WO2013155970A1 - 人工心脏瓣膜及其瓣膜支架 - Google Patents
人工心脏瓣膜及其瓣膜支架 Download PDFInfo
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- WO2013155970A1 WO2013155970A1 PCT/CN2013/074329 CN2013074329W WO2013155970A1 WO 2013155970 A1 WO2013155970 A1 WO 2013155970A1 CN 2013074329 W CN2013074329 W CN 2013074329W WO 2013155970 A1 WO2013155970 A1 WO 2013155970A1
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- WIPO (PCT)
- Prior art keywords
- valve
- valve stent
- stent
- suture edge
- suture
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
- A61F2/2418—Scaffolds therefor, e.g. support stents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2409—Support rings therefor, e.g. for connecting valves to tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
- A61F2230/0004—Rounded shapes, e.g. with rounded corners
- A61F2230/0013—Horseshoe-shaped, e.g. crescent-shaped, C-shaped, U-shaped
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
- A61F2230/0017—Angular shapes
- A61F2230/0023—Angular shapes triangular
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/0039—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in diameter
Definitions
- the invention relates to the field of medical instruments, in particular to a prosthetic heart valve and a valve support thereof.
- valvular heart disease can be divided into two categories: congenital and acquired.
- Congenital valvular heart disease is due to dysplasia or hypoplasia at birth.
- aortic valve two-valve deformity can cause aortic stenosis or regurgitation. If the aortic stenosis or regurgitation is severe, it will seriously affect hemodynamic changes, causing progressive valve function decline, and finally leading to heart failure and death.
- the underlying cause of acquired valvular heart disease can be divided into infection, degenerative changes, rheumatic immune changes, or other causes.
- Infection is the passage of bacteria through the blood to the heart and invades the valve; degenerative changes are gradually degraded with age, and the aortic valve is most common; rheumatic immune changes mainly refer to rheumatic heart disease, due to streptococcal infection, This in turn triggers an immune response that destroys the heart valve.
- Other causes may include trauma, spontaneous rupture of the chordae, and the like.
- valvular heart disease there are two main types of surgical treatment for valvular heart disease: one is valvuloplasty, which repairs the damaged valve; the other is valve replacement, which uses a prosthetic heart valve for valve replacement.
- the existing artificial biological valve has the following problems in the surgical replacement process:
- the main object of the present invention is to provide a valve stent, which is intended to enable the artificial heart valve formed by the valve stent to be used in both interventional and surgical implantation, and the interventional procedure is safer and the implantation procedure is faster. .
- the present invention provides a valve stent for a prosthetic heart valve, the valve stent being an axially contractible elastic stent, and the valve stent is hollowed out, and the valve stent is provided with a U-shaped opening at a position corresponding to the leaflet.
- the lower portion of the U-shaped opening of the valve support is provided with a positioning structure.
- the positioning structure includes a recess formed by the inwardly recessed valve support, the recess for engaging the valve to limit sliding of the valve support.
- the positioning structure includes a securing portion formed by the valve stent extending outwardly, the securing portion being engaged at a valve position to limit sliding of the valve support.
- the positioning structure includes a suture edge for positioning the valve support at a valve position.
- the suture edge is a semi-finished suture edge, and the suture edge is made of a water-swellable material; or the suture edge is a wave-shaped suture edge.
- the U-shaped open top end extends upwardly and an extension is also provided.
- the root of the U-shaped opening extends outwardly.
- the lower end of the U-shaped opening of the valve stent is provided with a hollow mouth.
- the upper end of the valve stent is provided with a connecting portion, the U-shaped opening is formed between the two adjacent connecting portions, and the outer wall of the connecting portion is provided with a coating; the lower end of the valve bracket is inside Buckle structure.
- the invention also provides a prosthetic heart valve comprising a leaflet and a valve support supporting the leaflet, the valve support being an axially contractible elastic support, the valve support being hollowed out, and the valve support corresponding to the valve A U-shaped opening is provided at the position of the leaf.
- the invention provides a hollow valve-shaped valve stent with a U-shaped opening, so that the overall metal structure of the heart valve is greatly reduced, which is very advantageous for the loading and recovery of the intervention and implantation, and reduces the human body's rejection of the implantability.
- the present invention also provides a positioning structure through the outer wall of the valve support such that the positioning structure can be adapted to the position of the valve and allows for better positioning of the valve support.
- the invention also effectively solves the problem that the annulus of the artificial surgical heart valve implanted by the prior surgical surgery is a steel structure, the model number is limited, and the shape of the patient's heart annulus is different and the shape is different by providing a suture edge on the outer wall of the valve stent. contradiction.
- the self-expanding stent (which can be made of memory alloy) has the characteristics of growth, chronic expansion and self-adaptation with the body. During the operation, the operation is simpler and more convenient, so as to shorten the operation time and reduce the risk of surgery.
- the flap and the flap can be better shrunk and placed more easily in the annulus, thereby avoiding the possibility of augmentation.
- the invention also spreads out through the root of the U-shaped opening, so that the inner wall of the blood vessel which is attached to the valve support can be opened, and the possibility that the artificial heart valve is blocked to the coronary artery due to fatigue damage after long-term use is reduced.
- the present invention also extends through the U-shaped open top end to form an extension that allows the extension to better support the ascending artery, thereby making the heart valve more stable and maintaining blood flow.
- the present invention also provides a film by the outer wall of the top end of the U-shaped opening, so that the metal tip can be prevented from coming into contact with the inner wall of the blood vessel, thereby puncturing the blood vessel.
- the invention also provides a hollow mouth corresponding to the coronary vein through the lower part of the U-shaped opening, thereby ensuring a smoother blood flow and avoiding the occurrence of intermittent coronary occlusion.
- FIG. 1 is a schematic structural view of a first embodiment of a prosthetic heart valve of the present invention
- FIG. 2 is a schematic structural view of a second embodiment of the artificial heart valve of the present invention.
- Figure 3 is a schematic view showing the structure of a third embodiment of the artificial heart valve of the present invention.
- Figure 4 is a schematic view showing the structure of a fourth embodiment of the artificial heart valve of the present invention.
- Figure 5 is a schematic view showing the structure of a fifth embodiment of the artificial heart valve of the present invention.
- Figure 6 is a top plan view of the prosthetic heart valve shown in Figure 1;
- Figure 7 is a schematic view showing the structure of a sixth embodiment of the artificial heart valve of the present invention.
- Figure 8 is a schematic view showing the structure of a seventh embodiment of the artificial heart valve of the present invention.
- FIG. 1 is a schematic view showing the structure of a first embodiment of a prosthetic heart valve of the present invention.
- the inventive artificial heart valve includes a leaflet 20 and a valve support 10 that supports the leaflet 20.
- the valve stent 10 is a meshed hollow stent made of an elastic material and axially expandable.
- the leaflets 20 are made of a polymeric biomaterial or biological tissue.
- the valve holder 10 is provided with a U-shaped opening 30 at a position corresponding to the leaflets.
- the leaflet 20 is 2-3 flaps.
- the aortic valve is taken as an example, and the leaflets are three-lobed, and the corresponding U-shaped openings 30 on the corresponding valve stent 10 are also three.
- the root of the U-shaped opening 30 extends to more than half of the leaflets 20 and extends up to the root of the leaflets 20.
- the valve stent 10 includes an upper end 11 and a lower end 12, wherein the lower end 12 is a blood inflow.
- the upper end 11 includes a connecting portion 111 in which the leaflets 20 are disposed, and the U-shaped opening 30 is formed between the two connecting portions 111.
- the edge of the U-shaped opening 30 is a circular arc transition rib connecting the adjacent two connecting portions 111, so that stress concentration can be reduced, and the valve holder 10 can be prevented from being broken due to fatigue.
- the overall metal structure of the heart valve is greatly reduced, which is very advantageous for loading and recycling of the intervention and implantation, and reducing the human body's rejection of the implant.
- the lower portion of the U-shaped opening 30 of the valve stent 10 is further provided with a positioning structure for aligning the valve stent 10 with the valve position, that is, the junction of the upper end 11 and the lower end 12.
- the positioning structure includes a recessed portion 41 formed by recessing the outer wall of the valve stent 10, the recessed portion 41 being engageable with the valve position to restrict sliding of the valve support. Since the valve stent 10 is a resilient stent, after the valve stent in the sheath is delivered to the valve position, the valve stent 10 is elastically opened when the sheath is detached, so that the recess 41 can also elastically cooperate with the valve position. Limiting the sliding of the valve support 10.
- FIG 2 is a schematic view showing the structure of a second embodiment of the prosthetic heart valve of the present invention.
- the positioning structure may further include only the fastening portion 42 formed by the extension of the stent; or the positioning portion of the valve stent formed by the fastening portion 42 and the concave portion 41.
- the leaflets of the human body remain in the original position (ie, the valve position), and the locking portion 42 can engage the human valve leaflets to restrict the sliding of the valve stent, thereby realizing the valve stent 10 Positioning.
- the securing portion 42 is coupled to the recessed portion 41, the recessed portion 41 also cooperates with the valve position to further enhance the positioning of the valve support 10.
- FIG 3 is a schematic view showing the structure of a third embodiment of the prosthetic heart valve of the present invention.
- the positioning structure may further include a suture edge 43 including a suture portion 431 having an annular shape that fits the valve stent 10, as shown in FIG.
- the suture margin 43 is primarily used for the replacement of prosthetic heart valves during surgery. For example, after the heart is opened, the diseased valve is first removed, the suture portion 431 is sutured with the human annulus, and the heart and the thoracic cavity are finally sutured.
- the present invention effectively solves the problem that the annulus of the artificially implanted artificial heart valve is a steel structure, the model number is limited, and the shape of the patient's heart annulus is different and the shape is formed by providing the suture margin 43 on the outer wall of the valve stent 10.
- the self-expanding stent (which can be made of memory alloy) has the characteristics of growth, chronic expansion and self-adaptation with the body. During the operation, the operation is simpler and more convenient. Thereby achieving the purpose of shortening the operation time and reducing the risk of surgery.
- the valve body and the valve frame can better adapt to the size of the annulus and cooperate with the annulus of the human body, thereby avoiding the possibility of augmentation of the annulus.
- FIG 4 is a schematic view showing the structure of a fourth embodiment of the prosthetic heart valve of the present invention.
- the difference from the third embodiment is that the stitching edge 43 is a wave stitching edge.
- the suture edge 43 is wavy, and the inner wall of the suture edge 43 is attached to the outer wall of the valve stent 10. Since the annulus of the human body is not a flat cross section, the undulating suture edge can be fitted with an annulus having an uneven cross section through which the corrugated suture margin 43 can be brought into closer contact with the annulus and can be more with the native flap. Good fit, reducing the possibility of paravalvular leaks.
- This undulating suture margin 43 is also primarily used for the replacement of prosthetic heart valves during surgery. For example, after the heart is opened, the diseased valve is first removed, the wavy suture margin 43 is sutured to the human annulus, and the heart and chest are finally sutured.
- FIG 5 is a schematic view showing the structure of a fifth embodiment of the prosthetic heart valve of the present invention.
- the difference from the third and fourth embodiments is that the stitching edge 43 is a semi-finished stitching edge.
- the stitching edge 43 is provided with a recess 432 which is adapted to the annulus.
- the diseased valve is first removed, and then the artificial heart valve is placed through the groove 432 at a suitable position of the annulus, and the groove 432 is also engaged with the annulus, and then the groove 432 is further engaged.
- the wall is sutured with the annulus and the heart and chest are finally sutured.
- the suture edge 43 Since the groove 432 of the suture edge 43 can be engaged with the annulus, the number of sutures can be reduced when the suture edge 43 and the annulus are sutured, thereby shortening the operation time and reducing the risk of surgery.
- the suture edge also has the property of swelling with water, and can be closely adhered to human tissue after implantation. Or the suture edge has the property of gradually degrading with the climbing of the valve stent with human tissue.
- a prosthetic heart valve having the semi-finished suture edge can also be used in an invasive manner.
- the suture edge 43 is expanded with water such that the recess 432 can engage the body valve therein, and the expanded recess 432 can be engaged with the annulus position such that the prosthetic heart valve and flap The rings are stronger.
- the leaflet 20 described above is attached to the inner surface of the valve stent 10, and both ends of the leaflet 20 are fixed to the connecting portion 111.
- the leaflet 20 junction has a concave structure, which reduces the opening of the leaflet 20, thereby reducing the likelihood of the leaflet 20 blocking the coronary artery.
- the concave structure at the junction of the leaflets 20 allows the actual opening of the leaflets 20 to be defined within the dashed line, reducing the likelihood that the valve leaflets 20 will touch the coronary artery after prolonged use of the valve. Sex.
- the root portion of the U-shaped opening 30 is extended to form a protrusion 31 which can appropriately expand the inner wall of the blood vessel to which the valve stent 10 is attached, thereby increasing the distance between the coronary vein and the leaflet 20, and further Reduce the possibility of prosthetic heart valve blocking the coronary artery due to fatigue damage after long-term use.
- the lower portion of the U-shaped opening 30 is provided with a hollow port 32 corresponding to the coronary ostium, thereby ensuring a smoother blood flow and avoiding the occurrence of intermittent coronary occlusion.
- the bottom of the lower end 12 is gathered inwardly to form an inner buckle structure, so that the lower end can be prevented from pressing the atrioventricular node and affecting the heart conduction tissue.
- Figure 7 is a schematic view showing the structure of a sixth embodiment of the prosthetic heart valve of the present invention.
- the difference from the first to fifth embodiments is that the outer wall of the connecting portion 111 is provided with a coating film 112 which prevents the metal tip from coming into contact with the inner wall of the blood vessel, thereby puncturing the blood vessel.
- Figure 8 is a schematic view showing the structure of a seventh embodiment of the artificial heart valve of the present invention.
- the difference from the first to sixth embodiments is that the connecting portion 111 of the upper end 11 is further provided with an extension portion 113, which can better support the support at the ascending artery, making the heart valve more stable and maintaining blood flow direction.
- the axial length of the valve stent is increased, so that the heart valve begins to work after releasing 2/3 of the valve stent 10 during use, and the operator can determine whether to retract according to the working condition and position of the heart valve.
- the artificial heart valve is delivered to the aortic valve site through the infusion through the body through the femoral artery incision.
- the prosthetic heart valve is then released to stabilize it.
- the distal end of the sheath tube of the delivery device passes through the outer sheath, and the outer sheath can be pulled to realize the relative movement of the inner tube and the outer tube.
- the outer tube is withdrawn a certain distance to expose the valve stent 10
- the released partial valve stent 10 is raised by body temperature. At this time, the in-position effect of the valve stent 10 can be observed according to the situation after the ascending.
- the inner sheath can be pulled while pushing the outer sheath to drive the valve stent to fix the head. Since the fixed ear of the valve stent 10 has not been released at this time, it is still in the positioning groove under the sheath of the outer sheath, and the valve stent fixing head can pull the fixed ear so that the valve stent 10 gradually enters the outer sheath, and the inner wall of the outer sheath is squeezed. Upon depression, the valve stent 10 will gradually collapse until completely wrapped by the outer sheath back to the pre-release state, and then repositioned and released until the prosthetic heart valve is secured in the optimal position.
Abstract
Description
Claims (13)
- 一种人工心脏瓣膜的瓣膜支架,其特征在于,所述瓣膜支架为可轴向收缩的弹性支架,而且所述瓣膜支架呈镂空状,所述瓣膜支架对应瓣叶的位置处设置U形开口。
- 根据权利要求1所述的瓣膜支架,其特征在于,所述瓣膜支架的U形开口下部设有定位结构。
- 根据权利要求2所述的瓣膜支架,其特征在于,所述定位结构包括由瓣膜支架向内凹设而形成的凹设部,所述凹设部用于与瓣膜位置配合,限制所述瓣膜支架滑动。
- 根据权利要求2或3所述的瓣膜支架,其特征在于,所述定位结构包括由瓣膜支架向外延展形成的卡固部,所述卡固部卡合在瓣膜位置处,限制所述瓣膜支架滑动。
- 根据权利要求4所述的瓣膜支架,其特征在于,所述定位结构还包括用于瓣膜支架在瓣膜位置进行定位的缝合缘。
- 根据权利要求5所述的瓣膜支架,其特征在于,所述缝合缘为半工型缝合缘,且该缝合缘的材质为遇水膨胀性材料;或者所述缝合缘为波浪型缝合缘。
- 根据权利要求2或3所述的瓣膜支架,其特征在于,所述定位结构包括用于瓣膜支架在瓣膜位置进行定位的缝合缘。
- 根据权利要求7所述的瓣膜支架,其特征在于,所述缝合缘为半工型缝合缘,且该缝合缘的材质为遇水膨胀性材料;或者所述缝合缘为波浪型缝合缘。
- 根据权利要求1至3中任一项所述的瓣膜支架,其特征在于,所述U形开口顶端向上延伸还设置延长部。
- 根据权利要求1至3中任一项所述的瓣膜支架,其特征在于,所述U形开口的根部向外延展。
- 根据权利要求1至3中任一项所述的瓣膜支架,其特征在于,所述瓣膜支架的U形口的下部设有镂空口。
- 根据权利要求7所述的瓣膜支架,其特征在于,所述瓣膜支架的上端设有连接部,所述两相邻的连接部之间形成所述U形开口,而且连接部的外壁上设有覆膜;所述瓣膜支架的下端呈内扣结构。
- 一种人工心脏瓣膜,其特征在于,包括瓣叶及支撑所述瓣叶的瓣膜支架,所述瓣膜支架为权利要求1-12中任一项所述的瓣膜支架。
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DE212013000104.5U DE212013000104U1 (de) | 2012-04-19 | 2013-04-18 | Künstliche Herzklappe sowie deren Klappenhalter |
JP2015600012U JP3196976U (ja) | 2012-04-19 | 2013-04-18 | 人工心臓弁及びその弁ステント |
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CN201210116475.8 | 2012-04-19 | ||
CN201210116475.8A CN102764169B (zh) | 2012-04-19 | 2012-04-19 | 人工心脏瓣膜及其瓣膜支架 |
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WO2014110023A1 (en) * | 2013-01-08 | 2014-07-17 | Medtronic Inc. | Valve prosthesis |
JP2015177971A (ja) * | 2014-03-18 | 2015-10-08 | エヌヴィーティー アーゲー | 移植用心臓弁 |
JP2016107078A (ja) * | 2014-12-05 | 2016-06-20 | エヌヴィーティー アーゲー | 人工心臓弁システムおよび該システムのための送達システム |
CN108378960A (zh) * | 2017-10-24 | 2018-08-10 | 杭州启明医疗器械有限公司 | 一种介入心脏瓣膜的可调弯输送系统 |
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US11672661B2 (en) | 2019-08-22 | 2023-06-13 | Silara Medtech Inc. | Annuloplasty systems and methods |
US11744699B2 (en) | 2015-10-09 | 2023-09-05 | Medtronic Vascular, Inc. | Heart valve prostheses and methods for percutaneous heart valve replacement |
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US8579964B2 (en) | 2010-05-05 | 2013-11-12 | Neovasc Inc. | Transcatheter mitral valve prosthesis |
US9554897B2 (en) | 2011-04-28 | 2017-01-31 | Neovasc Tiara Inc. | Methods and apparatus for engaging a valve prosthesis with tissue |
US9308087B2 (en) | 2011-04-28 | 2016-04-12 | Neovasc Tiara Inc. | Sequentially deployed transcatheter mitral valve prosthesis |
CN102764169B (zh) * | 2012-04-19 | 2015-07-29 | 杭州启明医疗器械有限公司 | 人工心脏瓣膜及其瓣膜支架 |
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CN102764169A (zh) | 2012-11-07 |
DE212013000104U1 (de) | 2014-11-20 |
CN102764169B (zh) | 2015-07-29 |
JP3196976U (ja) | 2015-04-16 |
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