WO2013055258A3 - Применение глутарилгистамина для лечения заболеваний дыхательных путей - Google Patents

Применение глутарилгистамина для лечения заболеваний дыхательных путей Download PDF

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Publication number
WO2013055258A3
WO2013055258A3 PCT/RU2012/000821 RU2012000821W WO2013055258A3 WO 2013055258 A3 WO2013055258 A3 WO 2013055258A3 RU 2012000821 W RU2012000821 W RU 2012000821W WO 2013055258 A3 WO2013055258 A3 WO 2013055258A3
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WO
WIPO (PCT)
Prior art keywords
respiratory tract
glutaryl histamine
drug
tract infections
treatment
Prior art date
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PCT/RU2012/000821
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English (en)
French (fr)
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WO2013055258A2 (ru
WO2013055258A9 (ru
Inventor
Владимир Евгеньевич НЕБОЛЬСИН
Людмила Васильевна КОЛОБУХИНА
Original Assignee
Общество С Ограниченной Ответственностью "Валента-Интеллект"
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to UAA201404936A priority Critical patent/UA115431C2/ru
Priority to US14/351,352 priority patent/US20140357587A1/en
Priority to CN201280055495.7A priority patent/CN104023719B/zh
Priority to EP12839969.8A priority patent/EP2767282B8/en
Priority to ES12839969T priority patent/ES2792064T3/es
Priority to KR1020147012576A priority patent/KR102007280B1/ko
Application filed by Общество С Ограниченной Ответственностью "Валента-Интеллект" filed Critical Общество С Ограниченной Ответственностью "Валента-Интеллект"
Priority to JP2014535690A priority patent/JP6069331B2/ja
Priority to PL12839969T priority patent/PL2767282T3/pl
Priority to EA201490750A priority patent/EA029461B1/ru
Publication of WO2013055258A2 publication Critical patent/WO2013055258A2/ru
Publication of WO2013055258A3 publication Critical patent/WO2013055258A3/ru
Publication of WO2013055258A9 publication Critical patent/WO2013055258A9/ru
Priority to HK15101140.0A priority patent/HK1200699A1/xx
Priority to US15/334,636 priority patent/US20170143674A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/417—Imidazole-alkylamines, e.g. histamine, phentolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Изобретение относится к лекарственному средству для лечения заболевания дыхательных путей, выбранного из группы, включающей риносинусит, синусит, тонзиллит, бронхиолит, пневмонию и острый респираторный дистресс-синдром, содержащему глутарилгистамин или его фармацевтически приемлемую соль в эффективном количестве. Изобретение также включает применение глутарилгистамина или его фармацевтически приемлемой соли для производства лекарственного средства для лечения заболевания дыхательных путей. Данное лекарственное средство позволяет повысить эффективность антибактериальной терапии при лечении заболеваний дыхательных путей.
PCT/RU2012/000821 2011-10-11 2012-10-09 Применение глутарилгистамина для лечения заболеваний дыхательных путей WO2013055258A2 (ru)

Priority Applications (11)

Application Number Priority Date Filing Date Title
UAA201404936A UA115431C2 (ru) 2011-10-11 2012-09-10 Применение глутарилгистамина для лечения заболеваний дыхательных путей
PL12839969T PL2767282T3 (pl) 2011-10-11 2012-10-09 Zastosowanie glutarylohistaminy w leczeniu infekcji dróg oddechowych
EP12839969.8A EP2767282B8 (en) 2011-10-11 2012-10-09 Use of glutaryl histamine to treat respiratory tract infections
ES12839969T ES2792064T3 (es) 2011-10-11 2012-10-09 Uso de glutaril histamina para tratar infecciones de las vías respiratorias
KR1020147012576A KR102007280B1 (ko) 2011-10-11 2012-10-09 글루타릴 히스타민의 기도 질환 치료 용도
US14/351,352 US20140357587A1 (en) 2011-10-11 2012-10-09 Use of Glutaryl Histamine for the Treatment of Respiratory Tract Diseases
JP2014535690A JP6069331B2 (ja) 2011-10-11 2012-10-09 気道疾患を治療するためのグルタリルヒスタミンの使用
CN201280055495.7A CN104023719B (zh) 2011-10-11 2012-10-09 戊二酰组胺用于治疗呼吸道疾病的用途
EA201490750A EA029461B1 (ru) 2011-10-11 2012-10-09 Применение глутарилгистамина для лечения заболеваний дыхательных путей
HK15101140.0A HK1200699A1 (en) 2011-10-11 2015-02-03 Use of glutaryl histamine to treat respiratory tract infections
US15/334,636 US20170143674A1 (en) 2011-10-11 2016-10-26 Use of Glutaryl Histamine for the Treatment of Respiratory Tract Diseases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2011141288 2011-10-11
RU2011141288 2011-10-11

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US14/351,352 A-371-Of-International US20140357587A1 (en) 2011-10-11 2012-10-09 Use of Glutaryl Histamine for the Treatment of Respiratory Tract Diseases
US15/334,636 Division US20170143674A1 (en) 2011-10-11 2016-10-26 Use of Glutaryl Histamine for the Treatment of Respiratory Tract Diseases

Publications (3)

Publication Number Publication Date
WO2013055258A2 WO2013055258A2 (ru) 2013-04-18
WO2013055258A3 true WO2013055258A3 (ru) 2013-06-06
WO2013055258A9 WO2013055258A9 (ru) 2013-07-25

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/RU2012/000821 WO2013055258A2 (ru) 2011-10-11 2012-10-09 Применение глутарилгистамина для лечения заболеваний дыхательных путей

Country Status (11)

Country Link
US (2) US20140357587A1 (ru)
EP (1) EP2767282B8 (ru)
JP (1) JP6069331B2 (ru)
KR (1) KR102007280B1 (ru)
CN (1) CN104023719B (ru)
EA (1) EA029461B1 (ru)
ES (1) ES2792064T3 (ru)
HK (1) HK1200699A1 (ru)
PL (1) PL2767282T3 (ru)
UA (1) UA115431C2 (ru)
WO (1) WO2013055258A2 (ru)

Families Citing this family (9)

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US9504673B2 (en) * 2009-05-21 2016-11-29 LTD “Valenta-Intellekt” Agent for the prophylaxis and treatment of highly pathogenic infectious diseases
CN103382179A (zh) * 2013-06-05 2013-11-06 四川百利药业有限责任公司 英加韦林的多晶型物及其制备方法
RU2628800C2 (ru) * 2014-03-12 2017-08-22 Общество С Ограниченной Ответственностью "Фарминтерпрайсез" Амидные соединения, способы получения, применение в качестве средств для лечения и профилактики заболеваний, вызываемых рнк-содержащими вирусами
WO2018217139A1 (ru) * 2017-05-26 2018-11-29 Общество С Ограниченной Ответственностью "Фарминтерпрайсез" Новые ингибиторы глутаминилциклаз и их применение для лечения различных заболеваний
WO2021049980A1 (ru) * 2019-09-12 2021-03-18 Общество С Ограниченной Ответственностью "Валента-Интеллект" Новые составы для лечения и профилактики вирусных заболеваний
RU2746692C1 (ru) * 2020-04-14 2021-04-19 Общество С Ограниченной Ответственностью "Валента - Интеллект" Новые составы 2-(имидазол-4-ил)-этанамида пентандиовой-1,5 кислоты для лечения и профилактики вирусных заболеваний
RU2770518C2 (ru) * 2020-02-11 2022-04-18 Общество С Ограниченной Ответственностью "Валента-Интеллект" Жидкая лекарственная форма для лечения и профилактики гриппа и орви
RU2770521C2 (ru) * 2020-02-11 2022-04-18 Общество С Ограниченной Ответственностью "Валента-Интеллект" Жидкая лекарственная форма для лечения и профилактики гриппа и орви
MA58653B1 (fr) * 2020-06-26 2024-02-29 Valenta Intellekt Ltd Utilisation d'un dérivé de glutarimide pour traiter des maladies liées à l'activité aberrante d'interleukine-6

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Also Published As

Publication number Publication date
KR102007280B1 (ko) 2019-08-06
KR20140107190A (ko) 2014-09-04
EP2767282A4 (en) 2015-03-11
JP6069331B2 (ja) 2017-02-01
US20170143674A1 (en) 2017-05-25
EP2767282B8 (en) 2020-06-03
EP2767282B1 (en) 2020-04-15
EA029461B1 (ru) 2018-03-30
US20140357587A1 (en) 2014-12-04
CN104023719B (zh) 2017-05-24
JP2014528473A (ja) 2014-10-27
WO2013055258A2 (ru) 2013-04-18
PL2767282T3 (pl) 2021-02-08
ES2792064T3 (es) 2020-11-06
WO2013055258A9 (ru) 2013-07-25
HK1200699A1 (en) 2015-08-14
EA201490750A1 (ru) 2014-07-30
UA115431C2 (ru) 2017-11-10
CN104023719A (zh) 2014-09-03
EP2767282A2 (en) 2014-08-20

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