WO2014001007A1 - Polymerisation mit latenten initiatoren - Google Patents
Polymerisation mit latenten initiatoren Download PDFInfo
- Publication number
- WO2014001007A1 WO2014001007A1 PCT/EP2013/060916 EP2013060916W WO2014001007A1 WO 2014001007 A1 WO2014001007 A1 WO 2014001007A1 EP 2013060916 W EP2013060916 W EP 2013060916W WO 2014001007 A1 WO2014001007 A1 WO 2014001007A1
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- WO
- WIPO (PCT)
- Prior art keywords
- polymerization
- radical
- substituted
- carbon atoms
- cyclic
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F2/00—Processes of polymerisation
- C08F2/38—Polymerisation using regulators, e.g. chain terminating agents, e.g. telomerisation
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F120/00—Homopolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride, ester, amide, imide or nitrile thereof
- C08F120/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F120/10—Esters
- C08F120/12—Esters of monohydric alcohols or phenols
- C08F120/16—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms
- C08F120/18—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F2/00—Processes of polymerisation
- C08F2/38—Polymerisation using regulators, e.g. chain terminating agents, e.g. telomerisation
- C08F2/40—Polymerisation using regulators, e.g. chain terminating agents, e.g. telomerisation using retarding agents
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F4/00—Polymerisation catalysts
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F2438/00—Living radical polymerisation
- C08F2438/01—Atom Transfer Radical Polymerization [ATRP] or reverse ATRP
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F2438/00—Living radical polymerisation
- C08F2438/03—Use of a di- or tri-thiocarbonylthio compound, e.g. di- or tri-thioester, di- or tri-thiocarbamate, or a xanthate as chain transfer agent, e.g . Reversible Addition Fragmentation chain Transfer [RAFT] or Macromolecular Design via Interchange of Xanthates [MADIX]
Definitions
- the present invention relates to a novel, rapid initiation mechanism for the polymerization of (meth) acrylates by means of latent initiators based on thermally activatable N-heterocyclic carbene compounds, in particular N-heterocyclic carbene-C0 2 -, carbene-CS 2 - or Carbene-metal compounds (NHC).
- RAFT polymerization reversible addition fragmentation chain transfer polymerization
- the mechanism of the RAFT polymerization is described in more detail in EP 0 910 587. Disadvantages of RAFT polymerization are mainly the limited
- NMP method nitroxide mediated polymerization
- This method has major disadvantages with respect to various functional groups and the targeted adjustment of the molecular weight.
- ATRP atom transfer radical polymerization
- WO 201 1/085856 discloses a process for the initiation of the (meth) acrylate polymerization, in which the initiation by means of the combination of isocyanates or
- Carbodiimides on the one hand and an organic base on the other hand takes place. Such initiation is capable of achieving high molecular weights, but overall is relatively slow.
- N-heterocyclic carbenes have long been known as catalysts for the silyl initiators in group transfer polymerization (GTP) (see Raynaud et al.
- N-heterocyclic carbenes are known as catalysts in a step-growth polymerization of terephthalaldehyde (see Pionaud et al., Macromolecules, 2009, 42, p.4932).
- Zhang et al. Angew.Chem.Int. Ed., 2010, 49, p.10158
- NHC Lewis base in combination with Lewis acids, such as NHOAl (C 6 F 5 ) 3 or NHOBF 3 . This combination is suitable as an initiator for MMA.
- the object of the present invention in the light of the prior art discussed, was to develop novel latent initiators for the polymerization of (meth) acrylates
- a compound as a latent initiator which is stable in the presence of monomers at temperatures of up to 25 ° C for at least 8 h, i. E. maximally lead to a 5% monomer conversion, and at the same time lead to an at least 90% conversion of the monomers to polymers after activation.
- the compounds used as latent initiators should in themselves be storage-stable and light, as well as safely tradable.
- the tasks are solved by a novel method for initiating a
- Starting temperature which is at least 40 ° C, preferably at least 50 ° C, started.
- the polymerization is particularly preferably started at a temperature between 50 ° C. and 100 ° C.
- This process is suitable for the polymerization of vinylic monomers such as acrylates, methacrylates, styrene or styrene-derived monomers. Mixtures of these monomers can also be polymerized by the process according to the invention.
- the protected N-heterocyclic carbene is a compound having one of the two formulas (I) or (II)
- R- 1 is a CH 2 -, C 2 H 4 -, C 3 H 6 - or a corresponding substituted radical.
- R 2 and R 3 may be identical or in each case different from each other.
- R 2 or R 3 is preferably a cyclic, branched or linear, optional
- R 4 and R 5 may be identical or different from each other.
- R 4 or R 5 is preferably hydrogen, a cyclic, branched or linear, optionally heteroatom
- X is C0 2 , CS 2 , Zn, Bi, Sn or Mg.
- Carbenes having one of these X groups are storage stable and simple and safe to use. Prefers are carboxylates (C0 2 protection group) or dithionates (CS 2 protecting group), since with these compounds the polymerization can be carried out metal-free.
- N-heterocyclic skeleton of the initiators used according to the invention are in particular imidazole, imidazoline, tetrahydropyrimidine and diazepine.
- the protected N-heterocyclic carbene may be a metal-free compound having one of the two formulas (III) or (IV)
- R-1 in turn represents a CH 2 -, C 2 H 4 -, C 3 H 6 - or a corresponding substituted radical.
- R 2 and R 3 can also be identical or in each case again
- R 4 and R 5 may be identical or in each case different from one another.
- R 4 or R 5 is preferably hydrogen, a cyclic, branched or linear, optionally heteroatom-containing alkyl radical having 1 to 20 carbon atoms or a substituted or unsubstituted aromatic radical.
- the protective group Y may be a CF 3 , C 6 F 4 , C 6 F 5 , CCI 3 or OR 4 , radical with R 4 as an alkyl radical of 1 to 10 carbon atoms.
- N-heterocyclic carbenes of the formula (I) having a six-membered ring, ie R 1 is a (CH 2 ) 2 group are 1,3-dimethyltetrahydropyrimidinium-2-carboxylate (1), 1, 3 Diisopropyltetrahydropyrimidinium 2-carboxylate (2), 1, 3-bis (2,4,6-trimethylphenyl) tetrahydropyrimidinium-2-carboxylate (3), 1, 3-bis (2,6-diisopropylphenyl) tetrahydropyrimidinium-2 carboxylate (4), 1, 3 Biscyclohexyltetrahydropyrimidinium 2-carboxylate (12) and 1, 3-bis (4-heptyl) tetrahydropyr
- Examples of compounds according to formula (II) are 1,3-diisopropylimidazolium-2-carboxylate (5), 1,3-di-tert-butylimidazolium-2-carboxylate (6), 1,3-dicyclohexylimidazolium-2-carboxylate (7), 1, 3-Bis (2,4,6-trimethylphenyl) imidazolium-2-carboxylate (8) and 1,3-adamantylimidazolium-2-carboxylate (9):
- Cy is a cyclohexyl group and Ad is an adamantyl group.
- initiators of the formula (I) where R 1 is CH 2 is 1,3-di-tert-butylimidazolinium-2-carboxylate (14):
- Deprotonation is then preferably carried out with a strong, sterically hindered base, such as potassium hexamethyldisilizane (KHMDS) in a solvent such as THF.
- KHMDS potassium hexamethyldisilizane
- THF a solvent
- the solvent is removed and the residue z.
- Et 2 0. After filtration, C0 2 or another protecting group such as SnCl 2 is added.
- Further subsequent filtration in, for example, diethyl ether and drying in vacuo allows the synthesis of clean target compounds, so that often no longer has to be recrystallized.
- reactions can also be carried out in an air atmosphere. Only the formation of the free carbene by reaction with the strong base must be carried out under exclusion of air.
- the synthesis can be found, for example, in Iglesias et al., Organometallics 2008, 27, 3279-3289.
- the synthesis of corresponding CS 2 complexes for example in Delaude, Eur. J.lnorg. Chem. 2009, 1681-1699 or in Delaude et al. , Eur. J. lnorg. Chem. 2009, 1882-1891 be read. Surprisingly, it was found that the polymerization at relatively low
- reaction mixtures can be prepared and started controlled at any time by a simple increase in temperature.
- the mixtures can be mixed, for example, outside of a reaction vessel and transferred only for the pure polymerization in a reaction vessel.
- a continuous polymerization with continuous addition of the reaction mixture in a tube or loop reactor or an extruder or kneader can be carried out.
- the polymerization can be optimized so that a nearly quantitative conversion of the monomers takes place. This is both in solution as well as in one
- a polar, aprotic solvent such as DMSO (dimethyl sulfoxide), DMF (dimethylformamide) or DMAC (dimethylacetamide) are used. Therefore, the protected N-heterocyclic carbenes may be first dissolved in such a solvent before being added to another solvent or an otherwise pure monomer mixture.
- the molecular weights of the polymers can be adjusted in a broad spectrum.
- polymers with a weight-average molecular weight, determined by GPC measurement against a polystyrene standard, of between 5000 and 10 000 000 g / mol can be prepared.
- the monomers, the initiator and optionally solvent e.g. DMSO, DMF or toluene, weighed together in a glove box under an argon atmosphere and transferred into an overpressure glass vessel or Schlenk flask.
- solvent e.g. DMSO, DMF or toluene
- the pressure glass vessel or the Schlenk flask was heated in an oil bath pregotten to the desired temperature for the duration of the polymerization. Demolition was carried out by dropping the reaction mixture into a methanol precipitation bath. After centrifugation, the supernatant solution was separated and the polymer dried in vacuo. The yields given are the isolated amounts of polymer after drying.
- Table 1 gives first results of a solution polymerization.
- the initiator was used in a molar ratio of 1 to 280 to MMA as a monomer.
- results were obtained both in bulk and in nonpolar solvents such as toluene, or dimethoxyethane (DME). This was due to the good solubility of the compound (6) no DMSO addition. It has also been found here that significantly higher molecular weights can be achieved in substance or polar solvents. Examples 26 to 28 show correspondingly low molecular weights in a polar solvent such as DMF (dimethylformamide). These too occur at very high sales. By contrast, comparative experiment VB3 did not lead to any sales. There is obviously a "true" latency here: The described RT polymerization does not proceed when the carboxylate is used instead of the free carbene, i.e. the latency is due to thermally switchable blocking of the active species, not to a very slow RT
- the initiators (12), (13) and (14) are all soluble in MMA without the addition of polar solvents.
- (13) proves to be active: high yields in short reaction times of 5 h are possible, molecular weights of about 20,000 g / mol being achieved. speed
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Polymerization Catalysts (AREA)
- Pyridine Compounds (AREA)
Abstract
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2015518933A JP2015521674A (ja) | 2012-06-25 | 2013-05-28 | 潜在性開始剤による重合 |
BR112014026767A BR112014026767A2 (pt) | 2012-06-25 | 2013-05-28 | polimerização usando iniciadores latentes |
US14/394,603 US20150126696A1 (en) | 2012-06-25 | 2013-05-28 | Polymerization using latent initiators |
EP13726725.8A EP2864368A1 (de) | 2012-06-25 | 2013-05-28 | Polymerisation mit latenten initiatoren |
CA2872959A CA2872959A1 (en) | 2012-06-25 | 2013-05-28 | Polymerization using latent initiators |
CN201380027293.6A CN104334587A (zh) | 2012-06-25 | 2013-05-28 | 使用潜伏性引发剂的聚合 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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DE201210210774 DE102012210774A1 (de) | 2012-06-25 | 2012-06-25 | Polymerisation mit latenten Initiatoren |
DE102012210774.6 | 2012-06-25 |
Publications (1)
Publication Number | Publication Date |
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WO2014001007A1 true WO2014001007A1 (de) | 2014-01-03 |
Family
ID=48576379
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PCT/EP2013/060916 WO2014001007A1 (de) | 2012-06-25 | 2013-05-28 | Polymerisation mit latenten initiatoren |
Country Status (8)
Country | Link |
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US (1) | US20150126696A1 (de) |
EP (1) | EP2864368A1 (de) |
JP (1) | JP2015521674A (de) |
CN (1) | CN104334587A (de) |
BR (1) | BR112014026767A2 (de) |
CA (1) | CA2872959A1 (de) |
DE (1) | DE102012210774A1 (de) |
WO (1) | WO2014001007A1 (de) |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997018247A1 (en) | 1995-11-15 | 1997-05-22 | Carnegie Mellon University | Improved processes based on atom (or group) transfer radical polymerization and novel (co)polymers having useful structures and properties |
EP0910587A1 (de) | 1996-07-10 | 1999-04-28 | E.I. Du Pont De Nemours And Company | Polymerisation mit "living" kennzeichen |
DE10128144A1 (de) * | 2001-06-09 | 2002-12-12 | Oxeno Olefinchemie Gmbh | Verfahren zur Telomerisation von nicht cyclischen Olefinen |
US20030144437A1 (en) * | 2001-03-23 | 2003-07-31 | Andrew Bell | High activity metal carbene metathesis catalysts generated using a thermally activated N-heterocyclic carbene precursor |
WO2009155170A2 (en) * | 2008-06-20 | 2009-12-23 | Bridgestone Corporation | Catalysts for preparing cis 1,4-polydienes |
WO2011085856A1 (de) | 2009-12-21 | 2011-07-21 | Evonik Degussa Gmbh | Neues initiierungsverfahren zur polymerisation von (meth) acrylaten |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
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US8907031B2 (en) * | 2011-04-20 | 2014-12-09 | Chevron Phillips Chemical Company Lp | Imino carbene compounds and derivatives, and catalyst compositions made therefrom |
-
2012
- 2012-06-25 DE DE201210210774 patent/DE102012210774A1/de not_active Withdrawn
-
2013
- 2013-05-28 WO PCT/EP2013/060916 patent/WO2014001007A1/de active Application Filing
- 2013-05-28 CA CA2872959A patent/CA2872959A1/en not_active Abandoned
- 2013-05-28 EP EP13726725.8A patent/EP2864368A1/de not_active Withdrawn
- 2013-05-28 CN CN201380027293.6A patent/CN104334587A/zh active Pending
- 2013-05-28 BR BR112014026767A patent/BR112014026767A2/pt not_active IP Right Cessation
- 2013-05-28 US US14/394,603 patent/US20150126696A1/en not_active Abandoned
- 2013-05-28 JP JP2015518933A patent/JP2015521674A/ja active Pending
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997018247A1 (en) | 1995-11-15 | 1997-05-22 | Carnegie Mellon University | Improved processes based on atom (or group) transfer radical polymerization and novel (co)polymers having useful structures and properties |
EP0910587A1 (de) | 1996-07-10 | 1999-04-28 | E.I. Du Pont De Nemours And Company | Polymerisation mit "living" kennzeichen |
US20030144437A1 (en) * | 2001-03-23 | 2003-07-31 | Andrew Bell | High activity metal carbene metathesis catalysts generated using a thermally activated N-heterocyclic carbene precursor |
DE10128144A1 (de) * | 2001-06-09 | 2002-12-12 | Oxeno Olefinchemie Gmbh | Verfahren zur Telomerisation von nicht cyclischen Olefinen |
WO2009155170A2 (en) * | 2008-06-20 | 2009-12-23 | Bridgestone Corporation | Catalysts for preparing cis 1,4-polydienes |
WO2011085856A1 (de) | 2009-12-21 | 2011-07-21 | Evonik Degussa Gmbh | Neues initiierungsverfahren zur polymerisation von (meth) acrylaten |
Non-Patent Citations (9)
Title |
---|
ATSUSHI GOTO ET AL: "Reversible Complexation Mediated Living Radical Polymerization (RCMP) Using Organic Catalysts", MACROMOLECULES, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC; US, vol. 44, no. 22, 22 November 2011 (2011-11-22), pages 8709 - 8715, XP001570718, ISSN: 0024-9297, [retrieved on 20111019], DOI: 10.1021/MA2014589 * |
DELAUDE ET AL., EUR. J.INORG.CHEM., 2009, pages 1882 - 1891 |
DELAUDE, EUR. J.INORG.CHEM., 2009, pages 1681 - 1699 |
IGLESIAS ET AL., ORGANOMETALLICS, vol. 27, 2008, pages 3279 - 3289 |
LIONEL DELAUDE: "Betaine Adducts of N-Heterocyclic Carbenes: Synthesis, Properties, and Reactivity", EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, 1 April 2009 (2009-04-01), pages 1681 - 1699, XP007922159, ISSN: 1434-1948, [retrieved on 20090401], DOI: 10.1002/EJIC.200801227 * |
MARC D SCHOLTEN ET AL: "Group Transfer Polymerization of Acrylates Catalyzed by N-Heterocyclic Carbenes", MACROMOLECULES, vol. 41, 25 September 2008 (2008-09-25), pages 7399 - 7404, XP007922161, ISSN: 0024-9297, [retrieved on 20080925], DOI: 10.1021/MA801281Q * |
MATYJASZEWSKI ET AL., J.AM.CHEM.SOC., vol. 117, 1995, pages 5614 |
SCIENCE, vol. 272, 1996, pages 866 |
ZHANG ET AL., ANGEW.CHEM., vol. 124, 2012, pages 2515 |
Also Published As
Publication number | Publication date |
---|---|
EP2864368A1 (de) | 2015-04-29 |
US20150126696A1 (en) | 2015-05-07 |
JP2015521674A (ja) | 2015-07-30 |
CN104334587A (zh) | 2015-02-04 |
DE102012210774A1 (de) | 2014-01-02 |
BR112014026767A2 (pt) | 2017-06-27 |
CA2872959A1 (en) | 2014-01-03 |
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