WO2013060707A2 - Produits cosmétiques contenant de l'oxytocine et des substances odorantes - Google Patents

Produits cosmétiques contenant de l'oxytocine et des substances odorantes Download PDF

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Publication number
WO2013060707A2
WO2013060707A2 PCT/EP2012/071019 EP2012071019W WO2013060707A2 WO 2013060707 A2 WO2013060707 A2 WO 2013060707A2 EP 2012071019 W EP2012071019 W EP 2012071019W WO 2013060707 A2 WO2013060707 A2 WO 2013060707A2
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WO
WIPO (PCT)
Prior art keywords
oil
oxytocin
composition according
weight
acid
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PCT/EP2012/071019
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German (de)
English (en)
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WO2013060707A3 (fr
Inventor
Bernhard Banowski
Thomas Welss
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Henkel Ag & Co. Kgaa
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Publication of WO2013060707A2 publication Critical patent/WO2013060707A2/fr
Publication of WO2013060707A3 publication Critical patent/WO2013060707A3/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/095—Oxytocins; Vasopressins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00—Anti-perspirants or body deodorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Definitions

  • the present application relates to skin-applied cosmetic products for improving emotional well-being, which contain as active ingredient at least oxytocin or a derivative of oxytocin and a fragrance. Furthermore, the present application relates to a non-therapeutic method for cosmetically improving the emotional well-being using oxytocin and optionally at least one perfume. Furthermore, the present application relates to the use of oxytocin and optionally at least one perfume to improve the emotional well-being.
  • washing, cleansing and caring for one's own body is a fundamental human need, and modern industry is constantly trying to meet these needs of man in a variety of ways.
  • skin cleansing and subsequent conditioning of the skin with fats and moisturisers should also meet specific consumer requirements.
  • anti-wrinkle agents with active ingredients intended to slow down certain processes of skin aging sunscreens with UV-absorbing filter substances, and skin lighteners which contain active ingredients which break down the skin's own melanin.
  • antitraspirates or deodorant products are known which influence the body's sweat in various ways and lead to at least a reduction of the unpleasant odor.
  • These agents are formulated in a variety of dosage forms, mostly as (possibly oil and fat-free) gel, as a cream, in stick form, as a liquid or gel roll on application, as a soaked flexible substrate (anti-pimple pad), but also as a powder or spray.
  • the consumer also wants an emotional effect that can be experienced by him, a feeling of "feeling good", of "calm” and / or balanced feeling, depending on the situation, but also an invigorating feeling, a stimulating feeling when using the perceive different cosmetic compositions. This is insufficiently fulfilled by today's cosmetic compositions for the consumer.
  • WO 2008/050084 A1 discloses perfume compositions which influence the feelings of the user.
  • WO 2006/136828 A1 also discloses such fragrance compositions.
  • EP 1343466 B1 describes perfume compositions which can influence the feelings. The consumer is aware of this possibility as "aromatherapy.”
  • mixtures of different fragrances are always used for this purpose These mixtures often consist of at least 5 different fragrances, which are perceived as pleasant, as well as other fragrance components and other so-called neutral fragrances
  • the prior art are thus predominantly attributable to the perfumes and fragrance compositions, which are preferably sprayed as Eau de toilette on the skin, especially the facial skin, so that the user has a pleasant fragrance.
  • cosmetic agents containing in a cosmetically acceptable carrier oxytocin or a derivative of oxytocin and in a preferred embodiment furthermore at least one perfume are excellently suited to clean or care for the consumer in the use of the agent on the one hand and on the other hand he expected to give a pleasant, soothing, harmonizing, invigorating, stimulating, uplifting feeling, as well as reinforcing the sense of attachment between individuals such as mother and child and / or partners.
  • Oxytocin is a peptide hormone and is found in all mammals and humans. Particularly preferred according to the invention is human oxytocin.
  • the latter is a nonapeptide with the amino acid sequence Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly.
  • the invention includes the recognition that the oxytocin may be encapsulated by methods known to those skilled in the art. This encapsulation can be carried out by known methods and known methods. Special forms include oxytocin-filled liposomes or niosomes.
  • the present invention encompasses the recognition that the oxytocin can be used as adsorbent bound on a carrier such as silica gel or alumina or layer silicates or polymer fibers.
  • a carrier such as silica gel or alumina or layer silicates or polymer fibers.
  • polysaccharide-based matrix capsules, as well as hollow capsules based on gelatin coacervates and / or melamine tocacervates may contain the oxytocin or a derivative of oxytocin.
  • the oxytocin is present in an amount of 0.00001 to 1% by weight, preferably 0.00005 to 0.5% by weight, more preferably 0.0001 to 0.1% by weight, most preferably 0, 0005 to 0.01 wt.%, In each case based on the total weight of the agent.
  • a derivative of oxytocin is an acylated form of oxytotocin.
  • Acylated forms of oxytocin contain either short-chain or long-chain acyl groups.
  • Short-chain acyl groups are C 2 to C 6 acyl groups, preferably the acetyl group, the propionyl group or the butyryl group.
  • a particularly preferred short-chain acyl group is the acetyl group.
  • Long chain acyl groups are derived from C8 to C30 fatty acids.
  • Particularly preferred long-chain acyl groups are lauroyl, myristoyl, cocoyl, stearoyl and / or behenoyl radicals.
  • a final derivative of oxytocin is a precursor of oxytocin.
  • one of the derivatives of oxytocin as described above or a precursor substance of oxytocin is in an amount of 0.00001 to 1% by weight, preferably 0.00005 to 0.5% by weight, particularly preferably 0.0001 to 0, 1 wt.%, Most preferably 0.0005 to 0.01 wt.%, Each based on the total weight of the composition.
  • the second essential component of the present invention is a fragrance.
  • a fragrance in the sense of the present application is in accordance with the expert definition as it can be found in the R ⁇ MPP Chemie Lexikon, as of December 2007. Thereafter, a fragrance is a chemical compound with smell and / or taste that excites the hair cell receptors (adequate stimulus).
  • the necessary physical and chemical properties are a low molecular weight of at most 300 g / mol, a high vapor pressure, minimal water and high lipid solubility and weak polarity and the presence of at least one osmophoric group in the molecule.
  • fragrances according to the invention have a molecular weight of 74 to 300 g / mol, contain at least one osmophoric group in the molecule and have a smell and / or taste, that is, they excite the receptors of the hair cells of the olfactory system.
  • a fragrance in the sense of the present invention can be a singular substance but also an extract or essential oil or a resin or a resinoid.
  • fragments does not mean perfumes and / or perfume compositions or fragrance compositions with fragrance components composed of different sources.
  • Star anise oil is a fragrance within the meaning of the present invention, although this oil consists of 15 individual components.
  • Star aniseed oil is obtained by steam distillation.
  • fragment does not include the so-called "notes”.
  • fragrances in the sense of this invention does not include substances which, on the one hand, have an odor On the other hand, however, they usually also be used for other purposes in cosmetic compositions. These are in addition to the compounds already mentioned ethanol, propanol, isopropanol and acetone in particular phenoxyethanol and benzyl alcohol. Phenoxyethanol is commonly used for its preservative effect. Benzyl alcohol is commonly used as a solvent.
  • the essence of the invention is that at least one fragrance is formulated with oxytocin in a cosmetically acceptable carrier.
  • fragrances can be used, for example, all in the book "The cosmetic preparations, 4th Edition, Volume I, The perfumery, publishing house for chemical industry, H. Ziolkowsky KG, Augsburg, Ga Nowak, Chapter I and Chapter II listed fragrances.
  • a fragrance can itself already cause an emotion.
  • Such fragrances may be preferred for the purposes of the present invention. Particular preference may be given to fragrances which cause a pleasant and positive mood.
  • a fragrance according to the invention may for example be a synthetic product of the ester, ether, aldehyde, ketone, alcohol and hydrocarbon type. Fragrance compounds of the ester type are known e.g. Benzyl acetate, phenoxyethyl isobutyrate, p-tert-butylcyclohexyl acetate, linalyl acetate, dimethylbenzylcarbinylacetate (DMBCA), phenylethylacetate, benzylacetate, ethylmethylphenylglycinate, allylcyclohexylpropionate, styrallylpropionate, benzylsalicylate, cyclohexylsalicylate, floramate, melusate and jasmecyclate.
  • DMBCA dimethylbenzylcarbinylacetate
  • the ethers include, for example, benzyl ethyl ether and ambroxane, to the aldehydes e.g. the linear alkanals having 8-18 C atoms, citral, citronellal, citronellyloxy-acetaldehyde, cyclamen aldehyde, lilial and bourgeonal, to the ketones, e.g.
  • the ionones alpha-lsomethylionone and methylcedryl ketone
  • the alcohols anethole, citronellol, eugenol, geraniol, linalool, phenylethyl alcohol and terpineol
  • the hydrocarbons mainly include the terpenes such as limonene and pinene.
  • the fragrances may also contain natural fragrances as are available from plant sources, e.g. Pine, citrus, jasmine, patchouly, rose or ylang-ylang oil. Also suitable are Muskateller sage oil, chamomile oil, clove oil, lemon balm oil, mint oil, cinnamon leaf oil, lime blossom oil, juniper berry oil, vetiver oil, olibanum oil, galbanum oil and labdanum oil and orange blossom oil, neroliol, orange peel oil and sandalwood oil.
  • Adhesion-resistant fragrances which can advantageously be used in the context of the present invention are, for example, the essential oils such as angelica root oil, aniseed oil, arnica blossom oil, basilum oil, bay oil, champacilla oil, noble-pine oil, pinecone oil, elemi oil, eucalyptus oil, fenchel oil, spruce alder oil, galbanum oil, geranium oil , Gingergrass oil, guaiac wood oil, gurdy balm oil, helichrysum oil, ho oil, ginger oil, iris oil, cajeput oil, calamus oil, chamomile oil, camphor oil, kanga oil, cardamom oil, cassia oil, pine needle oil, copaiba balsam oil, coriander oil, spearmint oil, cumin oil, cumin oil, lemongrass oil, musk kernel oil, myrrh oil , Clove oil, Neroli oil, Niaouli oil, Olibanum oil, Or
  • fragrances of natural or synthetic origin can be used in the context of the present invention advantageously as adherent fragrances.
  • These compounds include the following compounds and mixtures thereof: ambrettolide, ⁇ -amylcinnamaldehyde, anethole, anisaldehyde, anisalcohol, anisole, methyl anthranilate, acetophenone, benzylacetone, benzaldehyde, ethyl benzoate, benzophenone, benzyl alcohol, borneol, bornyl acetate, ⁇ -bromostyrene , n-decyl aldehyde, n-dodecyl aldehyde, eugenol, eugenol methyl ether, eucalyptol, farnesol, fenchone, fenchyl acetate, geranyl acetate, geranyl formate, heliotropin
  • more volatile fragrances which can be used advantageously in the context of the present invention, include in particular the lower-boiling fragrances natural or synthetic origin, which can be used alone or in mixtures.
  • Examples of more readily volatile fragrances are alkyl isothiocyanates (alkyl mustard oils), butanedione, limonene, linalool, linalyl acetate and propionate, menthol, menthone, methyl-n-heptenone, phellandrene, phenylacetaldehyde, terpinyl acetate, citral, citronellal.
  • odoriferous substances from the group of allyl alcohol esters, esters of secondary alcohols, esters of tertiary alcohols, allylic ketones, acetals, ketals, condensation products of amines and aldehydes and / or mixtures thereof can also be used.
  • fragrances in the context of the invention are bergamot oil, coriander oil, damascenia, ginger oil, orange oil, patchouli oil, rosemary oil, peppermint oil, tamarin, geraniol, geranium oil, eugenol, tangerine and orange oil, anise, jasmine, isoeugenol, menthol, coumarin, melonal , Terpineol, vanillin, ylang-ylang oil, cinnamyl alcohol, methylionone, ethyl vanillin, ethyl 2,6,6-trimethylcyclohexadiene carboxylate, methyl 2-nonenoate.
  • At least one fragrance is present in the cosmetic agent according to the invention in a total amount of 0.001 to 40% by weight, preferably 0.01 to 20% by weight, more preferably of 0.1 to 10 wt.%, Most preferably 0.3 to 8 wt.%, Each based on the total weight of the composition.
  • the cosmetically acceptable carriers are in particular aqueous or aqueous-alcoholic.
  • An aqueous cosmetic carrier contains at least 50% by weight of water, preferably at least 70% by weight of water, and most preferably at least 80% by weight of water.
  • Aqueous-alcoholic cosmetic carriers rule aqueous solutions containing 3 to 70 wt .-% of a Ci-C ö alcohol, especially methanol, ethanol or propanol, isopropanol, butanol, isobutanol, tert purposes of the present invention.
  • compositions of the invention may additionally contain other organic solvents, such as methoxybutanol, benzyl alcohol, ethyl diglycol or 1, 2-propylene glycol. Preference is given to all water-soluble organic solvents.
  • compositions according to the invention is preferably based on the requirements of the intended use.
  • compositions of the invention may be in solid, semi-solid, liquid, disperse, emulsified, suspended or gel form.
  • the agents according to the invention can be formulated as an aerosol, that is, they are packaged in a pressure vessel, from which they can be sprayed with the aid of a propellant.
  • the agents according to the invention can be sprayed as a propellant-free pump spray.
  • the agents according to the invention are in the form of a hydrogel.
  • Hydrogels are water-containing gels based on hydrophilic but water-insoluble polymers, which exist as three-dimensional networks.
  • Synthetic hydrogels are based inter alia on poly (meth) acrylic acids, poly (meth) acrylates, polyvinylpyrrolidone or polyvinyl alcohol.
  • Preferred anionic polymeric hydrogel formers which can support the action of the active ingredient used according to the invention contain carboxylate and / or sulfonate groups and as monomers, for example, acrylic acid, methacrylic acid, crotonic acid, maleic anhydride and 2-acrylamido-2-methylpropanesulfonic acid.
  • the acidic groups may be wholly or partly present as sodium, potassium, ammonium, mono- or triethanolammonium salt.
  • Preferred monomers are 2-acrylamido-2-methylpropanesulfonic acid and acrylic acid.
  • Very particularly preferred anionic polymers contain 2-acrylamido-2-methylpropanesulfonic acid as the sole monomer or as a comonomer, it being possible for the sulfonic acid group to be wholly or partly in salt form.
  • copolymers of at least one anionic monomer and at least one nonionic monomer With regard to the anionic monomers, reference is made to the substances listed above.
  • Preferred nonionic monomers are acrylamide, methacrylamide, acrylic esters, methacrylic acid esters, vinylpyrrolidone, vinyl ethers and vinyl esters.
  • Preferred anionic copolymers are acrylic acid-acrylamide copolymers and in particular polyacrylamide copolymers with monomers containing sulfonic acid groups.
  • a particularly preferred anionic copolymer consists of 70 to 55 mol% of acrylamide and 30 to 45 mol% of 2-acrylamido-2 methylpropanesulfonic acid, wherein the sulfonic acid groups are completely or partially present as sodium, potassium, ammonium, mono- or triethanolammonium salt.
  • This copolymer may also be crosslinked, with crosslinking agents preferably polyolefinically unsaturated compounds such as tetraallyloxyethane, allylsucrose, allylpentaerythritol and methylene-bisacrylamide are used.
  • crosslinking agents preferably polyolefinically unsaturated compounds such as tetraallyloxyethane, allylsucrose, allylpentaerythritol and methylene-bisacrylamide are used.
  • crosslinking agents preferably polyolefinically unsaturated compounds such as tetraallyloxyethane, allylsucrose, allylpentaerythritol and methylene-bisacrylamide are used.
  • Such a polymer is contained in the commercial product Sepigel ® 305 from SEPPIC. The use of this compound has proven to be particularly advantageous in the context of the teaching of the invention.
  • the NS under the designations Simulgel ® 600, Simulgel ®, Simulgel ® EG, Simulgel EPG ® and Sepiplus ® 400 as a compound with an oil such as Isohexa- decane, squalane or hydrogenated polyisobutene, and an emulsifier, such as polysorbate, Laureth-7, or Caprylyl / capryl glucosides, sold sodium acryloyldimethyltaurate copolymers (with monomers selected from acrylamide, sodium acrylate, hydroxyethyl acrylate and / or acrylic acid) have proven to be particularly effective according to the invention.
  • Hydrogel Kunststoff- ammonium acryloyldimethyltaurate vinylpyrrolidone copolymer in particular the commercial product Aristoflex ® AVC from Clariant.
  • anionic homopolymer hydrogel formers are uncrosslinked and crosslinked polyacrylic acids. Allyl ethers of pentaerythritol, sucrose and propylene may be preferred crosslinking agents. Such compounds are for example the commercial products Carbopol ®. A particularly preferred anionic copolymer contains 80 to 98% of an unsaturated C 3 monomer. 6- carboxylic acid or its anhydride and to 2 - 20% of acrylic acid esters of saturated Cio-30-carboxylic acids, wherein the copolymer may be crosslinked with the aforementioned crosslinking agents. Corresponding commercial products are Pemulen ®, and Carbopol ® grades 954, 980, 1342 and ETD 2020 (ex Noveon or BF Goodrich).
  • Preferred nonionic polymeric hydrogel formers are, for example, polyvinyl alcohols which may be partially saponified, e.g. B. the commercial products Mowiol ® and vinylpyrrolidone / vinyl ester copolymers and polyvinylpyrrolidones, the z. B. under the trademark Luviskol ® (BASF) are sold.
  • Natural hydrogel-forming agents which are preferred according to the invention are in particular selected from, if desired, physically (thermally) and / or chemically modified cellulose derivatives, preferably hydroxyalkylcelluloses such as hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, methylcellulose, hydroxymethylcellulose, carboxymethylcellulose, in particular starches and starch degradation products such as amylose and amylopectin, chemically and / or thermally modified starches, e.g. B.
  • hydroxyalkylcelluloses such as hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, methylcellulose, hydroxymethylcellulose, carboxymethylcellulose
  • starches and starch degradation products such as amylose and amylopectin, chemically and / or thermally modified starches, e.g. B.
  • the agents according to the invention are in the form of an oil-in-water emulsion.
  • oil-in-water emulsions may, also preferably, be stabilized by at least one of the abovementioned hydrogel formers.
  • the agents according to the invention are in liquid form.
  • the application can be carried out preferably with spray devices.
  • These spray devices contain in a container a filling of the inventive (liquid, mushy or powdery) means.
  • the filling may be under the pressure of a propellant (compressed gas cans, compressed gas packages, aerosol dispensers), or it may be a mechanically operated pump sprayer.
  • the containers have a removal device, preferably in the form of valves, which allow the removal of the contents as fog, smoke, foam, powder, paste or liquid jet.
  • a container for the sprayers are mainly cylindrical vessels made of metal (aluminum, tinplate, volume preferably ⁇ 1000 ml), protected or non-splintering glass or plastic (volume preferably ⁇ 220 ml) or splintering glass or plastic (volume preferably ⁇ 150 ml ) in question.
  • Spray dispensers contribute to a particularly uniform application of the skin care agent according to the invention, which is particularly important for the final result of the treatment according to the invention.
  • Creamy, gelatinous, pastose and liquid agents may e.g. be packaged in pump or squeeze dispensers, especially in multi-chamber pump or squeeze dispensers.
  • liquid also includes any solid dispersions in liquids.
  • Compositions according to the invention may also be present as pastes, ointments, lotions or creams.
  • Solid funds can be present as a loose powder, pressed powder or as a pen.
  • the application may e.g. in the case of liquid agents, preferably also with a roller applicator, as e.g. is known from the field of deodorant scooters.
  • rollers have a ball mounted in a ball bed, which can be moved by movement over a surface. The ball absorbs some of the agent to be distributed and conveys this to the surface to be treated.
  • the application may e.g. also be carried out with substrates which are acted upon by a preparation according to the invention.
  • wet wipes i. prefabricated for the user, preferably individually packaged, wet wipes, such as. B. from the field of glass cleaning (eyeglass cleaning cloths) or from the field of wet toilet paper are well known.
  • Such wet wipes which may advantageously also contain preservatives, are then advantageously impregnated or applied with an agent according to the invention, advantageously they are individually packaged.
  • Preferred substrate materials are preferably selected from porous sheet-like cloths. They can be made of a fibrous or cellular flexible material that is sufficient has mechanical stability and at the same time softness for use on the skin. These wipes include cloths of woven and non-woven synthetic and natural fibers, felt, paper or foam, such as hydrophilic polyurethane foam.
  • nonwovens conventional cloths of nonwoven material (nonwovens) are used here.
  • the agents according to the invention preferably liquid agents, may also be multi-phase, the phases may, for. B. horizontally, so one above the other, or vertically, so next to each other, be arranged. It may also be a disperse system in which e.g. the solid constituents are distributed inhomogeneously in the liquid matrix, so that such a dispersed system should be shaken before use.
  • Preferred optional ingredients of the cosmetic compositions of the invention can be defined by their function. Of course, some ingredients can also be multifunctional.
  • compositions according to the invention preferably cosmetic products
  • cosmetic products can be:
  • These preferably have the task of absorbing water and / or oil-soluble dissolved or finely divided substances.
  • microorganisms particularly microorganisms responsible, for example, for the formation of acne or body odor.
  • These germs include, among others, various species from the group of staphylococci, the group of Corynebacteria, anaerococci and micrococci, in particular Corynebacterium acnes, Corynebacterium granulosum, Propionibacterium acnes, Propionibacterium avidum and Propionibacterium granulosum, Staphylococcus hominis, Anerococcus octavius, Corynebacterium tub.
  • Preferred antimicrobial or antimicrobial agents according to the invention are in particular organohalogen compounds and halides, quaternary ammonium compounds, a number of plant extracts and zinc compounds.
  • triclosan chlorhexidine and chlorhexidine gluconate
  • 3,4,4'-trichlorocarbanilide bromochlorophene, dichlorophen, chlorothymol, chloroxylenol, hexachlorophene, dichloro-m-xylenol, dequalinium chloride, domiphenbromide, ammonium phenolsulfonate, benzalkonium halides, benzalkonium cetyl phosphate, Benzalkonium saccharinates, benzethonium chloride, cetylpyridinium chloride, laurylpyridinium chloride, laurylisoquinolinium bromide, methylbenzedonium chloride.
  • phenol phenoxyethanol, disodium dihydroxyethylsulfosuccinyl undecylenate, sodium bicarbonate, zinc lactate, sodium phenolsulfonate and zinc phenolsulfonate, ketoglutaric acid, terpene alcohols such as. B.
  • farnesol chlorophyllin copper complexes
  • ⁇ -monoalkyl glycerol ether with a branched or linear saturated or unsaturated, optionally hydroxylated C 6 - C 2 2 alkyl radical, particularly preferably a- (2-ethylhexyl) glycerol ether, commercially available as Sen- Siva ® SC 50 (ex Schulke & Mayr), Carbonklar of mono-, di- and triglycerol (z. B. Gly cerinmonolaurate, diglycerol monocaprinate), lantibiotics and plant extracts (eg green tea and components of lime blossom oil).
  • Antibacterial substances especially for deodorants can be selected from the group of linear, branched and unbranched, but also aromatic alcohols and acids, for example phenoxyethanol, benzyl alcohol, benzylheptanol and others.
  • Further preferred antimicrobial active ingredients are selected from so-called prebiotically active components, which according to the invention are to be understood as meaning those components which inhibit only or at least predominantly the odor or acne-forming germs of the skin microflora, but not the desired, that is, the non-odor-causing or not -Anmaking germs that belong to a healthy skin microflora.
  • active ingredients which are disclosed in the published patent applications DE 10333245 and DE 10 2004 01 1 968 as prebiotically effective, also included; these include conifer extracts, in particular from the group of Pinaceae, and plant extracts from the group of Sapindaceae, Araliaceae, Lamiaceae and Saxifragaceae, in particular extracts from Picea spp., Paullinia sp., Panax sp., Lamium album or Ribes nigrum and mixtures of these substances,
  • Antiperspirant active ingredients have a pore-astringent action and are therefore frequently used in skin treatment preparations for sebum suppression.
  • the amounts used for sebum suppression are usually lower than the amounts used for antiperspirancy and are in the range of 0, 1 to 10 wt .-%, preferably 2 to 3 wt .-%.
  • antiperspirant products contain from 2 to 25% by weight of the antiperspirant active ingredient for a sufficient sweat-reducing effect.
  • the amount is based on the propellant-containing composition.
  • Preferred agents according to the invention contain at least one astringent antiperspirant active substance selected from the water-soluble astringent inorganic and organic salts of aluminum, zirconium and zinc or any desired mixtures of these salts.
  • Particularly preferred antiperspirant active ingredients are selected from the aluminum chlorohydrates, in particular the aluminum chlorohydrates having the general formula [Al 2 (OH) 5 Cl ⁇ 2-3 H 2 O] n , which may be present in non-activated or in activated (depolymerized) form , furthermore aluminum sesquichlorohydrate, aluminum chlorohydrex propylene glycol (PG) or polyethylene glycol (PEG), aluminum sesquichlorohydrex PG or - PEG, aluminum PG-dichlorhydrex or aluminum PEG-dichlorhydrex, aluminum hydroxide, furthermore selected from the aluminum zirconium chlorohydrates, such as aluminum zirconium trichlorohydrate, aluminum zirconium tetrachlorohydrate , Aluminum zircon
  • water solubility is understood as meaning a solubility of at least 5% by weight at 20 ° C., that is to say amounts of at least 5 g of the antiperspirant active are soluble in 95 g of water at 20 ° C.
  • the antiperspirant active ingredients can be used as an aqueous solution.
  • Preferred anhydrous agents according to the invention preferably contain at least one activated aluminum chlorohydrate, preferably a raw material from the REACH® series from Summit-Reheis.
  • the antiperspirant effect may be enhanced by the addition of further ions such as calcium salts.
  • binder may be added, e.g. to eliminate foam during manufacture or to reduce the tendency of finished products to over-foam.
  • certain plant ingredients e.g. Green tea extract. They are intended to impart certain desired properties to a product which are related to the corresponding biological material, or to further improve existing properties or to suppress undesirable properties or reduce them as much as possible.
  • These may e.g. serve to lighten the color of the hair or skin.
  • a complex-forming substance is ethylenediaminetetraacetic acid (EDTA) and its sodium salts, furthermore nitrilotriacetic acid (NTA) and its sodium salts, beta-alaninediacetic acid and its salts and phosphonic acids and salts thereof.
  • EDTA ethylenediaminetetraacetic acid
  • NTA nitrilotriacetic acid
  • the at least one complex-forming substance is preferably contained in a total amount of 0.01-0.5% by weight, particularly preferably 0.08-0.2% by weight, based on the total weight of the composition according to the invention.
  • the agents according to the invention may contain at least one deodorant active ingredient.
  • This may preferably be selected from the already mentioned antimicrobial agents.
  • an active substance which contains the enzymes responsible for the sweat decomposition in particular the arylsulfatase, ⁇ -glucuronidase, aminoacylase, cystathion ⁇ -lyase, esterases, lipases and / or lipoxigenase, inhibits, e.g. B. trialkylcitric acid, in particular triethyl citrate, or zinc glycinate.
  • WO 03/039505 A2 WO 01/99376 A2, EP 1430879 A2, EP 1428520 A2, EP 1738803 A1, EP 1576946 A1 and DE 10216368 A1.
  • Further inventively preferred deodorant agents are odor absorbers and deodorizing ion exchangers. Silicates serve as odor absorbers, which at the same time advantageously support the rheological properties of the composition according to the invention.
  • the silicates which are particularly advantageous according to the invention include, in particular, phyllosilicates and, among these, in particular montmorillonite, kaolinite, mit, beidellite, nontronite, saponite, hectorite, bentonite, smectite and talcum.
  • Further advantageous odor absorbers are, for example, zeolites, zinc ricinoleate, cyclodextrins, certain metal oxides, such as. As alumina, and chlorophyll. They are preferably used in an amount of 0.1-10% by weight, more preferably 0.5-7% by weight and most preferably 1-5% by weight, based in each case on the total composition.
  • compositions according to the invention which are present as an emulsion, suspension, spray or stick, comprise as emollient at least one oil which is liquid at 20 ° C. and which does not constitute a fragrance component and does not represent an essential oil.
  • Oils preferred according to the invention are selected from branched saturated or unsaturated fatty alcohols having 6 to 30 carbon atoms. These alcohols are also often referred to as Guerbet alcohols, as they are obtainable by the Guerbet reaction.
  • Preferred oils are alcohol hexyldecanol, octyldodecanol (Eutanol ® G, Guerbitol ® 20), 2-ethylhexyl alcohol.
  • Components further preferred ⁇ lkom- are mixtures of Guerbet alcohols and Guerbet alcohol esters, for example the commercial product Cetiol ® PGL (hexyldecanol and hexyldecyl laurate.
  • preferred emollient oils are selected from the triglycerides of linear or branched, saturated or unsaturated, optionally hydroxylated C 8 -3O- Particularly suitable may be the use of natural oils, for example soybean oil, cottonseed oil, sunflower oil, palm oil, palm kernel oil, linseed oil, almond oil, castor oil, corn oil, olive oil, rapeseed oil, sesame oil, thistle oil, wheat germ oil, peach kernel oil and the liquid portions of coconut oil and the like.
  • natural oils for example soybean oil, cottonseed oil, sunflower oil, palm oil, palm kernel oil, linseed oil, almond oil, castor oil, corn oil, olive oil, rapeseed oil, sesame oil, thistle oil, wheat germ oil, peach kernel oil and the liquid portions of coconut oil and the like.
  • suitable but also synthetic triglyceride oils in particular capric / caprylic triglycerides, for example., the commercial products Myritol ® 318, Myritol ® More 331 (Cognis) or Miglyol ® 812 (Hüls) using unbranched fatty acid residues.
  • particularly preferred oils are selected from the Dicarbon Textree star of linear or branched C 2 -C 0 - alkanols, especially diisopropyl adipate, di-n-butyl adipate, di- (2-ethylhexyl) adipate, dioctyl adipate, diethyl / di-n-butyl / dioctyl sebacate, diisopropyl sebacate, dioctyl malate, Dioctyl maleate, dicaprylyl maleate, diisooctyl succinate, di-2-ethylhexyl succinate and di (2-hexyldecyl) succinate.
  • Further oil components preferred according to the invention are selected from the esters of linear or branched saturated or unsaturated fatty alcohols having 2 to 30 carbon atoms with linear or branched saturated or unsaturated fatty acids having 2 to 30 carbon atoms, which may be hydroxylated.
  • hexyldecyl stearate (Eutanol ® G 16 S), hexyldecyl, Isodecylneopen- tanoat, isononyl isononanoate, 2-ethylhexyl palmitate (Cegesoft ® C 24) and 2-ethylhexyl stearate (Cetiol ® 868).
  • Further oil components preferred according to the invention are selected from the adducts of at least 6 ethylene oxide and / or propylene oxide units with monovalent or polyvalent C 3 .
  • 2 2-alkanols such as butanol, butanediol, myristyl alcohol and stearyl alcohol, eg. As PPG-14 butyl ether (Ucon Fluid ® AP), PPG-9-butyl ether (Breox B25 ®), PPG-10 butanediol (Macol ® 57) and PPG-15 stearyl ether (Arlamol ® E).
  • Further preferred oil components according to the invention are selected from the C 8 -C 2 2 fatty alcohol esters of monohydric or polyhydric C 2 -C 7 hydroxycarboxylic acids, in particular the esters of glycolic acid, lactic acid, malic acid, tartaric acid, citric acid and salicylic acid.
  • esters based on linear Ci 4 / i 5 alkanols, eg. B.
  • Ci 2 -Ci 5 -alkyllactate, and of branched in 2-position Ci 2 / i 3-alkanols are under the trademark Cosmacol ® from the company Nordmann, Rassmann GmbH & Co, Hamburg, refer, in particular the commercial products Cosmacol ® ESI, Cosmacol® ® EMI and Cosmacol® ® EIT.
  • Further inventively preferred oil components are selected from the symmetrical, asymmetrical or cyclic esters of carbonic acid with fatty alcohols, eg. As glycerol carbonate, dicaprylyl carbonate (Cetiol ® CC).
  • Further preferred oil components according to the invention are selected from the esters of dimers of unsaturated C 12 -C 22 -fatty acids (dimer fatty acids) with monovalent linear, branched or cyclic C 2 -C 18 -alkanols or with polyvalent linear or branched C 2 -C 6 -alkanols. It may be extraordinarily preferred according to the invention to use mixtures of the abovementioned oils. Further oil components preferred according to the invention are selected from silicone oils and hydrocarbon oils.
  • Silicone oils preferred according to the invention are selected from among dialkyl and alkylaryl siloxanes, such as, for example, cyclopentasiloxane, cyclohexasiloxane, dimethylpolysiloxane and methylphenylpolysiloxane, but also include hexamethyldisiloxane, octamethyltrisiloxane and decamethyltetrasiloxane. Further inventively preferred silicone oils are selected from volatile silicone oils which may be cyclic, such as. Octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane and dodecamethylcyclohexasiloxane, and mixtures thereof, as they are z. B.
  • dialkyl and alkylaryl siloxanes such as, for example, cyclopentasiloxane, cyclohexasiloxane, dimethylpolysiloxane and methylphenylpolysi
  • preferred natural and synthetic hydrocarbons selected from paraffinic oils, isohexadecane, isoeicosane, (optionally hydrogenated) polyisobutenes and polydecenes, which are obtainable for example under the designation Emery ® 3004, 3006, 3010 or under the name Ethylflo ® from Albemarle or Nexbase ® 2004G from Nestle, and 1, 3 di- (2-ethylhexyl) -cyclohexane (Cetiol ® S).
  • mixtures of isoparaffins such as Pioneer ® 2094, Isopar ® G, Isopar ® M or Isopar ® L can be used.
  • Particularly preferred skin care agents according to the invention are characterized in that the oil (s) liquid at 20 ° C. in a total amount of 0.1 to 80% by weight, preferably 2 to 20% by weight, particularly preferably 3 to 15 Wt .-%, each based on the total weight of the composition, is / are included.
  • a proportion of the oil components of at least 80% by weight has a refractive index n D of 1.39-1.51.
  • the oils that is to say the substances which are liquid under normal conditions, it is also possible to use solid lipid or wax components as emollients under normal conditions.
  • Particularly preferred lipid or wax components are selected from coconut fatty acid glycerol mono-, di- and triesters, Butyrospermum Parkii (shea butter) and esters of saturated, monohydric C 8 -C 18 alcohols with saturated C 12 -C 18 monocarboxylic acids and mixtures thereof Substances contained.
  • Emollients preferred according to the invention are furthermore natural vegetable waxes, eg. Candelilla wax, carnauba wax, Japan wax, sugarcane wax, ouricoury wax, cork wax, sunflower wax, fruit waxes such as orange waxes, lemon waxes, grapefruit wax, and animal waxes, e.g. Beeswax, shellac wax and spermaceti.
  • waxes For the purposes of the invention, it may be particularly preferred to use hydrogenated or hardened waxes.
  • a wax component and chemically modified waxes especially the hard waxes, such as.
  • montan ester waxes hydrogenated jojoba waxes and Sasol waxes used.
  • Synthetic waxes which are also preferable in the invention include, for example, polyalkylene waxes and polyethylene glycol waxes, C 2 ° C 40 dialkyl esters of dimer acids, C 30 -5o-alkyl and alkylaryl esters of Alkylbienenwachs and dimer fatty acids.
  • compositions according to the invention which are formulated as a water-in-oil emulsion, preferably contain at least one water-in-oil emulsifier.
  • the at least one water-in-oil emulsifier is preferably in an amount of 0, 1-7 wt .-%, particularly preferably 1, 0 - 3.5 - 4.5 wt .-%, each based on the total weight of Emulsion, included.
  • water-soluble polyvalent C 2 -C 9 -alkanols having 2 to 6 hydroxyl groups and / or water-soluble polyethylene glycols containing 3 to 20 ethylene oxide units and mixtures thereof are suitable for this purpose.
  • These components are preferably selected from 1,2-propylene glycol, 2-methyl-1,3-propanediol, glycerol, butylene glycols such as 1,2-butylene glycol, 1,3-butylene glycol and 1,4-butylene glycol, pentylene glycols such as 1,2.
  • Pentanediol and 1,5-pentanediol such as 1,6-hexanediol, hexanetriols such as 1, 2,6-hexanetriol, 1,2-octanediol, 1,8-octanediol, dipropylene glycol, tripropylene glycol, diglycerol, triglycerol, erythritol, Sorbitol and mixtures of the aforementioned substances.
  • Suitable water-soluble polyethylene glycols are selected from PEG-3, PEG-4, PEG-6, PEG-7, PEG-8, PEG-9, PEG-10, PEG-12, PEG-14, PEG-16, PEG-18 and PEG-20 and mixtures thereof, with PEG-3 to PEG-8 being preferred.
  • sugars and certain sugar derivatives such as fucose, rhamnose, fructose, glucose, maltose, maltitol, mannitol, inositol, sucrose, trehalose and xylose are suitable according to the invention.
  • Preferred skin care agents according to the invention are characterized in that the at least one water-soluble polyhydric C 2 -C 9 -alkanol having 2 to 6 hydroxyl groups and / or at least one water-soluble polyethylene glycol having 3 to 20 ethylene oxide units is selected from
  • 1,2-propylene glycol 2-methyl-1,3-propanediol, glycerol, butylene glycols such as 1,2-butylene glycol,
  • 1,3-butylene glycol and 1,4-butylene glycol pentylene glycols such as 1,2-pentanediol and 1,5-pentanediol, hexanediols such as 1,6-hexanediol, hexanetriols such as 1,2,6-hexanetriol, 1,2-octanediol, 1, 8-octanediol, dipropylene glycol, tripropylene glycol, diglycerol, triglycerol, erythritol, sorbitol and mixtures of the aforementioned substances.
  • pentylene glycols such as 1,2-pentanediol and 1,5-pentanediol
  • hexanediols such as 1,6-hexanediol
  • hexanetriols such as 1,2,6-hexanetriol
  • Particularly preferred skin treatment compositions according to the invention are characterized in that the at least one water-soluble polyhydric C 2 -C 9 -alkanol having 2 to 6 hydroxyl groups and / or at least one water-soluble polyethylene glycol having 3 to 20 ethylene oxide units in total in amounts of 3 to 30% by weight. %, preferably 8 to 25 wt .-%, particularly preferably 10 to 18 wt .-%, in each case based on the total composition is included.
  • Preferred furchttechniksspei- chernde film formers are selected from polysaccharides which contain at least one deoxy-block, particularly preferably from the commercial products Fucogel ® (INCI name Biosaccharide Gum-1) from Solabia, Rhamnosoft ® (INCI name Biosaccharide Gum-2) from Solabia , Fucogenol ® (INCI name Biosaccharide Gum-3) of Solabia and Glycofilm ® (INCI name Biosaccharide Gum-4) of Solabia, furthermore mixtures of the aforementioned polysaccharides containing at least one deoxy sugar building block, for example the mixture of biosaccharides Gum-2 and Biosaccharide Gum-3, available as a commercial product Elastinol plus ® from Solabia, glycosaminoglycan
  • Benzoic acid and its derivatives for example propyl, phenyl and butyl benzoate, ammonium, sodium, potassium and magnesium benzoate), propionic acid and derivatives thereof (for example ammonium, sodium and potassium) are particularly suitable as preservatives for cosmetics.
  • Potassium and magnesium propionate sodium, potassium and magnesium salicylate
  • 4-hydroxybenzoic acid and its esters and alkali metal salts eg methyl, ethyl, propyl, isopropyl.
  • These may e.g. serve to prevent corrosion of the package, e.g. of a cosmetic agent or even the corrosion of parts that otherwise come into contact with the agent.
  • Compositions which are particularly preferred according to the invention furthermore preferably contain at least one skin-cooling active substance.
  • Skin-cooling active ingredients suitable according to the invention are, for example, menthol, isopulegol and menthol derivatives, eg. Menthyl lactate, menthyl glycolate, menthyl pyrrolidone carboxylic acid, menthyl methyl ether, menthoxypropanediol, menthone glycerol acetal (9-methyl-6- (1-methylethyl) -1, 4-dioxaspiro (4.5) decane-2-methanol), monomethyl succinate and 2-hydroxymethyl-3,5 , 5-trimethylcyclohexanol.
  • menthol isopulegol, menthyl lactate, and menthoxypropanediol menthylpyrrolidone carboxylic acid and mixtures of these substances, in particular mixtures of menthol and menthyl lactate, menthol, menthyl lactate and Mentholglycolat, menthol and menthoxypropanediol or menthol, isopulegol or the commercial product Frescolat ® Ice (Symrise).
  • At least one skin-cooling active substance is present in a total amount of 0.01-2% by weight, more preferably 0.02-0.5% by weight and most preferably 0.05-0.2% by weight, each based on the total weight of the composition.
  • compositions according to the invention which are formulated as a propellant-driven aerosol, contain at least one propellant.
  • Preferred propellants are propane, propene, n-butane, isobutane, isobutene, n-pentane, pentene, isopentane, isopentene, methane, ethane, dimethyl ether, nitrogen, air, oxygen, nitrous oxide, 1, 1, 1, 3-tetrafluoroethane, heptafluoro-n-propane, perfluoroethane, monochlorodifluoromethane, 1,1-difluoroethane, both individually and in combination. Also hydrophilic propellants, such.
  • hydrophilic gases can be used advantageously in the context of the present invention, when the proportion of hydrophilic gases is selected low and lipophilic propellant gas (eg., Propane / butane) is present in excess.
  • propellant gas eg., Propane / butane
  • propane, n-butane, isobutane and mixtures of these propellants propane, n-butane, isobutane and mixtures of these propellants. It has been found that the use of n-butane as the only propellant gas according to the invention can be particularly preferred.
  • the amount of blowing agent is preferably 10-95% by weight, more preferably 20-90% by weight and most preferably 40-85% by weight, based in each case on the total weight of the preparation, consisting of the composition according to the invention and the blowing agent.
  • UV absorbers can also be used in small quantities as product protection. x) denaturant
  • ingredients may be contained according to further preferred embodiments as the sole additive or in any combination in the inventive compositions.
  • the content of water in preferred agents according to the invention depends i.a. Accordingly, whether the agent is in liquid or solid form, is therefore preferably 0 to less than 100 wt .-% and in particular 0.5 to 95 wt .-%, with values of at most 5 wt .-%, in particular for solid or non-aqueous find special preference for liquid funds. Not included here was the water of crystallization present in individual raw materials, in particular the antiperspirant aluminum and / or zirconium compounds.
  • the composition of the invention contains water in an amount of more than 20 wt .-%, advantageously more than 30 wt .-%., More preferably more than 40 wt .-%, even more advantageous as 50 wt .-%, in particular 60 to 99 wt .-%, particularly preferably 70 to 98 wt .-% and most preferably 80 to 95 wt .-%, based on the total agent.
  • the upper limit of water may also be 80 wt%, 70 wt%, 60 wt%, 50 wt%, 40 wt%, 30 wt%, 20 wt%, or 10 Wt .-% wt .-%, based on the total agent.
  • the lower limit of water may e.g. also at 80 wt .-%, 70 wt .-%, 60 wt .-%, 50 wt .-%, 40 wt .-%, 30 wt .-%, 20 wt .-% or 10 wt .-% are , relative to the entire remedy.
  • the above upper and lower limits can of course be meaningfully combined, z. B. to water contents of 60-80 wt .-% or 10-30 wt .-%, etc.
  • the agent according to the invention comprises at least one UV-absorbing substance.
  • the at least one UV-absorbing substance is in preferred skin treatment compositions according to the invention in a total amount of 0.01% by weight to 20 wt .-%, particularly preferably 1-10 wt .-%, most preferably 2 wt .-% to 7 wt .-%, contain.
  • compositions according to the invention contain at least one vitamin, provitamin or a compound designated as vitamin precursor from the vitamin groups A, B, C, E, H and K and the esters of the aforementioned substances.
  • vitamin A The group of substances referred to as vitamin A include retinol (vitamin A-1) and 3,4-didehydroretinol (vitamin A 2 ).
  • the ß-carotene is the provitamin of retinol.
  • Particularly preferred vitamin A components according to the invention are vitamin A acid and its esters, vitamin A aldehyde and vitamin A alcohol, and also esters thereof, such as retinyl palmitate and retinyl acetate.
  • Particularly preferred compositions according to the invention are characterized in that it contains at least one vitamin, provitamin or a compound designated as vitamin precursor from the vitamin group A or at least one ester thereof in total amounts of 0.001-2% by weight, preferably 0.05-0.05-1% by weight, based on the total composition.
  • the vitamin B group or the vitamin B complex include, among others
  • Thiamine hydrochloride is preferably used in amounts of from 0.0005 to 0.1 to 1% by weight, based on the total composition according to the invention.
  • Vitamin B 2 Riboflavin or its derivatives are preferably used in amounts of from 0.0005 to 0.1-1% by weight, based on the total composition according to the invention.
  • Vitamin B 3 the compounds nicotinic acid and nicotinamide (niacinamide) are performed.
  • Preferred according to the invention is the nicotinic acid amide, which is preferably present in the compositions according to the invention in amounts of from 0.0005 to 0.1-1% by weight, based on the total composition according to the invention.
  • Vitamin B 5 pantothenic acid and panthenol. Panthenol is preferably used.
  • Preferred derivatives of panthenol according to the invention are, in particular, the esters and ethers of panthenol and also cationically derivatized panthenols.
  • derivatives of 2-furanone having the general structural formula (VIT-I) are used instead of and in addition to pantothenic acid or panthenol.
  • the 2-furanone derivatives in which the substituents R to R 6 independently of one another are a hydrogen atom, a hydroxyl radical, a methyl, methoxy, amino methyl or hydroxymethyl radical, a saturated or mono- or diunsaturated, linear or branched C 2 -C 4 - hydrocarbon radical, a saturated or mono- or diunsaturated, branched or linear mono-, di- or trihydroxy-C 2 -C 4 - hydrocarbon radical or a saturated or mono- or diunsaturated, branched or linear Mono-, di- or triamino-C 2 -C 4 - hydrocarbon radical represent.
  • Particularly preferred derivatives are the commercially available substances dihydro-3-hydroxy-4,4-dimethyl-2 (3H) -furanone with the trivial name pantolactone (Merck), 4-hydroxymethyl- ⁇ -butyrolactone (Merck). , 3,3-dimethyl-2-hydroxy- ⁇ -butyrolactone (Aldrich) and 2,5-dihydro-5-methoxy-2-furanone (Merck), expressly including all stereoisomers.
  • the extremely preferred 2-furanone derivative according to the invention is pantolactone (dihydro-3-hydroxy-4,4-dimethyl-2 (3H) -furanone), where in formula (I) R is a hydroxyl group, R 2 is a water atom, R 3 and R 4 is a methyl group and R 5 and R 6 is a hydrogen atom.
  • Stereoisomer (R) -pantolactone is formed during the degradation of pantothenic acid.
  • compositions according to the invention are characterized in that they contain at least one of the said compounds of the vitamin B 5 type and the 2-
  • Furanone derivatives in a total amount of 0.01 to 5 wt .-%, preferably 0, 1 to 3 wt .-%, particularly preferably 0.5 to 2 wt .-%, each based on the total composition.
  • Vitamin B 6 which is understood hereunder no uniform substance, but the known under the common names pyridoxine, pyridoxamine and pyridoxal derivatives of 5-hydroxymethyl-2-methylpyridin-3-ols.
  • Particularly preferred compositions according to the invention are characterized in that they contain at least one vitamin B 6 component in a total amount of from 0.0001 to 1.0% by weight, in particular in amounts of from 0.001 to 0.01% by weight.
  • compositions according to the invention comprise at least one component selected from biotin and the biotin esters, in a total amount of 0.0001 to 1.0% by weight, in particular 0.001 to 0.01% by weight.
  • Folic acid (vitamin B 9 , vitamin B c ).
  • Folate is used synonymously with pteroylglutamate.
  • Folate is the generic term for all folic acid-active compounds and refers to a class of compounds containing a pteridine ring linked to 4-aminobenzoic acid and L-glutamic acid.
  • compositions according to the invention are characterized in that they contain at least one component selected from folic acid, folates and their esters, in a total amount of 0.0001 to 1.0% by weight, in particular 0.01 to 0.5% by weight. %, based on the composition.
  • Orotic acid (vitamin B 3 ).
  • Orotic acid, its choline ester or orotic acid metal salts (orotates of Ca, Cr, Fe, K, Co, Cu, Li, Mg, Mn, Na, Zn, Sn) are particularly preferred according to the invention.
  • Particularly preferred compositions according to the invention are characterized in that they contain at least one component selected from orotic acid, orotates and their esters, in a total amount of 0.0001-1.0% by weight, in particular 0.01-0.5% by weight. %, based on the composition.
  • compositions according to the invention contain at least one substance which is selected from the vitamins, provitamins and vitamin precursors of the group Bi, B 2 , B 3 , B 6 , B 7 , B 9 B 3 and their esters and from pantolactone.
  • Preferred vitamins, provitamins and vitamin precursors of group C and their esters are vitamin C (ascorbic acid) and the derivatives ascorbyl palmitate, stearate, dipalmitate, acetate, magnesium ascorbyl phosphate, sodium ascorbyl phosphate, sodium and magnesium ascorbate, disodium ascorbyl phosphate and sulfate, potassium ascorbyl tocopheryl phosphate, chitosan ascorbate or ascorbyl.
  • vitamin C ascorbic acid
  • vitamin C ascorbic acid
  • compositions according to the invention are characterized in that they contain at least one of the said compounds of the vitamin C type in a total amount of 0.01 to 5 wt.%, Preferably 0.1 to 3 wt.%, Particularly preferably 0.5 to 1 - 2 wt .-%, each based on the total composition.
  • the vitamin E group includes tocopherol, especially ⁇ -tocopherol, and its derivatives.
  • Preferred derivatives are in particular the esters, such as tocopheryl acetate, nicotinate, phosphate, succinate, linoleate, oleate, tocophereth-5, tocophereth-10, tocophereth-12, tocophereth-18, tocophereth-50 and tocopherol.
  • compositions according to the invention are characterized in that they contain at least one substance selected from tocopherol and its derivatives in a total amount of 0.05 to 5 wt.%, Preferably 0, 1 to 3 wt.%, Particularly preferably 0, 5 to 1 - 2 wt .-%, each based on the total composition.
  • Vitamin H is another name for biotin or vitamin B 7 (see above).
  • compositions according to the invention are characterized in that they contain at least one vitamin K in a total amount of 0001 to 1.0% by weight, preferably 0.05 to 0.01% by weight, particularly preferably 0.1 to 0.5 Wt .-%, each based on the total composition included.
  • Vitamin A palmitate (retinyl palmitate), pantolactone, nicotinamide, pyridoxine, pyridoxamine, pyridoxal, biotin, ascorbyl palmitate, ascorbyl acetate, Mg ascorbyl phosphate, Na ascorbyl phosphate, sodium and magnesium ascorbate, and the tocopherol esters, especially tocopheryl acetate, are particularly preferred in the present invention.
  • compositions according to the invention also contain at least one astringent active ingredient which leads to a temporary narrowing of the skin pores, for example tannins or tanning agents or polyphenols in general, furthermore aluminum salts, such as are also used as antiperspirant active ingredients. These agents regulate the amount of sebum on the skin surface by delaying sebum secretion.
  • the skin treatment compositions according to the invention are in the form of a liquid, flowable or solid oil-in-water emulsion, water-in-oil emulsion, multiple emulsion, in particular an oil-in-water-in-oil or water-in-water emulsion.
  • the agents may also be presented in anhydrous form, such as an oil or a balm.
  • the carrier may be a vegetable or animal oil, a mineral oil, a synthetic oil or a mixture of such oils.
  • the agents are present as a microemulsion.
  • microemulsions are understood as meaning, in addition to the thermodynamically stable microemulsions, also the so-called "PIT" emulsions These emulsions are systems containing the three components water, oil and emulsifier, which are oil-in at room temperature When these systems are heated, microemulsions are formed in a certain temperature range (referred to as the phase inversion temperature or "PIT") and, on further heating, convert to water-in-oil emulsions.
  • PIT phase inversion temperature
  • W emulsions are also present, but which are also present at room temperature as microemulsions or as very finely divided emulsions having a mean particle diameter of less than 400 nm and in particular of about 100 to 300 nm have an average particle diameter of about 200 nm.
  • the inventive form of administering the composition according to the invention may take the form of sticks, aerosols, creams, gels, spray applications with and without the formation of a foam facilitating the application, as a cloth impregnated with the composition according to the invention or as plaster.
  • the dosage form depends on the desired application, deodorant, skincare skin cleanser and more.
  • Another object of this invention is a method for influencing the mood after the application of a cosmetic composition, wherein a cosmetic composition according to any one of claims 1 to 6 is applied to the skin and there until their removal, for example, by washing or make-up or showering at least 30 minutes to several hours remains.
  • Another object of the present invention is the use of a cosmetic agent according to any one of claims 1 to 9 for the purpose of achieving a calming or harmonizing or invigorating or stimulating or exhilarating or aphodising effect.
  • oxytocin The functional effect of oxytocin on skin cells is determined in vitro. Dermal papilla cells were treated with different concentrations of oxytocin in the picomolar range for 24 h and the gene expression values of various skin-specific genes were analyzed. NGF P75NTR
  • the quantities are based on wt .-%.
  • Vitamin E acetate 0.5
  • Vitamin E acetate 0.5
  • Phenonip® ME 1 Phenonip® ME 1, 0
  • Vitamin E acetate 0.5
  • Vitamin A palmitate 1 7mlU / g 0.03
  • the emulsion according to Example 1 had a viscosity of 1800 mPas on the first day after the preparation, measured with a Brookfield viscometer, spindle RV 4, 20 s-1, without helipath, at 20 ° C. ambient temperature and 20 ° C. sample temperature.
  • Suspensions for spraying as an antiperspirant spray had a viscosity of 1800 mPas on the first day after the preparation, measured with a Brookfield viscometer, spindle RV 4, 20 s-1, without helipath, at 20 ° C. ambient temperature and 20 ° C. sample temperature.
  • Cosmacol PLG (INCI: DI-C12-13 ALKYL TARTRATE, TRI-C12-13 ALKYL CITRATE, SILICA)
  • Compositions 1.1 to 1.6 were filled into aluminum-painted aluminum spray cans and admixed with an isobutane / butane / propane blowing agent mixture in a weight ratio of suspension: propellant of 25:75, 22:78, 20:80, 18:82, 15:85 and 13: 87.
  • Cyclomethicone ad 100 ad 100 ad 100 Compositions I-3 were packed in aluminum-painted aluminum spray cans and admixed with an isobutane / butane / propane propellant mixture in a weight ratio of suspension: propellant of 25:75, 22:78, 20:80, 18:82, 15:85 and 13: 87.

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Abstract

La présente invention concerne des produits cosmétiques contenant, en tant que substances actives, au moins de l'oxytocine ou un dérivé d'oxytocine et une substance odorante, et destinés à être utilisés sur la peau pour améliorer le bien-être émotionnel. La présente invention concerne également un procédé non thérapeutique pour améliorer de manière cosmétique le bien-être émotionnel à l'aide d'oxytocine et d'au moins une substance odorante. En outre, la présente invention concerne l'utilisation d'oxytocine et d'au moins une substance odorante pour améliorer le bien-être émotionnel.
PCT/EP2012/071019 2011-10-26 2012-10-24 Produits cosmétiques contenant de l'oxytocine et des substances odorantes WO2013060707A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102011118016A DE102011118016A1 (de) 2011-10-26 2011-10-26 Kosmetische Mittel enthaltend Oxytocin und Riechstoffe
DE102011118016.1 2011-10-26

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US10286030B2 (en) 2016-02-04 2019-05-14 Alastin Skincare, Inc Compositions and methods for invasive and non-invasive procedural skincare
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