WO2014021591A3 - 신규한 화합물, 이의 제조방법 및 이를 포함하는 약제학적 조성물 - Google Patents

신규한 화합물, 이의 제조방법 및 이를 포함하는 약제학적 조성물 Download PDF

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Publication number
WO2014021591A3
WO2014021591A3 PCT/KR2013/006753 KR2013006753W WO2014021591A3 WO 2014021591 A3 WO2014021591 A3 WO 2014021591A3 KR 2013006753 W KR2013006753 W KR 2013006753W WO 2014021591 A3 WO2014021591 A3 WO 2014021591A3
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WO
WIPO (PCT)
Prior art keywords
same
pharmaceutical composition
novel compound
preparing
present
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PCT/KR2013/006753
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English (en)
French (fr)
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WO2014021591A2 (ko
Inventor
김제학
정원근
정희진
박용
남은혜
이주한
김윤식
우태선
엄재현
임종진
이재열
이경태
최흥우
박진영
이동규
Original Assignee
보령제약 주식회사
경희대학교 산학협력단
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Application filed by 보령제약 주식회사, 경희대학교 산학협력단 filed Critical 보령제약 주식회사
Publication of WO2014021591A2 publication Critical patent/WO2014021591A2/ko
Publication of WO2014021591A3 publication Critical patent/WO2014021591A3/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

본 발명은 T-타입 칼슘 채널의 길항제로서 T-타입 칼슘채널의 기능과 관계된 장애와 질환의 치료 및 예방에 유용한 하이드로퀴나졸린 유도체에 관한 것이다. 본 발명은 또한 약학적으로 받아들여지는 이러한 화합물 유도체를 포함하는 조성물 및 이러한 화합물의 사용을 포함한다.
PCT/KR2013/006753 2012-07-31 2013-07-26 신규한 화합물, 이의 제조방법 및 이를 포함하는 약제학적 조성물 WO2014021591A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020120084035A KR101473453B1 (ko) 2012-07-31 2012-07-31 신규한 화합물, 이의 제조방법 및 이를 포함하는 약제학적 조성물
KR10-2012-0084035 2012-07-31

Publications (2)

Publication Number Publication Date
WO2014021591A2 WO2014021591A2 (ko) 2014-02-06
WO2014021591A3 true WO2014021591A3 (ko) 2014-03-20

Family

ID=50028606

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2013/006753 WO2014021591A2 (ko) 2012-07-31 2013-07-26 신규한 화합물, 이의 제조방법 및 이를 포함하는 약제학적 조성물

Country Status (2)

Country Link
KR (1) KR101473453B1 (ko)
WO (1) WO2014021591A2 (ko)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101693326B1 (ko) 2014-05-23 2017-01-05 경희대학교 산학협력단 3,4-디히드로퀴나졸린 유도체 및 그를 포함하는 복합제

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20050003080A (ko) * 2003-06-30 2005-01-10 한국과학기술연구원 3,4-디히드로퀴나졸린 유도체 및 그의 제조 방법
KR20050084739A (ko) * 2004-02-24 2005-08-29 한국과학기술연구원 Ｔ-형 칼슘 채널 차단제로서 유용한 ３,４-디히로퀴나졸린유도체 및 그의 제조 방법
KR100784195B1 (ko) * 2007-01-05 2007-12-11 경희대학교 산학협력단 3,4-디히드로퀴나졸린 유도체를 포함하는 항암제 조성물
KR20080099108A (ko) * 2007-05-08 2008-11-12 동우신테크 주식회사 3,4-디히드로퀴나졸린 유도체 및 그를 포함하는 항암제조성물

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20050003080A (ko) * 2003-06-30 2005-01-10 한국과학기술연구원 3,4-디히드로퀴나졸린 유도체 및 그의 제조 방법
KR20050084739A (ko) * 2004-02-24 2005-08-29 한국과학기술연구원 Ｔ-형 칼슘 채널 차단제로서 유용한 ３,４-디히로퀴나졸린유도체 및 그의 제조 방법
KR100784195B1 (ko) * 2007-01-05 2007-12-11 경희대학교 산학협력단 3,4-디히드로퀴나졸린 유도체를 포함하는 항암제 조성물
KR20080099108A (ko) * 2007-05-08 2008-11-12 동우신테크 주식회사 3,4-디히드로퀴나졸린 유도체 및 그를 포함하는 항암제조성물

Also Published As

Publication number Publication date
KR101473453B1 (ko) 2014-12-19
WO2014021591A2 (ko) 2014-02-06
KR20140017748A (ko) 2014-02-12

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