WO2014049745A1 - Instrument d'administration de liquide - Google Patents

Instrument d'administration de liquide Download PDF

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Publication number
WO2014049745A1
WO2014049745A1 PCT/JP2012/074772 JP2012074772W WO2014049745A1 WO 2014049745 A1 WO2014049745 A1 WO 2014049745A1 JP 2012074772 W JP2012074772 W JP 2012074772W WO 2014049745 A1 WO2014049745 A1 WO 2014049745A1
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WO
WIPO (PCT)
Prior art keywords
housing
drive gear
gear
plunger
administration device
Prior art date
Application number
PCT/JP2012/074772
Other languages
English (en)
Japanese (ja)
Inventor
滋晃 冨家
正臣 今井
学 有延
Original Assignee
テルモ株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by テルモ株式会社 filed Critical テルモ株式会社
Priority to PCT/JP2012/074772 priority Critical patent/WO2014049745A1/fr
Publication of WO2014049745A1 publication Critical patent/WO2014049745A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M2005/14533—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons cam actuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M2005/3152—Piston or piston-rod constructions, e.g. connection of piston with piston-rod including gearings to multiply or attenuate the piston displacing force

Definitions

  • the present invention relates to a liquid administration device.
  • Patent Document 1 a prefilled syringe that is filled with a chemical solution aseptically and that can administer the chemical solution is known (for example, see Patent Document 1).
  • the prefilled syringe is a syringe outer cylinder having a mouth part for discharging a chemical solution, a needle tube provided at the mouth part of the syringe outer cylinder and having a sharp needle tip at the tip, a gasket capable of sliding in the syringe outer cylinder, A drug solution filled in a space surrounded by the syringe outer cylinder and the gasket, and a plunger connected to the proximal end side of the gasket and pressing the gasket toward the distal end to discharge the drug solution from the mouth.
  • the needle tube is punctured into the living body, and the plunger is pressed in this punctured state.
  • medical solution will be discharged from a mouth part with a gasket, Therefore The said chemical
  • the object of the present invention is to reduce the force required for liquid administration, to easily reduce the liquid administration speed, and to easily apply liquid to a user who is difficult to press the plunger.
  • the object is to provide a liquid administration device that can be administered.
  • the present invention is provided with a syringe having a discharge port provided at a tip end, filled with a liquid and having a cylindrical shape, and a gasket slidably installed in the outer tube, and the discharge port
  • a liquid administration device for administering the liquid via A housing having a mounting portion to which the syringe is mounted at a tip portion;
  • a drive gear provided with a drive rotary shaft and installed in the housing so as to be rotatable around the drive rotary shaft, and at least a part of the drive gear protrudes from the housing and is operated to rotate the drive gear.
  • a reduction mechanism that reduces the rotational speed of the drive gear and transmits the rotational force of the drive gear to the rack;
  • By rotating the drive gear by operating the operation unit in a mounted state in which the syringe is mounted on the mounting unit, the rotational speed of the drive gear is reduced by the reduction mechanism, and the drive gear
  • a liquid administration device wherein a rotational force is transmitted to the rack, the plunger moves in a distal direction, and the plunger pushes the gasket in the distal direction to move in the distal direction. is there.
  • the speed reduction mechanism is rotatably installed in the housing, includes a speed reduction rotation shaft, and rotates about the speed reduction rotation shaft by rotation of the drive gear.
  • the gear wheel has a smaller pitch circle radius than the first gear, and rotates integrally with the first gear about the reduction rotation shaft, and the rotational force associated with the rotation is transmitted to the rack. It is preferable to provide a gear assembly having a second gear.
  • the pitch circle radius of the first gear is preferably larger than the pitch circle radius of the drive gear.
  • liquid administration device of the present invention it is preferable that a part of the operation portion protrudes to the outside from a side portion on the opposite side of the rack of the housing with the reduction rotation shaft interposed therebetween.
  • the plunger moves in the distal direction. It is preferable that it is comprised.
  • the operation portion is disposed at a base end portion of the housing, and a part of the operation portion protrudes outside from the base end portion of the housing.
  • the distance from the drive rotation shaft to the power point in the operation unit when operating the operation unit is longer than the pitch circle radius of the drive gear.
  • the operation unit has a disk shape.
  • the syringe that is attached to the attachment portion and filled with the liquid in advance.
  • the plunger is moved while being decelerated by the deceleration mechanism, the force required for the liquid administration operation can be reduced, so that even a liquid having a relatively high viscosity can be easily and reliably obtained. Can be administered.
  • the liquid administration rate can be easily reduced. As a result, it is possible to easily and reliably administer a liquid that needs to be administered at a low rate, reduce pain during the administration of the liquid, and prevent leakage of the liquid. it can.
  • the plunger is moved by rotating the rotating body with the operation unit, for example, even a user who has difficulty with fingers and cannot easily press the plunger directly uses the palm of his hand. By operating the operation unit, the liquid can be easily administered.
  • FIG. 1 is a perspective view showing a first embodiment of the liquid administration device of the present invention.
  • FIG. 2 is a cross-sectional view of the liquid administration device shown in FIG.
  • FIG. 3 is a sectional view of a first housing member of the housing of the liquid administration device shown in FIG. 4 is a cross-sectional view of a second housing member of the housing of the liquid administration device shown in FIG.
  • FIG. 5 is a perspective view of a rotating body of the liquid administration device shown in FIG.
  • FIG. 6 is a perspective view of the gear assembly of the liquid administration device shown in FIG.
  • FIG. 7 is a perspective view of a plunger of the liquid administration device shown in FIG. FIG.
  • FIG. 8 is a perspective view of the outer cylinder and needle tube of the syringe of the liquid administration device shown in FIG.
  • FIG. 9 is a perspective view for explaining an assembly procedure of the liquid administration device shown in FIG.
  • FIG. 10 is a perspective view for explaining an assembly procedure of the liquid administration device shown in FIG.
  • FIG. 11 is a perspective view for explaining an assembly procedure of the liquid administration device shown in FIG. 1.
  • FIG. 12 is a perspective view for explaining an assembly procedure of the liquid administration device shown in FIG.
  • FIG. 13 is a cross-sectional view for explaining the operation in using the liquid administration device shown in FIG.
  • FIG. 14 is a cross-sectional view for explaining the operation when using the liquid administration device shown in FIG. FIG.
  • FIG. 15 is a cross-sectional view for explaining an operation when the liquid administration device shown in FIG. 1 is used.
  • FIG. 16 is a cross-sectional view for explaining the operation in using the liquid administration device shown in FIG.
  • FIG. 17 is a cross-sectional view for explaining the operation when using the liquid administration device shown in FIG.
  • FIG. 18 is a cross-sectional view for explaining the operation in using the liquid administration device shown in FIG.
  • FIG. 19 is a cross-sectional view showing a second embodiment of the liquid administration device of the present invention.
  • liquid administration device of the present invention will be described in detail based on preferred embodiments shown in the accompanying drawings.
  • FIG. 1 is a perspective view showing a first embodiment of the liquid administration device of the present invention.
  • FIG. 2 is a cross-sectional view of the liquid administration device shown in FIG.
  • FIG. 3 is a sectional view of a first housing member of the housing of the liquid administration device shown in FIG. 4 is a cross-sectional view of a second housing member of the housing of the liquid administration device shown in FIG.
  • FIG. 5 is a perspective view of a rotating body of the liquid administration device shown in FIG.
  • FIG. 6 is a perspective view of the gear assembly of the liquid administration device shown in FIG.
  • FIG. 7 is a perspective view of a plunger of the liquid administration device shown in FIG. FIG.
  • FIG. 8 is a perspective view of the outer cylinder and needle tube of the syringe of the liquid administration device shown in FIG. 9 to 12 are perspective views for explaining the procedure for assembling the liquid administration device shown in FIG. 13 to 18 are cross-sectional views for explaining the operation when using the liquid administration device shown in FIG.
  • the upper side in FIGS. 1 to 4 and 7 to 18 is referred to as “base end (rear end)”, the lower side is referred to as “tip”, and the vertical direction is referred to as “axial direction” or “longitudinal direction”.
  • a liquid administration device 1 shown in FIGS. 1 to 18 is a medical instrument used when a liquid is administered (injected) into a living body.
  • the liquid is appropriately selected according to the purpose of use.
  • protein drugs such as antibodies, peptide drugs such as low molecular weight proteins and hormones, nucleic acid drugs, cell drugs, blood products, various infectious diseases Examples include vaccines, anticancer agents, anesthetics, narcotics, antibiotics, steroids, proteolytic enzyme inhibitors, etc. that are mainly injected subcutaneously.
  • the liquid administration device 1 includes a rotating body 3, a gear assembly 4 that is a speed reduction mechanism, a plunger 5, a syringe 6, and a housing 2 that houses them. I have.
  • the housing 2 has a long box shape in the vertical direction in FIG. 1, and an opening is formed at the tip thereof.
  • the housing 2 includes two members, that is, a first housing member 2a and a second housing member 2b joined to each other.
  • four holes 26 are formed in the wall portion of the distal end portion of the first housing member 2a, and the inner surface of the distal end portion of the second housing member 2b is fitted into the four holes 26.
  • Four protrusions 27 are formed. And each 1st housing member 2a and 2nd housing member 2b are joined because each protrusion part 27 fits in each hole 26, respectively.
  • the joining method of the 1st housing member 2a and the 2nd housing member 2b is not restricted to this,
  • fusion such as heat fusion, high frequency fusion, ultrasonic fusion, or an adhesive agent or solvent
  • adhesive agent such as heat fusion, high frequency fusion, ultrasonic fusion
  • solvent such as solvent
  • the housing 2 has a mounting portion 24 to which the syringe 6 is mounted at the tip thereof.
  • the longitudinal direction of the housing 2 and the axial direction of the outer cylinder 7 described later of the syringe 6 coincide with each other, and at least the distal end portion of the needle tube 9 described later of the syringe 6 It protrudes outside from the front-end
  • the entire needle tube 9 protrudes to the outside.
  • the present invention is not limited to this. For example, only the distal end portion of the needle tube 9 may protrude to the outside.
  • the mounting portion 24 has engaging portions 241 and 242 that engage with a flange 71 of an outer cylinder 7 (described later) of the syringe 6 in a mounting state in which the syringe 6 is mounted on the mounting portion 24.
  • the engaging portion 241 is a rib formed on the inner surface of the first housing member 2a
  • the engaging portion 242 is a rib formed on the inner surface of the second housing member 2b.
  • the engaging portions 241 and 242 are arranged so as to face each other with a predetermined distance therebetween. The engagement portions 241 and 242 can prevent the syringe 6 from being detached from the mounting portion 24.
  • the housing 2 has a pair of bearings 21 that rotatably support a shaft portion 33 (described later) of the rotating body 3 and a shaft portion 43 (described later) of the gear assembly 4 at the base end portion thereof. It has a pair of bearings 22 to support. These bearings 21 and 22 are provided such that the shaft portion 33 and the shaft portion 43 are parallel to each other.
  • the bearings 21 are arranged at the base end of the housing 2 so as to be separated from each other by a predetermined distance and to face each other.
  • Each bearing 21 includes a unit support portion 21a formed on the first housing member 2a and a unit support portion 21b formed on the second housing member 2b.
  • the unit support portion 21a and the unit support portion It is formed by abutting 21b.
  • each bearing 22 is arranged at the base end portion of the housing 2 so as to be separated from each other by a predetermined distance and to face each other.
  • Each bearing 22 includes a unit support portion 22a formed on the first housing member 2a and a unit support portion 22b formed on the second housing member 2b. The unit support portion 22a and the unit support portion It is formed by abutting 22b.
  • each support part 22 is located in the front end side rather than each support part 21.
  • the housing 2 has a rail 25 that supports a rack 513 of a main body 51 (described later) of the plunger 5 so as to be movable in the longitudinal direction.
  • the rail 25 extends in the longitudinal direction of the housing 2.
  • the rack 513 moves along the rail 25 in the longitudinal direction of the housing 2, that is, in the longitudinal direction of the rack 513.
  • the housing 2 has a support portion 23 that supports the plunger 5 so as to be movable in the axial direction.
  • the support portion 23 includes a unit support portion 23a formed on the first housing member 2a and a unit support portion 23b formed on the second housing member 2b.
  • the support portion 23 is arranged in the longitudinal direction of the housing.
  • a through hole 231 is provided.
  • a main shaft portion 511 of a main body portion 51 described later of the plunger 5 is inserted into the hole 231, and the moving direction is restricted by an edge portion facing the hole 231 of the support portion 23, so that the plunger 5 has a longitudinal direction of the housing, That is, it can move only in the axial direction of the main shaft portion 511.
  • the housing 2 has an opening 28 at its base end.
  • the opening 28 is formed from the base end wall to the side wall of the housing.
  • a part of a later-described operation unit 31 of the rotating body 3 protrudes from the opening 28 to the outside.
  • the rotating body 3 includes an operation unit 31 and a drive gear 32, and is rotatably installed at the base end of the housing 2.
  • the operation unit 31 is a member to be rotated, and in the present embodiment, has a disk shape, that is, a relatively low columnar shape.
  • a plurality of grooves (not shown), that is, knurls, are formed on the outer peripheral surface of the operation unit 31 along the circumferential direction. Thereby, smoothness of the fingers and palms when the operation unit 31 is rotated with the fingers and palms can be prevented.
  • the rotating body 3 may be formed of an elastic material such as various rubber materials such as a constituent material of the gasket body 81 of the gasket 8 to be described later, various thermoplastic elastomers, and a mixture thereof. Without forming the plurality of grooves, it is possible to prevent a finger or palm from slipping when the operation unit 31 is rotated.
  • the operation unit 31 and the drive gear 32 are arranged concentrically, and the drive gear 32 is fixed to the side surface of the operation unit 31.
  • the operation portion 31 and the drive gear 32 are fixed to the shaft portion 33, and the shaft portion 33 is supported by the pair of bearings 21 of the housing 2 so as to be rotatable about the central axis with respect to the housing 2.
  • the drive gear 32 has a drive rotation shaft that coincides with the central axis of the shaft portion 33. Accordingly, when the operation unit 31 is rotated, the rotating body 3 is rotated, that is, the drive gear 32 is rotated around the drive rotation axis.
  • the operation unit 31 and the drive gear 32 may be separated from each other.
  • the drive gear 32 is accommodated in the housing 2, and a part of the operation portion 31 protrudes from the housing 2, and the remaining portion is accommodated in the housing 2.
  • a part of the operation part 31 protrudes outside from the opening 28 of the housing. That is, a part of the operation unit 31 protrudes outside from a side portion opposite to the rack 513 of the housing 2 across a later-described reduction rotation shaft that is a rotation shaft of the first gear 41, and further, Projects to the outside from the base end.
  • the operation part 31 can be operated easily. That is, since the operation part 31 protrudes outside from two places, the base end part and side part of the housing 2, it can be operated in any of the two places.
  • the distance from the drive rotation shaft to the outer peripheral surface of the operation unit 31, that is, the radius of the operation unit 31 is from the drive rotation shaft to a position where the drive gear 32 meshes with a first gear 41 described later of the gear assembly 4. Is greater than the pitch circle radius of the drive gear 32.
  • the radius of the operation unit 31 is preferably 2 to 10 times the pitch circle radius of the drive gear 32, and more preferably 3 to 5 times.
  • the drive rotation shaft is a fulcrum
  • the outer peripheral surface of the operation unit 31 is a power point
  • the position where the drive gear 32 meshes with a first gear 41 (to be described later) of the gear assembly 4 acts. It becomes a point.
  • the drive unit 32 can be rotated by rotating the operation unit 31 with a relatively small force. That is, the plunger 5 can be moved by rotating the operation unit 31 with a relatively small force, and the plunger 5 can be easily moved at a relatively low speed.
  • the pitch circle radius of a gear is the distance from the rotation axis (center) of the gear to the position where the gear meshes with another gear. That is, the pitch circle radius of the drive gear 32 is a distance from the drive rotation shaft (center of the drive gear 32) to a position where the drive gear 32 meshes with a first gear 41 (to be described later) of the gear assembly 4. .
  • the gear assembly 4 has a first gear 41 and a second gear 42, and is rotatably installed at the base end portion of the housing 2. Yes.
  • the gear assembly 4 is a reduction mechanism that reduces the rotational speed of the drive gear 32, amplifies the rotational force of the drive gear 32, and transmits it to a rack 513 (to be described later) of the plunger 5.
  • the first gear 41 and the second gear 42 are arranged concentrically, the first gear 41 meshes with the drive gear 32, and the second gear 42 is attached to a rack 513, which will be described later, of the plunger 5. It meshes and is fixed to the side surface of the first gear 41.
  • the first gears 41 and 42 are fixed to the shaft portion 43, and the shaft portion 43 is supported by the pair of bearings 22 of the housing 2 so as to be rotatable about the central axis with respect to the housing 2.
  • the first gear 41 has a reduction rotation shaft that coincides with the central axis of the shaft portion 43.
  • the first gear 41 and the second gear 42 rotate integrally around the same rotation axis, that is, the reduction rotation axis.
  • the first gear 41 is rotated by the rotation of the drive gear 32, and the rotational force associated with the rotation is transmitted from the second gear 42 to the rack 513.
  • the shaft portion 43 is installed so as to be parallel to the shaft portion 33.
  • the first gears 41 and 42 are housed in the housing 2, respectively. The first gears 41 and 42 may be separated from each other.
  • the pitch circle radius of the second gear 42 is smaller than the pitch circle radius of the first gear 41.
  • the pitch circle radius of the second gear 42 is preferably 1/4 to 2/3 of the pitch circle radius of the first gear 41, and more preferably 1/3 to 1/2.
  • the reduction rotation shaft is a fulcrum
  • the position where the first gear 41 meshes with the drive gear 32 is the power point
  • the second gear 42 meshes with the rack 513 of the plunger 5.
  • the position is the point of action.
  • the pitch circle radius of the second gear 42 is smaller than the pitch circle radius of the first gear 41, the rotational force of the second gear is amplified and transmitted to the rack 513.
  • the rotational speed of the drive gear 32 is reduced, and the rotational force of the drive gear 32 is transmitted to the rack 513 of the plunger 5. Can be moved.
  • the pitch circle radius of the first gear 41 is larger than the pitch circle radius of the drive gear 32.
  • the pitch circle radius of the first gear 41 is preferably 1.5 to 5 times, more preferably 2 to 3 times the pitch circle radius of the drive gear 32.
  • the plunger 5 is a member that presses a gasket 8, which will be described later, of the syringe 6 in the distal direction, that is, from a proximal end position in an outer cylinder 7 which will be described later toward the distal end position.
  • the plunger 5 includes a main body portion 51 and a pressing portion 52 that is provided at the distal end portion of the main body portion 51 and abuts against the gasket 8 during use and presses the gasket 8 in the distal end direction.
  • the main body 51 is connected to the main shaft portion 511 provided on the distal end side, the rack 513 provided on the proximal end side and meshing with the second gear 42 of the gear assembly 4, and the main shaft portion 511 and the rack 513.
  • the connection part 512 is comprised. Note that the axial direction of the main shaft portion 511 and the longitudinal direction of the rack 513 coincide.
  • the plunger 5 is installed in the housing 2 so that the axial direction of the main shaft portion 511 coincides with the longitudinal direction of the housing 2 and is movable in the axial direction of the main shaft portion 511. That is, first, the rack 513 of the plunger 5 is supported by the rail 25 of the housing 2 so as to be movable in the longitudinal direction.
  • the main shaft portion 511 of the plunger 5 is inserted into the hole 231 of the support portion 23 of the housing 2, and the movement direction is restricted by the edge portion facing the hole 231 of the support portion 23. It can move only in the direction, that is, the axial direction of the main shaft portion 511.
  • the plunger 5 is movable in the distal direction and the proximal direction.
  • the plunger 5 is not limited thereto, and may be installed to be movable only in the distal direction, for example.
  • the pressing portion 52 of the plunger 5 has a plate shape in the present embodiment, and the shape in plan view is a circular shape.
  • the pressing portion 52 is provided at the tip of the main shaft portion 511.
  • the pressing portion 52 In the initial state, that is, in the unused state, the pressing portion 52 is located at a position spaced apart from the core member 82 of the gasket 8 (described later) of the syringe 6 by a predetermined distance in the proximal direction (see FIGS. 1, 13, and 14). ). Thereby, when assembling the liquid administration tool 1, interference with the plunger 5 and the syringe 6 can be prevented, and it can assemble easily and reliably.
  • the position of the plunger 5 when not in use is referred to as an “initial position”.
  • the base end portion of the rack 513 contacts the base end wall of the housing 2, thereby preventing the plunger 5 from moving in the base end direction (see FIG. 14). Thereby, in the unused state, even if it is going to rotate the operation part 31 in the direction where the plunger 5 moves to a base end direction, the operation part 31 does not rotate.
  • the connecting portion 512 of the plunger 5 has an L shape in this embodiment.
  • the rack 513 is disposed at a position shifted from the axis of the plunger 5, that is, the axis of the main shaft portion 511.
  • the rotating body 3 and the gear assembly 4 can be disposed above the gasket 8, that is, in the space on the proximal end side of the gasket 8, whereby the liquid administration device 1 can be reduced in size.
  • Rotational motion of the second gear 42 is converted into linear motion of the rack 513 of the plunger 5. That is, the rotational force of the second gear 42 is transmitted to the rack 513 of the plunger 5, the plunger 5 moves in the distal direction, and the pressing portion 52 presses the gasket 8 of the syringe 6 in the distal direction. As a result, the gasket 8 moves in the distal direction in the outer cylinder 7.
  • the liquid administration device 1 when the rotating body 3, that is, the drive gear 32 is rotated such that a portion of the operation portion 31 that protrudes from the side portion of the housing 2 to the outside is moved in the distal direction.
  • the plunger 5 moves in the distal direction, and the gasket 8 moves in the distal direction.
  • the operation direction of the operation unit 31 and the movement direction of the plunger 5 coincide with each other, thereby enabling operation without a sense of incongruity.
  • the syringe 6 is provided with a bottom portion at the distal end portion and an opening portion at the proximal end portion, and is mounted on the outer cylinder 7 that can be filled with liquid, and the bottom portion of the outer cylinder 7.
  • a needle tube 9 having a sharp needle tip 91 at the distal end and a proximal end communicating with the outer cylinder 7, and moving from the proximal end position, which will be described later, to the distal end position along the axial direction of the outer cylinder 7 within the outer cylinder 7.
  • a gasket 8 to be obtained.
  • the outer cylinder 7 is composed of a bottomed cylindrical member having a bottom portion at the tip and an opening at the base end.
  • the side wall of the outer cylinder 7 has a cylindrical shape.
  • the outer diameter and the inner diameter of the bottom portion of the outer cylinder 7, that is, the distal end portion gradually decrease from the proximal end side toward the distal end side.
  • a needle tube 9 is attached to the central portion of the distal end portion of the outer cylinder 7.
  • tip part of the outer cylinder 7 comprises the discharge port which discharges
  • a plate-like flange 71 is integrally formed on the outer periphery of the base end of the outer cylinder 7.
  • a gasket 8 is accommodated (inserted) so as to be slidable (movable) along the axial direction of the outer cylinder 7.
  • the gasket 8 includes a gasket main body 81 made of an elastic material, and a core member 82 that is provided on the proximal end side of the gasket main body 81 and supports the gasket main body 81.
  • the base end of the core member 82 is located on the base end side with respect to the base end of the gasket body 81, and the pressing portion 52 of the plunger 5 comes into contact with the base end surface of the core member 82 in use. Yes.
  • a plurality (two in this embodiment) of ring-shaped protrusions 811 are formed on the entire outer periphery of the gasket body 81, and these protrusions 811 are in close contact with the inner peripheral surface of the outer cylinder 7. By sliding while sliding, the liquid-tightness can be more reliably maintained and the slidability can be improved.
  • the gasket body 81 is formed with a hollow portion that opens to the base end surface thereof, and the distal end portion of the core member 82 is fitted into the hollow portion, whereby the core member 82 supports the gasket body 81. .
  • the gasket body 81 and the core member 82 are not limited to the connection by fitting, for example, a structure connected by screwing or the like, a structure fixed by adhesion, fusion, or the like, or a structure in which the core member 82 is omitted. May be.
  • the space surrounded by the gasket 8 and the outer cylinder 7 is filled with a liquid in advance. Then, by moving the gasket 8 toward the distal end, that is, from the base end position in the outer cylinder 7 to the distal end position, the liquid in the outer cylinder 7 can be pushed out from the needle tube 9, that is, discharged.
  • the base end position of the gasket 8 is the position of the gasket 8 in the axial direction of the outer cylinder 7 in a state where the space surrounded by the gasket 8 and the outer cylinder 7 is filled with the liquid.
  • the tip position is the position of the gasket 8 in the axial direction of the outer cylinder 7 in a state where all of the filled liquid is discharged.
  • polyvinyl chloride polyethylene, polypropylene, cyclic polyolefin, Polystyrene such as polystyrene, poly- (4-methylpentene-1), polycarbonate, acrylic resin, acrylonitrile-butadiene-styrene copolymer, polyethylene terephthalate, polyethylene naphthalate, butadiene-styrene copolymer, polyamide (for example, nylon) 6, various types of resins such as nylon 6,6, nylon 6,10, nylon 12).
  • polypropylene, cyclic polyolefin, polyester, poly- (4-methyl) are easy to mold.
  • pentene-1) Resin are easy to mold.
  • the material constituting the gasket body 81 is not particularly limited.
  • various rubber materials such as natural rubber, butyl rubber, isoprene rubber, butadiene rubber, styrene-butadiene rubber, silicone rubber, polyurethane, polyester, Examples thereof include various thermoplastic elastomers such as polyamide, olefin, and styrene, or elastic materials such as a mixture thereof.
  • the needle tube 9 is attached to the center of the tip of the outer cylinder 7 and has a sharp needle tip 91 at the tip. A living body can be punctured with the needle tip 91. Further, the lumen (hollow part) of the needle tube 9 communicates with the outer cylinder 7 and functions as a flow path through which the liquid from the outer cylinder 7 passes. And in the state which punctured the biological body with the needle point 91, a liquid is inject
  • the constituent material of the needle tube 9 is not particularly limited.
  • the needle tube 9 is made of a metal material such as stainless steel, aluminum or an aluminum alloy, titanium or a titanium alloy.
  • a cap (not shown) is attached to the needle tube 9, and the needle tube 9 is covered with the cap.
  • the syringe 6 is mounted on the mounting portion 24 of the housing 2.
  • the flange 71 of the outer cylinder 7 is engaged with the engaging portions 241 and 242 of the mounting portion 24 from the proximal end side, and thereby the syringe 6 is prevented from being detached from the mounting portion 24.
  • the plunger 5 is installed on the second housing member 2 b of the housing 2.
  • the rack 513 of the plunger 5 is installed on the rail 25, and the main shaft portion 511 is inserted into the unit support portion 23 b that forms a part of the hole 231 of the support portion 23.
  • the gear assembly 4 is installed in the second housing member 2b.
  • the shaft portion 43 of the gear assembly 4 is installed on a pair of unit support portions 22 b constituting a part of the pair of bearings 22, and the second gear 42 is engaged with the rack 513.
  • the rotating body 3 is installed in the second housing member 2b.
  • the shaft portion 33 of the rotating body 3 is installed on a pair of unit support portions 21 b constituting a part of the pair of bearings 21, and the drive gear 32 is engaged with the first gear 41.
  • the syringe 6 is attached to the second housing member 2b.
  • the flange 71 of the outer cylinder 7 is engaged with the engaging portion 242 of the mounting portion 24 from the proximal end side.
  • the second housing member 2b and the first housing member 2a are joined.
  • the protrusions 27 of the second housing member 2b are fitted into the holes 26 of the first housing member 2a while aligning the second housing member 2b and the first housing member 2a.
  • the assembly of the liquid administration device 1 is completed.
  • an unused liquid administration device 1 is prepared, and a needle tube 9 of the liquid administration device 1 is punctured into a living body.
  • the operation unit 31 is rotated (turned) clockwise in FIG. 15 to administer the liquid in the outer cylinder 7 to the living body.
  • the operation of the operation unit 31 can be performed with a finger or a palm, for example.
  • the operation unit 31 by operating the operation unit 31 to rotate the drive gear 32, the rotation of the drive gear 32 is decelerated by the gear assembly 4, which is a reduction mechanism, and the rotational force of the drive gear 32 is applied to the plunger 5. Transmitted to the rack 513, the plunger 5 moves in the distal direction, and the pressing portion 52 of the plunger 5 comes into contact with the gasket 8.
  • the operation gear 31 When the operation gear 31 is further operated to further rotate the drive gear 32, the plunger 5 further moves in the distal direction, and the plunger 8 is pressed in the distal direction by the plunger 5 and moved in the distal direction.
  • the gasket 8 moves from the proximal end position in the outer cylinder 7 to the distal end position, whereby the liquid in the outer cylinder 7 is discharged from the needle tube 9 and administered to the living body.
  • the gear assembly 4 decelerates the rotation of the drive gear 32 and transmits the rotational force of the drive gear 32 to the rack 513 to move the plunger 5.
  • the force required for the operation of the operation unit 31 during the administration of the liquid can be reduced, so that even a liquid having a relatively high viscosity can be easily and reliably administered.
  • the gear assembly 4 decelerates the rotation of the drive gear 32 and transmits the rotational force of the drive gear 32 to the rack 513 to move the plunger 5, the liquid administration speed can be easily reduced. it can. As a result, it is possible to easily and reliably administer a liquid that needs to be administered at a low rate, reduce pain during the administration of the liquid, and prevent leakage of the liquid. it can.
  • the plunger 5 is moved by rotating the operation unit 31, for example, even a user who has difficulty with fingers and is difficult to press the plunger 5 directly uses the palm of his hand. By operating the operation unit 31, the liquid can be easily administered.
  • the operation unit 31 and the drive gear 32 are fixed to the shaft portion 33, and the shaft portion 33 is rotatably installed with respect to the housing 2.
  • the present invention is not limited to this.
  • 33 may be fixed to the housing 2, and the operation unit 31 and the drive gear 32 may be rotatably installed with respect to the shaft unit 33.
  • the first gears 41 and 42 are fixed to the shaft portion 43, and the shaft portion 43 is rotatably installed with respect to the housing 2.
  • the present invention is not limited to this.
  • 43 may be fixed to the housing 2, and the first gears 41 and 42 may be rotatably installed with respect to the shaft portion 43.
  • FIG. 19 is a cross-sectional view showing a second embodiment of the liquid administration device of the present invention.
  • the upper side in Fig. 19 is referred to as “base end (rear end)”
  • the lower side is referred to as “tip end”
  • the vertical direction is referred to as "axial direction” or “longitudinal direction.”
  • the part 31 and the ratchet 11 are side views.
  • the liquid administration device 1 includes a ratchet 11 including a gear 111 and a pawl 112 as a rotation direction restricting portion that restricts the rotation direction of the rotating body 3. .
  • the gear 111 of the ratchet 11 is fixed to the shaft portion 33 of the rotating body 3 and is disposed concentrically with the operation portion 31 and the drive gear 32. Further, the pawl 112 is fixed to the housing 2.
  • the teeth of the gear 111 are inclined counterclockwise in FIG. 19, and the pawl 112 is arranged on the left side of the gear 111 in FIG.
  • the ratchet 11 prevents the rotating body 3 from rotating counterclockwise in FIG. 19, and the rotating body 3 rotates only clockwise in FIG.
  • the ratchet 11 prevents the operation unit 31 from rotating counterclockwise in FIG. 19, thereby preventing the plunger 5 from moving in the proximal direction. it can. For this reason, for example, even when the plunger 5 and the gasket 8 are connected, it is possible to prevent the gasket 8 from moving in the proximal direction.
  • liquid administration device of the present invention has been described based on the illustrated embodiment, but the present invention is not limited to this, and the configuration of each part is replaced with an arbitrary configuration having the same function. can do. In addition, any other component may be added to the present invention.
  • the present invention may be a combination of any two or more configurations (features) of the above embodiments.
  • the liquid administration device of the above embodiment is a disposable type in which a syringe is previously mounted on the mounting portion of the housing.
  • the syringe is detachable from the mounting portion of the housing. You may be comprised so that it may mount
  • the syringe has no flange, the outer cylinder in which the discharge port at the tip is sealed with a rubber stopper, and both heads that support the outer cylinder and can be pierced with the rubber stopper of the outer cylinder at the tip.
  • a needle can be attached, and a holder having a threaded portion at the proximal end portion is provided, and the syringe can be detachably mounted on the housing mounted portion by the threaded portion of the holder.
  • the syringe is preliminarily filled with the liquid.
  • the present invention is not limited to this, and the syringe may be filled with the liquid later.
  • the syringe is included in the component of the liquid administration device.
  • the present invention is not limited to this, and the syringe may not be included in the component of the liquid administration device.
  • the operation unit has a disk shape.
  • the operation unit may have any shape as long as it forms a part of the rotating body. Examples of other shapes of the operation unit include a rod shape extending in the radial direction of the drive gear from the drive rotation shaft.
  • a plurality of protrusions protruding in the radial direction along the circumferential direction may be formed on the outer peripheral part of the disk-shaped operation part.
  • the protrusions are arranged at equiangular intervals.
  • the number of the protrusions may be one.
  • a notch may be formed in a part of the disk-shaped operation unit. In this case, it is preferable that the notch is located in the housing while the gasket moves from the proximal end position to the distal end position.
  • the operation unit may be constituted by the outer peripheral part of the drive gear, and the drive gear may be rotated by operating the outer peripheral part.
  • the drive gear may be rotated by operating the outer peripheral part.
  • at least a part of the drive gear protrudes from the housing to the outside.
  • the speed reduction mechanism is configured by the gear assembly 4 having the first gear 41 and the second gear 42.
  • the present invention is not limited to this.
  • One or more other gears may be interposed between the first gear and one or more other gears may be interposed between the second gear and the rack. Good.
  • the rotational force transmitted from the drive gear to the rack of the plunger is reduced, so that the drive gear and the first gear mesh with each other as in the above embodiment, and the second gear and It is preferable that the rack meshes.
  • the drive gear and the speed reduction mechanism may be composed of a worm gear.
  • the drive gear is a worm whose teeth are continuously cut in a spiral shape on a cylinder
  • the speed reduction mechanism is a worm wheel whose teeth are cut on the side surface of the disk in accordance with the worm.
  • the liquid administration device of the present invention is provided with a syringe having a discharge port provided at the tip, filled with a liquid, and having a cylindrical outer cylinder and a gasket slidably installed in the outer cylinder.
  • a liquid administration device for administering the liquid through the outlet A housing having a mounting portion to which the syringe is mounted at a tip portion;
  • a drive gear provided with a drive rotary shaft and installed in the housing so as to be rotatable around the drive rotary shaft, and at least a part of the drive gear protrudes from the housing and is operated to rotate the drive gear.
  • a rotating body having an operation unit;
  • a plunger having a rack, installed in the housing so as to be movable in a distal direction, and pressing the gasket in the distal direction;
  • a reduction mechanism that reduces the rotational speed of the drive gear and transmits the rotational force of the drive gear to the rack;
  • the plunger is moved while being decelerated by the deceleration mechanism, the force required for the liquid administration operation can be reduced, so that even a liquid having a relatively high viscosity can be easily and reliably obtained. Can be administered.
  • the liquid administration rate can be easily reduced. As a result, it is possible to easily and reliably administer a liquid that needs to be administered at a low rate, reduce pain during the administration of the liquid, and prevent leakage of the liquid. it can.
  • the plunger is moved by rotating the rotating body with the operation unit, for example, even a user who has difficulty with fingers and cannot easily press the plunger directly uses the palm of his hand. By operating the operation unit, the liquid can be easily administered.

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'instrument d'administration de liquide (1) de l'invention est équipé : d'un logement (2) possédant une partie montage (24) sur laquelle est montée une seringue (6) ; d'un corps de rotation (3) qui possède un engrenage d'entraînement (32) disposé de manière à pouvoir tourner à l'intérieur du logement (2), et une partie manipulation (31) dont une partie est en saillie depuis le logement (2) vers une partie externe et qui fait tourner l'engrenage d'entraînement (32) ; d'un piston (5) qui possède une crémaillère (513), qui est disposé de manière à pouvoir se déplacer dans une direction extrémité avant à l'intérieur du logement (2), et qui presse un joint d'étanchéité (8) dans la direction extrémité avant ; et d'un mécanisme de réduction de vitesse qui réduit la vitesse de rotation de l'engrenage d'entraînement (32), et qui transmet la force de rotation de ce dernier à la crémaillère (513). Dans un état dans lequel la seringue (6) est montée sur la partie montage (24), comme l'engrenage d'entraînement (32) est mis en rotation par manipulation de la partie manipulation (31), alors la vitesse de rotation de l'engrenage d'entraînement (32) est réduite à l'aide du mécanisme de réduction de vitesse, la force de rotation de l'engrenage d'entraînement (32) est transmise à la à la crémaillère (513), le piston (5) est déplacé dans la direction extrémité avant, et le joint d'étanchéité (8) de la seringue (6) est pressé et déplacé dans la direction extrémité avant par le piston (5).
PCT/JP2012/074772 2012-09-26 2012-09-26 Instrument d'administration de liquide WO2014049745A1 (fr)

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Application Number Priority Date Filing Date Title
PCT/JP2012/074772 WO2014049745A1 (fr) 2012-09-26 2012-09-26 Instrument d'administration de liquide

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Application Number Priority Date Filing Date Title
PCT/JP2012/074772 WO2014049745A1 (fr) 2012-09-26 2012-09-26 Instrument d'administration de liquide

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018204779A1 (fr) * 2017-05-05 2018-11-08 Regeneron Pharmaceuticals, Inc. Auto-injecteur
US11406565B2 (en) 2015-03-10 2022-08-09 Regeneran Pharmaceuticals, Inc. Aseptic piercing system and method
USD1007676S1 (en) 2021-11-16 2023-12-12 Regeneron Pharmaceuticals, Inc. Wearable autoinjector

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005245999A (ja) * 2004-03-01 2005-09-15 Tekutoron:Kk 手動液体注入器
JP2011518018A (ja) * 2008-04-21 2011-06-23 メドトロニック カルディオ ヴァスキュラー インコーポレイテッド 深度が制御された注入のための装置および方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005245999A (ja) * 2004-03-01 2005-09-15 Tekutoron:Kk 手動液体注入器
JP2011518018A (ja) * 2008-04-21 2011-06-23 メドトロニック カルディオ ヴァスキュラー インコーポレイテッド 深度が制御された注入のための装置および方法

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11406565B2 (en) 2015-03-10 2022-08-09 Regeneran Pharmaceuticals, Inc. Aseptic piercing system and method
WO2018204779A1 (fr) * 2017-05-05 2018-11-08 Regeneron Pharmaceuticals, Inc. Auto-injecteur
KR20200004805A (ko) 2017-05-05 2020-01-14 리제너론 파아마슈티컬스, 인크. 자동 주사기
US11547801B2 (en) 2017-05-05 2023-01-10 Regeneron Pharmaceuticals, Inc. Auto-injector
USD1007676S1 (en) 2021-11-16 2023-12-12 Regeneron Pharmaceuticals, Inc. Wearable autoinjector

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