WO2014086702A3 - Enzymatische reduktion von hydroxymethylfurfuralen - Google Patents

Enzymatische reduktion von hydroxymethylfurfuralen Download PDF

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Publication number
WO2014086702A3
WO2014086702A3 PCT/EP2013/075212 EP2013075212W WO2014086702A3 WO 2014086702 A3 WO2014086702 A3 WO 2014086702A3 EP 2013075212 W EP2013075212 W EP 2013075212W WO 2014086702 A3 WO2014086702 A3 WO 2014086702A3
Authority
WO
WIPO (PCT)
Prior art keywords
hydroxymethylfurfurals
enzymatic reduction
furandimethanols
dimethanols
catalysed
Prior art date
Application number
PCT/EP2013/075212
Other languages
English (en)
French (fr)
Other versions
WO2014086702A2 (de
Inventor
Michael Breuer
Benoit BLANK
Original Assignee
Basf Se
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Se filed Critical Basf Se
Publication of WO2014086702A2 publication Critical patent/WO2014086702A2/de
Publication of WO2014086702A3 publication Critical patent/WO2014086702A3/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/42—Singly bound oxygen atoms
    • C07D307/44—Furfuryl alcohol
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Die vorliegende Erfindung betrifft ein biokatalytisches Verfahren zur Herstellung von Furandimethanolen aus Hydroxymethylfurfuralen, katalysiert von geeigneten Alkoholdehydrogenase-Enzymen und die Verwendung der so hergestellten Dimethanole zur Herstellung von bzw. in Polyestern, Bisphenol-A Ersatzstoffen, Harzen, Bindern, Polyethern, Lösemitteln, Aminen.
PCT/EP2013/075212 2012-12-03 2013-12-02 Enzymatische reduktion von hydroxymethylfurfuralen WO2014086702A2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261732421P 2012-12-03 2012-12-03
EP12195216.2 2012-12-03
EP12195216 2012-12-03
US61/732,421 2012-12-03

Publications (2)

Publication Number Publication Date
WO2014086702A2 WO2014086702A2 (de) 2014-06-12
WO2014086702A3 true WO2014086702A3 (de) 2014-09-12

Family

ID=47325909

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2013/075212 WO2014086702A2 (de) 2012-12-03 2013-12-02 Enzymatische reduktion von hydroxymethylfurfuralen

Country Status (1)

Country Link
WO (1) WO2014086702A2 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2675527T3 (es) 2013-12-06 2018-07-11 Basf Se Composición plastificante que contiene derivados de tetrahidrofurano y ésteres de ácido 1,2-ciclohexano dicarboxílico
CN110066837B (zh) * 2019-04-24 2020-12-22 清华大学 微生物高效催化5-羟甲基糠醛生产2,5-呋喃二甲醇的方法
JP2023544969A (ja) 2020-09-01 2023-10-26 ブラスケム エス．エー． フランジメタノールの嫌気的発酵産生とフランジカルボン酸の酵素的産生
CN112725233B (zh) * 2021-01-08 2023-02-10 南京科技职业学院 一株生产2，5-呋喃二甲醇的菌株及其应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005111214A1 (en) * 2004-05-19 2005-11-24 Forskarpatent I Syd Ab Ethanol productivities of saccharomyces cerevisiae strains in fermentation of dilute-acid hydrolyzates depend on their furan reduction capacities
WO2007012428A1 (de) * 2005-07-27 2007-02-01 Iep Gmbh Oxidoreduktasen zur stereoselektiven reduktion von ketoverbindungen
WO2009017441A1 (en) * 2007-07-31 2009-02-05 Bärbel Hahn Ab Polypeptide having nadh dependent hmf reductase activity
WO2010031776A2 (de) * 2008-09-17 2010-03-25 Basf Se Verfahren zur herstellung von optisch aktiven alkoholen

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19931847A1 (de) 1999-07-09 2001-01-11 Basf Ag Immobilisierte Lipase
DE10019380A1 (de) 2000-04-19 2001-10-25 Basf Ag Verfahren zur Herstellung von kovalent gebundenen biologisch aktiven Stoffen an Polyurethanschaumstoffen sowie Verwendung der geträgerten Polyurethanschaumstoffe für chirale Synthesen
DE10019377A1 (de) 2000-04-19 2001-10-25 Basf Ag Verfahren zur Immobilisierung von biologisch aktiven Stoffen auf Trägermaterialien und Verwendung der mit biologisch aktiven Stoffen geträgerten Materialien für chirale Synthesen
DE102004022686A1 (de) 2004-05-05 2005-11-24 Basf Ag Verfahren zur Herstellung optisch aktiver Alkohole
DE102005010804A1 (de) 2005-03-07 2006-09-14 Basf Ag Verfahren zur Herstellung optisch aktiver Alkohole

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005111214A1 (en) * 2004-05-19 2005-11-24 Forskarpatent I Syd Ab Ethanol productivities of saccharomyces cerevisiae strains in fermentation of dilute-acid hydrolyzates depend on their furan reduction capacities
WO2007012428A1 (de) * 2005-07-27 2007-02-01 Iep Gmbh Oxidoreduktasen zur stereoselektiven reduktion von ketoverbindungen
WO2009017441A1 (en) * 2007-07-31 2009-02-05 Bärbel Hahn Ab Polypeptide having nadh dependent hmf reductase activity
WO2010031776A2 (de) * 2008-09-17 2010-03-25 Basf Se Verfahren zur herstellung von optisch aktiven alkoholen

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE UniProt [online] 16 May 2012 (2012-05-16), "SubName: Full=Oxidoreductase;", XP002726880, retrieved from EBI accession no. UNIPROT:Q7AKC8 Database accession no. Q7AKC8 *
DATABASE UniProt [online] 22 February 2012 (2012-02-22), "SubName: Full=Alcohol dehydrogenase, 1-propanol preferring;", XP002726881, retrieved from EBI accession no. UNIPROT:H0QCS2 Database accession no. H0QCS2 *
DATABASE UniProt [online] 23 September 2008 (2008-09-23), "SubName: Full=Alcohol dehydrogenase GroES domain protein;", XP002726879, retrieved from EBI accession no. UNIPROT:B4SR32 Database accession no. B4SR32 *
JOÃ GBP O R M ALMEIDA ET AL: "NADHvs NADPH-coupled reduction of 5-hydroxymethyl furfural (HMF) and its implications on product distribution in Saccharomyces cerevisiae", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, SPRINGER, BERLIN, DE, vol. 78, no. 6, 11 March 2008 (2008-03-11), pages 939 - 945, XP019586341, ISSN: 1432-0614 *

Also Published As

Publication number Publication date
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