WO2013099621A1 - Composition destinée à être administrée par voie orale - Google Patents

Composition destinée à être administrée par voie orale Download PDF

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Publication number
WO2013099621A1
WO2013099621A1 PCT/JP2012/082300 JP2012082300W WO2013099621A1 WO 2013099621 A1 WO2013099621 A1 WO 2013099621A1 JP 2012082300 W JP2012082300 W JP 2012082300W WO 2013099621 A1 WO2013099621 A1 WO 2013099621A1
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WO
WIPO (PCT)
Prior art keywords
component
composition
oil
mass
salt
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PCT/JP2012/082300
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English (en)
Japanese (ja)
Inventor
安雄 野村
沙織 滝
翼 山口
菅野　秀明
佐藤　純子
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ライオン株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by ライオン株式会社 filed Critical ライオン株式会社
Publication of WO2013099621A1 publication Critical patent/WO2013099621A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

  • the present invention relates to a composition for oral cavity which is preferably prepared as a liquid preparation, in particular, having a good aftertaste with a sense of incongruity associated with sweetness felt in the throat derived from glycyrrhizic acid or a salt thereof.
  • oral compositions containing glycyrrhizic acid or a salt thereof have an uncomfortable feeling associated with the sweetness peculiar to high-intensity sweeteners derived from glycyrrhizic acid or a salt thereof after use and the sweetness felt in the throat after use. It was a cause of impairing palatability.
  • the liquid oral composition is 10 to 20 mL per use and is 10 to 20 times the amount of toothpaste, and easily spreads in the oral cavity and does not require water rinsing, so glycyrrhizic acid or its The salt tends to stay in the throat, so that the sense of incongruity associated with the sweetness felt in the throat after use is more strongly felt and the palatability is easily impaired.
  • Patent Document 5 Japanese Laid-Open Patent Publication No. 2001-64136, Japanese Laid-Open Patent Publication No. 8-24535.
  • Patent Document 7 3-L-menthoxypropane-1,2-diol, menthyl lactate, and monomenthyl succinate are used as cooling agents (Patent Document 7; JP-T 9-510627, Patent Document 8). Japanese Patent Publication No. 61-48813).
  • Patent Document 9 a plurality of oral compositions using glycyrrhizic acid and salts thereof in combination with 3-L-menthoxypropane-1,2-diol, menthyl lactate, and monomenthyl succinate are disclosed, and these are used to impart a cool feeling.
  • Patent Document 9 Example 6 of Japanese Patent No. 4591680, Patent Document 10; Example 11 of Japanese Patent Application Laid-Open No. 2009-256228
  • Patent Document 11 a metal taste masking agent derived from a compound that releases metal ions to be used together (Patent Document 11; JP-A-2003-137755).
  • the conventional technology cannot eliminate the uncomfortable feeling associated with the sweetness felt in the throat derived from glycyrrhizic acid or a salt thereof. Therefore, in the oral composition containing glycyrrhizic acid or a salt thereof, the sweetness felt in the throat. Resolving the uncomfortable feelings associated with was a technical issue.
  • the present invention has been made in order to solve the above problems, and an object of the present invention is to provide an oral composition having a good aftertaste that eliminates the uncomfortable feeling associated with sweetness perceived in the throat derived from glycyrrhizic acid or a salt thereof. To do.
  • glycyrrhizic acid or a salt thereof when glycyrrhizic acid or a salt thereof is blended in an oral composition, particularly a liquid oral composition, after use and vomiting in the oral cavity, the sweetness and throat peculiar to a high-intensity sweetener derived from glycyrrhizic acid or a salt thereof is used.
  • the component (B) is a derivative of menthol and is known as a fragrance component of an oral composition
  • the present inventors cannot make such a component (B) with other fragrance components such as menthol, The present inventors have newly found that the above-mentioned feeling of incongruity and aftertaste are improved.
  • the present invention (A) Glycyrrhizic acid or a salt thereof, (B) one or more components selected from 3-L-menthoxypropane-1,2-diol, menthyl lactate and monomenthyl succinate, (C) Provided is a composition for oral cavity which contains a nonionic surfactant and has a component (B) / component (A) in a mass ratio of 0.05 to 5.
  • an oral composition having a good aftertaste that eliminates the unpleasant sensation associated with sweetness felt in the throat derived from glycyrrhizic acid or a salt thereof.
  • the oral composition of the present invention comprises one or more components selected from (A) glycyrrhizic acid or a salt thereof, (B) 3-L-menthoxypropane-1,2-diol, menthyl lactate and monomenthyl succinate And (C) a nonionic surfactant.
  • Examples of the component (A) glycyrrhizic acid or a salt thereof include glycyrrhizic acid, dipotassium glycyrrhizinate, trisodium glycyrrhizinate, monoammonium glycyrrhizinate, and the like. One of these may be used alone or in combination of two or more. it can. Among them, dipotassium glycyrrhizinate is more preferable from the viewpoint of solubility in water and taste. A commercially available product can be used as glycyrrhizic acid or a salt thereof.
  • products such as Maruzen Pharmaceutical Co., Ltd.'s standard glycyrrhizinate glycyrrhizinate (standard product for quasi-drugs), monoammonium glycyrrhizinate quaternary standard, glycinone manufactured by Tokiwa Plant Chemical Laboratory Examples are those that are commercialized by name.
  • the amount of component (A) is usually 0.25% or less (mass%, the same applies hereinafter) of the total composition, particularly preferably 0.001 to 0.25%, more preferably 0.05 to 0.2. %. If it exceeds 0.25%, the discomfort associated with the sweetness perceived by the throat derived from glycyrrhizic acid or its salt may not be sufficiently obtained, and the aftertaste may be deteriorated. If it is less than 0.001%, a blending effect such as an anti-inflammatory effect may not be obtained.
  • Component (B) is a usability improving component that improves the taste derived from component (A).
  • Component (B) is an ester derivative or an ether derivative of menthol, and is a component selected from 3-L-menthoxypropane-1,2-diol, menthyl lactate and monomenthyl succinate. These may be used alone or in combination of two or more. Among these, 3-L-menthoxypropane-1,2-diol is more preferable because of its solubility in water and good aftertaste.
  • 3-S-mentoxypropane-1,2-diol is a cooling agent 10 manufactured by Takasago Inc.
  • Menthyl lactate is FRESCOLAT ML manufactured by Simrise
  • monomenthyl succinate is a cooling agent 10 manufactured by Takasago Inc.
  • Fischer made by Ve Man Fis Fragrance Co., Ltd. can be mentioned, and commercially available products can be used.
  • the blending amount of component (B) is preferably 0.01 to 1% of the total composition, more preferably 0.05 to 1%, and still more preferably 0.05 to 0.5%.
  • the greater the amount the better the sense of incongruity associated with the sweetness felt in the throat derived from component (A), and the aftertaste is improved. However, if it exceeds 1%, the aftertaste is impaired due to irritation by component (B) and unpleasant taste. There is a case.
  • the combination of components (A) and (B) at an appropriate ratio is important for effect expression.
  • the component (B) / component (A) has a mass ratio of 0.05 to 5, particularly preferably 0.5 to 3, and more preferably 1.10 to 3.
  • the uncomfortable feeling associated with the sweetness felt in the throat derived from the component (A) cannot be suppressed, the aftertaste is deteriorated, and the feeling in use cannot be improved.
  • it exceeds 5 the irritation
  • nonionic surfactant of component (C) examples include sugar alcohol fatty acid esters, polyhydric alcohol fatty acid esters, ether type or ester type activators, fatty acid alkanolamides, polyoxyethylene polyoxypropylene block polymers, and the like. Is mentioned.
  • polyoxyethylene hydrogenated castor oil polyoxyethylene alkyl ether, decaglycerin fatty acid ester, sucrose fatty acid ester, and polyoxyethylene polyoxypropylene block copolymer are particularly preferred from the viewpoint of dispersibility of component (B).
  • polyoxyethylene hydrogenated castor oil is more preferable from the viewpoint of aftertaste.
  • the amount of the nonionic surfactant as the component (C) is not particularly limited as long as the component (B) can be solubilized, but is preferably 0.2 to 2%, more preferably 0.3 to 1% of the total composition. It is. The more blended, the more the component (B) is solubilized and the unpleasantness and aftertaste associated with the sweetness felt in the throat derived from the component (A) can be improved, but if it exceeds 2%, the unpleasant taste derived from the nonionic surfactant May have a strong aftertaste.
  • the concentration ratio of the components (B) and (C) is not particularly limited, but the mass ratio of the component (C) / component (B) is preferably 2 to 100, more preferably 3 to 10. If it is less than 2, the usability improvement effect is not exhibited, and there is a case where the uncomfortable feeling and the aftertaste are not improved due to the sweetness felt in the throat derived from the component (A). When it exceeds 100, the off-taste derived from a nonionic surfactant may be strong and aftertaste may be impaired.
  • the composition of the present invention is particularly suitably prepared as a liquid oral composition in which the blending components are solubilized.
  • the composition of the present invention is also effective in a paste-form preparation such as a dentifrice.
  • a liquid preparation such as a mouthwash or a liquid dentifrice has a particularly strong taste.
  • a liquid preparation can improve the unpleasant taste and aftertaste.
  • it is prepared and applied as a mouthwash of the type that is used as it is, a freshener in the mouth, a mouthwash that is diluted at the time of use in a concentrated type, and a liquid dentifrice that is used by brushing with a toothbrush. And is particularly suitable as a mouthwash.
  • the liquid oral composition contains a wetting agent, a surfactant, a solvent, and if necessary, a sweetener, a coloring agent, a fragrance, a pH adjuster, an active ingredient, and the like.
  • solid components which do not solubilize such as an abrasive
  • wetting agent examples include sugar alcohols such as sorbitol, malt, and lactit, and examples of the polyhydric alcohol include glycerin, propylene glycol, ethylene glycol, and polyethylene glycol.
  • the blending amount of these wetting agents is preferably 2 to 20% of the total composition.
  • Anionic surfactants include sodium alkyl sulfates such as sodium lauryl sulfate and sodium myristyl sulfate, sodium N-acyl sarcosine such as sodium N-lauroyl sarcosine, sodium N-myristoyl sarcosine, sodium dodecylbenzenesulfonate, hydrogenated coconut fatty acid Sodium monoglyceride monosulfate, sodium lauryl sulfoacetate, N-acyl glutamate such as sodium N-palmitoyl glutamate, sodium N-methyl-N-acyl taurate, sodium N-methyl-N-acylalanine, sodium ⁇ -olefin sulfonate, etc.
  • Examples of the cationic surfactant include alkyl ammonium and alkyl benzyl ammonium salts.
  • Amphoteric surfactants include betaine acetate-type amphoteric surfactants such as alkyldimethylaminoacetic acid betaines and fatty acid amidopropyldimethylaminoacetic acid betaines, and imidazoline types such as N-fatty acid acyl-N-carboxymethyl-N-hydroxyethylethylenediamine salts. Examples include amphoteric surfactants. The amount of these surfactants is usually 0.01 to 2% of the total composition.
  • sweeteners xylitol, maltitol, saccharin, saccharin sodium, stevioside, aspartame and the like can be blended.
  • a colorant a highly safe water-soluble pigment such as Blue No. 1, Green No. 3, Yellow No. 4, Red No. 105, and the like can be added.
  • fragrances other than component (B) include eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, basil oil, cardamom oil, coriander oil, peppermint oil, spearmint oil, peppermint oil, orange Oil, lemon oil, mandarin oil, lime oil, grapefruit oil, coconut oil, sweetie oil, lavender oil, rosemary oil, laurel oil, camomile oil, caraway oil, marjoram oil, celery oil, bay oil, origanum oil, pine Needle oil, neroli oil, lemongrass oil, rose oil, jasmine oil, patchouli oil, Iris concrete, rose absolute, orange flower absolute, vanilla absolute, mango absolute, patchouli absolute, ginger oleoresin, pepper olea Natural fragrances such as resin, capsicum oleoresin, pepper extract, etc., and fragrances processed by these natural fragrances (front reservoir cut, rear reservoir cut, fractionated liquid extraction, essence, powdered fragrance, etc.) Limon
  • a pH adjuster a known one can be blended as necessary. Specific examples include citric acid, malic acid, lactic acid, tartaric acid, acetic acid, phosphoric acid, pyrophosphoric acid, polyphosphoric acid, glycerophosphoric acid, various salts thereof, sodium hydroxide, potassium hydroxide, and the like.
  • Active ingredients include antibacterial substances such as cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, isopropylmethylphenol, triclosan, hinokitiol, enzymes such as glucanase (dextranase, mutanase, etc.), protease, lysozyme chloride, fluoride Fluorides such as sodium, stannous fluoride, sodium monofluorophosphate, aluminum chlorohydroxy allantoin, allantoin, glycyrrhizinate, tranexamic acid, epsilon aminocaproic acid, azulene sulfonate, and other anti-inflammatory agents, ascorbic acid, acetic acid Various vitamins such as tocopherol, pyridoxine, dihydrocholesterol, hydrocholesterol, chlorophyll, copper chlorophyllin sodium, thyme, urgonum, duckweed extract, cabbage Plant extracts such
  • water is usually used, and the water content is preferably 60% or more of the total composition. Moreover, you may mix
  • Glycyrrhizic acid manufactured by Tokiwa Plant Chemical Research Co., Ltd.
  • dipotassium glycyrrhizinate manufactured by Maruzen Pharmaceutical Co., Ltd.
  • monoammonium glycyrrhizinate manufactured by Maruzen Pharmaceutical Co., Ltd.
  • 3-L-menthoxypropane-1,2-diol manufactured by Takasago Fragrance Co., Ltd., menthyl lactate (manufactured by Simrise), monomenthyl succinate (manufactured by We Mann Fis Fragrance Co., Ltd.)
  • polyoxyethylene 60) hydrogenated castor oil (manufactured by Nikko Chemicals), poly Oxyethylene (40) hydrogenated castor oil (Nikko Chemicals), polyoxyethylene (100) hydrogenated castor oil (Nihon Emulsion), polyoxyethylene (40) cetylene (60) hydrogenated castor oil (manufactured by Nikko Chemicals), poly Ox
  • the oral composition is prepared by dissolving a water-soluble raw material (excluding nonionic surfactant and solvent) in purified water, and then adding an oil-soluble raw material to ethanol and / or polyhydric alcohol. A solution in which the nonionic surfactant was dissolved was added with stirring to achieve uniform dissolution. A three-one motor (BL1200, manufactured by HEIDON) was used for manufacturing.
  • Oral compositions (mouthwashes) having the compositions shown in Tables 1 to 3 were prepared by the above methods and evaluated by the following methods. The results are shown in Tables 1 to 3.
  • Evaluation methods The mouthfeel containing 10 mL of the mouthwash (sample) shown in the table was evaluated in the following four stages for the feeling of use after rinsing and discharging for 30 seconds, and the average score of 10 panelists was evaluated according to the following criteria: ⁇ , ⁇ , ⁇ , X in the table.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)

Abstract

La présente invention concerne une composition destinée à être administrée par voie orale qui n'entraîne aucune sensation désagréable associée à un goût sucré dans la gorge, qui est dérivée de l'acide glycyrrhizique ou d'un sel de celui-ci et qui a un bon arrière-goût. La présente invention concerne une composition destinée à être administrée par voie orale caractérisée en ce qu'elle comprend (A) de l'acide glycyrrhizique ou un sel de celui-ci, (B) au moins un composant sélectionné parmi le 3-L-menthoxypropane-1,2-diol, le lactate de menthyle et le succinate de monométhyle et (C) un surfactant non ionique, le rapport (composant (B))/(composant (A)) étant de 0,05 à 5 en masse.
PCT/JP2012/082300 2011-12-26 2012-12-13 Composition destinée à être administrée par voie orale WO2013099621A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2011282721A JP5825093B2 (ja) 2011-12-26 2011-12-26 洗口剤組成物
JP2011-282721 2011-12-26

Publications (1)

Publication Number Publication Date
WO2013099621A1 true WO2013099621A1 (fr) 2013-07-04

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018221621A1 (fr) * 2017-05-31 2018-12-06 ライオン株式会社 Composition pour utilisation dans la cavité buccale
WO2022122144A1 (fr) 2020-12-09 2022-06-16 Symrise Ag Procédé de lutte contre les micro-organismes utilisant des dérivés du menthol

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10324619A (ja) * 1997-05-22 1998-12-08 Kao Corp 口腔用組成物
JP2007223942A (ja) * 2006-02-23 2007-09-06 Kao Corp 歯磨剤
WO2010143589A1 (fr) * 2009-06-08 2010-12-16 ライオン株式会社 Composition pour la cavité buccale
JP2011126818A (ja) * 2009-12-18 2011-06-30 Lion Corp 歯磨剤組成物
WO2011115034A1 (fr) * 2010-03-19 2011-09-22 ライオン株式会社 Composition orale liquide et méthode de production de ladite composition

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3639563A (en) * 1970-07-23 1972-02-01 Colgate Palmolive Co Mouthwash containing polymeric polyoxyethylene nonionic surface active agent and chloroform
CA1145261A (fr) * 1980-12-15 1983-04-26 Irving R. Schmolka Preparation orale contenant un derive polyoxyethylenique d'un alcool gras
JPH04159212A (ja) * 1990-10-19 1992-06-02 Lion Corp 液状透明口腔用組成物
US5292527A (en) * 1992-07-02 1994-03-08 Bausch & Lomb Incorporated Non-alcoholic aqueous mouthwash
JP2000026257A (ja) * 1998-07-08 2000-01-25 Kao Corp 口腔用組成物
JP2004051511A (ja) * 2002-07-18 2004-02-19 Toa Yakuhin Kk うがい薬

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10324619A (ja) * 1997-05-22 1998-12-08 Kao Corp 口腔用組成物
JP2007223942A (ja) * 2006-02-23 2007-09-06 Kao Corp 歯磨剤
WO2010143589A1 (fr) * 2009-06-08 2010-12-16 ライオン株式会社 Composition pour la cavité buccale
JP2011126818A (ja) * 2009-12-18 2011-06-30 Lion Corp 歯磨剤組成物
WO2011115034A1 (fr) * 2010-03-19 2011-09-22 ライオン株式会社 Composition orale liquide et méthode de production de ladite composition

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018221621A1 (fr) * 2017-05-31 2018-12-06 ライオン株式会社 Composition pour utilisation dans la cavité buccale
JPWO2018221621A1 (ja) * 2017-05-31 2020-04-02 ライオン株式会社 口腔用組成物
JP7264049B2 (ja) 2017-05-31 2023-04-25 ライオン株式会社 口腔用組成物
WO2022122144A1 (fr) 2020-12-09 2022-06-16 Symrise Ag Procédé de lutte contre les micro-organismes utilisant des dérivés du menthol

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JP2013133280A (ja) 2013-07-08
JP5825093B2 (ja) 2015-12-02

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