WO2014061838A1 - Composition comprenant de l'extrait de feuilles de dendropanax morbifera en qualité d'ingrédient actif afin de traiter et prévenir les maladies intestinales - Google Patents

Composition comprenant de l'extrait de feuilles de dendropanax morbifera en qualité d'ingrédient actif afin de traiter et prévenir les maladies intestinales Download PDF

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Publication number
WO2014061838A1
WO2014061838A1 PCT/KR2012/008596 KR2012008596W WO2014061838A1 WO 2014061838 A1 WO2014061838 A1 WO 2014061838A1 KR 2012008596 W KR2012008596 W KR 2012008596W WO 2014061838 A1 WO2014061838 A1 WO 2014061838A1
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Prior art keywords
constipation
extract
hwangchil
leaf extract
composition
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PCT/KR2012/008596
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English (en)
Korean (ko)
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이동욱
김선오
나주련
오교녀
배동혁
최은진
정명아
박상언
최철웅
김재갑
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재단법인 전라남도생물산업진흥재단
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Priority to PCT/KR2012/008596 priority Critical patent/WO2014061838A1/fr
Publication of WO2014061838A1 publication Critical patent/WO2014061838A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches

Definitions

  • composition containing the Hwangchil-tree leaf extract of the present invention as an active ingredient is useful for the treatment and prevention of intestinal diseases because it is excellent in the promotion of intestinal motility, intestinal effect and constipation improvement in rats.
  • Constipation has long been known as the source of all kinds of illnesses, and the appetite and bloat are not only inflated, but also the excreted toxins in the stool that are not excreted are absorbed into the intestine, which promotes skin aging, headaches, acne, and skin rashes. If constipation is severe, it causes hemorrhoids such as breakage of dentition and escape of hemorrhoids during defecation, and even colon cancer. As a result, constipation occurs in a country with a high cultural level. In particular, women and office workers suffer a lot from constipation.
  • Constipation is less than twice a week to see if the stool is less than 35g stool is due to lack of exercise or stress accumulates bowel movements, the ability to move the stool is reduced. Constipation refers to a case in which the stool remains in the colon for more than a normal time. The stool is usually excreted 12 to 72 hours after the food is eaten, and the type of food ingested affects the bowel time. In other words, high fiber foods absorb liquid in the intestine to increase volume, make excreta, and excrete, whereas low fiber content is the opposite.
  • Constipation itself is not a disease but a symptom of headache, vision disorders and allergies caused by toxic gases (hydrogen sulfide, nitrosoamine, ammonia, phenol) due to abnormal intestinal fermentation caused by constipation
  • Active prevention and treatment are needed because it causes various serious secondary diseases such as diseases (depression), skin diseases (acne, etc.), bad breath, colon diseases (hemorrhoids, colon cancer, etc.), arteriosclerosis, high blood pressure, stroke, and immunodeficiency.
  • constipation therapeutic agent that has a high effect of improving, treating or preventing intestinal diseases, including constipation, and lacking side effects, by improving intestinal activity among natural products that are expected to minimize the possibility of safety problems.
  • constipation itself is not a disease, but it causes headache, vision disorder and allergy due to toxic gas caused by abnormal fermentation of the intestine due to constipation, and decreases appetite.
  • the abdomen is always in a swelling state, and toxins of the unexcreted stool are delivered to the blood through the intestine to promote skin aging, skin diseases such as acne, mental diseases, bad breath, etc. It causes breakage of the hemorrhoids and the escape of hemorrhoids, which causes colon disease (hemorrhoids) and, in severe cases, colorectal cancer.
  • Korean Patent Registration No. 10-0716123 discloses a food composition for preventing and improving constipation and obesity containing lactic acid fermentation broth
  • Korean Patent Registration No. 10-0506824 contains radish and tea.
  • a herbal composition for improving constipation diseases has been disclosed
  • Korean Patent Registration No. 10-0720695 discloses a constipation treatment and prevention composition mainly composed of Sook-ji-hwang, Cheong-gung and Angelica mixed extract and Cha-Phi powder.
  • constipation improvement composition containing the dietary fiber of plants
  • the study to investigate the effect of constipation improvement by dietary fiber (fiber) contained in most plants which is the most vegetable
  • the improvement effect of constipation not only can not be seen as a specific phenomenon by a specific active ingredient, but also does not have a direct function in improving the intestinal motility, which is a fundamental problem of constipation.
  • most studies on constipation were conducted using a laboratory animal induced by constipation using an animal model through a chemical method called loperamide, but it was not clinically proven and the mechanism of development was unclear. It is described in ways that are inaccessible and are less reproducible to humans.
  • Hwangchil- tree Dendropanax morbifera
  • Hwangchil- tree is an evergreen broad-leaved forest belonging to the family Araliaceae, and is a subtropical species that grows and grows only on the southwestern coast and the island of Jeonnam.
  • Hwangchil's resin is golden, heat resistant, durable, water resistant, and has good adhesiveness and luster. It has been used as a natural paint and folk medicine material in traditional crafts since ancient times.
  • Hwangchil contains various ingredients such as arachidic acid, palmitic acid, arginine, etc. It is known to have.
  • the present invention provides a pharmaceutical composition for treating and preventing intestinal diseases, which contains the extract of Hwangchil-tree as an active ingredient.
  • the present invention provides a health functional food for the prevention and improvement of intestinal diseases containing Hwangchil-tree extract as an active ingredient.
  • Extracts as defined herein include water, lower alcohols of C 1 to C 4 or mixed solvents thereof, preferably extracts available in water or a mixed solvent of water and ethanol, more preferably 50 to 90% ethanol extracts. do.
  • the bowel disease includes functional constipation such as laxative constipation, constipation, constipation, constipation disorders; Stenosis of the intestinal tract, elongated S. colitis, organic constipation such as giant colon syndrome, diarrhea, diverticulitis, diarrhea constipation symptom, irritable bowel syndrome (IBS) and the like, preferably characterized by containing constipation.
  • functional constipation such as laxative constipation, constipation, constipation, constipation disorders
  • Stenosis of the intestinal tract elongated S. colitis
  • organic constipation such as giant colon syndrome, diarrhea, diverticulitis, diarrhea constipation symptom, irritable bowel syndrome (IBS) and the like, preferably characterized by containing constipation.
  • IBS irritable bowel syndrome
  • the Hwangchil-tree leaf extract of the present invention confirms the excellent intestinal motility, intestinal effect and constipation improvement effect in rats, which is useful for the treatment and prevention of various bowel diseases such as constipation, and is useful for the treatment of intestinal diseases.
  • 1 is a measure of the state of the stool and the weight before or after drying the stool when treated with a concentration of Hwangchil-tree leaf extract in rats that caused constipation through low dietary fiber intake;
  • Figure 2 shows the number of stools collected for each group administered the extract extracted in each rat according to the ratio of solvent to rats that caused constipation through low dietary fiber intake;
  • Figure 3 shows the experimental results of observing the change in the number of stools when treated with a concentration of Hwangchil-tree leaf extract in rats that caused constipation through low dietary fiber intake;
  • Figure 4 shows the water content by collecting the feces excreted for 24 hours in each group in the constipation improvement effect of the hwangchil extract
  • Figure 5 is an experimental result confirming the moisture content of the excreted fecal excreted by administering the hwangchil extract to an animal model causing constipation;
  • Figure 6 is to observe the number of remaining stool in the colon by administering the hwangchil extract to rats that caused constipation;
  • Figure 7 shows a graph that the yellow lacquer extract promotes contractile relaxation exercise of the colon at a concentration of 1 mg / ml.
  • the leaves were separated only from the branches of Hwangchil-tree (Jangheung, Haenam, Wando and other southern coasts of Jeonnam) and then dried by freeze drying or freeze drying to remove moisture.
  • 100 ml of the extraction solvent is mixed with 5 g of the yellow lacquer tree leaves (1:20) and extracted by stirring at 55 ° C. for 24 hours.
  • the used extraction solvent was mixed with distilled water and alcohol ethanol, 0%, 25%, 50%, 75% and 100% by alcohol ethanol ratio for 24 hours extraction using filter paper (Wattman 41) After filtration, the filtrate was concentrated under reduced pressure and lyophilized at -40 ° C.
  • DM0 water extract of 0.67 g of yellow Chilli leaves and 0.615 g of 25% ethanol extract
  • DM25E 0.71 g of 50% ethanol extract
  • DM75E 0.775 g of 75% ethanol extract
  • DM100E 0.855 g of 100% ethanol extract
  • the male rats (Sam taco) of the SD rat strain were maintained at 22 to 24 ° C and 60 to 80% humidity, and the day and night cycles were set at 12 hour intervals one week before the experiment. and, after each divided into 6 groups of 5 rats, the control group and negative control group were administered with the distilled water oral administration, the positive control is an osmotic drug flux dulko ???? (dulcolax; Boehringer Ingelheim) balance was administered orally twice a day at a concentration of 160 mg / kg Hwangchil-tree leaves hot water extract at a concentration of 100 mg / kg and 300 mg / kg.
  • Low fiber diet low fiber diet
  • the composition is as follows.
  • composition contains 9.0% of moisture, 21.9% of crude protein, 6.1% of crude fat, 0.1% of dietary fiber, 5.9% of crude starch, and 57.0% of soluble nitrogen.
  • the composition is 41.5% of corn starch and 24.5% of milk casein.
  • Sucrose 10.0%, dextrin, 7.0% mineral mixture, corn oil 6.0%, vitamin mixture 1.0%.
  • the control group provided the feed for general experimental animals, and the negative control group, the positive control group and the hwangchil extract administration group provided a low dietary fiber feed.
  • the control group provided the feed for general experimental animals
  • the negative control group, the positive control group and the hwangchil extract administration group provided a low dietary fiber feed.
  • Example 1 constipation-inducing animal model extracted from Example 1 for constipation-induced constipation improvement effect was confirmed, the number of stools and water content of each group was compared with the negative control group, statistical analysis was Student T test method ( Student's t-test).
  • Hwangchil-tree leaf extract prepared in Example 1 was administered at concentrations of 100 mg / kg 300 mg / kg and 500 mg / kg, and after 1 hour to 10% Arabian rubber (arabic gum, Sigma, USA) solution to experimental animals A suspension of 5% activated carbon (Sigma, USA) dissolved in (0.2 ml / animal po) was administered and the stools were observed every 2 hours to determine the time, number and weight of black stools coming out.
  • Activated carbon is produced by burning various organic materials (wood, etc.), and is a material having strong adsorption, nontoxicity, and no pharmacological effect. Activation removes impurities that are already adsorbed and increases the surface area by reducing the size of the particles.
  • control group was confirmed to have black stools from 8 to 10 hours and finished excretion until 18 to 20 hours, whereas the negative control group fed low dietary fiber feed had a slight black stool from 10 to 12 hours until 20 hours later. Confirmed. All of the yellow leaf extract showed earlier black stools or more stools compared to the negative control (see Table 1).
  • a weight of 150-200 g of SD-rat (Sam taco) was sacrificed by cervical distal bone, the abdomen was cut and the colon was separated and then washed with Krebs solution.
  • Krebs solution is 111 mM sodium chloride (NaCl), 5.9 mM potassium chloride (KCl), 1.2 mM magnesium chloride (MgCl 2 ) 2.0 mM calcium chloride (CaCl 2 ), 1.2 mM sodium hydrogen phosphate (NaH 2 PO 4 ), 25 mM sodium bicarbonate ( NaHCO 3 ), a composition of 11.5 mM glucose.
  • Hwangchil-tree leaf extract The effect of Hwangchil-tree leaf extract on the basic tension of isolated colon slices was determined by adding 0.5 mg / ml and 1 mg / ml of Hwangchil-tree leaf extract when the motility of the colon tissue was stabilized and the tension was kept constant. The change of and amplitude was measured.
  • Hwangchil-tree leaf extract was found to affect the intestinal motility.
  • 1 mg / ml of the extract was administered, it was confirmed that the contractile relaxation response of the colon was increased, and it was observed that the bowel movement was improved to improve the bowel function (see FIG. 6).
  • the above ingredients are mixed and filled in an airtight cloth to prepare a powder.
  • tablets are prepared by tableting according to a conventional method for preparing tablets.
  • the above ingredients are mixed and filled into gelatin capsules to prepare capsules.
  • the amount of the above ingredient is prepared per ampoule (2 ml).
  • Vitamin B6 0.5 mg
  • composition ratio of the above-mentioned vitamin and mineral mixtures is mixed with a component suitable for a health food in a preferred embodiment, the compounding ratio may be arbitrarily modified, and the above ingredients are mixed according to a conventional health food manufacturing method.
  • the granules may be prepared and used for preparing a health food composition according to a conventional method.
  • the resulting solution is filtered and obtained in a sterilized 2 L container, sealed sterilization and refrigerated Used to prepare the healthy beverage composition of the invention.
  • composition ratio is a composition that is relatively suitable for the preferred beverage in a preferred embodiment
  • compounding ratio may be arbitrarily modified according to regional and ethnic preferences such as demand hierarchy, demand country, and usage.
  • the present invention relates to a composition for treating and preventing intestinal diseases, which contains the extract of Hilchi chinensis as an active ingredient.
  • the present inventors have studied the present invention to find a natural product excellent in the treatment of intestinal diseases, in particular constipation, Hwangchil-tree leaf extract was confirmed that the excellent intestinal motility, intestinal effect and constipation improvement effect in rats and various intestines such as constipation
  • the present invention was completed by confirming that it is useful for the treatment and prevention of diseases.
  • the present invention relates to a pharmaceutical composition for the treatment and prevention of bowel disease, containing the Hwangchil-tree leaf extract as an active ingredient.
  • the present invention also relates to a health functional food for the prevention and improvement of intestinal diseases containing the Hwangchil-tree leaf extract as an active ingredient.
  • Extracts as defined herein include water, lower alcohols of C 1 to C 4 or mixed solvents thereof, preferably extracts available in water or a mixed solvent of water and ethanol, more preferably 50 to 90% ethanol extracts. do.
  • the bowel disease includes functional constipation such as laxative constipation, constipation, constipation, constipation disorders; Stenosis of the intestinal tract, elongated S. colitis, organic constipation such as giant colon syndrome, diarrhea, diverticulitis, diarrhea constipation symptom, irritable bowel syndrome (IBS) and the like, preferably characterized by containing constipation.
  • functional constipation such as laxative constipation, constipation, constipation, constipation disorders
  • Stenosis of the intestinal tract elongated S. colitis
  • organic constipation such as giant colon syndrome, diarrhea, diverticulitis, diarrhea constipation symptom, irritable bowel syndrome (IBS) and the like, preferably characterized by containing constipation.
  • IBS irritable bowel syndrome
  • the extract of the present invention after washing and drying the yellow lacquer leaves, about 1 to 100 times the weight of the sample, preferably about 1 to 50 times (w / v) volume of water, C 1 to C Lower alcohol of 4 or a mixed solvent thereof, preferably water or water and ethanol as an extraction solvent, about 2 to 7 days at a reaction temperature of about 10 to 120 °C, preferably 30 to 90 °C, preferably
  • Hwangchil-tree leaves extract of the present invention can be obtained through a step comprising a method of preparing a fourth step of freeze-drying the concentrated extract.
  • the present invention provides a pharmaceutical composition and health functional food for the treatment and prevention of intestinal diseases containing the production method and the Hwangchil-tree leaf extract prepared by the production method as an active ingredient.
  • the Hwangchil-tree leaf extract prepared above was confirmed to be effective in the treatment and prevention of various bowel diseases such as constipation by confirming the excellent intestinal motility, intestinal effect and constipation improvement effect in rats.
  • composition of the present invention comprises 0.01 to 99% by weight of the herbal extract based on the total weight of the composition.
  • composition as described above is not necessarily limited thereto, and may vary according to the condition of the patient and the type and extent of the disease.
  • composition comprising the extract of the present invention may further comprise suitable carriers, excipients and diluents commonly used in the manufacture of pharmaceutical compositions.
  • compositions comprising extracts according to the invention are formulated in the form of powders, granules, tablets, capsules, suspensions, emulsions, syrups, aerosols and the like, oral preparations, suppositories and sterile injectable solutions, respectively, according to conventional methods.
  • the carriers, excipients and diluents that may be incorporated therein include lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, acacia rubber, alginate, gelatin, calcium phosphate, calcium Silicates, cellulose, methyl cellulose, microcrystalline cellulose, polyvinyl pyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, magnesium stearate and mineral oil.
  • diluents or excipients such as fillers, extenders, binders, wetting agents, disintegrating agents, and surfactants are usually used.
  • Solid preparations for oral administration include tablets, pills, powders, granules, capsules, and the like, and such solid preparations include at least one or more excipients in the compound, at least cotton, starch, calcium carbonate, sucrose. Or lactose, gelatin, or the like is mixed. In addition to simple excipients, lubricants such as magnesium styrate talc are also used. Oral liquid preparations include suspending agents, liquid solutions, emulsions, and syrups, and may include various excipients, such as wetting agents, sweeteners, fragrances, and preservatives, in addition to commonly used simple diluents such as water and liquid paraffin. .
  • Formulations for parenteral administration include sterile aqueous solutions, non-aqueous solvents, suspensions, emulsions, lyophilized preparations, suppositories.
  • non-aqueous solvent and suspending agent propylene glycol, polyethylene glycol, vegetable oil such as olive oil, injectable ester such as ethyl oleate and the like can be used.
  • base of the suppository witepsol, macrogol, tween 61, cacao butter, laurin butter, glycerol gelatin and the like can be used.
  • Preferred dosages of the extracts of the present invention vary depending on the condition and weight of the patient, the extent of the disease, the form of the drug, the route of administration and the duration, and may be appropriately selected by those skilled in the art.
  • the extract is preferably administered at 0.01 mg / kg to 10 g / kg, preferably 1 mg / kg to 1 g / kg per day. Administration may be administered once a day or may be divided several times. Therefore, the above dosage does not limit the scope of the present invention in any aspect.
  • composition of the present invention can be administered to mammals such as rats, mice, livestock, humans, etc. by various routes. All modes of administration can be expected, for example by oral and rectal or intravenous methods.
  • the present invention provides a health functional food for the improvement and prevention of intestinal diseases containing hwangchil tree leaf extract as an active ingredient.
  • Health functional foods containing the extract of the present invention can be used in a variety of drugs, foods and drinks for the prevention and improvement of intestinal diseases.
  • Foods to which the extract of the present invention may be added include, for example, various foods, beverages, gums, teas, vitamin complexes, leach teas, health supplements, and the like, and are in the form of powders, granules, tablets, capsules, or beverages. Can be used.
  • the present invention also provides a food or food additive containing the Hwangchil-tree leaf extract having an effect of preventing and improving intestinal diseases as an active ingredient.
  • Food forms to which the extract of the present invention can be added include various foods, beverages, gums, teas, vitamin complexes, or health supplements of candy.
  • Extract of the present invention may be added to food or beverages for the purpose of preventing and improving bowel disease.
  • the amount of the extract in the food or beverage is generally added to the health food composition of the present invention to 0.01 to 15% by weight of the total food weight, the health beverage composition is 0.02 to 10 g based on 100 ml, preferably Can be added in a ratio of 0.3 to 1 g.
  • the health beverage composition of the present invention contains a mixture of the extract as an essential ingredient in the indicated ratios, and there is no particular limitation on the liquid component, and may contain various flavors or natural carbohydrates as additional ingredients, such as ordinary drinks.
  • natural carbohydrates are conventional monosaccharides such as disaccharides such as glucose and fructose, such as maltose, sucrose and the like, and polysaccharides such as dextrin, cyclodextrin and the like.
  • Sugars and sugar alcohols such as xylitol, sorbitol, and erythritol.
  • natural flavoring agents such as, tauumatin, stevia extract (e.g., Rebaudioside A, glycyrrhizin, etc.) and synthetic flavoring agents (saccharin, aspartame, etc.) can be advantageously used.
  • the proportion of such natural carbohydrates is generally about 1 to 20 g, preferably about 5 to 12 g per 100 ml of the composition of the present invention.
  • the composition of the present invention includes various nutrients, vitamins, minerals (electrolytes), flavors such as synthetic flavors and natural flavors, coloring and neutralizing agents (such as cheese and chocolate), pectic acid and salts thereof, alginic acid and its Salts, organic acids, protective colloidal thickeners, pH adjusters, stabilizers, preservatives, glycerin, alcohols, carbonation agents used in carbonated beverages, and the like.
  • the compositions of the present invention may also contain pulp for the production of natural fruit juices and fruit juice beverages and vegetable beverages. These components can be used independently or in combination. The proportion of such additives is not so critical but is generally selected from the range of 0 to about 20 parts by weight per 100 parts by weight of the composition of the present invention.

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Abstract

L'invvention concerne une composition comprenant de l'extrait de feuilles de Dendropanax Morbifera, ainsi qu'une composition pharmaceutique et une nourriture fonctionnelle saine comprenant un poudre ou un extrait obtenu par extraction et concentration de3 feuille de Dendropanax Morbifera à l'aide de différents solvants, ceci afin de prévenir et de traiter les maladies intestinales comme la constipation par activation de l'entérokinésie. Il a été prouvé que l'extrait de feuilles de Dendropanax Morbifera selon la présente invention possède d'excellents effets de promotion de l'entérokinèse, de traitement des troubles intestinaux, et d'amélioration de la constipation lors d'une expérience chez les rats. L'extrait de feuilles de Dendropanax Morbifera peuvent avantageusement être utilisé comme composition pharmaceutique et comme nourriture fonctionnelle saine afin de prévenir et de traiter les maladies intestinales comme la constipation par activation de l'entérokinèse.
PCT/KR2012/008596 2012-10-19 2012-10-19 Composition comprenant de l'extrait de feuilles de dendropanax morbifera en qualité d'ingrédient actif afin de traiter et prévenir les maladies intestinales WO2014061838A1 (fr)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108208516A (zh) * 2018-02-06 2018-06-29 张艳飞 一种固体饮料及其制备方法与应用

Citations (4)

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Publication number Priority date Publication date Assignee Title
KR20000004499A (ko) * 1998-06-30 2000-01-25 박호군 항암 활성을 가지는 황칠나무 추출물
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