WO2014051318A3 - Système de délivrance de gènes d'un arn interférent court pour la circulation systémique - Google Patents

Système de délivrance de gènes d'un arn interférent court pour la circulation systémique Download PDF

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Publication number
WO2014051318A3
WO2014051318A3 PCT/KR2013/008560 KR2013008560W WO2014051318A3 WO 2014051318 A3 WO2014051318 A3 WO 2014051318A3 KR 2013008560 W KR2013008560 W KR 2013008560W WO 2014051318 A3 WO2014051318 A3 WO 2014051318A3
Authority
WO
WIPO (PCT)
Prior art keywords
delivery system
systemic circulation
gene delivery
rna gene
interference rna
Prior art date
Application number
PCT/KR2013/008560
Other languages
English (en)
Korean (ko)
Other versions
WO2014051318A2 (fr
Inventor
김용희
임광석
이현린
Original Assignee
한양대학교 산학협력단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020130060230A external-priority patent/KR101497668B1/ko
Application filed by 한양대학교 산학협력단 filed Critical 한양대학교 산학협력단
Priority to US14/431,586 priority Critical patent/US9713645B2/en
Priority to CN201380061873.7A priority patent/CN104870023A/zh
Publication of WO2014051318A2 publication Critical patent/WO2014051318A2/fr
Publication of WO2014051318A3 publication Critical patent/WO2014051318A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/32—Special delivery means, e.g. tissue-specific

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne un système de délivrance de gènes qui améliore la délivrance de siRNA et l'efficacité de la circulation systémique in vivo de celui-ci. L'invention concerne plus particulièrement un système de délivrance de gènes siRNA pour la circulation systémique à base de polyéthylène glycol (PEG) et d'un peptide d'arginine 9 (R9).
PCT/KR2013/008560 2012-09-28 2013-09-25 Système de délivrance de gènes d'un arn interférent court pour la circulation systémique WO2014051318A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US14/431,586 US9713645B2 (en) 2012-09-28 2013-09-25 Short interference RNA gene delivery system for systemic circulation
CN201380061873.7A CN104870023A (zh) 2012-09-28 2013-09-25 用于全身循环的短干扰rna基因传递系统

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR10-2012-0109003 2012-09-28
KR20120109003 2012-09-28
KR10-2013-0060230 2013-05-28
KR1020130060230A KR101497668B1 (ko) 2012-09-28 2013-05-28 전신 순환을 위한 짧은 간섭 rna 유전자 전달체

Publications (2)

Publication Number Publication Date
WO2014051318A2 WO2014051318A2 (fr) 2014-04-03
WO2014051318A3 true WO2014051318A3 (fr) 2014-05-22

Family

ID=50389092

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2013/008560 WO2014051318A2 (fr) 2012-09-28 2013-09-25 Système de délivrance de gènes d'un arn interférent court pour la circulation systémique

Country Status (1)

Country Link
WO (1) WO2014051318A2 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070207966A1 (en) * 2006-03-03 2007-09-06 University Of Utah Polymeric carrier for delivery of small interfering RNA
KR100825519B1 (ko) * 2007-01-05 2008-04-25 주식회사 바이오폴리메드 키토산 기재 고분자 접합체 및 그 제조방법
KR20100105674A (ko) * 2007-12-13 2010-09-29 뽈리쁠뤼스-트랑스펙씨옹 합성 중합체를 사용하여 유전자 사일런싱에 활성이 있는 핵산을 전달하기 위한 수단
US20110053829A1 (en) * 2009-09-03 2011-03-03 Curevac Gmbh Disulfide-linked polyethyleneglycol/peptide conjugates for the transfection of nucleic acids

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070207966A1 (en) * 2006-03-03 2007-09-06 University Of Utah Polymeric carrier for delivery of small interfering RNA
KR100825519B1 (ko) * 2007-01-05 2008-04-25 주식회사 바이오폴리메드 키토산 기재 고분자 접합체 및 그 제조방법
KR20100105674A (ko) * 2007-12-13 2010-09-29 뽈리쁠뤼스-트랑스펙씨옹 합성 중합체를 사용하여 유전자 사일런싱에 활성이 있는 핵산을 전달하기 위한 수단
US20110053829A1 (en) * 2009-09-03 2011-03-03 Curevac Gmbh Disulfide-linked polyethyleneglycol/peptide conjugates for the transfection of nucleic acids

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EL-SAYED, AYMAN ET AL.: "Delivery of macromolecules using arginine-rich cell-penetrating peptides: ways to overcome endosomal entrapment", THE AAPS JOURNAL, vol. 11, no. 1, 2009, pages 13 - 22 *

Also Published As

Publication number Publication date
WO2014051318A2 (fr) 2014-04-03

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