WO2013112583A1 - Rupture de tissu intravasculaire - Google Patents

Rupture de tissu intravasculaire Download PDF

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Publication number
WO2013112583A1
WO2013112583A1 PCT/US2013/022745 US2013022745W WO2013112583A1 WO 2013112583 A1 WO2013112583 A1 WO 2013112583A1 US 2013022745 W US2013022745 W US 2013022745W WO 2013112583 A1 WO2013112583 A1 WO 2013112583A1
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WO
WIPO (PCT)
Prior art keywords
fluid
aperture
pressure
agent
delivery
Prior art date
Application number
PCT/US2013/022745
Other languages
English (en)
Inventor
Amr Salahieh
Tom Saul
Eliot T. Kim
Ari Ryan
Original Assignee
Shifamed Holdings, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shifamed Holdings, Llc filed Critical Shifamed Holdings, Llc
Priority to CN201380006262.2A priority Critical patent/CN104066463B/zh
Priority to EP13741379.5A priority patent/EP2806920A4/fr
Priority to JP2014553531A priority patent/JP2015506758A/ja
Priority to AU2013212265A priority patent/AU2013212265B2/en
Priority to CA2860593A priority patent/CA2860593A1/fr
Publication of WO2013112583A1 publication Critical patent/WO2013112583A1/fr
Priority to HK14112339.9A priority patent/HK1198818A1/xx
Priority to AU2018200228A priority patent/AU2018200228A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16804—Flow controllers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16877—Adjusting flow; Devices for setting a flow rate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M2005/14208—Pressure infusion, e.g. using pumps with a programmable infusion control system, characterised by the infusion program
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M2005/14506—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons mechanically driven, e.g. spring or clockwork
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/10—Trunk
    • A61M2210/1078—Urinary tract
    • A61M2210/1082—Kidney
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/12—Blood circulatory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/14526—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons the piston being actuated by fluid pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/1454—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons spring-actuated, e.g. by a clockwork

Definitions

  • a fluid source houses a fluid that is delivered from the fluid source through a delivery device positioned in the patient and into the patient.
  • Needleless applications include a delivery device that has an aperture therein, and fluid is allowed to be moved from the fluid source, through the delivery device, out of the aperture, and into the patient.
  • One aspect of the disclosure is a system for delivering fluid into a patient, comprising: a high pressure fluid source adapted to be positioned external to a patient and adapted to maintain a fluid agent under high pressure within a fluid reservoir; a delivery device adapted to be positioned within a patient, the delivery device comprising a fluid delivery aperture; and a fluid control adapted to be disposed external to the patient and downstream the fluid reservoir, the fluid control adapted to allow for fluid to flow under high pressure from the fluid reservoir to the fluid delivery aperture and out of the delivery device.
  • the fluid control is a valve with an open configuration and a closed configuration.
  • the fluid control is adapted to be disposed external to the patient.
  • the apparatus further comprises an expandable member adapted to reposition the aperture against the lumen wall.
  • the fluid control is adapted to be activated from an off state to an on state and then back to the off state, with both on/off and off/on transitions less than about 15 msec.
  • the fluid delivery aperture has a diameter between about 1 mil and about 5 mils.
  • the high pressure fluid source is adapted to maintain a fluid agent under pressure between 750 psi and 5000 psi within the fluid reservoir.
  • One aspect of the disclosure is a fluid delivery device adapted to deliver fluid to a target location within a patient, comprising: a fluid source comprising a fluid reservoir adapted to house a fluid therein; a delivery device adapted to be positioned within the patient and adapted to be in communication with the fluid source, the delivery device comprising a fluid delivery line, the fluid delivery line having an aperture therein adapted to be in fluid communication with the fluid reservoir, the fluid delivery line secured to the expandable member such that the aperture faces radially outward relative to a longitudinal axis of the expandable member.
  • the expandable member is an inflatable balloon.
  • the aperture is disposed at substantially the center of the expandable member along the longitudinal axis of the expandable member.
  • One aspect of the disclosure is a method of delivering fluid into a patient, comprising: maintaining a fluid agent under high pressure within a fluid reservoir; opening a fluid control that is positioned downstream the fluid reservoir and external to the patient from a closed configuration to allow the fluid agent maintained at high pressure to flow under high pressure from the fluid reservoir to a fluid aperture disposed downstream to the fluid control; and delivering the fluid agent at high velocity out of the aperture and into the patient.
  • the method further comprises positioning a delivery device comprising the aperture within a renal artery, and wherein the delivering step comprises delivering the fluid agent at high velocity out of the aperture and into the patient such that the fluid agent interacts with nerves surrounding the renal artery and disrupts neural communication along the nerves to reduce hypertension.
  • maintaining a fluid agent under high pressure comprises maintaining a fluid agent at between 750 psi and 5000 psi.
  • the method further comprises positioning a delivery device comprising the aperture within a lumen, and positioning the aperture such that it faces radially outward from the longitudinal axis of the delivery device.
  • the method can further comprise expanding an expandable member to position the aperture into engagement with the lumen wall. Expanding the expandable member can reconfigure a fluid delivery line secured to the expandable member.
  • the method further comprises closing the fluid control to thereby control the volume of the fluid agent that is delivered out of the fluid aperture.
  • delivering the fluid agent at high velocity out of the aperture and into the patient comprises delivering the fluid agent at between 50 m/sec and 400 m/sec.
  • the fluid agent flows out of the fluid reservoir at between about
  • delivering the fluid agent at high velocity out of the aperture and into the patient comprises delivering the fluid agent in a fluid pulse with a duration of between about 50 and 500 msec.
  • delivering the fluid agent comprises delivering the fluid agent in a fluid pulse of between about 10 uL and about 500 uL of the fluid agent.
  • Figure 1 shows an exemplary fluid delivery system.
  • Figure 2 depicts a portion of an exemplary fluid delivery system.
  • Figure 3 illustrates an exemplary high pressure fluid source.
  • Figure 4 shows an exemplary breadboard fluid control system configured for a pump source described in Figure 3.
  • Figure 5 illustrates an exemplary embodiment of a high velocity fluid delivery system adapted to deliver a fluid agent under high pressure into a patient.
  • Figures 6 and 7 illustrate an exemplary high pressure fluid source.
  • Figure 8 is a graph illustrating pressure vs. time and illustrates the pressure of the fluid within the fluid reservoir 13 in figures 6 and 7.
  • Figure 9 illustrates an embodiment of a fluid delivery system in which an exemplary high pressure fluid source is coupled to an elongate delivery device.
  • Figures 10 and 1 1 illustrate alternative embodiments of alternate metering outflow valve variations.
  • Figures 12 and 13 illustrate two variations that incorporate automatic high pressure refilling systems.
  • Figures 14 and 15 illustrate exemplary distal regions of two exemplary delivery devices.
  • Figures 16A-16C illustrates an expandable member that is radially offset with respect to a catheter shaft.
  • Figure 17 illustrates a typical pressure diameter profile associated with an artery.
  • Figure 18 illustrates the pressure waveform generated in the system from Figure 4.
  • Figures 19A-19D show various images of tissue treated with fluid injections exhibiting a pressure pulse similar to that illustrated in Figure 18.
  • Figures 20A-20D illustrate different generalized waveforms useful in needle-less injection of fluid agents into periluminal spaces.
  • Figures 21 A and 2 IB are fluoroscopic images illustrating a cloud of injectate.
  • the disclosure herein relates generally to medical devices, and particularly to systems and methods of use for delivering a fluid agent to a target location within a patient.
  • the devices and systems herein are used to deliver a fluid agent out of an aperture in a delivery device, through tissue adjacent the aperture (which may be referred to herein as "intermediate tissue"), and to target tissue that is more distant from the aperture than the tissue adjacent the aperture (which may be referred to herein as "target tissue"). Exposing the target tissue to the fluid agent causes a desired change in the target tissue.
  • minimal damage to the intermediate tissue is generally considered similar or less than is caused by a small gauge needle penetrating the intermediate tissue, and substantially less than is caused to the intermediate tissue by the delivery of RF ablation energy delivered at the lumen wall for treatment of a tissue peripheral or distant to the lumen wall. If RF energy is delivered the lumen wall will sustain more damage than the target tissue because the RF energy source is adjacent to the lumen wall and the energy density at the lumen wall is greater than at the target tissue. As described herein the fluid agent pierces through, or penetrates through, the intermediate tissue with minimal damage to the intermediate tissue.
  • One manner in which the damage is minimized is by delivering a high velocity fluid jet out of the aperture.
  • the disclosure herein focuses primarily on creating the high velocity fluid jet by creating a relatively high pressure gradient across a relatively small fluid aperture.
  • the high velocity fluid delivery also ensures that minimal leaking of the fluid agent into the lumen occurs when the fluid agent is delivered out of the aperture.
  • the one or more apertures can be positioned in any lumen within the body, and as used herein "lumen” includes spaces in the body other than tubular structures. For example without limitation, any portion of the vasculature, the interior of the gastrointestinal tract, the esophagus, urethra, and the stomach are “lumens” as used herein.
  • the intermediate and target tissues are characterized as the same type of tissue, but the target type of tissue is more distant, relative to the aperture, than the intermediate type of tissue. In some embodiments the intermediate and target tissues are different types of tissue.
  • An exemplary situation in which it may be desirable to minimize damage to the intermediate tissue is when the fluid is being delivered through the lumen of an arterial wall to target tissue peripheral to the lumen wall.
  • the fluid is delivered at high velocity through a renal artery lumen and wherein the target tissue is the medial layer and/or adventitial layers, in which nerves that innervate the kidneys are disposed.
  • the systems herein include a fluid reservoir adapted to house a fluid agent therein.
  • the systems also include a delivery device with at least one aperture adapted to allow for the delivery of the fluid agent from the reservoir and out of the aperture and into the patient at high velocity.
  • the velocity of the fluid exiting the aperture is related to the pressure gradient of the fluid agent across the aperture, among other variables.
  • Figure 1 illustrates conceptually an exemplary fluid delivery system 102 that includes high pressure fluid source 104 that is adapted to maintain a fluid agent under high pressure, a high pressure fluid control, and fluid delivery device 106 capable of communication with high pressure fluid source 104.
  • High pressure fluid source 104 includes at least one fluid reservoir adapted to house a fluid agent therein.
  • Delivery device 106 includes at least one fluid delivery lumen adapted to receive fluid from the fluid reservoir, and at least one aperture, or port, adapted to allow the fluid agent to be delivered into the patient from delivery device 106.
  • Figure 2 depicts a portion of an exemplary fluid delivery system illustrating fluid reservoir 230 adapted to house a fluid agent therein, inline fluid control 210, and optional bypass fluid control 220.
  • Fluid controls 210 and 220 can be any type of suitable valve. Fluid control
  • 210 is disposed between delivery device inflow 201 and the fluid reservoir 230.
  • Bypass fluid control 220 "T's" off the outflow line and empties to a low pressure exhaust point such as ambient pressure.
  • fluid control 210 is in a closed configuration and fluid control 220 is in an open configuration.
  • idle also referred to herein as the primed state, the fluid in fluid reservoir 230 is maintained under substantially constant high pressure.
  • fluid control 220 is closed, and fluid control 210 is then opened for the requisite period of time to cause the fluid to be delivered under high pressure out of the reservoir. Fluid control 210 is then closed and fluid control 220 is opened.
  • fluid control 220 may be opened only long enough to relieve pressure in the fluid delivery system. This sequence causes the inflow to the delivery device to be vented through fluid control 220 and a more rapid pressure decrease on the delivery device. As described above the rapid pressure decrease helps minimize the amount of fluid leaked into the lumen, if desired.
  • the dotted arrows indicate the directions of flows across the two valves. In some embodiments where relatively small amounts of leakage of the delivered agent into the body lumen is allowable, valve 220 may not be required.
  • An exemplary advantage in using a system shown in figure 2 is that because the high pressure source holds therein multiple doses and the valve is operable at high rates, the system can be used for multiple fluid deliveries without re-filling.
  • the fluid source maintained at a substantially constant high pressure may be maintained at high pressure by means of, for example without limitation, pneumatic, hydraulic, or mechanical means such as one or more springs.
  • Figure 3 illustrates an exemplary high pressure fluid source.
  • the fluid source includes low pressure fluid reservoir 340, high pressure fluid pump 330, inline fluid control 310, and return valve 320.
  • bypass fluid control 320 is open and inline fluid control 310 is closed. Fluid is then circulated through low pressure 340 reservoir during idle.
  • fluid control 320 is first closed for a period of time generating high pressure in the system to prime the fluid source. Fluid control 310 is then opened for an appropriate duration thereby delivering fluid at a rate consistent with the pump flow rate. Fluid control 320 is then opened and fluid control 310 is closed.
  • the outflow resistance associated with the delivery device is much higher than the return path resistance.
  • Pressure therefore drops rapidly in the outflow path when the bypass fluid control 320 is opened. This quick drop in pressure in the outflow path helps prevent leakage of the fluid agent into the lumen in which the medical device is positioned, if in fact this is desired.
  • Fluid controls as described herein can be any type of suitable valve, such as, for example without limitation, shuttle valves or poppit valves.
  • the valves are actuated by interfacing a control interface with a system controller.
  • Figure 4 shows an exemplary breadboard fluid control system configured for a pump source described in Figure 3 that was used to investigate the characteristic associated with needle-less injections into renal artery tissues.
  • the system is comprised of an outflow 401 for interfacing with a delivery catheter, pressure transducer 405 for monitoring the pressure at the outflow port 401 , inline fluid control 410, bypass fluid control 420; low pressure fluid reservoir 409, high pressure pump source 408, controller interface 402, and a personal computer used as a controller (not shown).
  • FIG. 5 illustrates an exemplary embodiment of a high velocity fluid delivery system adapted to deliver a fluid agent under high pressure into a patient.
  • System 500 includes system controller 510, delivery device 520, and delivery device control interface 530.
  • the system controller may be a completely mechanical system or may comprise an electro-mechanical interface.
  • the system controller non-sterile
  • the features of the system controller, delivery device, and control interface are incorporated in a single disposable unit.
  • Delivery device control interface 530 comprises an optional expandable member control interface, a fluid source, and a fluid control block.
  • the expandable member can be in the form of a balloon, self-expanding structure, or any other suitable expandable or deformable member.
  • the fluid source is a pump capable of delivering appropriate flows at the desired pressures as described herein, or a reservoir maintained at the appropriate operating pressure as described herein.
  • Delivery device 520 is generally configured for endovascular or endoluminal delivery. Delivery device as used herein can be any type of suitable delivery catheter or other suitable medical device that can be positioned within a patient. The delivery device is shown including catheter shaft 521, the proximal end of which interfaces with delivery device control interface 530.
  • the distal region of delivery device 520 comprises expandable member 523, radio opaque markers 524, a high pressure delivery lumen (not shown), and features associated with facilitating rapid exchange on a guide wire. Delivery device also includes an aperture near expandable member 523 adapted to deliver fluid into the patient.
  • Figures 6 and 7 illustrate an exemplary high pressure fluid source, which can be used as high pressure fluid source 104 from figure 1.
  • the high pressure fluid source includes power source 615, fluid reservoir 613 with fluid 612 therein, outflow control valve 61 1 , and delivery device 610.
  • the fluid source also includes optional fluid input 616 and optional fluid fill valve 617, and vents 618 in both power source 615 and fluid reservoir 613 through which air is pushed or pulled depending on the use of the system.
  • Power source 615 includes power mechanism 614, which in some embodiments can be a spring, compressed gas reservoir as shown, or other suitable mechanisms for generating power. Power mechanism 614 is adapted to push piston 620 distally within fluid reservoir 613 to maintain fluid 612 in fluid reservoir 613 under high pressure while valve 61 1 is closed.
  • Figure 6 illustrates the system in a primed configuration, ready to delivery fluid 612. Fluid 612 is maintained under a pressure high enough to source an aperture in delivery device 610 at a pressure sufficient to allow for a high pressure fluid agent injection.
  • fluid control 61 1 is opened and fluid is delivered from reservoir 613, through open control 61 1, and through delivery device 610 and out an aperture in the delivery device (not labeled but described below).
  • Figure 7 illustrates the system at the conclusion of a high pressure injection after the front face seal 619 of piston 620 has seated on the distal surface fluid reservoir 613 thereby cutting off the flow of fluid to delivery device 610.
  • Fluid control 61 1 can then be closed in preparation for subsequent injections of fluid.
  • the reservoir houses fluid for one fluid delivery.
  • the fluid delivery step involves delivering the entire volume of fluid housed in reservoir 612 at one time.
  • the reservoir can subsequently be re-filled with fluid, either manually or automatically.
  • the front face seal 619 in the embodiment in figures 6 and 7 allows for precise control of delivered fluid volume in a system which only requires that valve 61 1 be opened rapidly. This is in contrast to the system of figure 2 in which valve 210 must be both opened and closed to facilitate a controlled volume of delivery.
  • One exemplary advantage of the system in figures 6 and 7 is primarily in the reduced complexity and therefore cost of the fluid control mechanisms.
  • Figure 8 is a graph illustrating pressure vs. time and illustrates the pressure of the fluid within the fluid reservoir 613 in figures 6 and 7, which is represented by the solid line, and the pressure of the fluid distal to fluid control 61 1 , which is represented as the dashed line.
  • Time epoch Tl is the time period after which the system has been primed (figure 6), and pressure 822 indicates the high fluid pressure of fluid 612 within fluid reservoir 613.
  • Time epoch 821 indicates the period in which the high pressure fluid is in communication with the delivery system 610, and pressure 824 is the high fluid pressure during the delivery phase. There is a negative pressure difference between time epoch 821 and time epoch Tl .
  • Time epoch T3 is the time period following the fluid delivery after seal 619 closes. During time epoch T3 the fluid pressure of fluid 612 within reservoir 613 returns to pressure 822.
  • the dashed line in figure 8 represents the fluid pressure at a location distal to fluid control 61 1.
  • this pressure is zero.
  • control 61 1 is initially opened and fluid 612 is released under pressure from fluid reservoir 613. The fluid is forced down the fluid line lumen to the aperture.
  • the pressure distal to fluid control 61 1 in time epoch 821 therefore increases abruptly to pressure 824, and after the fluid has been delivered from the aperture, as indicated in time epoch T3, the pressure distal to fluid control 61 1 drops abruptly back to ambient.
  • fluid that is "maintained" under high pressure refers at least to the fact that the system is maintained in a primed state under high pressure.
  • a fluid control is then opened distal to the fluid reservoir to release the fluid primed and maintained under high pressure. This is different than systems that generate a high pressure transient at the fluid source and thereby do not require a control valve downstream the fluid reservoir.
  • FIG. 9 illustrates an embodiment of a system in which an exemplary high pressure fluid source 915 is coupled to elongate delivery device 960.
  • the high pressure source comprises a fluid reservoir adapted to house a volume of fluid sufficient for multiple discrete fluid injections and associated control mechanisms capable of controlling the volume of an individual injection.
  • primary power source 915 is pneumatically driven, but may be, for example, hydraulically or spring driven.
  • Power source 915 comprises relatively low pressure fluid source 930 that is used to power pilot valve 940.
  • Pilot valve 940 comprises valve seat 941 adapted to interface with a high pressure piston 945.
  • High pressure piston 945 is in turn coupled to low pressure piston 944.
  • the surface areas of pistons 944 and 945 are sized such that the pressure generated in the chamber at the valve seat 941 by pilot valve 940 is greater than the pressure generated in the high pressure fluid source. Pilot valve volume adjustment is facilitated by volume adjustment 943.
  • Low pressure fluid in low pressure fluid source 930 is communicated through adjustable fluid resistor 932 and 3-way valve 931 to the low pressure side of adjustable pilot valve 940. Exemplary usage in the system is as follows. As the pressure generated by the low pressure fluid source 930 on the pilot valve low pressure piston 944 is sufficient to generate a pressure greater than that generated in the high pressure fluid, the pilot valve is in the off, or closed, position.
  • Figure 9 shows valve 940 in an open, or on, configuration.
  • a delivery volume is defined by adjusting volume adjustment 943 some distance away from low pressure piston 944 surface.
  • valve 931 is then momentarily reconfigured for flow from “b” to “a” to flow from “b” to “c”
  • the low pressure fluid pressure drops to ambient on the low pressure side of pilot valve 940.
  • the pilot valve piston then shifts position until it encounters the volume adjustment 943 and the valve seat is opened. What is meant by momentarily in this context is a time sufficient for the pilot valve piston to shift to the fully open position.
  • valve 931 On re-attaining the default configuration of valve 931 where flow is "b" to "a,” low pressure fluid begins to leak back into the low pressure side of the pilot valve 940 at a rate defined by the value of the adjustable fluid resistor 932.
  • the length of time to close the pilot valve 940 is therefore adjusted by both the length of travel (required volume) defined by adjustment of adjuster 943 and on the filling rate defined by fluid resistor 932.
  • the delivered volume of fluid is therefore the volume associated with period during which the pilot valve is open.
  • only one of the two controls 932 and 943 are included. In others one will be used as a calibration means and the other as a user control.
  • the embodiment in figure 9 can be modified to include a sensor such as a pressure transducer (such as the pressure transducer shown in the embodiment above in figure 4) or other means to infer velocity.
  • the sensor can be added, for example, at valve seat 941.
  • the sensor is adapted to provide feedback information indicative of the pressure differential across the delivery aperture, or the velocity of the fluid.
  • An exemplary method of use compares the feedback data from the sensor with reference data to determine if the pressure is sufficiently high, or if the velocity is sufficiently high. If either parameter is not high enough damage may occur to the intermediate tissue, which can be disadvantageous when the intermediate tissue is, for example, an arterial wall.
  • the method could include delivering one or more jets of fluid, and again determining if either the pressure or velocity were sufficiently high.
  • the time of the rise in pressure from baseline to peak or plateau can be determined and compared to reference data. When the pressure does not rise from baseline to peak or plateau quickly enough, damage to the intermediate tissue may not be minimized.
  • the rise in pressure occurs over a time longer than 15 msec, and in some embodiments over a time longer than 5 msec. If it does take longer than the reference time, feedback can be provided that indicates that, for example, the fluid delivery was ineffective or that damage occurred to the intermediate tissue. Towards this end it is also useful to purge the system with one or two test shots prior to deployment of the device adjacent to the target tissue. Doing so insures that air is not trapped in the system. Air trapped in the system can compress, and thereby slow the rise time of the pressure pulse.
  • Figures 10 and 1 1 illustrate alternative embodiments of alternate metering outflow valve variations.
  • Figure 10 illustrates valve 1045 secured to delivery device 1010.
  • metering adjustment 1043 is linearly displaced an amount "A" such that linear displacement "A” equates to the expected delivered volume.
  • Piston 1043 seals against the inner walls of valve 1045.
  • Fluid resistor 1032 has very high fluid resistance and allows fluid to translate from one side of piston 1043 to the other as adjustments are made.
  • a high pressure source 1013 feeds fluid into metering valve 1045 on the upstream side of piston 1043.
  • control valve 101 1 When control valve 101 1 is opened a slight pressure differential develops across piston 1043 driving it to the right in the figure, closing fluid off at valve 1019.
  • Fluid resistor 1032 is sized such that its resistance is sufficient to limit fluid flow from one side to the other at the change in pressure associated with the piston displacement during fluid delivery.
  • the external resistor 1032 can be incorporated into piston 1043 or it can be inherent in the design of the interface between piston 1043 and the cylinder wall.
  • Figure 1 1 illustrates an embodiment similar to the embodiment shown in figure 10.
  • valve 1 1 1 1 when valve 1 1 1 1 is opened, a small pressure differential is generated across piston 1 143 by fluid resistor 1 132.
  • the fluid resistor may be incorporated in the piston or the interface of the piston and the cylinder wall.
  • valve 1 1 1 1 1 When valve 1 1 1 1 1 is opened, piston 1 143 will travel distance A and seal against the distal end of the cylinder, thereby delivering a volume equivalent to distance A times the area of the cylinder. When valve 1 1 1 1 1 is closed, pressure will equalize across piston 1 143 and spring 1 1 19 will return the piston 1 143 to its primed position.
  • FIGs 12 and 13 illustrate two variations of the system of figures 6 and 7 which incorporate automatic high pressure refilling systems.
  • high pressure delivery system 1200 is similar to the system of figures 6 and 7 with the exception that volume control mechanism 1201 is incorporated in the high pressure reservoir.
  • High pressure refilling system 1210 comprises a power source 121 1 interfaced with a high pressure fluid source 1212, which in turn is interfaced with high pressure delivery system input valve 1217 and optional filling valve 1213.
  • High pressure refilling system 1210 is configured such that the pressure within high pressure refilling reservoir 1212 is maintained at a pressure somewhat greater than the pressure in the high pressure delivery system 1200.
  • volume adjustment mechanism 1201 is adjusted to the appropriate volume.
  • Valve 1217 is then opened allowing fluid to pass from the refill reservoir to the high pressure delivery reservoir. Valve 1217 is then closed and the high pressure delivery system is ready to use. Optional valve 1213 may be used to fill the refilling reservoir.
  • the power source 121 1 is a low pressure pneumatic drive where the drive pressure will be equivalent to the low pressure drive pressure times the ratio of the surface areas of the power source piston/high pressure refilling reservoir.
  • the high pressure delivery system input valve 1217 has been replaced by a three way valve 1302, but other similar components are similarly labeled.
  • the delivery devices described herein which are indirectly or directly coupled to the substantially constant high pressure fluid source, have at least one aperture therein adapted to allow a fluid agent to be delivered from the fluid source and out of the aperture under high velocity.
  • Figures 14 and 15 illustrate two exemplary distal regions of two exemplary delivery devices.
  • Figure 14 illustrates a distal region of a deliver device 1400 that includes an over-the- wire configuration for delivery.
  • the delivery device includes catheter shaft 1401, comprising high pressure fluid delivery line 1405, expandable member 1403, a guide wire lumen (not labeled), balloon inflation lumen (not labeled), and radio opaque markers 1404.
  • Expandable member 1403 is shown as a rigid 20 mm long and 6 mm diameter cylindrical balloon but can have other configurations, and is secured to the outer surface of the distal region of catheter shaft 1401.
  • High pressure fluid line 1405 has at least one aperture formed therein in its distal region, and is secured to expandable member 1403 such that a fluid jet aperture (which is not visible but is included in the device) faces (i.e., opens) radially outward from the long axis of the expandable member 1403.
  • the aperture can be anywhere along the length of fluid line 1405, but in this embodiment is positioned at the longitudinal center of expandable member 1403.
  • the delivery device is primed with fluid so that fluid is disposed in the delivery device fluid delivery line.
  • a delivery catheter examples of which are well known, is advanced to a region of interest within the patient.
  • a guidewire is then fed through the delivery catheter to the distal end of the delivery catheter.
  • the guide wire is delivered to a location adjacent to the target tissue, then the delivery catheter is advanced over the guidewire near the target location.
  • Delivery device 1400 is then advanced over the guidewire with the guidewire disposed in the guidewire lumen. Once in the desired position, delivery device 1400 is moved distally relative to the delivery catheter.
  • Catheter shaft 1402 is advanced to position the jet aperture adjacent to the target tissue (and directly adjacent and engaging the intermediate tissue).
  • Expandable member 1403 is inflated with fluid advanced through the inflation lumen in catheter shaft 1402. A high velocity jet of fluid agent is then delivered as described herein.
  • Three radio opaque markers 1404 are also incorporated into the distal region of the delivery device.
  • the two markers 1404 on catheter 1402 delineate the axial location of the fluid jet aperture, and the most distal marker 1404 provides information on the radial orientation of the aperture.
  • the high pressure delivery line, or lumen is substantially flush with the outer surface of the balloon (or other expandable member).
  • the high pressure lumen does not extend further radially than the outer surface of the balloon. This configuration provides better engagement between the balloon and the lumen wall in which the balloon is disposed and expanded. This provides a better seal between the balloon and the lumen wall, which reduces the likelihood of fluid leaking back into the lumen once it is delivered out of the aperture.
  • the high pressure delivery lumen is integrated into the balloon structure. This can be accomplished by incorporating one or more lumens into the extrusion used to form the balloon. The lumens are maintained during the balloon forming process and the resulting balloon structure would therefore include one or more integrated high pressure delivery lumens.
  • a channel is formed in the balloon to accommodate the high pressure fluid lumen.
  • a channel with a general "U" cross sectional shape is formed in the balloon, and the high pressure lumen is secured within this channel. The high pressure lumen is therefore substantially flush with the outer surface of the balloon.
  • Figure 15 shows an alternate embodiment of a distal region of a delivery device similar to that shown in figure 14 and comprising the features of a rapid exchange guide wire configuration.
  • Guide wire 1502 is shown entering the catheter shaft on the proximal side of balloon 1503 and exiting the shaft on the distal end of delivery catheter 1500.
  • the expandable member 1 03 in this embodiment is a generally spherical inflatable elastomeric balloon.
  • High pressure delivery line 1505 is secured to the surface of the balloon as described above in the embodiment in Figure 14.
  • the balloon is radially offset relative to the expandable member shaft such that the high pressure line has a substantially straight configuration across the surface of the balloon when the balloon is expanded.
  • the embodiment in figures 16A-16C enhances the precision with which interface pressure can be measured and controlled.
  • the embodiment in Figures 16A-16C includes balloon 1603 that is radially offset with respect to catheter shaft 1601. High pressure fluid delivery line
  • High pressure line 1605 is secured to balloon 1603.
  • High pressure line 1605 also includes radio opaque markers
  • FIG. 1604 The embodiment comprises a rapid exchange guide wire interface demonstrated by the path of guide wire 1602.
  • Balloon 1603 is carried on catheter shaft 1601 which may incorporate a braid or other stiffening elements to facilitate larger torque carrying capacity. General features of the catheter shaft are not shown.
  • Figure 16B illustrates a cross section of the delivery device of Figure 16A configured for delivery and prior to inflation, wherein the delivery device is positioned within vessel 1600. In this configuration balloon 1603 is deflated and folded.
  • 16C represents the balloon in its inflated state where the balloon has a larger diameter then the vessel 1600 in which it is expanded.
  • the pressure required to expand the balloon will be minimal, and the pressure monitored during inflation will be indicative of that associated with stretching the vessel wall.
  • the diameter pressure curve of Figure 17 can be calculated and a desired pressure range can be determined.
  • Such a system can be used to identify the appropriate inflation pressure by monitoring the relative change in modulus as opposed to targeting a particular absolute pressure.
  • the systems and devices are adapted to be used to deliver a fluid agent to target tissue that is more distant to the aperture than tissue directly adjacent the aperture.
  • the systems can be used to minimize the damage done to the intermediate tissue, and one manner in which this can be accomplished is with fluid delivered at high velocity out of the aperture.
  • An exemplary use is to position the delivery device within a renal artery and deliver a fluid agent out of an aperture at high velocity.
  • the fluid passes through the wall (with minimal damage to the intermediate wall tissue) to a location where it can interact with neural tissue surrounding the renal artery.
  • the interaction of the fluid and nerves disrupts the neural transmission along the nerves, reducing hypertension.
  • the fluid agent is delivered out of the delivery device, pierces through the renal artery lumen wall, and is exposed to target neural tissue more distant from the lumen to disrupt neural transmission along the nerves and reduce hypertension.
  • the systems, devices, and methods herein provide sufficient penetration of the fluid through the renal artery such that neural tissue is exposed to the fluid, while minimizing the amount of fluid that is leaked back into the renal artery, and thus the vasculature.
  • the systems, devices, and methods herein also provide fluid penetration through the renal artery such that the injury associated with the fluid penetration is minimized at the luminal entry point.
  • the fluid pressure within the fluid source is relatively low prior to and after fluid delivery into the patient, but may be relatively high during fluid delivery and immediately prior in time to the delivery of the fluid.
  • An exemplary disadvantage to these systems is that if the fluid pressure is initially too low, the fluid may not be delivered far enough into the target tissue. For example, in systems use to deliver fluid from the renal artery and into neural tissue surrounding the renal artery to disrupt neural transmission along those nerves, the fluid may ultimately be delivered only partially into the medial layer, when the desired outcome is that the fluid is delivered completely through the medial layer, in which the target nerve tissue is disposed.
  • An additional exemplary disadvantage to these systems is that, because the pressure will drop back down to the relatively low pressure, if the pressure drops off too quickly, the fluid might not penetrate all the way through the medial layer, which is undesirable for reasons set forth above.
  • the fluid pressure By maintaining the fluid pressure within the fluid source at a substantially high pressure, the fluid pressure doesn't return to a relatively low pressure, but rather is maintained at the substantially constant high pressure. The potential problems of not penetrating deep enough into the medial layer, and thus failing to sufficiently disrupt neural transmission along the neural pathway, are therefore eliminated.
  • Figure 18 illustrates the pressure waveform generated in the system from Figure 4 when using a jet aperture of 1.5 mil diameter, as measured in the pressure transducer 405.
  • the delivery volume was approximately 35 uL delivered over a period of approximately 200 msec.
  • the pressure transient, as measured at pressure transducer 405, associated with the increasing pressure 1801 occurred over a period of approximately 5 msec, and the pressure transient associated with the release of pressure 1802 occurred over a similar time frame.
  • the pressure pulse attains a relatively constant plateau pressure of approximately 900 psi.
  • the diameter of the one or more fluid jet apertures is between about 1 and about 5 mils.
  • the velocity of the fluid jetting from the medical device is between about 50 and about 400 m/sec.
  • the flow rate of the fluid from the constant high pressure source is between about 5 and about 40 mL/min.
  • the duration of the fluid pulse is between about 50 and 500 msec. In yet other embodiments the duration is multiple seconds.
  • the volume of fluid delivered per pulse is between about 10 uL and about 500 uL. In yet other embodiments the delivered volume may be multiple mL's.
  • the time of the transition between the baseline pressure and the elevated pressure, and the time of the transition between the elevated pressure and the baseline pressure is less than about 15 msec, and may be less than 5msec, and additionally may be less than 1 msec. In general, shorter transition times translate into more efficient penetration and less fluid leaking into the lumen.
  • high pressure refers to pressure above about 750 psi, and includes pressures between 750 psi and 5000 psi.
  • the systems are adapted to maintain the fluid in the fluid reservoir in the high pressure fluid source under pressures of about 750 psi and about 5000 psi.
  • Figures 19A-19D show various images of tissue treated with fluid injections exhibiting a pressure pulse similar to that illustrated in Figure 18, delivered with the system shown in Figure 4 and the delivery catheter shown in Figure 14.
  • Figure 19A shows the luminal surface 1901 of a sample of porcine renal artery tested in vitro that has been split after the injection such that the entry injury can be viewed.
  • the injectate comprised a blue dye.
  • the injection site is indicated by 1902 and distinguished by the darkening from the dye.
  • the visibly stained area on the luminal surface is approximately 2 mm long in the radial direction (vertical in image) and about .5 mm wide. Darkened area 1903 corresponds to the location of the high pressure delivery line 505.
  • FIG. 19B and 19C show fluoroscopic images taken during an in vivo porcine study. Balloon 1903 is visible via contrast agent which has been used to inflate the balloon. The balloon is shown in the renal artery where it has been delivered via an endovascular approach. In this study the injectate contained both a fluoroscopic contrast agent and a blue dye.
  • Figure 19B shows the balloon and surrounding tissue just prior to an injection.
  • Figure 19C shows the balloon and surrounding tissue just after an injection. The injectate is visible in Figure 19C at 1905.
  • Figure 19D is a photograph from the necropsy of the same treatment zone from another animal. Darkened area 1906 within the dotted line shows the stained injury zone in contrast and beside a non-injured zone 1907 on a renal artery.
  • Figures 21 A and 21B are fluoroscopic images and illustrate the cloud of a
  • FIG. 21 B is a view of the same injectate cloud from a different angle which demonstrates a greater than 180 degree radial spread of injectate around the long axis of the renal artery.
  • Inflatable balloon 2103 is visible in figure 2 I B.
  • Figures 20A-20D illustrate different generalized waveforms 2000 useful in needleless injection of fluids into periluminal spaces.
  • Figure 20A represents the type of waveform depicted in Figure 18 where the region between the rising and falling transitions 2003 is relatively flat.
  • Exemplary features include the rapid transitions associated with the onset of the pressure pulse and the decay of the pressure pulse.
  • a rapid onset pressure transition 2001 is important in creating a well-defined injury of minimal size wherein the injectate is primarily delivered through the injury with very little leakage around the injury entry surface.
  • a very rapid final decay transition 2002 is important in minimizing leakage of fluid around the injury entry surface.
  • Transition times should be at least less than 15 msec and preferably less than 5 msec as demonstrated in the experiments described herein, and optimally less than 1 msec. Apart from leakage, a sharp rising edge facilitates better penetration.
  • pressure can be dropped and injectate will spread on the distal side of a well-defined puncture injury. In such a procedure, injury to the tissues at the entry site associated with the injectate can be minimized while larger volumes of injectate can be delivered deeper into the tissue without increasing the depth of injury.
  • Figures 20B and 20C illustrate two pressure waveforms useful in producing such injuries. In figure 20B, after the peak pressure is attained the pressure is allowed to trail off via a ramp to a pressure still sufficient to penetrate through the entry injury.
  • Figure 20D is similar to that of Figure 20B except that as opposed to ramping down pressure an initial short high pressure peak 2004 is used to create the injury, which is then followed by a lower pressure plateau of sufficient pressure and duration to deliver the requisite volume of injectate to an appropriate depth via the entry injury. In some situations it may be useful to spread that injectate more evenly through the depth of tissue, in which the pulse of Figure 20C could be desirable.
  • the volume of injectate may be additionally regulated by delivering multiple pulses at a specific location, wherein the pulses may be comprised of various combinations of those described herein and/or various delivery velocities.
  • the volume of injectate delivered may be increased via multiple injections in a single location or multiple injections in multiple sites, or a large volume delivered to one site and allowed to spread.
  • the spreading of the injectate may be monitored by fluoroscopy when a contrast agent is comprised in the injectate.
  • the number of injections may be controlled by watching how the injectate spreads under fluoroscopy, and stopping the procedure when the desired spread has occurred.
  • a device such as that of Figure 15 may be relocated for each injection or alternatively a device similar to that of Figure 14 may incorporate multiple parallel injection systems, wherein each line is coupled to a single fluid source or individual fluid sources.
  • Devices described in U.S. Pat. App. Pub. No. 201 1/0257622 can also be modified to be used with any of the system
  • Figure 17 illustrates a typical pressure diameter profile associated with an artery.
  • An appropriate pressure at the interface between the jet aperture of the medical device and the luminal wall is important when minimal injury at the luminal surface of the vessel and control of the depth of injectate delivery is desired. The greater the interface pressure, the smaller the luminal injury and the greater control of penetration depth. However, if the interface pressure is increased too much the vessel may be injured. A balance must therefore be reached between interface pressure vessel distension. A typical vessel exhibits a low modulus during initial extension, begins to stiffen, and then exhibits a much higher modulus. As the vessel is extended further into the high- modulus region the tissue will be damaged. Region 1702 indicates a target region of interface pressure where damage to the vessel can be minimized and interface pressure is high enough to create a clean puncture of the lumen wall.
  • high pressure delivery lines 1405 and 1505 have a 14 mil outer diameter and 12 mil inner diameter polyimide tube.
  • the delivery apertures, not visible in the figures as they are too small, are 1.5 mil.
  • the total length of the delivery lines is approximately 32 inches.
  • volume_delivered / (duration* Area_aperture) this implies an average delivery velocity of 82 m/sec.
  • the average fluid velocity would be approximately 78m/sec at 1200 psi as measured at the exit valve.
  • this would imply a pressure differential of approximately 1 135 psi across the exit aperture.
  • C0 2 cartridges provide a means for maintaining a constant pressure within the constant pressure source as the internal pressure in a C0 2 cartridge will remain relatively constant at a given temperature as long as there remains a mixture of gas and liquid within the cartridge. Pressure could hence be adjusted by adjusting the temperature of the cartridge.
  • the following table lists the internal pressure as a function of temperature for a C0 2 cylinder containing C0 2 in both liquid and vapor phases.
  • Exemplary fluid agents that can be delivered can be found in U.S. Pat. App. Pub. No. 201 1/0257622, U.S. Pat. App. Pub. No. 201 1/0104061 , and U.S. Pat. App. Pub. No. 201 1/0104060, the complete disclosures of which are incorporated by reference herein.
  • the systems herein can be used to ablate target tissue.
  • an ablatant that is chosen to specifically target a particular tissue or tissue function, and to impart minimal effects on adjacent tissues.
  • the residence time of an ablatant cocktail will be dependent on the rate of its removal by normal body functions which include uptake by the capillary bed and the lymphatic system.
  • a well targeted ablatant it will often be the case that it will have very little effect on the tissues associated with the normal removal processes. In such cases, the body will remove the ablatant as efficiently and quickly as possible.
  • ablatants targeted at neural function such as guanethidine, reserpine, tetrodotoxins, botulinum toxin, or other ablatants have particular significance in the treatment of hypertension, such as in the ablation of renal nerves. These ablatants may have some effect on capillary uptake but should have little to no effect on lymphatic uptake.
  • One aspect of the disclosure is a method of treating hypertension (e.g., but not limited to, from within the renal artery, such as in the applications incorporated by reference herein) by delivering a cocktail of a general ablatant (e.g., ethanol, glacial acetic acid, etc.) and an ablatant targeted at neural function.
  • a general ablatant e.g., ethanol, glacial acetic acid, etc.
  • the targeted ablatant can be any of those listed herein.
  • the cocktail comprises ethanol as the general ablatant and guanethidine as the targeted ablatant.
  • the general ablatant will increase the residence time of the guanethidine and achieve a more successful ablation of the renal nerves.
  • One aspect of the disclosure is a method of treating hypertension by sequentially delivering a relatively smaller amount of a general ablatant, followed or preceded by delivery of the targeted ablatant.
  • the general and targeted ablatants can be any of those described herein or any other suitable ablatants.
  • the amount of general ablatant will be an amount smaller than is typically delivered to ablate the nerves, but is sufficient to increase the residence time of the targeted ablatant by inhibiting the body's ability to clear the targeted ablatant.
  • One aspect of the disclosure is a method of treating hypertension by delivering a cocktail of an ablatant targeted to neural function and an ablatant specifically targeted to impede capillary and/or the lymphatic uptake to slow the body's ability to remove therapy targeted ablatant.
  • a general ablatant could also be added to the cocktail in even smaller amounts than in the previous aspect.

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Abstract

L'invention concerne des systèmes et des dispositifs médicaux conçus pour administrer un agent liquide à un tissu cible dans le corps d'un patient.
PCT/US2013/022745 2012-01-23 2013-01-23 Rupture de tissu intravasculaire WO2013112583A1 (fr)

Priority Applications (7)

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CN201380006262.2A CN104066463B (zh) 2012-01-23 2013-01-23 血管内组织干扰
EP13741379.5A EP2806920A4 (fr) 2012-01-23 2013-01-23 Rupture de tissu intravasculaire
JP2014553531A JP2015506758A (ja) 2012-01-23 2013-01-23 血管内組織破壊
AU2013212265A AU2013212265B2 (en) 2012-01-23 2013-01-23 Intravascular tissue disruption
CA2860593A CA2860593A1 (fr) 2012-01-23 2013-01-23 Rupture de tissu intravasculaire
HK14112339.9A HK1198818A1 (en) 2012-01-23 2014-12-08 Intravascular tissue disruption
AU2018200228A AU2018200228A1 (en) 2012-01-23 2018-01-11 Intravascular tissue disruption

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US201261589669P 2012-01-23 2012-01-23
US61/589,669 2012-01-23
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HK1198818A1 (en) 2015-06-12
AU2018200228A1 (en) 2018-02-08
CN104066463A (zh) 2014-09-24
AU2013212265A1 (en) 2014-07-24
CN104066463B (zh) 2017-05-31
EP2806920A4 (fr) 2015-08-05
CA2860593A1 (fr) 2013-08-01
EP2806920A1 (fr) 2014-12-03
AU2013212265B2 (en) 2017-10-12

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