WO2013188546A3 - Procédés pour la biosynthèse de 1,3-butadiène - Google Patents

Procédés pour la biosynthèse de 1,3-butadiène Download PDF

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Publication number
WO2013188546A3
WO2013188546A3 PCT/US2013/045430 US2013045430W WO2013188546A3 WO 2013188546 A3 WO2013188546 A3 WO 2013188546A3 US 2013045430 W US2013045430 W US 2013045430W WO 2013188546 A3 WO2013188546 A3 WO 2013188546A3
Authority
WO
WIPO (PCT)
Prior art keywords
butadiene
biosynthesizing
methods
pathways
dehydratases
Prior art date
Application number
PCT/US2013/045430
Other languages
English (en)
Other versions
WO2013188546A2 (fr
Inventor
Paul S. Pearlman
Changlin Chen
Adriana BOTES
Alex van Eck CONRADIE
Original Assignee
Invista Technologies S.À.R.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2012/042757 external-priority patent/WO2012174439A2/fr
Priority claimed from PCT/US2012/067463 external-priority patent/WO2013082542A2/fr
Application filed by Invista Technologies S.À.R.L. filed Critical Invista Technologies S.À.R.L.
Priority to CN201380043586.3A priority Critical patent/CN104769119A/zh
Priority to JP2015517396A priority patent/JP2015519083A/ja
Priority to EP13739305.4A priority patent/EP2861745A2/fr
Priority to IN309DEN2015 priority patent/IN2015DN00309A/en
Publication of WO2013188546A2 publication Critical patent/WO2013188546A2/fr
Publication of WO2013188546A3 publication Critical patent/WO2013188546A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/02—Preparation of hydrocarbons or halogenated hydrocarbons acyclic
    • C12P5/026—Unsaturated compounds, i.e. alkenes, alkynes or allenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01033—Diphosphomevalonate decarboxylase (4.1.1.33), i.e. mevalonate-pyrophosphate decarboxylase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/01—Hydro-lyases (4.2.1)
    • C12Y402/01127—Linalool dehydratase (4.2.1.127)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/03—Carbon-oxygen lyases (4.2) acting on phosphates (4.2.3)
    • C12Y402/03027—Isoprene synthase (4.2.3.27)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/30—Fuel from waste, e.g. synthetic alcohol or diesel

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention concerne des voies biochimiques de fabrication de butadiène par la formation de deux groupes vinyle dans un substrat de synthèse de butadiène. Ces voies selon l'invention reposent sur des enzymes telles que la mévalonate diphosphate décarboxylase, l'isoprène synthase et les déshydratases pour l'étape enzymatique finale.
PCT/US2013/045430 2011-06-17 2013-06-12 Procédés pour la biosynthèse de 1,3-butadiène WO2013188546A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CN201380043586.3A CN104769119A (zh) 2012-06-15 2013-06-12 生物合成1,3丁二烯的方法
JP2015517396A JP2015519083A (ja) 2012-06-15 2013-06-12 １，３−ブタジエンを生合成するための方法
EP13739305.4A EP2861745A2 (fr) 2012-06-15 2013-06-12 Procédés pour la biosynthèse de 1,3-butadiène
IN309DEN2015 IN2015DN00309A (fr) 2011-06-17 2013-06-12

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
PCT/US2012/042757 WO2012174439A2 (fr) 2011-06-17 2012-06-15 Procédés d'obtention de molécules à quatre carbones
USPCT/US2012/042757 2012-06-15
PCT/US2012/067463 WO2013082542A2 (fr) 2011-12-02 2012-11-30 Procédés de biosynthèse du 1,3-butadiène
USPCT/US2012/067463 2012-11-30

Publications (2)

Publication Number Publication Date
WO2013188546A2 WO2013188546A2 (fr) 2013-12-19
WO2013188546A3 true WO2013188546A3 (fr) 2014-03-27

Family

ID=48803595

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2013/045430 WO2013188546A2 (fr) 2011-06-17 2013-06-12 Procédés pour la biosynthèse de 1,3-butadiène

Country Status (3)

Country Link
EP (1) EP2861745A2 (fr)
CN (1) CN104769119A (fr)
WO (1) WO2013188546A2 (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9422578B2 (en) 2011-06-17 2016-08-23 Invista North America S.A.R.L. Methods for biosynthesizing 1,3 butadiene
WO2012174439A2 (fr) 2011-06-17 2012-12-20 Invista Technologies S.A R.L. Procédés d'obtention de molécules à quatre carbones
EP2785848A2 (fr) * 2011-12-02 2014-10-08 INVISTA Technologies S.à.r.l. Procédés de biosynthèse du 1,3-butadiène
WO2014085612A1 (fr) * 2012-11-28 2014-06-05 INVISTA North America S.á r.l. Procédés de biosynthèse d'isobutène
US10294496B2 (en) 2013-07-19 2019-05-21 Invista North America S.A.R.L. Methods for biosynthesizing 1,3 butadiene
CN105683384A (zh) 2013-08-05 2016-06-15 英威达技术有限责任公司 用于生物合成异丁烯的方法
CN105683385A (zh) 2013-08-05 2016-06-15 英威达技术有限责任公司 用于生物合成异戊二烯的方法
CN106795519A (zh) 2014-06-16 2017-05-31 英威达技术有限责任公司 用于生成戊二酸和戊二酸甲酯的方法
JP2017525380A (ja) * 2014-09-03 2017-09-07 グローバル・バイオエナジーズ アセチルＣｏＡからアルケンを生成する組換え微生物
EP3237634A1 (fr) * 2014-12-22 2017-11-01 Invista Technologies S.à r.l. Matériaux et procédés de production de monomères à 7 carbones
US9220742B1 (en) 2015-02-27 2015-12-29 Invista North America S.A.R.L. Mutant polypeptides and uses thereof
CN107849101A (zh) * 2015-02-27 2018-03-27 英威达技术有限责任公司 新的多肽及其用途
EP3280808B1 (fr) 2015-04-09 2020-09-16 Genomatica, Inc. E. coli génétiquement modifiés et procédés pour améliorer la production d'alcool crotylique
US20170009263A1 (en) * 2015-07-08 2017-01-12 Invista North America S.A.R.L. Methods and host cells for enhancing production of 1, 3-butanediol
EP3333263B1 (fr) * 2015-08-03 2021-12-29 Riken Variant de diphosphomévalonate décarboxylase et procédé de fabrication d'un composé oléfinique l'utilisant
US20180282768A1 (en) * 2015-08-28 2018-10-04 Universitaet Des Saarlandes Means and methods for production of organic compounds
US10801050B2 (en) 2015-10-23 2020-10-13 Metabolic Explorer Microorganism modified for the assimilation of levulinic acid
CN105237420B (zh) * 2015-11-06 2017-09-12 安徽赛诺制药有限公司 L‑苏氨酸合成工艺
US11286490B2 (en) 2016-07-12 2022-03-29 Braskem S.A. Formation of alkenes through enzymatic dehydration of alkanols
US11162115B2 (en) 2017-06-30 2021-11-02 Inv Nylon Chemicals Americas, Llc Methods, synthetic hosts and reagents for the biosynthesis of hydrocarbons
WO2019006255A1 (fr) 2017-06-30 2019-01-03 Invista North America S.A.R.L. Procédés, matériaux, hôtes synthétiques et réactifs pour la biosynthèse d'hydrocarbures et leurs dérivés
US11505809B2 (en) 2017-09-28 2022-11-22 Inv Nylon Chemicals Americas Llc Organisms and biosynthetic processes for hydrocarbon synthesis
CN109666683B (zh) * 2019-02-27 2021-10-29 昆明理工大学 乙酰辅酶A乙酰转移酶基因RKAcaT2及其应用
CN110241103B (zh) * 2019-07-04 2021-01-19 江西邦泰绿色生物合成生态产业园发展有限公司 一种生物酶法生产异戊二烯的方法
CN111334514B (zh) * 2020-02-26 2021-06-22 广西大学 应用花生AhGSNOR基因提高植物耐铝性的方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009155382A1 (fr) * 2008-06-17 2009-12-23 Genomatica, Inc. Micro-organismes et procédés pour la biosynthèse de fumarate, malate, et acrylate
WO2011140171A2 (fr) * 2010-05-05 2011-11-10 Genomatica, Inc. Micro-organismes et procédés pour la biosynthèse de butadiène
US20120021478A1 (en) * 2010-07-26 2012-01-26 Osterhout Robin E Microorganisms and methods for the biosynthesis of aromatics, 2,4-pentadienoate and 1,3-butadiene
WO2013082542A2 (fr) * 2011-12-02 2013-06-06 Invista North America S.A.R.L. Procédés de biosynthèse du 1,3-butadiène

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8703455B2 (en) * 2012-08-29 2014-04-22 Scientist of Fourtune, S.A. Production of volatile dienes by enzymatic dehydration of light alkenols

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009155382A1 (fr) * 2008-06-17 2009-12-23 Genomatica, Inc. Micro-organismes et procédés pour la biosynthèse de fumarate, malate, et acrylate
WO2011140171A2 (fr) * 2010-05-05 2011-11-10 Genomatica, Inc. Micro-organismes et procédés pour la biosynthèse de butadiène
US20110300597A1 (en) * 2010-05-05 2011-12-08 Burk Mark J Microorganisms and methods for the biosynthesis of butadiene
US20120021478A1 (en) * 2010-07-26 2012-01-26 Osterhout Robin E Microorganisms and methods for the biosynthesis of aromatics, 2,4-pentadienoate and 1,3-butadiene
WO2013082542A2 (fr) * 2011-12-02 2013-06-06 Invista North America S.A.R.L. Procédés de biosynthèse du 1,3-butadiène

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2861745A2 *

Also Published As

Publication number Publication date
EP2861745A2 (fr) 2015-04-22
WO2013188546A2 (fr) 2013-12-19
CN104769119A (zh) 2015-07-08

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