 (fr) Compositions de blanchiment de la peau comprenant de la madécassoside
KR100829718B1 (ko) 먼나무 추출물을 유효성분으로 포함하는 피부 미백용화장료 조성물
KR20190007704A (ko) 4'-o-메틸알피눔 이소플라본을 유효성분으로 포함하는 피부 미백용 조성물
WO2018151563A1 (fr) Composition pour prévenir le photovieillissement et soulager les rides de la peau, contenant un extrait de cosmos bipinnatus
KR101317433B1 (ko) 지구자, 길경, 밀싹 및 세이지 추출물을 함유하는 미백 화장용 조성물
KR100862969B1 (ko) 바르비투르산을 유효성분으로 포함하는 피부 미백제
KR20110029740A (ko) 온주 밀감 과피 추출물의 분획물 및 그것의 용도
WO2023277616A1 (fr) Composition fonctionnelle pour l'alopécie comprenant un extrait dérivé de centipeda minima
WO2022050819A1 (fr) Composition anti-inflammatoire pour réduire les rides cutanées et hydrater et activer la régénération de la peau, contenant, en tant que principe actif, un extrait d'huile de krill traitée par une enzyme
WO2024128370A1 (fr) Composition cosmétique pour le blanchiment ou la réduction des rides, comprenant un produit de fermentation d'extrait de racine de pueraria lobata
WO2013070018A1 (fr) Composition comprenant de l'acide carnosique ou un dérivé de celui-ci

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 13873529

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 13873529

Country of ref document: EP

Kind code of ref document: A1