WO2014051318A3 - Short interference rna gene delivery system for systemic circulation - Google Patents
Short interference rna gene delivery system for systemic circulation Download PDFInfo
- Publication number
- WO2014051318A3 WO2014051318A3 PCT/KR2013/008560 KR2013008560W WO2014051318A3 WO 2014051318 A3 WO2014051318 A3 WO 2014051318A3 KR 2013008560 W KR2013008560 W KR 2013008560W WO 2014051318 A3 WO2014051318 A3 WO 2014051318A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- delivery system
- systemic circulation
- gene delivery
- rna gene
- interference rna
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/32—Special delivery means, e.g. tissue-specific
Abstract
The present invention relates to a gene delivery system which improves siRNA delivery and the in vivo systemic circulation efficiency thereof More particularly, the present invention is a siRNA gene delivery system for systemic circulation based on polyethylene glycol (PEG) and an arginine 9 (R9) peptide.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14/431,586 US9713645B2 (en) | 2012-09-28 | 2013-09-25 | Short interference RNA gene delivery system for systemic circulation |
CN201380061873.7A CN104870023A (en) | 2012-09-28 | 2013-09-25 | Short interference RNA gene delivery system for systemic circulation |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2012-0109003 | 2012-09-28 | ||
KR20120109003 | 2012-09-28 | ||
KR1020130060230A KR101497668B1 (en) | 2012-09-28 | 2013-05-28 | A siRNA gene Delivery System for Systemic Circulation |
KR10-2013-0060230 | 2013-05-28 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2014051318A2 WO2014051318A2 (en) | 2014-04-03 |
WO2014051318A3 true WO2014051318A3 (en) | 2014-05-22 |
Family
ID=50389092
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/KR2013/008560 WO2014051318A2 (en) | 2012-09-28 | 2013-09-25 | Short interference rna gene delivery system for systemic circulation |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2014051318A2 (en) |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070207966A1 (en) * | 2006-03-03 | 2007-09-06 | University Of Utah | Polymeric carrier for delivery of small interfering RNA |
KR100825519B1 (en) * | 2007-01-05 | 2008-04-25 | 주식회사 바이오폴리메드 | A chitosan based polymer conjugate and a method for producing the same |
KR20100105674A (en) * | 2007-12-13 | 2010-09-29 | 뽈리쁠뤼스-트랑스펙씨옹 | Means for delivery of nucleic acids active for gene silencing using synthetic polymers |
US20110053829A1 (en) * | 2009-09-03 | 2011-03-03 | Curevac Gmbh | Disulfide-linked polyethyleneglycol/peptide conjugates for the transfection of nucleic acids |
-
2013
- 2013-09-25 WO PCT/KR2013/008560 patent/WO2014051318A2/en active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070207966A1 (en) * | 2006-03-03 | 2007-09-06 | University Of Utah | Polymeric carrier for delivery of small interfering RNA |
KR100825519B1 (en) * | 2007-01-05 | 2008-04-25 | 주식회사 바이오폴리메드 | A chitosan based polymer conjugate and a method for producing the same |
KR20100105674A (en) * | 2007-12-13 | 2010-09-29 | 뽈리쁠뤼스-트랑스펙씨옹 | Means for delivery of nucleic acids active for gene silencing using synthetic polymers |
US20110053829A1 (en) * | 2009-09-03 | 2011-03-03 | Curevac Gmbh | Disulfide-linked polyethyleneglycol/peptide conjugates for the transfection of nucleic acids |
Non-Patent Citations (1)
Title |
---|
EL-SAYED, AYMAN ET AL.: "Delivery of macromolecules using arginine-rich cell-penetrating peptides: ways to overcome endosomal entrapment", THE AAPS JOURNAL, vol. 11, no. 1, 2009, pages 13 - 22 * |
Also Published As
Publication number | Publication date |
---|---|
WO2014051318A2 (en) | 2014-04-03 |
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