WO2013187158A1 - Unité ultrasonore et endoscope ultrasonore - Google Patents

Unité ultrasonore et endoscope ultrasonore Download PDF

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Publication number
WO2013187158A1
WO2013187158A1 PCT/JP2013/063173 JP2013063173W WO2013187158A1 WO 2013187158 A1 WO2013187158 A1 WO 2013187158A1 JP 2013063173 W JP2013063173 W JP 2013063173W WO 2013187158 A1 WO2013187158 A1 WO 2013187158A1
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WO
WIPO (PCT)
Prior art keywords
ultrasonic
cell
transmission
ultrasonic transducer
cells
Prior art date
Application number
PCT/JP2013/063173
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English (en)
Japanese (ja)
Inventor
憲 佐藤
Original Assignee
オリンパス株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by オリンパス株式会社 filed Critical オリンパス株式会社
Priority to CN201380030605.9A priority Critical patent/CN104349722B/zh
Priority to JP2014521024A priority patent/JP5927294B2/ja
Priority to EP13804607.3A priority patent/EP2859852A4/fr
Publication of WO2013187158A1 publication Critical patent/WO2013187158A1/fr
Priority to US14/565,952 priority patent/US10034654B2/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/005Flexible endoscopes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/12Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/44Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
    • A61B8/4444Constructional features of the ultrasonic, sonic or infrasonic diagnostic device related to the probe
    • A61B8/445Details of catheter construction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/44Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
    • A61B8/4483Constructional features of the ultrasonic, sonic or infrasonic diagnostic device characterised by features of the ultrasound transducer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/44Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
    • A61B8/4483Constructional features of the ultrasonic, sonic or infrasonic diagnostic device characterised by features of the ultrasound transducer
    • A61B8/4494Constructional features of the ultrasonic, sonic or infrasonic diagnostic device characterised by features of the ultrasound transducer characterised by the arrangement of the transducer elements
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B06GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS IN GENERAL
    • B06BMETHODS OR APPARATUS FOR GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS OF INFRASONIC, SONIC, OR ULTRASONIC FREQUENCY, e.g. FOR PERFORMING MECHANICAL WORK IN GENERAL
    • B06B1/00Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency
    • B06B1/02Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency making use of electrical energy
    • B06B1/0292Electrostatic transducers, e.g. electret-type
    • HELECTRICITY
    • H02GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02NELECTRIC MACHINES NOT OTHERWISE PROVIDED FOR
    • H02N1/00Electrostatic generators or motors using a solid moving electrostatic charge carrier
    • H02N1/06Influence generators
    • H02N1/08Influence generators with conductive charge carrier, i.e. capacitor machines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/44Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
    • A61B8/4444Constructional features of the ultrasonic, sonic or infrasonic diagnostic device related to the probe
    • A61B8/4455Features of the external shape of the probe, e.g. ergonomic aspects
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B06GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS IN GENERAL
    • B06BMETHODS OR APPARATUS FOR GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS OF INFRASONIC, SONIC, OR ULTRASONIC FREQUENCY, e.g. FOR PERFORMING MECHANICAL WORK IN GENERAL
    • B06B2201/00Indexing scheme associated with B06B1/0207 for details covered by B06B1/0207 but not provided for in any of its subgroups
    • B06B2201/20Application to multi-element transducer

Definitions

  • the present invention relates to an ultrasonic unit having a plurality of capacitive ultrasonic transducer cells and an ultrasonic endoscope including the ultrasonic unit.
  • An ultrasonic diagnostic method in which an ultrasonic wave is irradiated to a test object and an internal state is imaged from an echo signal is diagnosed.
  • One of ultrasonic diagnostic apparatuses used for ultrasonic diagnostic methods is an ultrasonic endoscope.
  • an ultrasonic unit is disposed at a distal end portion of an insertion portion to be inserted into the body.
  • the ultrasonic unit has a function of converting an electric signal into an ultrasonic wave and transmitting it into the body, and receiving an ultrasonic wave reflected in the body and converting it into an electric signal.
  • a piezoelectric ultrasonic vibrator using a piezoelectric ceramic material (for example, PZT: lead zirconate titanate), or a capacitive ultrasonic vibration manufactured using MEMS technology.
  • PZT lead zirconate titanate
  • the child Capacitive Micro-machined Ultrasonic Transducer: c-MUT is used.
  • the lower electrode and the upper electrode constituting the membrane are arranged to face each other via a cavity.
  • the membrane is deformed by an electrostatic force and ultrasonic waves are generated.
  • the reflected ultrasonic wave (echo) reflected by the subject is incident on the cell, the membrane is deformed, so that the ultrasonic wave is received by measuring the capacitance between the electrodes.
  • Japanese National Publication No. 2005-210264 discloses an ultrasonic unit having a transmission-only cell with a structure that emphasizes transmission sensitivity and a reception-only cell with a structure that emphasizes reception sensitivity. Yes.
  • the transmission-only cell or the reception-only cell is used only for transmission or reception, respectively, and the number and occupied area are the same. For this reason, it cannot be said that it has sufficiently high characteristics from the viewpoint of transmission / reception efficiency.
  • Embodiments of the present invention are intended to provide an ultrasonic unit with high transmission / reception sensitivity and an ultrasonic endoscope with high transmission / reception sensitivity.
  • an ultrasonic endoscope includes a plurality of ultrasonic waves including N ultrasonic transducer cells in which a lower electrode and an upper electrode constituting a membrane are arranged to face each other via a cavity.
  • the ultrasonic endoscope 2 constitutes an ultrasonic endoscope system 1 together with an ultrasonic observation device 3 and a monitor 4.
  • the ultrasonic endoscope 2 includes an elongated insertion portion 41 to be inserted into the body, an operation portion 42 disposed at the proximal end of the insertion portion 41, a universal cord 43 extending from a side portion of the operation portion 42, It comprises.
  • a connector 44A connected to a light source device (not shown) is disposed at the base end of the universal cord 43. From the connector 44A, there are a cable 45 that is detachably connected to a camera control unit (not shown) via a connector 45A, and a cable 46 that is detachably connected to the ultrasonic observation apparatus 3 via a connector 46A. It is extended.
  • a monitor 4 is connected to the ultrasonic observation apparatus 3.
  • the insertion portion 41 is, in order from the distal end side, a distal end portion 47, a bending portion 48 positioned at the rear end of the distal end portion 47, and a small diameter and long length reaching the operation portion 42 at the rear end of the bending portion 48.
  • a flexible tube portion 49 having flexibility is provided in series.
  • the ultrasonic unit 30 is arrange
  • the operation unit 42 includes an angle knob 42A that controls the bending of the bending portion 48 in a desired direction, an air / water supply button 42B that performs air supply and water supply operations, a suction button 42C that performs suction operations, and a body that will be described later.
  • a treatment instrument insertion port 42D or the like serving as an entrance of a treatment instrument having a puncture needle or the like is disposed.
  • the distal end portion 47 where the ultrasonic unit 30 of the ultrasonic endoscope 2 is disposed has an illumination lens cover 31 constituting an illumination optical system and an observation optical system for observation.
  • a lens cover 32, a forceps port 33, and an air / water supply nozzle (not shown) are disposed.
  • the ultrasonic unit 30 includes a plurality of ultrasonic transducer elements (hereinafter referred to as “elements”) 60.
  • the external electrode 62A is connected to the conductor 81A of the cable 80, and the external electrode 62B is connected to the conductor 81B of the cable 80.
  • the element 60 which is a basic unit for transmitting and receiving ultrasonic waves, has a first main surface 60SA and a second main surface 60SB facing the first main surface 60SA.
  • a transmitter / receiver 61 that transmits and receives ultrasonic waves is formed at a substantially central portion of the first main surface 60SA of the element 60, and external electrodes 62A and 62B are disposed at both ends of the first main surface 60SA.
  • the element 60 has a plurality of ultrasonic transducer cells (hereinafter referred to as “cells”) 9.
  • the cell 9 of the element 60 includes a lower electrode layer 11, a lower insulating layer 12, a cavity 13, and a support layer 14, which are sequentially stacked on a silicon substrate 10 that is a base.
  • the upper insulating layer 15, the upper electrode layer 16, and the protective layer 17 are included.
  • FIG. 5 shows a cross-sectional structure of one cell 9, but generally several tens to several thousand cells 9 constitute one element 60.
  • the lower electrode layer 11 has a plurality of lower electrodes 11A and a plurality of lower electrode wirings (not shown) extending from the edge of the lower electrode 11A.
  • the lower electrode layer 11 connects the lower electrodes 11 ⁇ / b> A of other cells 9 of the same element 60.
  • the upper electrode layer 16 includes a plurality of upper electrodes 16A and a plurality of upper electrode wirings (not shown) extending from the upper electrode 16A.
  • the upper electrode layer 16 connects the upper electrodes 16 ⁇ / b> A of other cells 9 of the same element 60.
  • Each cell 9 includes a lower electrode 11 ⁇ / b> A and an upper electrode 16 ⁇ / b> A that are opposed to each other with the cavity 13 interposed therebetween.
  • all the lower electrodes 11A of the plurality of cells 9 arranged in the same element 60 are connected to each other, and all the upper electrodes 16A are also connected to each other.
  • a driving voltage is applied to the lower electrode layer 11, and the upper electrode layer 16 is at ground potential.
  • the membrane (vibrating part) 18 including the upper electrode 16A is vibrated by an electrostatic force, thereby generating an ultrasonic wave. Further, when ultrasonic waves are incident from the outside, the membrane 18 is deformed and the distance between the lower electrode layer 11 and the upper electrode layer 16 is changed, so that the ultrasonic waves are converted into electric signals from the change in capacitance.
  • the N cells 9 of the element 60 include N 1a first cells 9A and N 2a second cells 9B (provided that N 1a ⁇ N 2a ).
  • the second cell 9B has higher reception sensitivity and lower transmission sensitivity than the first cell 9A. That is, the first cell 9A has the transmission sensitivity S T1a and the reception sensitivity S R1a , and the second cell 9B has the transmission sensitivity S T2a (where S T1a > S T2a ) and the reception sensitivity S R2a (where S R1a ⁇ S R2a ).
  • the transmission sensitivity and reception sensitivity of the cell 9 can be optimized for transmission or reception by changing the thickness of the membrane 18, for example.
  • the transmission / reception sensitivity S of the ultrasonic unit 30 (element 60) is defined as the product of the transmission sensitivity S T (unit: Pa / V) and the reception sensitivity S R (unit: V / Pa).
  • the maximum condition is derived theoretically.
  • transmission and reception sensitivity S a of the element 60 is defined by Equation (14).
  • the ultrasonic unit 30 performs transmission and reception using both the first cell 9A suitable for transmission and the second cell 9B suitable for reception. For this reason, the transmission sensitivity is higher than that of a conventional ultrasonic unit that performs transmission using only the first cell 9A suitable for transmission. Similarly, the reception sensitivity is higher than that of a conventional ultrasonic unit that performs reception using only the second cell 9B suitable for reception.
  • the ultrasonic unit 30 having the number of first cells 9A represented by (Expression 15) and the number of second cells 9B represented by (Expression 16) has high transmission / reception sensitivity.
  • the ultrasonic endoscope 2 including the ultrasonic unit 30 has high transmission / reception sensitivity.
  • the number (ratio) of the cells 9 is not strictly limited to the number indicated by (Equation 15) or the like, but from the number indicated by (Equation 15) or the like from the relationship of the arrangement in the element. It may be within a range of ⁇ 10%.
  • the number N 1a of the first cells 9A only needs to satisfy the following (Formula 15A) with respect to the number (X) represented by (Formula 15).
  • Equation 15 the number N 1a of the first cell 9A, the number N 2a of the second cell. 9B (Equation 17) and (Equation 18).
  • the number N 1a of the first cells 9A is 22.5% (25 ⁇ 0.9) or more and 27.5% (25 ⁇ 1.1) or less of the number N a of the plurality of cells 9, As described above, it is effective.
  • the number N 1b of the first cells 9Ab is an exclusive area A 1b transmission cell
  • the number N 2b of the second cells 9Bb is the area A 2b (provided that A 1b ⁇ A 2b ) reception-only cell.
  • the lower electrode of the first cell 9Ab and the lower electrode of the second cell 9Bb which are drive potential electrodes arranged in the element 60b, are not connected.
  • the upper electrode of the first cell 9Ab which is a ground potential electrode, and the upper electrode of the second cell 9Bb may be connected.
  • the occupied area of the cell 9b does not mean, for example, the diameter or the like of each cavity, but as shown in FIG. 7, the center when arranged in the element 60 and the center of other surrounding cells 9b This is the area of the portion surrounded by the line connecting the midpoints.
  • the number (ratio) of the cells 9 is not strictly limited to the number indicated by (Expression 29) or the like, but from the number indicated by (Expression 29) or the like from the relationship of the arrangement in the element. It may be within a range of ⁇ 10%.
  • the number N 1b of the first cells 9Ab only needs to satisfy the following (Expression 29A) with respect to the number (Y) indicated by (Expression 29).
  • the number N 1b of the first cell 9Ab is, 60% of the number N b of a plurality of cells 9 ((2/3) ⁇ 0.9) or more 73.3% ((2/3) ⁇ 1.1 ) As described above, the following effects are effective.
  • the ultrasonic unit 30b performs transmission using only the first cell 9Ab dedicated to transmission, and performs reception using only the second cell 9Bb dedicated to reception.
  • the area occupied by A 1b of the first cell 9Ab, and the area occupied by A 2b of the second cell 9Bb it is different.
  • the number (ratio) of cells having the maximum transmission / reception sensitivity is not related to the transmission sensitivity or the reception sensitivity.
  • each element 60b has the number of cells 9Ab and 9Bb indicated by (Expression 31) and (Expression 32) has high transmission / reception sensitivity.
  • the ultrasonic endoscope 2b including the ultrasonic unit 30b has high transmission / reception sensitivity.
  • the ultrasonic unit 30c and the ultrasonic endoscope 2c of the third embodiment will be described. Since the ultrasonic unit 30c and the like are similar to the ultrasonic unit 30 and the like, the same components are denoted by the same reference numerals and description thereof is omitted.
  • the element 60c of the ultrasonic unit 30c has an area where the ultrasonic cell can be arranged as A c , the first cell 9Ac has a transmission sensitivity S T1c , a reception sensitivity S R1c , and an area is A 1c , and the second cell 9Ac is the transmission sensitivity S T2c (where S T1c > S T2c ), the reception sensitivity S R2c (where S R1c ⁇ S R2c ), and the area A 2c (where A 1c ⁇ A 2c ).
  • the number (ratio) of the cells 9 is not strictly limited to the number indicated by (Equation 50) or the like, but from the number indicated by (Equation 50) or the like from the relationship of the arrangement in the element. It may be within a range of ⁇ 10%.
  • the number N 1c of the first cells 9Ac only needs to satisfy the following (Expression 50A) with respect to the number (Z) indicated by (Expression 50).
  • N c 1000
  • transmission sensitivity S T1c 100 Pa / V
  • transmission sensitivity S T2c 20 Pa / V
  • reception sensitivity S R1c 300 pV / Pa
  • reception sensitivity S R2c 900 pV / Pa
  • a 2c 5000 ⁇ m 2
  • the effect is obtained if the number N 1c of the first cells 9Ac is 720 (800 ⁇ 0.9) or more and 880 (800 ⁇ 1.1) or less.
  • the ultrasonic unit 30c Since the ultrasonic unit 30c has the effects of the ultrasonic units 30 and 30b, the transmission / reception sensitivity is higher.
  • the ultrasonic endoscope 2c including the ultrasonic unit 30c has higher transmission / reception sensitivity.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Optics & Photonics (AREA)
  • Mechanical Engineering (AREA)
  • Power Engineering (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Transducers For Ultrasonic Waves (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)

Abstract

La présente invention concerne une unité ultrasonore (30) qui est dotée d'éléments multiples (60) comprenant un nombre N de cellules (9) dans lesquelles une électrode inférieure (11A) est disposée face à une électrode supérieure (16A), qui configure une membrane (18), à travers une cavité (13). Les éléments (60) ont un nombre N1 de premières cellules (9A) et un nombre N2 de secondes cellules (9B), qui ont une sensibilité de récepteur supérieure et une sensibilité de transmetteur inférieure à celles des premières cellules (9A) (à condition que N1≠N2, N1+N2=N).
PCT/JP2013/063173 2012-06-11 2013-05-10 Unité ultrasonore et endoscope ultrasonore WO2013187158A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CN201380030605.9A CN104349722B (zh) 2012-06-11 2013-05-10 超声波部件以及超声波内窥镜
JP2014521024A JP5927294B2 (ja) 2012-06-11 2013-05-10 超音波ユニットおよび超音波内視鏡
EP13804607.3A EP2859852A4 (fr) 2012-06-11 2013-05-10 Unité ultrasonore et endoscope ultrasonore
US14/565,952 US10034654B2 (en) 2012-06-11 2014-12-10 Ultrasound unit and ultrasound endoscope

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2012-132026 2012-06-11
JP2012132026 2012-06-11

Related Child Applications (1)

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US14/565,952 Continuation US10034654B2 (en) 2012-06-11 2014-12-10 Ultrasound unit and ultrasound endoscope

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WO2013187158A1 true WO2013187158A1 (fr) 2013-12-19

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US (1) US10034654B2 (fr)
EP (1) EP2859852A4 (fr)
JP (1) JP5927294B2 (fr)
CN (1) CN104349722B (fr)
WO (1) WO2013187158A1 (fr)

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RU2691926C2 (ru) * 2014-12-11 2019-06-18 Конинклейке Филипс Н.В. Катетер-преобразователь с расположенными в шахматном порядке рядами микромашинных ультразвуковых преобразователей
CN109925004A (zh) * 2017-12-19 2019-06-25 苏州国科昂卓医疗科技有限公司 一种超声内窥探头和具有其的超声内窥导管及成像装置

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JPH03165749A (ja) * 1989-11-24 1991-07-17 Aloka Co Ltd 超音波探触子
JP2002336248A (ja) * 2001-05-14 2002-11-26 Aloka Co Ltd 超音波探触子
JP2005210264A (ja) 2004-01-21 2005-08-04 Fujitsu Ltd 光受信器及び光伝送装置
JP2011025055A (ja) * 2010-08-23 2011-02-10 Olympus Corp 静電容量型超音波振動子
JP2012132026A (ja) 2006-07-18 2012-07-12 Arakawa Chem Ind Co Ltd 導電性高分子/ドーパント錯体有機溶媒分散体の製造方法
JP2013034665A (ja) * 2011-08-08 2013-02-21 Olympus Medical Systems Corp 超音波エレメントおよび超音波内視鏡

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US6314057B1 (en) * 1999-05-11 2001-11-06 Rodney J Solomon Micro-machined ultrasonic transducer array
US6585653B2 (en) 2001-07-31 2003-07-01 Koninklijke Philips Electronics N.V. Micro-machined ultrasonic transducer (MUT) array
WO2006046471A1 (fr) * 2004-10-27 2006-05-04 Olympus Corporation Transducteur ultrasonore micro-usine capacitif et systeme de diagnostic a ultrasons intracorporel utilisant celui-ci
DE602005006419T2 (de) * 2005-09-14 2008-09-25 Esaote S.P.A. Elektroakustischer Wandler für Hochfrequenzanwendungen
JP5024989B2 (ja) * 2007-01-23 2012-09-12 株式会社東芝 2次元アレイ超音波プローブ及び超音波診断システム
JP4891182B2 (ja) * 2007-08-28 2012-03-07 オリンパスメディカルシステムズ株式会社 超音波トランスデューサ、超音波診断装置及び超音波顕微鏡
JP5511260B2 (ja) * 2009-08-19 2014-06-04 キヤノン株式会社 容量型電気機械変換装置、及びその感度調整方法

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JPH03165749A (ja) * 1989-11-24 1991-07-17 Aloka Co Ltd 超音波探触子
JP2002336248A (ja) * 2001-05-14 2002-11-26 Aloka Co Ltd 超音波探触子
JP2005210264A (ja) 2004-01-21 2005-08-04 Fujitsu Ltd 光受信器及び光伝送装置
JP2012132026A (ja) 2006-07-18 2012-07-12 Arakawa Chem Ind Co Ltd 導電性高分子/ドーパント錯体有機溶媒分散体の製造方法
JP2011025055A (ja) * 2010-08-23 2011-02-10 Olympus Corp 静電容量型超音波振動子
JP2013034665A (ja) * 2011-08-08 2013-02-21 Olympus Medical Systems Corp 超音波エレメントおよび超音波内視鏡

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Title
See also references of EP2859852A4

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Publication number Publication date
CN104349722B (zh) 2016-08-31
CN104349722A (zh) 2015-02-11
US20150087993A1 (en) 2015-03-26
US10034654B2 (en) 2018-07-31
JP5927294B2 (ja) 2016-06-01
JPWO2013187158A1 (ja) 2016-02-04
EP2859852A1 (fr) 2015-04-15
EP2859852A4 (fr) 2016-03-02

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