WO2014036945A1

WO2014036945A1 - Centrifuge tube structure

Info

Publication number: WO2014036945A1
Application number: PCT/CN2013/082940
Authority: WO
Inventors: 杨朝城
Original assignee: Yang Chaocheng
Priority date: 2012-09-10
Filing date: 2013-09-04
Publication date: 2014-03-13
Also published as: AU2013312546A1; AU2013312546B2; CN103657756A

Abstract

Disclosed is a centrifuge tube structure. The centrifuge tube structure comprises a tube body (2), a first blocking body (3), and a second blocking body (4). The tube body (2) has a first receiving trough (20), a second receiving trough (22), and a necking portion (21). The necking portion (21) is connected to the first receiving trough (20) and the second receiving trough (22). The first blocking body (3) is fixed on the first receiving trough (20), and defines a fixed volume compartment (200) with the first receiving trough (20) commonly. The second blocking body (4) moves along the second receiving trough (22), and defines a variable volume compartment (220) with the second receiving trough (22) commonly. The necking portion (21) defines a fluid communication path (210) to communicate the fixed volume compartment (200) with the variable volume compartment (220).

Description

Technical field

The invention relates to a centrifuge tube structure, in particular to a centrifuge tube structure for conveniently extracting a thin layer solution. Background technique

With the daily development of biomedical technology, the medical community has also been more and more complete research on human blood. Among them, all kinds of ingredients contained in the blood have their corresponding important effects. Therefore, if these components contained in the blood can be smoothly separated and used as medical adjuvant treatment, the current medical effects can be greatly improved. . At present, a common way to separate various components in blood is to put a blood-containing test tube into a centrifuge to start, so that the blood in the test tube is centrifuged, and various components in the blood will be simply layered. .

As described above, after the centrifugation of the test tube by the centrifuge, at least the upper liquid, the middle liquid, and the lower liquid are usually formed in the test tube. The upper liquid is mainly plasma, the lower liquid is mainly red blood cells, and the middle liquid is a blood clot yellow layer, mainly platelets, white blood cells and stem cells. Among them, the yellow blood clot is especially valuable because of its medical and commercial value. However, the yellow layer of the blood clot in the test tube is a thin layer. Because the thickness of the yellow layer of the blood clot is small, it is not easy to extract in an ordinary test tube, so it is necessary to be extra careful when extracting, otherwise it is easy to accidentally extract the upper liquid. Or the lower layer of liquid, so this step is indeed difficult for the extractor to operate.

For example, Chinese Patent Publication No. 201124191 discloses a "biological device for extracting hematopoietic stem cells and mesenchymal stem cells from peripheral blood". As shown in Fig. 1, the biological device comprises a body 11 and a top cover 10. Wherein, the body 11 has a bottle neck portion 110, and the top cover 10 is movable forwardly and backwardly in the longitudinal direction of the body 11, and the top cover 10 is operated by a user to rotate the top cover 10 along the body. 11 forward and backward. However, the top cover 10 of the biological device has no need for movement. If the top cover 10 can be changed to a fixed type, even if the top cover 10 and the body 11 are integrally formed, the structure and the ease of manufacture thereof will be In addition, if the top cover 10 is modified from the movable type to the fixed body 11, the biological device can be emphasized as a one-time use, so as to prevent the unscrupulous person from lowering the cost of the biological device. The cover 10 is unscrewed, removed, cleaned and reused.

Furthermore, the biological device further includes a bottom cover 13, and the bottom cover 13 is operated by rotation by an operator to advance and retreat the bottom cover 13 in the longitudinal direction of the body 11. The package further discloses an encapsulation portion 12 for closing the lower storage tank 120 of the body 11. The operator can rotate the bottom cover 13 to push the encapsulation portion 12, thereby reducing The volume of the storage tank 120 is reduced. However, the operator's action of twisting the bottom cover by the finger causes the force component of the force application to be perpendicular to the longitudinal axis of the body 11 when the force is applied, so that the entire biological device is likely to be shaken left and right, resulting in It is clear that the layered upper liquid, the middle liquid, and the lower liquid are mutually mixed.

In view of the above, a centrifugal tube structure is provided, which not only facilitates the extraction of the stratified solution, but also greatly simplifies the structure for manufacturing convenience, and further ensures the disposable use of the centrifuge tube structure, and reduces the use of the lower storage tank. In the case of volume, the operator's direction of application is along a longitudinal axis to avoid sloshing the layered solution in the centrifuge tube structure, which is a current goal in the industry. Summary of the invention

In view of the deficiencies of the prior art, the main object of the present invention is to provide a centrifugal tube structure, which fixes the first blocking body to the first receiving groove to ensure that it is used once and at the same time simplifies the structure. Designed for easier manufacturing.

Another object of the present invention is to provide a centrifugal tube structure that receives an axial thrust, so that when the solution pushed into the centrifuge tube structure rises, it is difficult to shake left and right, so that the operator extracts the layered solution. .

In order to achieve the above object, the technical solution provided by the present invention is to provide a centrifuge tube structure, comprising a tube body, a first blocking body and a second blocking body, the tube body having a first receiving groove, a second accommodating groove and a necking portion connecting the first accommodating groove and the second accommodating groove; the first blocking body is fixed to the first accommodating groove, and the first accommodating groove The second blocking body includes a bottom cover and a piston portion, the bottom cover is fixed to the bottom end of the second receiving groove, and the piston portion closes the second receiving groove; The piston portion is received in the second accommodating groove, and the piston portion and the second accommodating groove together define a variable volume space; wherein the neck portion defines a communication channel, and the communication channel The fixed volume space and the variable volume space are communicated.

Preferably, the first receiving groove has a first opening, and the first blocking body is fixed to the first opening of the first receiving groove.

Preferably, the first blocking body and the first receiving groove are integrally formed.

Preferably, the first blocking body has an air hole corresponding to the necking portion, wherein the fixed volume space is connected to an outside via the air hole.

Preferably, the first blocking body further has a liquid inflow hole, and the liquid inflow hole is adjacent to the air hole. Preferably, the first blocking body includes two plugs for blocking the liquid inflow hole and the air hole respectively; wherein the plug blocking the air hole has a socket, and a fine pin is disposed through The plug of the plug a hole to enter the first receiving groove.

Preferably, the neck portion has a cross-sectional area smaller than a cross-sectional area of the first receiving groove and a cross-sectional area of the second receiving groove.

Preferably, the piston portion moves in the second accommodating groove to define the variable volume space together with the second accommodating groove; or the piston portion is received in the second accommodating groove, And the piston portion is adapted to receive an external force to deform to jointly define the variable volume space with the second receiving groove.

Preferably, the second blocking body further includes a push rod, and a central portion of the bottom cover is a hollow portion; the push rod passes through the hollow portion and is connected to the piston portion, and the push rod receives an external force The push rod is adapted to push the piston portion toward the neck portion.

The present invention also provides a centrifuge tube structure, comprising a tube body, a first blocking body and a second blocking body, the tube body having a first receiving groove, a second receiving groove and connecting the same a first receiving groove and a necking portion of the second receiving groove; the first blocking body is fixed to the first receiving groove and defines a fixed volume space together with the first receiving groove; The second blocking body and the second receiving groove define a variable volume space; wherein the necking portion defines a communication passage, and the communication passage communicates with the fixed volume space and the variable volume space.

Preferably, the first receiving groove has a first opening, and the first blocking body is fixed to the first opening.

Preferably, the first blocking body further has a liquid inflow hole, and the liquid inflow hole is adjacent to the air hole. Preferably, the first blocking body includes two plugs for blocking the liquid inflow hole and the air hole respectively; wherein the plug blocking the air hole has a socket, and a fine pin is disposed through The jack of the plug is inserted into the first receiving slot.

Preferably, the second blocking body includes a piston portion, and the piston portion is received in the second receiving groove and moves in the second receiving groove to define the second receiving groove. Or the second blocking body includes a piston portion, the piston portion is received in the second receiving groove, and the piston portion is adapted to receive an external force to deform The second receiving groove collectively defines the variable volume space. Preferably, the second blocking body further includes a bottom cover, and the bottom cover is disposed at a bottom end of the second receiving groove, such that the piston portion is located between the bottom cover and the neck portion.

Preferably, the bottom cover is movably disposed in the second receiving groove, and when the bottom cover moves toward the neck portion, the bottom cover is adapted to push the piston portion together, and the piston portion faces the The neck is moving.

Preferably, the surface of the bottom cover is formed with a male thread, and the surface of the second receiving groove is formed with a female thread, and the male thread is adapted to cooperate with the female thread to make the bottom cover rotate in an axial direction. It is appropriate to make a movement along the axial direction at the same time.

Preferably, the bottom cover has a negative structure, and the second receiving groove has a positive structure, and the negative structure is adapted to cooperate with the male structure to make the bottom cover slide relative to the second receiving groove.

Preferably, the bottom cover is fixed to the second receiving groove, and a central portion of the bottom cover is a hollow portion.

Preferably, the second blocking body further comprises a push rod, wherein the push rod passes through the hollow portion and is connected to the piston portion, and when the push rod receives an external force, the push rod is adapted to push the piston portion Move toward the neck portion.

Preferably, the second blocking body further includes a push rod, wherein the push rod is coupled to the piston portion, and when the push rod receives an external force, the push rod is adapted to push the piston portion toward the neck portion .

The present invention also provides a centrifuge tube structure, comprising a tube body, a fixed cover body and a bottom cover, the tube body having a first accommodating groove, a second accommodating groove and connecting the first accommodating groove a fixing portion of the second accommodating groove; wherein the first accommodating groove has a fixing means; the fixing cover body is coupled to the fixing means of the first accommodating groove, and the fixing means makes the fixing The cover body is fixed to the first receiving groove; the bottom cover is disposed at the bottom end of the second receiving groove.

Preferably, the fixed cover body has air holes and a liquid inlet and outlet hole corresponding to the neck portion; wherein the fixed volume space is connected to an outside through the air hole. When a pumping device is housed in the liquid inlet and outlet, a portion of the pumping device enters the neck portion.

Preferably, the centrifugal tube structure further includes a piston portion, and the piston portion is received in the second receiving groove and movable in the second receiving groove.

Preferably, the second receiving slot has a movable means, and the bottom cover is coupled to the movable means to enable the bottom cover to be movably disposed in the second receiving groove.

Preferably, the piston portion is located between the bottom cover and the neck portion. When the bottom cover moves toward the neck portion, the bottom cover is adapted to push the piston portion together, and the piston portion faces the neck portion. The contraction moves.

Preferably, the movable means of the second accommodating groove is a female thread of the second accommodating groove, and a surface of the bottom cover is formed with a male thread, and the male thread is adapted to cooperate with the female thread to make the bottom The cover is rotated in an axial direction It is appropriate to move at the same time along the axial direction.

Preferably, the movable means of the second receiving groove is a positive structure of the second receiving groove, the bottom cover has a negative structure, and the male structure is adapted to cooperate with the negative structure, so that the bottom cover can be opposite The second receiving groove is made to slide.

Preferably, the centrifuge tube structure further includes a push rod, wherein the push rod is coupled to the piston portion, and the push rod is adapted to push the piston portion toward the neck portion when the push rod receives an external force.

The present invention also provides a centrifuge tube structure, comprising a tube body, a first blocking body and a second blocking body, the tube body having a first receiving groove, a second receiving groove and connecting the same a first receiving groove and a necking portion of the second receiving groove; the first blocking body is fixed and limited to the upper edge of the groove of the first receiving groove; the second blocking body is movably coupled to The lower edge of the groove of the second accommodating groove; wherein, the first blocking body, the first accommodating groove, the necking portion, the second accommodating groove and the second blocking body are common A volume space is defined; a capacity distribution state of the volume space can be changed by moving the second blocking body.

Preferably, the second blocking body further includes a piston portion, and the piston portion is received in the second receiving groove and movable in the second receiving groove.

Preferably, the second blocking body further includes a push rod connected to the piston portion; wherein the push rod is adapted to push along a longitudinal axis when the push rod receives an axial thrust The piston portion linearly moves toward the neck portion to reduce the volume; or, when the push rod receives an axial pulling force, the push rod is adapted to pull the piston portion along a longitudinal axis, Moving linearly away from the necking to increase the volume.

Preferably, one end of the push rod is connected to the piston portion to be integrally formed with the piston portion; or, one end of the push rod is hooked to the piston portion.

Preferably, the second blocking body further includes a bottom cover, the bottom cover is movably disposed at a lower edge of the groove of the second receiving groove; wherein, when the bottom cover moves toward the necking portion, The bottom cover is adapted to push the piston portion together to move the piston portion toward the neck portion to reduce the volume; or, when the bottom cover moves away from the neck portion, the bottom cover Preferably, the piston portion is pulled together to move the piston portion away from the neck portion to increase the volume.

The present invention also provides a centrifuge tube structure, comprising a tube body, a first blocking body and a second blocking body, the tube body having a first receiving groove, a second receiving groove and connecting the same a first receiving groove and a necking portion of the second receiving groove; the first blocking body covers the first receiving groove; the second blocking body comprises a bottom cover and a piston portion, the bottom The cover is fixed to the bottom end of the second accommodating groove, the piston portion closes the second accommodating groove, and the piston portion is movable in the second accommodating groove. Preferably, the centrifugal tube structure further includes a push rod, wherein the push rod is connected to the piston portion, and when the push rod receives an axial thrust, the push rod is adapted to push the piston portion along a longitudinal axis The direction moves linearly in the direction of the neck portion.

Preferably, the central portion of the bottom cover is a hollow portion.

Preferably, the centrifugal tube structure further comprises a push rod, wherein the push rod passes through the hollow portion and is connected to the piston portion, and when the push rod receives an axial top thrust, the push rod is adapted to push the piston The portion moves linearly in the direction of the neck portion along a longitudinal axis.

Preferably, the first blocking body is fixed to the first receiving groove to define a fixed volume space together with the first receiving groove; or the first blocking body is movably disposed on the first blocking body A receiving groove cooperates with the first receiving groove to define a variable volume space.

Preferably, the first blocking body has an air hole corresponding to the necking portion, wherein the fixed volume space or the variable volume space is connected to an outside via the air hole.

Preferably, the necked portion has a cross-sectional area smaller than a cross-sectional area of the first receiving groove and a cross-sectional area of the second receiving groove, respectively.

The present invention also provides a centrifuge tube structure comprising a tube body, a first blocking body, a piston portion and a push rod, the tube body having a first receiving groove, a second receiving groove and a connection a first necking groove and a necking portion of the second receiving groove; the first blocking body covers the first receiving groove; the piston portion closes the second receiving groove, and the piston portion can Moving in the second accommodating groove; the push rod is connected to the piston portion, and when the push rod is pushed by an external force, the piston portion is correspondingly pushed along a longitudinal axis toward the neck portion The direction moves in a straight line.

Preferably, the external force received by the push rod is an axial top thrust to urge the piston portion to move linearly in a longitudinal direction toward the neck portion.

Preferably, the centrifuge tube structure further includes a bottom cover fixed to the bottom end of the second receiving groove, such that the piston portion is located between the bottom cover and the neck portion.

Preferably, the first blocking body is fixed to the first receiving groove to define a fixed volume space together with the first receiving groove; or the first blocking body is movably disposed on the first blocking body A receiving groove cooperates with the first receiving groove to define another variable volume space. Preferably, the first blocking body has an air hole corresponding to the necking portion; the fixed volume space or the variable volume space is connected to an outside via the air hole.

The present invention also provides a centrifuge tube structure, comprising a tube body, a first blocking body and a movable member, the tube body having a first receiving groove, a second receiving groove and connecting the first volume a necking portion and a necking portion of the second receiving groove; the first blocking body covers the first receiving groove; the movable member closes the second receiving groove, and the movable member is adapted to receive an axis The thrust is pushed upward to linearly move the movable member in a longitudinal direction toward the neck portion.

Preferably, the movable member includes a piston portion that together with the second receiving groove defines a variable volume space.

Preferably, the movable member further includes a push rod connected to the piston portion; wherein the push rod is adapted to receive the axial top thrust to push the piston portion along the axial direction toward the neck portion Moving, the variable volume is reduced.

Preferably, the first blocking body is fixed to the first receiving groove to define a fixed volume space together with the first receiving groove; or the first blocking body is movably disposed on the first blocking body A receiving groove cooperates with the first receiving groove to define another variable volume space.

Preferably, the first blocking body has an air hole corresponding to the necking portion; wherein the fixed volume space or the variable volume space is connected to an outside via the air hole.

The present invention also provides a centrifuge tube structure, comprising a tube body, a first blocking body and a movable member, the tube body having a first receiving groove, a second receiving groove and communicating the first volume a necking portion of the groove and the second receiving groove; the first blocking body covers the upper edge of the groove of the first receiving groove; the movable member closes the lower edge of the groove of the second receiving groove Wherein, a total volume space is defined between the first blocking body, the first receiving groove, the necking portion, the second receiving groove and the movable member, and the movable member is suitable An axial thrust is applied to move the movable member linearly in a longitudinal direction toward the neck portion and change a capacity distribution state of the total volume space.

Preferably, the movable member includes a piston portion that is received in the second receiving groove and movable in the second receiving groove.

Preferably, the movable member further includes a push rod connected to the piston portion; wherein the push rod is adapted to push the piston portion along a longitudinal axis when the push rod receives an axial thrust Moving linearly in the direction of the neck portion to reduce the total volume space; or, when the push rod receives an axial pulling force, the push rod is adapted to pull the piston portion along a longitudinal axis, Moving linearly away from the necking to increase the total volume. Preferably, one end of the push rod is connected to the piston portion to be integrally formed with the piston portion; or, one end of the push rod is hooked to the piston portion.

Preferably, the movable member further includes a bottom cover movably disposed at a lower edge of the groove of the second receiving groove; wherein the bottom cover is moved when the bottom cover moves toward the neck portion Suitably, the piston portion is pushed to move the piston portion toward the neck portion to reduce the total volume space; or, when the bottom cover moves away from the neck portion, the bottom cover is adapted The piston portion is pulled together to move the piston portion away from the neck portion to increase the total volume.

The centrifuge tube structure of the present invention makes it easier for the operator to extract the layered solution by designing a neck portion having a narrower cross-sectional area. The centrifuge tube structure of the present invention can be designed such that the first blocking body and the first receiving groove are fixed to each other and cannot be relatively moved or separated to ensure that the centrifugal tube structure disclosed in the present invention is disposable and simplified at the same time. The structural design of the centrifuge tube structure makes it easier to mass-produce in manufacturing. In addition, the centrifugal tube structure of the present invention can also be designed such that the bottom cover is fixed at the lower edge of the groove body of the second accommodating groove, so that the piston portion is limited. The movable member of the present invention is designed to receive an axial force to push the piston portion, so that when the operator performs the pulling action, the force can be prevented from being applied in other directions, which may result in a component force. It is applied to the structure of the centrifuge tube to cause the structure of the centrifuge tube to shake side to side. DRAWINGS

1 is a schematic cross-sectional view of a conventional biological device.

Figure 2 is a schematic cross-sectional view showing the first embodiment of the centrifuge tube structure of the present invention before the blood has been pushed up. Fig. 3 is a cross-sectional view showing the first embodiment of the structure of the centrifuge tube of the present invention after the blood has been pushed up and inserted into the fine needle.

Figure 4 is a cross-sectional view showing a second embodiment of the centrifuge tube structure of the present invention.

Figure 5 is a cross-sectional view showing a third embodiment of the centrifugal tube structure of the present invention.

Figure 6 is a cross-sectional view showing a fourth embodiment of the centrifugal tube structure of the present invention.

Figure 7 is a cross-sectional view showing a fifth embodiment of the centrifugal tube structure of the present invention.

Figure 8 is a cross-sectional view showing a sixth embodiment of the centrifugal tube structure of the present invention.

Figure 9 is a cross-sectional view showing a seventh embodiment of the centrifugal tube structure of the present invention.

Figure 10 is a cross-sectional view showing the eighth embodiment of the centrifugal tube structure of the present invention.

Figure 11 is a cross-sectional view showing a ninth embodiment of the structure of the centrifuge tube of the present invention. detailed description

The following examples are intended to illustrate the invention and are not intended to limit the invention. It should be noted that, in the following embodiments and drawings, elements that are not related to the present invention have been omitted and are not shown.

The main inventive spirit of the present invention is to disclose a centrifuge tube structure for accommodating blood to be separated and doped with a small amount of anticoagulant to prevent blood from solidifying during operation. After the operator seals the blood to the structure of the centrifuge tube, the centrifuge tube structure containing the blood is placed in a general centrifuge to perform a centrifugal operation. The principle is that, due to the different specific gravity of various components contained in the blood, the centrifugal action is performed using a centrifuge tube structure and a centrifuge, and after standing for a period of time, the blood in the centrifuge tube structure is clearly layered into three layers. The solution, the upper layer solution is a plasma layer, the middle layer solution is a blood clot layer, and the lower layer solution is a red blood cell layer. Among them, the yellow layer of blood clot sandwiched between the plasma layer and the red blood cell layer is rich in a large amount of growth factors, which helps to repair the function of the aging tissue, promotes metabolism and regenerates the skin, and is often applied to the medical treatment process. And make it rich in commercial value. However, since the buffy yellow layer is only a thin layer, the operator is more difficult to extract, and the centrifugal tube structure of the present invention is designed to facilitate the extraction of a thin layer solution (in the present invention, it is convenient to extract the yellow blood layer of the blood clot). Centrifuge tube structure.

First, please refer to FIG. 2 to FIG. 4 . FIG. 2 and FIG. 3 are schematic cross-sectional views showing the blood in the centrifuge tube structure of the first embodiment of the present invention before and after being lifted. FIG. A schematic cross-sectional view of a second embodiment of the centrifuge tube structure of the present invention. The centrifuge tube structure of the present invention comprises a tube body 2 having a first accommodating groove 20, a second accommodating groove 22 and a necking portion 21, and the necking portion 21 is connected to the first accommodating groove 20. And the second accommodating groove 22. Wherein, the cross-sectional area of the neck portion 21 is smaller than the cross-sectional area of the first accommodating groove 20 and the cross-sectional area of the second accommodating groove 22, that is, the neck portion 21 of the centrifuge tube structure is tapered, and the centrifuge tube structure is made. The overall shape presents an hourglass shape.

Furthermore, the structure of the centrifuge tube further includes a first blocking body 3 and a second blocking body 4. In this embodiment, the first blocking body 3 is fixed and limited to the groove of the first receiving groove 20. The upper edge is incapable of moving, and the second blocking body 4 is movably coupled to the lower edge of the groove of the second receiving groove 22. By this arrangement, the first resisting body 3, the first accommodating groove 20, the necking portion 21, the second accommodating groove 22 and the second blocking body 4 jointly define a total volume space 5, and By moving the second blocking body 4, a capacity distribution state of the total volume space 5 can be changed. In other words, since the first blocking body 3 is fixed to the first receiving groove 20, the first blocking body 3 and the first receiving groove 20 together define a fixed volume space 200; similarly, The second blocking body 4 is movably disposed in the second accommodating groove 22, so that the second blocking body 4 and the second accommodating groove 22 together define a variable volume space 220; and by the necking portion 21 a defined communication channel 210, connecting the fixed volume space 200 with the variable The volume space 220, in other words, the total volume space 5 is formed by the fixed volume space 200, the communication passage 210, and the variable volume space 220.

In this case, in order to fix the first blocking body 3 to the first receiving groove 20, the first resisting body 3 and the first receiving groove 20 may be fixed in the first blocking body 3. The first accommodating groove 20 is integrally formed with the first accommodating groove 20 (as shown in FIG. 2 and FIG. 3); or, as shown in FIG. 4, the first accommodating groove 20 can have a fixing means 205, and The fixing body 3 is a fixing cover 35. The fixing cover 35 is fastened to the fixing means 205 of the first receiving groove 20, and the fixing cover 35 is fixed to the first receiving groove 20 by the fixing means 205. The first resisting member 3 can be fixed to a first opening portion 201 of the first accommodating groove 20 by any fixing manner such as snapping, inlaying, and fixing. With this arrangement, it is intended to prevent the first blocking body 3 from being easily removed from the first accommodating groove 20, and the possibility of repeated use after cleaning the centrifuge tube structure, due to possible contagiousness in the blood. The germs and viruses, therefore, are absolutely necessary to ensure that the centrifuge tube structure is only for one-time use.

Furthermore, please continue to refer to FIG. 2 and FIG. 3, the centrifugal tube structure is used in an upright position, wherein the first resisting body 3 is located above and the second blocking body 4 is located below. Since the blood is contained in the total volume 5, if the blood has completed the separation step, a three-layered layered solution is present in the total volume space 5. At this time, if the second blocking body 4 is pushed to move toward the necking portion 21, the total volume space 5 can be reduced, and the solution of each layer can be moved up; otherwise, if the second blocking body 4 is pulled away from the necking When the portion 21 moves, the total volume space 5 can be increased, and the solution of each layer is lowered. Wherein, since the volume of each layer solution is kept fixed, the height of each layer solution can be adjusted by operating the second blocking body 4, so that any layer solution in each layer solution is adjusted to be located at the necking portion 21. It is affected by the reduction in the cross-sectional area of the neck portion 21, which increases the thickness of the layer solution, and allows the operator to perform a large increase in the ease of extracting the layer solution.

Please continue to refer to Figure 2 and Figure 3. The first resist 3 has an air hole 202 and a liquid inflow hole 203. In order to avoid the blood in the centrifuge tube structure may overflow from the air hole 202 or the liquid inflow hole 203 when the centrifugal operation is performed, the first resist 3 includes There are two plugs 204, 204', and when the centrifugal action is performed, the liquid inflow holes 203 and the air holes 202 on the first blocking body 3 can be blocked by the two plugs 204, 204', respectively. Among them, the plug 204' has a through hole 204'a for inserting a thin needle 6. The position of the air hole 202 corresponds to the neck portion 21, and when the thin needle 6 is received in the through hole 204'a, a part of the fine needle 6 can enter the first receiving groove 20 to take the points in the total volume space 5. Layer solution. Of course, the user can take any solution in the stratified solution according to the actual demand situation, and is not limited herein.

Further, the air hole 202 is adjacent to the liquid inflow hole 203 for a liquid to be injected from the outside, and the total volume space 5 is gas-connected to the outside through the air hole 202. The purpose of setting the stomata 202 is, when the blood When the total volume space 5 is injected, a part of the space in the total volume space 5 is occupied by the blood, so that the gas originally contained in the total volume space 5 can be discharged to the outside through the air holes 202.

Referring to FIG. 2 to FIG. 4, the second blocking body 4 includes a piston portion 41. The piston portion 41 is received in the second accommodating groove 22 and movable in the second accommodating groove 22. Here, the user can change the capacity distribution state of the total volume space 5 by moving the piston portion 41. For example, the user can push the piston portion 41 to reduce the total volume space 5 or pull the piston portion 41 to increase the total volume space 5. In addition, by applying force to the piston portion 41 to deform the piston portion 41, the total volume space 5 can also be reduced or increased, which is also a possible embodiment of the piston portion 41 of the centrifugal tube structure of the present invention.

Please refer to FIG. 5 to FIG. 6, which are schematic cross-sectional views showing the third and fourth embodiments of the centrifuge tube structure of the present invention. For the sake of indicating the possibility of various settings of the first blocking body 3 as much as possible, FIG. 5 is an example in which the first blocking body 3 and the first receiving groove 20 are integrally formed. FIG. 6 is an example in which the first blocking body 3 is capped on the first accommodating groove 20 . Of course, this is only an enumeration of the relationship between the first blocking body 3 and the first accommodating groove 20 , and thus is not limited thereto. Another possible way of fixing the resist 3 and the first receiving groove 20.

As shown in Fig. 5, it is an embodiment in which the push rod 42 is used to push the piston portion 41. In one embodiment, the second blocking body 4 further includes a push rod 42 connected to the piston portion 41, and the axial direction of the push rod 42 is parallel to a longitudinal axis of the tubular body 2, preferably a push rod. The axial direction of 42 is the longitudinal axis of the tubular body 2. Therefore, when the push rod 42 receives an axial thrust, the push rod 42 is adapted to push the piston portion 41 along the longitudinal direction to linearly move the piston portion 41 toward the neck portion 21, thereby reducing the total volume space. 5. Similarly, when the push rod 42 receives an axial pulling force, the push rod 42 is adapted to pull the piston portion 41 in the longitudinal direction and move linearly away from the neck portion 21, thereby increasing the total volume space 5. It should be noted that the push rod 42 and the piston portion 41 may be connected in such a manner that one end of the push rod 42 is integrally formed with the piston portion 41; or, one end of the push rod 42 is hooked on the piston portion 41, and thus, The upward or downward movement of the piston portion 41 can be controlled by the manipulation of the push rod 42. This is a possible embodiment and is not limited thereto.

Here, the operator can change the capacity distribution state of the total volume space 5 by moving the piston portion 41. For example, the operator can push the piston portion 41 to reduce the total volume space 5 or pull the piston portion 41 to increase the total volume space 5. In addition to this, the operator can also deform the piston portion 41 by applying force to the piston portion 41, so that the total volume space 5 is reduced or increased, which is also a possible embodiment.

As shown in FIG. 6, it is an embodiment in which a bottom cover 43 is additionally provided in addition to the use of the push rod 42 to push the piston portion 41. The second blocking body 4 further includes a bottom cover 43 fixed to the lower edge of the groove of the second receiving groove 22 for limiting the piston portion 41 to be located at the bottom cover 43 and the neck. Between the constrictions 21 . In the present embodiment, the central portion of the bottom cover 43 is a hollow portion 430 for the push rod 42 to pass through the hollow portion 430 and is coupled to the piston portion 41. In this way, when the push rod 42 receives an external force, the push rod 42 is adapted to move the piston portion 41 toward the neck portion 21 and/or pull the piston portion 41 to move away from the neck portion 21, thereby adjusting the inside of the centrifuge tube structure. The upper and lower displacement of the stratified blood is similar to that of the previous embodiment; at the same time, the present embodiment can limit the possibility that the piston portion 41 is excessively pulled away from the second accommodating groove 22 by the bottom cover 43. .

7 and 8, a schematic cross-sectional view showing the fifth and sixth embodiments of the centrifugal tube structure of the present invention, and is an embodiment in which the bottom cover is used to push the piston portion 41. The second blocking body 4 includes a bottom cover 44 or 45, and the bottom cover 44 or 45 is movably disposed at the lower edge of the groove of the second receiving groove 22, so that the piston portion 41 is located at the bottom cover 44. Or 45 is between the necking portion 21. The bottom covers 44 and 45 are connected to the piston portion 41. The bottom covers 44 and 45 are connected to the piston portion 41 in an integrally formed manner, and are engaged with each other, or are abutted against each other, and are not limited thereto. Wherein, when the bottom covers 44, 45 move toward the neck portion 21, the bottom covers 44, 45 push the piston portion 41 to move the piston portion 41 toward the neck portion 21, thereby reducing the total volume space 5; similarly, When the bottom covers 44, 45 are moved away from the necked portion 21, the bottom covers 44, 45 are adapted to pull the piston portion 41 to move the piston portion 41 away from the neck portion 21, thereby increasing the total volume. Space 5.

Continuing to refer to FIG. 7 and FIG. 8 , further, as shown in FIG. 7 , the mutual movement between the bottom cover 44 and the second accommodating groove 22 may be such that a surface of the bottom cover 44 is formed with a male thread 221 . The surface of the second accommodating groove 22 is formed with a female thread 222. The male thread 221 is adapted to cooperate with the female thread 222. Therefore, when the bottom cover 44 receives the force applied in all directions, the bottom cover 44 is adapted to rotate in the axial direction. Move and move along the axis. In addition, the mutual movement between the bottom cover and the second receiving groove 22 can also move in other ways.

As shown in FIG. 8, the bottom cover 45 is a lower edge of the trough body movably disposed in the second accommodating groove 22. Wherein, the bottom cover 45 can receive an axial thrust and move along the longitudinal axis toward the neck portion 21, and the piston portion 41 is pushed by the bottom cover 45 to move the piston portion 41 toward the neck portion 21 to reduce the total Alternatively, when the bottom cover 45 receives an axial pulling force to move in a direction away from the neck portion 21 in the longitudinal direction, the bottom cover 45 is adapted to pull the piston portion 41 together, so that the piston portion 41 is biased away from the neck. The direction of the portion 21 is moved to increase the total volume space 5. In detail, the bottom cover 45 has a negative structure 223, the second receiving groove 22 has a positive structure 224, and the negative structure 223 is adapted to cooperate with the male structure 224, so that the bottom cover 45 can be made opposite to the second receiving groove 22. slide.

As described above, a female thread 222 of the second accommodating groove 22 and a positive structure 224 of the second accommodating groove 22 are all possible movable means of the second accommodating groove 22 of the present invention, and the like. limit.

Please refer to FIG. 9, which is a cross-sectional view showing a seventh embodiment of the centrifugal tube structure of the present invention. In the embodiment, the first blocking body 3 of the centrifugal tube structure is a fixed cover body 35, and is fixed to the first receiving groove 20. The fixing means 205 is fixed to the first receiving groove 20 by the fixing means 205. In addition, the second blocking body 4 further includes a push rod 42 connected to the piston portion 41, and the axial direction of the push rod 42 is parallel to the longitudinal axis of the centrifugal tube structure for the user to push and pull.

Please refer to FIG. 10, which is a cross-sectional view showing an eighth embodiment of the centrifugal tube structure of the present invention. In the embodiment, the first blocking body 3 of the centrifugal tube structure is a fixed cover 35, which is connected to the first receiving groove 20, and the fixing cover 35 is fixed to the first receiving by the fixing means 205. Slot 20. Next, the second blocking body 4 further includes a bottom cover 46. The bottom cover 46 is a movable bottom cover, and can be rotated by the user in all directions, so that the bottom cover 46 is along the axial direction. Upon movement, the piston portion 41 is pushed, and/or as a blocking structure that restricts the piston portion 41 from being excessively pulled away from the second accommodating groove 22. In addition, the second blocking body 4 further includes a push rod 42 connected to the piston portion 41, and the axial direction of the push rod 42 is parallel to the longitudinal axis of the centrifugal tube structure, so that the user can push and pull The push rod 42 moves in the longitudinal direction with the traction piston portion 41.

Please refer to FIG. 11, which is a cross-sectional view showing a ninth embodiment of the centrifuge tube structure of the present invention. In the present embodiment, the first blocking body 3 of the centrifugal tube structure is a fixing cover 35, and is fixed to the fixing means 205 of the first receiving groove 20, and the fixing cover 35 is fixed to the fixing cover 35 by the fixing means 205. The first receiving groove 20 is provided. In addition, the second blocking body 4 further includes a bottom cover 44 for receiving the user's urging force along the line direction, so that the bottom cover 44 is rotated in the axial direction and moves along the axial direction. Further, the piston portion 41 is pushed to move toward the neck portion 21.

In summary, the centrifuge tube structure disclosed in the present invention makes it easier for the operator to extract the layered solution by designing a neck portion having a narrow cross-sectional area. The centrifuge tube structure of the present invention can be designed such that the first blocking body and the first receiving groove are fixed to each other and cannot be relatively moved or separated to ensure that the centrifugal tube structure disclosed in the present invention is disposable and simplified at the same time. The structural design of the centrifuge tube structure makes it easier to mass-produce in manufacturing. In addition, the centrifugal tube structure of the present invention can also be designed such that the bottom cover is fixed at the lower edge of the groove body of the second accommodating groove, so that the piston portion is limited; and the movable member (including the piston portion and the push rod) It is designed to receive an axial force to push the piston portion. In this way, when the operator performs the extraction action, the force can be prevented from being applied in the other direction, and the component force is applied to the centrifuge tube structure. , and the structure of the centrifuge tube is shaken left and right.

However, the above description is only the preferred embodiment of the present invention, and is not intended to limit the scope of the present invention. Therefore, the equivalent variations of the present invention and the contents of the drawings are all included in the present invention. Within the scope of rights protection, Chen Ming is awarded.

Claims

Rights request

1. A centrifuge tube structure, including:

A pipe body having a first accommodating groove, a second accommodating groove and a necked portion connecting the first accommodating groove and the second accommodating groove;

A first sealing body is fixed to the first accommodating groove, and together with the first accommodating groove defines a fixed volume space; and

A second blocking body includes a bottom cover and a piston part. The bottom cover is fixed on the bottom end of the second accommodation groove, and the piston part closes the second accommodation groove; wherein, the piston part is accommodated in In the second accommodation groove, the piston part and the second accommodation groove jointly define a variable volume space;

Wherein, the necked part defines a communication channel, and the communication channel connects the fixed volume space and the variable volume space.

2. The centrifuge tube structure of claim 1, wherein the first accommodating groove has a first opening, and the first blocking body is fixed to the first opening of the first accommodating groove; or , the first sealing body and the first accommodation groove are integrally formed.

3. The centrifuge tube structure of claim 2, wherein the first sealing body has an air hole and a liquid inflow hole, the air hole is positioned corresponding to the necking portion, and the fixed volume space is connected through the air hole. to an outside world, the liquid inflow hole is located adjacent to the air hole; wherein, the first sealing body includes two plugs, the two plugs are used to block the liquid inflow hole and the air hole respectively; wherein, the plug blocking the air hole has An insertion hole, through which a thin needle is inserted into the plug, enters the first accommodating groove.

4. The centrifuge tube structure as claimed in claim 1, wherein the piston part moves in the second accommodating groove to jointly define the variable volume space with the second accommodating groove, or the piston part contains is placed in the second accommodation groove, and the piston part is adapted to receive an external force and deform, so as to jointly define the variable volume space with the second accommodation groove; wherein, the second blocking body further includes A push rod, and the central area of the bottom cover is a hollow part; the push rod passes through the hollow part and is connected to the piston part. When the push rod receives an external force, the push rod is adapted to push the piston part toward the The necking portion moves; wherein, the cross-sectional area of the necking portion is smaller than the cross-sectional area of the first accommodating groove and the cross-sectional area of the second accommodating groove.

5. A centrifuge tube structure, including:

A pipe body has a first accommodation groove, a second accommodation groove, and connects the first accommodation groove and the second accommodation groove. a constriction of the slot;

a second blocking body, which together with the second accommodating groove defines a variable volume space;

6. The centrifuge tube structure as claimed in claim 5, wherein the first blocking body and the first accommodating groove are integrally formed; or, the first accommodating groove has a first opening, and the first accommodating groove has a first opening. The blocking body is fixed on the first opening.

7. The centrifuge tube structure of claim 6, wherein the first sealing body has an air hole and a liquid inflow hole, the air hole is positioned corresponding to the necking portion, and the fixed volume space passes through the air hole. Connected to an outside world, and the liquid inflow hole is located adjacent to the air hole; wherein, the first blocking body includes two plugs, the two plugs are used to block the liquid inflow hole and the air hole respectively; wherein, the first blocking body blocks the air hole The plug has an insertion hole, and a thin needle passes through the insertion hole of the plug to enter the first accommodating groove.

8. The centrifuge tube structure of claim Ί, wherein the second blocking body includes a piston part, the piston part is accommodated in the second accommodating groove, and moves in the second accommodating groove, to jointly define the variable volume space with the second accommodation groove; or, wherein the second blocking body includes a piston part, the piston part is accommodated in the second accommodation groove, and the piston part is adapted to It receives an external force and deforms to jointly define the variable volume space with the second accommodation groove.

9. The centrifuge tube structure according to claim 8, wherein the second blocking body further includes a bottom cover, the bottom cover is disposed at the bottom end of the second accommodating groove, so that the piston portion is located between the bottom cover and the bottom cover. between the necking parts; wherein, the bottom cover is movably disposed in the second accommodating groove, and when the bottom cover moves toward the necking part, the bottom cover is adapted to push the piston part together, so that The piston moves toward the constriction.

10. The centrifuge tube structure of claim 9, wherein a male thread is formed on the surface of the bottom cover, and a female thread is formed on the surface of the second accommodation groove, and the male thread is adapted to cooperate with the female thread, so that the When the bottom cover makes a rotational movement in an axial direction, it is adapted to make a movement along the axial direction at the same time; or, the bottom cover has a female structure, the second receiving groove has a male structure, and the female structure is adapted to cooperate with the The male structure cooperates so that the bottom cover can slide relative to the second accommodating groove.

11. The centrifuge tube structure as claimed in claim 9, wherein the bottom cover is fixed to the second accommodating groove, and the central area of the bottom cover is a hollow portion, and the second blocking body further includes a push rod, The push rod passes through the hollow part and is connected to the piston part. When the push rod receives an external force, the push rod is adapted to push the piston part to move toward the necking part; or, the second blocking body is more It includes a push rod, wherein the push rod is connected to the piston part, and when the push rod receives an external force, the push rod is adapted to push the piston part to move toward the necking part.

12. A centrifuge tube structure, including:

A tube body having a first accommodation groove, a second accommodation groove and a necked portion connecting the first accommodation groove and the second accommodation groove; wherein, the first accommodation groove has a fixed means; means

A fixed cover is in contact with the fixing means of the first accommodating groove, and the fixing means fixes the fixed cover to the first accommodating groove; and

A bottom cover is provided at the bottom of the second accommodating groove.

13. The centrifuge tube structure according to claim 12, further comprising a piston part, the piston part is accommodated in the second accommodating groove and can move in the second accommodating groove; wherein, the second The accommodating tank has a movable means, and the bottom cover is in contact with the movable means, so that the bottom cover can be movably arranged in the second accommodating tank.

14. The centrifuge tube structure of claim 13, wherein the piston part is located between the bottom cover and the necking part, and when the bottom cover moves toward the necking part, the bottom cover is adapted to push the bottom cover together. The piston part is moved toward the constriction part.

15. The centrifuge tube structure according to claim 14, wherein the movable means of the second accommodating groove is a female thread of the second accommodating groove, and a male thread is formed on the surface of the bottom cover, and the male thread is suitable for In order to cooperate with the female thread, the bottom cover is adapted to move along the axial direction at the same time when the bottom cover makes a rotational movement in the axial direction; or, the movable means of the second accommodating groove is the second accommodating groove. A male structure, the bottom cover has a female structure, the male structure is adapted to cooperate with the female structure, so that the bottom cover can slide relative to the second receiving groove; wherein, the centrifuge tube structure further includes a push rod. , wherein the push rod is connected to the piston part, and when the push rod receives an external force, the push rod is adapted to push the piston part to move toward the necking part.

16. A centrifuge tube structure, including:

A tube body having a first accommodation groove, a second accommodation groove and a necked portion connecting the first accommodation groove and the second accommodation groove;

A first sealing body, fixed and limited to the upper edge of the first accommodating groove; and a second blocking body movably connected to the lower edge of the second accommodating tank;

Wherein, the first blocking body, the first accommodating groove, the necking part, the second accommodating groove and the second blocking body jointly define a volume space; the capacity distribution of the volume space The state can be changed by moving the second blocking body.

17. The centrifuge tube structure of claim 16, wherein the second blocking body further includes a piston part and a push rod, the piston part is accommodated in the second accommodating groove, and can be inserted into the second accommodating groove. The push rod moves in the accommodation groove, and the push rod is connected to the piston part; wherein, when the push rod receives an axial thrust force, the push rod is adapted to push the piston part along a longitudinal axis toward the necking The direction of the push rod moves linearly in order to reduce the volume space; or, when the push rod receives an axial pulling force, the push rod is adapted to pull the piston part along a longitudinal axis in a direction away from the necked part. Move linearly to increase the volume space; wherein, one end of the push rod is connected to the piston part to be integrally formed with the piston part, or one end of the push rod is hooked on the piston part.

18. The centrifuge tube structure of claim 17, wherein the second blocking body further includes a bottom cover, which is movably disposed on the lower edge of the second accommodating tank; wherein, in the When the bottom cover moves toward the necked portion, the bottom cover can push the piston portion together to move the piston portion toward the necked portion to reduce the volume space; or, when the bottom cover moves away from the neck When the bottom cover moves in the direction of the constricted portion, the bottom cover can pull the piston portion together to move the piston portion away from the constricted portion to increase the volume space.

19. A centrifuge tube structure, including:

a first sealing body covering the first receiving groove; and

A second blocking body includes a bottom cover and a piston part. The bottom cover is fixed on the bottom end of the second accommodation groove. The piston part closes the second accommodation groove, and the piston part can be in the third accommodation groove. Move within the second accommodation slot.

20. The centrifuge tube structure of claim 19, further comprising a push rod, wherein the push rod is connected to the piston part, and when the push rod receives an axial thrust force, the push rod is adapted to push the piston part. Move linearly along a longitudinal axis toward the direction of the necking portion; or, the centrifuge tube structure further includes a push rod, wherein the push rod passes through a hollow portion in the central area of the bottom cover and is connected to the piston part, when the push rod receives an axial pushing force, the push rod is adapted to push the piston part to move linearly along a longitudinal axis toward the direction of the necking part.

21. The centrifuge tube structure as claimed in claim 20, wherein the first sealing body is fixed to the first accommodation groove, so as to jointly define a fixed volume space with the first accommodating groove; or, the first sealing body can be movably disposed in the first accommodating groove, so as to jointly define a fixed volume space with the first accommodating groove. Variable volume space; wherein, the first sealing body has an air hole and a liquid inflow hole, the position of the air hole corresponds to the necking portion, and the fixed volume space or the variable volume space is connected through the air hole. to an outside world, and the liquid inflow hole is located adjacent to the air hole; wherein, the first sealing body includes two plugs, the two plugs are used to block the liquid inflow hole and the air hole respectively; wherein, the plug blocking the air hole There is an insertion hole, and a thin needle passes through the insertion hole of the plug to enter the first accommodating groove.

22. A centrifuge tube structure, including:

a first sealing body to cover the first accommodation groove;

A piston part that closes the second accommodating groove, and the piston part can move in the second accommodating groove; and a push rod connected to the piston part, when the push rod is pushed by an external force, it is suitable to The piston part can be pushed accordingly to move linearly along a longitudinal axis toward the direction of the necking part.

23. The centrifuge tube structure as claimed in claim 22, further comprising a bottom cover fixed to the bottom end of the second accommodating groove so that the piston part is located between the bottom cover and the necked part; Wherein, the external force received by the push rod is an axial pushing force to push the piston part to move linearly in the direction of the necking part along a longitudinal axis.

24. A centrifuge tube structure, including:

a first sealing body covering the first receiving groove; and

A movable member closes the second receiving groove, and the movable member is adapted to receive an axial pushing force so that the movable member moves linearly along a longitudinal axis toward the direction of the necking portion.

25. The centrifuge tube structure of claim 24, wherein the movable member includes a piston part and a push rod, the piston part and the second accommodation groove jointly define a variable volume space, and the push rod is connected to the The piston part; wherein, the push rod is adapted to receive the axial pushing force to push the piston part to move toward the constriction part along the axial direction, so that the variable volume space is reduced.

26. The centrifuge tube structure as claimed in claim 25, wherein the first sealing body is fixed to the first accommodation groove, so as to jointly define a fixed volume space with the first accommodating groove; or, the first sealing body can be movably disposed in the first accommodating groove, so as to jointly define another space with the first accommodating groove. A variable volume space; wherein, the first sealing body has an air hole, and the position of the air hole corresponds to the necking portion; the fixed volume space or the variable volume space is connected to an outside world through the air hole.

27. A centrifuge tube structure, including:

a first sealing body covering the upper edge of the first accommodating groove; and

A movable component closes the lower edge of the second accommodating tank;

Wherein, a total volume space is defined between the first sealing body, the first accommodating groove, the necked portion, the second accommodating groove and the movable part, and the movable part is adapted to accept a The axial pushing force causes the movable member to move linearly along a longitudinal axis in the direction of the necking portion and changes the capacity distribution state of the total volume space.

28. The centrifuge tube structure of claim 27, wherein the movable member includes a piston part and a push rod, the piston part is accommodated in the second accommodating groove, and can be placed in the second accommodating groove. Move, the push rod is connected to the piston part; wherein, when the push rod receives an axial thrust force, the push rod is adapted to push the piston part along a longitudinal axis and move linearly in the direction of the necking part , to reduce the total volume space; or, when the push rod receives an axial pulling force, the push rod is adapted to pull the piston part along a longitudinal axis and move linearly in a direction away from the necking part, so as to Increase the total volume space; wherein, one end of the push rod is connected to the piston part to be integrally formed with the piston part, or one end of the push rod is hooked on the piston part.

29. The centrifuge tube structure of claim 28, wherein the movable member further includes a bottom cover, which is movably disposed on the lower edge of the tank body of the second accommodating tank; wherein, the bottom cover faces the When the necking part moves, the bottom cover can push the piston part together so that the piston part moves towards the necking part to reduce the total volume space; or, when the bottom cover moves away from the necking part When moving in the direction, the bottom cover can pull the piston part together, so that the piston part moves in a direction away from the constriction part, so as to increase the total volume space.