WO2014026875A1 - Ensemble de biopsie permettant d'obtenir un échantillon de tissus - Google Patents

Ensemble de biopsie permettant d'obtenir un échantillon de tissus Download PDF

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Publication number
WO2014026875A1
WO2014026875A1 PCT/EP2013/066411 EP2013066411W WO2014026875A1 WO 2014026875 A1 WO2014026875 A1 WO 2014026875A1 EP 2013066411 W EP2013066411 W EP 2013066411W WO 2014026875 A1 WO2014026875 A1 WO 2014026875A1
Authority
WO
WIPO (PCT)
Prior art keywords
sleeve
drill unit
cutting edge
state
assembly according
Prior art date
Application number
PCT/EP2013/066411
Other languages
English (en)
Inventor
Dan ÅKERFELDT
Gunnar ÅSTRÖM
Original Assignee
Apriomed Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Apriomed Ab filed Critical Apriomed Ab
Priority to US14/421,664 priority Critical patent/US20150201915A1/en
Priority to EP13745114.2A priority patent/EP2884902A1/fr
Publication of WO2014026875A1 publication Critical patent/WO2014026875A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B10/0233—Pointed or sharp biopsy instruments
    • A61B10/0266—Pointed or sharp biopsy instruments means for severing sample
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B10/0233—Pointed or sharp biopsy instruments
    • A61B10/025—Pointed or sharp biopsy instruments for taking bone, bone marrow or cartilage samples
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/16—Bone cutting, breaking or removal means other than saws, e.g. Osteoclasts; Drills or chisels for bones; Trepans
    • A61B17/17—Guides or aligning means for drills, mills, pins or wires
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B2010/0208—Biopsy devices with actuators, e.g. with triggered spring mechanisms

Definitions

  • Biopsy assembly for obtaining a tissue sample
  • the present invention relates to a biopsy assembly, and in particular to a biopsy assembly for bone marrow biopsy, according to the preamble of the independent claim.
  • Biopsy sampling in bone or sclerotic lesions may be difficult to carry out with the aid of a biopsy needle, e.g. in bone the lesion is often delimited by the hard surface layer of the bone, i.e. the cortical bone tissue.
  • the biopsy instrument must puncture the cortical bone in order to obtain a sample of the soft tissue, i.e. the marrow, located within the cortical bone.
  • the biopsy needle comprises an elongate stylet which is insertable into the needle and has a closed distal end which is positioned in close proximity to and cooperates with the distal cutting edge of the needle.
  • the stylet and needle are releasably interlocked together, whereupon removal of the stylet a biopsy tissue will be collected in the distal end portion of the needle.
  • the bone marrow extractor has an outer needle rod with a case having an upper portion and a lower portion in communication with each other.
  • the case has a front end with a crushing blade and a rear portion with a stopper groove.
  • An inner needle rod which has a main body having a front end with a crushing blade and a rear portion with a connector is inserted into the outer needle rod.
  • the main body of the inner needle rod has an outer surface from which a stopper lever is protruded.
  • the front end of the main body of the inner needle rod is protruded from the front end of the case of the outer needle rod when the stopper lever is fitted into the stopper groove.
  • the inner needle rod and the outer needle rod cooperate with each other to crush bones through a rotation when the head of a driving means coupled to the connector operates. After bone crushing, only the inner needle rod is removed, and the outer needle rod is kept within the human body to suck and extract bone marrow in a syringe-like manner.
  • a surgical puncture instrument including a drill and a cutter sleeve is disclosed.
  • the sleeve is shaped to continue the shape of the drill so that the sleeve participates in the drilling operation. This permits the sleeve to enter hard tissue and allows the sleeve to be used for access to inner tissue to, for example, obtain a biopsy with a biopsy needle.
  • a trocar comprising a rigid tube wherein may slide a rod with a perforating distal tip, is disclosed.
  • the distal tip zone of the rod forms a perforating drill capable of rotating on its axis while the distal end of the tube is divided into at least two segments with a helical cutting edge.
  • the invention is applicable in particular to bone biopsy.
  • US 2008/0045965 Al discloses an apparatus and a method to remove biopsy specimens from a bone and/or associated bone marrow using a powered drive and an intraosseous needle set.
  • Each needle set may include a cannula or catheter and an associated trocar stylet with respective tips operable to penetrate a bone and/or bone marrow with minimum trauma to a patient.
  • a stylet is releasably disposed within an associated generally hollow cannula.
  • the inventors of the present invention has identified a need for an improved biopsy device which provides for a simplified procedure which is less painful procedure for the patient.
  • an object of the present invention is to provide a device which provides for an improved and simplified procedure for obtaining a tissue sample, and which provides for a less painful procedure for the patient.
  • a further object of the present invention is to provide a device which is suitable to introduce, and to obtain a tissue sample with, in both hard and soft tissue. Summary of the invention
  • the biopsy assembly for obtaining a tissue sample, in accordance with the present invention, comprises an elongated tube shaped sleeve, extending along a longitudinal axis A, and comprising a first cutting edge arrangement at a distal end of said sleeve.
  • the sleeve is provided with an opening at said distal end, wherein said opening is in communication with a cavity adapted to receive said tissue sample.
  • the biopsy assembly further comprises an elongated drill unit, adapted to be removably arranged in said sleeve, and extending along a longitudinal axis B.
  • the elongated drill unit comprises a second cutting arrangement arranged at a distal tip of said drill unit.
  • the assembly is adapted to be in a first state, during an insertion phase of said assembly, in which state said elongated drill unit is arranged in said sleeve, and in a second state, during a tissue sampling phase, wherein said elongated drill unit is removed from said sleeve.
  • the assembly comprises a fixation member, wherein said sleeve and said drill unit are fixated in relation to each other by said fixation member, such that in said first state, said first cutting arrangement and said second cutting arrangement are adapted to perform a cooperating cutting action, when said assembly is rotated in a first direction.
  • the sleeve is shaped to continue the shape of the drill unit so that the sleeve participates in the drilling operation.
  • first cutting edge arrangement of said sleeve with a first cutting edge
  • second cutting arrangement of said drill unit with a longitudinal cutting edge extending at least partly along said drill unit.
  • the first cutting edge and said longitudinal cutting edge are adapted to be essentially aligned, in said first state.
  • a further advantage is that the assembly is introduced into hard tissue with a cutting action. Dilation of the tissue is thereby reduced. Thereafter, when the assembly has reached through the hard tissue the drill unit is removed and the sleeve is used to obtain the tissue sample.
  • the first cutting edge arrangement of said sleeve comprises a second cutting edge, and wherein, in said second state, said first cutting edge is adapted to perform a cutting action when said sleeve is rotated in a first direction (di), and wherein said second cutting edge is adapted to perform a cutting action when said sleeve (2) is rotated in a second direction (d 2 ), opposite said first direction (di).
  • Figure 1 shows an elevated view of the biopsy assembly when in a first state, according to one embodiment of the present invention.
  • Figure 2 shows a side view of the biopsy assembly illustrating that a recess of the sleeve and a flute of the drill unit are essentially aligned in the first state, according to one embodiment of the present invention.
  • Figure 3 shows a further side view of the biopsy assembly shown in Figure 2, wherein the biopsy assembly is rotated approximately 90° in relation to the view shown in Figure 2.
  • Figure 4 shows a front view of the biopsy assembly in the first state, according to one embodiment of the present invention.
  • Figure 5 a schematically shows the fixation member provided at a proximal end of the biopsy assembly, according to one embodiment of the present invention
  • Figure 5b schematically shows the fixation member, according to one embodiment of the present invention.
  • Figure 6 shows an elevated view of a portion of the biopsy assembly when in a second state, according to one embodiment of the present invention.
  • Figure 7 shows a side view of the biopsy assembly, when in the second state, the sleeve being provided with a recess, according to one embodiment of the present invention.
  • Figure 8 shows the embodiment shown in Figure 7, the biopsy assembly is rotated approximately 90° in relation to the view shown in Figure 6.
  • Figure 9 shows a longitudinal cross-section of the biopsy assembly when in the second state, according to one embodiment of the present invention.
  • the biopsy assembly 1 is adapted to be in a first state, during an insertion phase of the assembly 1 , and in a second state, during a tissue sampling phase.
  • the elongated drill unit 7 In the first state the elongated drill unit 7 is arranged in the sleeve 2, as illustrated in Figures 1-5, and in the second state, during a tissue sampling phase, the elongated drill unit 7 is removed from the sleeve 2, as illustrated in Figures 6-9.
  • the assembly 1 provides a cutting action during insertion
  • a tissue sample may be obtained by means of said sleeve 2.
  • FIG. 1 shows the biopsy assembly 1 , for obtaining a tissue sample, when in a first state, according to one embodiment of the present invention.
  • the biopsy assembly 1 comprises an elongated tube shaped sleeve 2, extending along a longitudinal axis A.
  • the sleeve 2 comprises a first cutting edge arrangement 3 at a distal end 4 of the sleeve 2, and the sleeve 2 is provided with an opening 5 at the distal end 4.
  • the opening 5 is in
  • the biopsy assembly 1 further comprises an elongated drill unit 7, adapted to be removably arranged in the sleeve 2, and extending along a longitudinal axis B.
  • the elongated drill unit 7 comprises a second cutting arrangement 8 arranged at a distal tip 9 of the drill unit 7. As seen in Figure 1, the longitudinal axis A and the longitudinal axis B are aligned in the first state.
  • the assembly 1 comprises a fixation member 10 (not shown in Figure 1), wherein the sleeve 2 and the drill unit 7 are fixated in relation to each other by the fixation member 10, such that in the first state, the first cutting arrangement 3 and the second cutting arrangement 8 are adapted to perform a cooperating cutting action, when the assembly 1 is rotated in a first direction (di).
  • the sleeve 2 is shaped such that it continues the shape of the drill unit 7 so that the drill unit 7 and the sleeve 2 participates in the drilling operation.
  • the assembly 1 reduces occurrence of dilation of tissue during insertion, and thereby the assembly 1 provides a less painful procedure for the patient.
  • the fixation member 10 is adapted to prevent rotation of the drill unit 7 in relation to the sleeve 2 in the first state. In one embodiment, the fixation member 10 is adapted to assure a predetermined longitudinal position of the drill unit 7 in relation to the sleeve 2 in the first state.
  • the distal tip 9 of the drill unit 7 projects a predetermined distance D from the distal end 4 of the sleeve 2 in the
  • the first cutting edge arrangement 3 of the sleeve 2 comprises a first cutting edge 11
  • the second cutting arrangement 8 of the drill unit 7 comprises a longitudinal cutting edge 12 extending at least partly along the drill unit 7, wherein the first cutting edge 11 and the longitudinal cutting edge 12 are adapted to be aligned, or essentially aligned, in the first state.
  • the elongated drill unit 7 comprises at least one flute 21 extending helically, from the distal tip 9, along a distance d f of the elongated drill unit 7.
  • the first cutting edge 11 is arranged to extend essentially in the same direction as the longitudinal axis A, as shown in Figures 1-2.
  • the arrangement 3 of the sleeve 2 comprises a second cutting edge 13.
  • the sleeve 2 is provided with a chamfering 14 at the distal end 4, preferably at said first cutting edge 11 and at said second cutting edge 13.
  • the chamfering 14 provides for an improved chip removal during the insertion phase.
  • the chamfering 14 also prevents soft tissue from being damaged during insertion of the biopsy assembly 1.
  • Figure 4 shows a front view of the biopsy assembly 1 when being in the first state.
  • the drill unit 7 is concentric and the diameter da of the drill unit is between 1-5 mm.
  • the inner diameter of the sleeve 2 is adapted to the diameter da of the drill unit 7 such that the drill unit 7 may be introduced into and arranged in said sleeve 2.
  • the inner diameter di of the sleeve 2 is preferably between 0,01-0,2 mm larger than the diameter da of the drill unit 7.
  • the outer diameter d s of the sleeve 2 is preferably between 1,5-6 mm.
  • the outer diameter d s may be decreasing towards the distal end 4, in a distal end portion 23 of the sleeve 2.
  • the fixation member 10 is provided essentially at a proximal end 15 of the biopsy assembly 1.
  • the biopsy assembly 1 is in the first state, thus the drill unit 7 is arranged in the sleeve 2, and the distal tip 9 of the drill unit 7 projects from the distal end 4 of the sleeve 2.
  • the biopsy assembly 1 is further provided with a handle 22 which facilitates rotation of the assembly 1.
  • the fixation member 10 comprises an indentation 16 and a mating recess 17.
  • the indentation 16 is provided at, or interconnected with said drill unit 7, and said mating recess 17 is provided at, or interconnected with, said sleeve 2.
  • the indentation 16 and the mating recess 17 assures longitudinal position and prevents rotation of the drill unit 7 and sleeve 2 in relation to each other.
  • the fixation member 10 may comprise any other suitable means for fixating said sleeve 2 and said drill unit 7 in relation to each other, such as e.g. pin and pin hole, snap lock or threads.
  • Figure 6 illustrates the biopsy assembly 1 in the second state.
  • the drill unit 7 has been removed from the sleeve 2, such that the cavity 6 within the drill unit 7 may receive the tissue sample via the opening 5.
  • the first cutting edge 11 is adapted to perform a cutting action when the sleeve 2 is rotated in a first direction di
  • the second cutting edge 13 is adapted to perform a cutting action when the sleeve 2 is rotated in a second direction d 2 , opposite the first direction di.
  • the shape of the first cutting edge 11 is advantageous when obtaining a tissue sample in bone or sclerotic lesions, i.e. in relatively hard tissue.
  • the sleeve 2 is preferably rotated in the first direction di.
  • the shape of the second cutting edge 13 is advantageous when obtaining a sample from relatively soft tissue. Therefore, when obtaining a sample in soft tissue, the sleeve 2 is preferably rotated in the second direction d 2 .
  • the first direction di may be clockwise direction and the second direction d 2 may be counter-clockwise direction.
  • the first cutting edge 1 1 is arranged in a recess 20 extending from the distal end 5 of the sleeve 2 at least partly along the sleeve 2.
  • the recess 20 extends a distance d r from the distal end 4 along the sleeve 2.
  • the distance d r is between 1-10 mm.
  • the recess 20 is arranged to be aligned, or essentially aligned, with the flute 21.
  • the distance d fs between the most proximal part of the flute 21 and the first cutting edge 1 1 extending along the recess 20, is preferably 0-3 mm.
  • the second cutting edge 13 comprises an inclined cutting edge, the inclined cutting edge extends in an angle a with respect to a plane P perpendicular to the longitudinal axis A.
  • the angle a is approximately 5-30 degrees.
  • the inclined cutting edge 13 is advantageous in that it facilitates cutting in soft tissue when the sleeve 2 is rotated in the second direction d 2 .
  • Figure 9 shows a longitudinal cross-section of the sleeve 2, according to one embodiment of the present invention.
  • the sleeve 2 is tubular and comprises a cavity 6 adapted to receive the tissue sample via the opening 5, when the assembly 1 is in the second state.
  • the inner diameter di of the sleeve 2, which corresponds to the diameter of the cavity 6, may be decreasing towards the distal end 4.
  • the cavity 6 then tapers towards the distal end 4.
  • the inner diameter d; of the sleeve 2 is decreasing in a distal end portion 23 of the sleeve 2, essentially at the distal end 4 of the sleeve 2.
  • the length L i of the distal end portion 23, having a decreasing inner diameter di is approximately 1-10 mm.
  • a decreasing inner diameter di is advantageous in that the friction is reduced, which facilitates forcing the tissue sample into the cavity 6.
  • the difference between the inner diameter di and the diameter d x at the distal end 4 of the sleeve 2 is
  • the sleeve 2 is provided with a reduced outer diameter d sr along a length L sr of the sleeve 2.
  • the length L sr is approximately between 5-40 mm.
  • the reduced outer diameter d sr is less than the outer diameter d s , and the difference between the outer diameter d s of the sleeve 2 and the reduced outer diameter d sr is approximately 0,05 - 0,3 mm.
  • a reduced outer diameter along part of the sleeve is advantageous in that it reduces friction during insertion of the assembly 1.
  • the length L 2 between the distal end 4 of the sleeve 2 and the most distal portion of the portion of the sleeve 2 having a reduced outer diameter d sr is between 1-10 mm.
  • the biopsy arrangement is adapted to perform an eccentric drilling procedure.
  • the most distal end of the distal tip 9 of the drill unit is offset the longitudinal axis B.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Dentistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Surgical Instruments (AREA)

Abstract

La présente invention concerne un ensemble de biopsie (1) permettant d'obtenir un échantillon de tissus. L'ensemble (1) selon l'invention comprend un manchon (2) en forme de tube allongé, qui s'étend le long d'un axe longitudinal A. Le manchon (2) comprend un premier agencement à bord tranchant (3) au niveau d'une extrémité distale (4) dudit manchon (2), ledit manchon (2) étant pourvu d'une ouverture (5) au niveau de ladite extrémité distale (4), ladite ouverture (5) se trouvant en communication avec une cavité (6) adaptée à recevoir ledit échantillon de tissus. L'ensemble (1) comprend en outre une unité foret allongée (7), adaptée à être agencée de manière amovible dans ledit manchon (2), et s'étendant le long d'un axe longitudinal B, ladite unité foret allongée (7) comprenant un second agencement tranchant (8) agencé au niveau d'une pointe distale (9) de ladite unité foret (7). L'ensemble (1) est adapté à se trouver dans un premier état, lors d'une phase d'insertion dudit ensemble (1), dans lequel état ladite unité foret allongée (7) est agencée dans ledit manchon (2), et dans un second état, lors d'une phase de prélèvement d'échantillon de tissus, ladite unité foret allongée (7) étant alors enlevée dudit manchon (2). L'ensemble (1) comprend un élément de fixation (10), ledit manchon (2) et ladite unité foret (7) étant fixés l'un à l'autre au moyen dudit élément de fixation (10) de sorte que, dans ledit premier état, ledit premier agencement tranchant (3) et ledit second agencement tranchant (8) soient adaptés à réaliser une action tranchante coopérante, lorsque ledit ensemble (1) est tourné dans une première direction (d).
PCT/EP2013/066411 2012-08-16 2013-08-05 Ensemble de biopsie permettant d'obtenir un échantillon de tissus WO2014026875A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US14/421,664 US20150201915A1 (en) 2012-08-16 2013-08-05 Biopsy assembly for obtaining a tissue sample
EP13745114.2A EP2884902A1 (fr) 2012-08-16 2013-08-05 Ensemble de biopsie permettant d'obtenir un échantillon de tissus

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12180658.2A EP2698116A1 (fr) 2012-08-16 2012-08-16 Ensemble de biopsie permettant de prélever un échantillon tissulaire
EP12180658.2 2012-08-16

Publications (1)

Publication Number Publication Date
WO2014026875A1 true WO2014026875A1 (fr) 2014-02-20

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PCT/EP2013/066411 WO2014026875A1 (fr) 2012-08-16 2013-08-05 Ensemble de biopsie permettant d'obtenir un échantillon de tissus

Country Status (3)

Country Link
US (1) US20150201915A1 (fr)
EP (2) EP2698116A1 (fr)
WO (1) WO2014026875A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9925068B2 (en) 2014-05-30 2018-03-27 Treace Medical Concepts, Inc. Bone harvester and bone marrow removal system and method

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10390806B2 (en) * 2014-03-28 2019-08-27 Covidien Lp Devices, systems, and methods for obtaining a tissue sample using a biopsy tool
CN105232092A (zh) * 2015-08-28 2016-01-13 陆宁 骨组织穿刺活检针针芯
CN107802295A (zh) * 2017-11-28 2018-03-16 刘建国 一种乳房活检与旋切探针的三凹面螺旋式刀头
RU204562U1 (ru) * 2018-01-09 2021-05-31 Федеральное государственное бюджетное учреждение высшего образования "Северо-Осетинская государственная медицинская академия" Министерства здравоохранения Российской Федерации Устройство для биопсии костной опухоли
US10813659B2 (en) * 2018-03-22 2020-10-27 Spiration, Inc. Rotational tissue cutting device
US20210298725A1 (en) * 2020-03-31 2021-09-30 Gyrus Acmi, Inc. D/B/A Olympus Surgical Technologies America Rotatable tissue sampling device

Citations (8)

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US3628524A (en) 1969-02-28 1971-12-21 Khosrow Jamshidi Biopsy needle
US5423824A (en) * 1992-03-23 1995-06-13 Radi Medical Systems Ab Method of accessing hard tissue
US20060247653A1 (en) 2005-04-28 2006-11-02 Radi Medical Systems Ab Sleeve, drill and puncture instrument
EP1864650A1 (fr) * 2005-03-29 2007-12-12 Nippon Cable System Inc. Aiguille double pour traitement medical, aiguille de ponction osseuse et dispositif d echantillonnage de moelle osseuse
US20080045965A1 (en) 2002-05-31 2008-02-21 Miller Larry J Apparatus and Methods for Biopsy and Aspiration of Bone Marrow
EP1949858A1 (fr) * 2007-01-23 2008-07-30 Jimro Co., Ltd. Trépan de collecte de moelle osseuse
US20080306405A1 (en) 2007-06-08 2008-12-11 Thierry Masseglia Perforating trocar
EP2351531A1 (fr) 2008-11-18 2011-08-03 Industry-Academic Cooperation Foundation Wonkwang University Extraction de moelle osseuse

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US6086543A (en) * 1998-06-24 2000-07-11 Rubicor Medical, Inc. Fine needle and core biopsy devices and methods

Patent Citations (8)

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Publication number Priority date Publication date Assignee Title
US3628524A (en) 1969-02-28 1971-12-21 Khosrow Jamshidi Biopsy needle
US5423824A (en) * 1992-03-23 1995-06-13 Radi Medical Systems Ab Method of accessing hard tissue
US20080045965A1 (en) 2002-05-31 2008-02-21 Miller Larry J Apparatus and Methods for Biopsy and Aspiration of Bone Marrow
EP1864650A1 (fr) * 2005-03-29 2007-12-12 Nippon Cable System Inc. Aiguille double pour traitement medical, aiguille de ponction osseuse et dispositif d echantillonnage de moelle osseuse
US20060247653A1 (en) 2005-04-28 2006-11-02 Radi Medical Systems Ab Sleeve, drill and puncture instrument
EP1949858A1 (fr) * 2007-01-23 2008-07-30 Jimro Co., Ltd. Trépan de collecte de moelle osseuse
US20080306405A1 (en) 2007-06-08 2008-12-11 Thierry Masseglia Perforating trocar
EP2351531A1 (fr) 2008-11-18 2011-08-03 Industry-Academic Cooperation Foundation Wonkwang University Extraction de moelle osseuse

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9925068B2 (en) 2014-05-30 2018-03-27 Treace Medical Concepts, Inc. Bone harvester and bone marrow removal system and method
US11020244B2 (en) 2014-05-30 2021-06-01 Treace Medical Concepts, Inc. Bone harvester and bone marrow removal system and method

Also Published As

Publication number Publication date
US20150201915A1 (en) 2015-07-23
EP2698116A1 (fr) 2014-02-19
EP2884902A1 (fr) 2015-06-24

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