WO2013025601A2 - Utilisation d'énergie ultrasonore dans la production de produits nutritionnels - Google Patents

Utilisation d'énergie ultrasonore dans la production de produits nutritionnels Download PDF

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Publication number
WO2013025601A2
WO2013025601A2 PCT/US2012/050563 US2012050563W WO2013025601A2 WO 2013025601 A2 WO2013025601 A2 WO 2013025601A2 US 2012050563 W US2012050563 W US 2012050563W WO 2013025601 A2 WO2013025601 A2 WO 2013025601A2
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WIPO (PCT)
Prior art keywords
nutritional
tablet
tablets
ultrasonically
powder
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Application number
PCT/US2012/050563
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English (en)
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WO2013025601A3 (fr
Inventor
Gary M. Gordon
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Abbott Laboratories
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Publication of WO2013025601A2 publication Critical patent/WO2013025601A2/fr
Publication of WO2013025601A3 publication Critical patent/WO2013025601A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
    • A23L5/30—Physical treatment, e.g. electrical or magnetic means, wave energy or irradiation
    • A23L5/32—Physical treatment, e.g. electrical or magnetic means, wave energy or irradiation using phonon wave energy, e.g. sound or ultrasonic waves
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/20—Agglomerating; Granulating; Tabletting
    • A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Definitions

  • the present disclosure relates to ultrasonically-produced nutritional tablets and methods for manufacturing the nutritional tablets. More particularly, the present disclosure relates to methods of manufacturing nutritional tablets, including infant nutritional tablets and adult nutritional tablets, using ultrasonic energy.
  • Powdered nutritional products including both powdered infant formulas and powdered adult nutritional products, are widely commercially available and their use has grown steadily over the years. These products typically contain at least one of fat, carbohydrate, and protein, along with various vitamins, and minerals, and potentially other nutritionally beneficial components. Prior to use, the powdered formula or product is reconstituted in water or another suitable liquid at a predetermined ratio to produce a ready- to-drink liquid.
  • tablets or solid products have been made from these powdered nutritional products.
  • tablets are made using mechanical presses that compact the powder using mechanical force into a solid shape having a uniform density.
  • the resulting tablet may provide for easy use as there is no measuring and no mess that occurs during handling.
  • the tablet or several tablets can then be placed into a liquid beverage, such as water, wherein the tablet can dissolve and behave similarly to the loose powder.
  • the tablets may require disintegrants so that when the tablet is placed in water, it rapidly breaks down, facilitating dissolution into the liquid.
  • the present disclosure is directed to a process for manufacturing a nutritional tablet.
  • the process comprises introducing a dry nutritional powder comprising at least one of protein, carbohydrate, and fat into a die and contacting the dry nutritional powder with ultrasonic energy to produce the nutritional tablet.
  • the present disclosure is further directed to a process for manufacturing a nutritional tablet.
  • the process comprises introducing a spray-dried nutritional powder comprising water in an amount of no more than 3% (by weight) into a die and contacting the spray-dried nutritional powder with ultrasonic energy to produce the nutritional tablet.
  • the present disclosure is further directed to a process for manufacturing an infant nutritional tablet.
  • the process comprises introducing a spray-dried infant nutritional powder into a die and contacting the spray-dried infant nutritional powder with ultrasonic energy to produce the infant nutritional tablet.
  • the present disclosure is further directed to an ultrasonically-produced nutritional tablet prepared by the process of introducing a dry nutritional powder comprising at least one of protein, carbohydrate, and fat into a die and contacting the dry nutritional powder with ultrasonic energy to produce the nutritional tablet.
  • the nutritional tablet may be an infant nutritional tablet or an adult nutritional tablet.
  • the infant nutritional tablet comprises from about 10% to about 35% fat, from about 5% to about 35% protein, and from about 30% to about 85% carbohydrates, all by weight of the infant nutritional tablet.
  • the adult nutritional tablet comprises from about 0.5% to about 20% fat, from about 10% to about 90% protein, and from about 5% to about 60% carbohydrates, all by weight of the adult nutritional tablet.
  • nutritional tablets can be prepared entirely from spray-dried nutritional powder utilizing ultrasonic energy; that is, the nutritional tablets can be prepared without the need for additional binders and disintegrants typically used in tableting processes. Further, the tablets can be prepared with minimal pressure as compared to conventional mechanical tableting presses.
  • the tablets, including infant and adult nutritional tablets, produced utilizing the methods described herein have sufficient hardness to resist breaking apart during handling, while being rapidly dissolvable when placed in water.
  • the tablet may be produced such that is has various zones of density; that is, it may be produced to include a loose powder in the core of the tablet and a more compacted powder shell surrounding the loose powder. This allows the tablet to rapidly dissolve in water.
  • Figure 1 is a schematic diagram of a block mold, including a die, for use in the methods of the present disclosure.
  • Figure 2 is a schematic diagram of an ultrasonic system and block mold for use in the methods of the present disclosure.
  • the ultrasonically-produced nutritional tablets and corresponding manufacturing methods of the present disclosure are directed to tablets made of dry nutritional powders that have been prepared utilizing ultrasonic energy.
  • nutritional tablets includes both infant nutritional tablets, adult nutritional tablets, and nutritional tablets generally.
  • infant formula includes both infant formulas and toddler formulas, wherein infant formulas are intended for infants up to about 1 year of age and toddler formulas are intended for children from about 1 year of age to about 10 years of age.
  • adult nutritional product includes formulas for generally maintaining or improving the health of an adult, and includes those formulas designed for adults who need to control their blood glucose.
  • shelf life refers to a product's commercially viable life-span, after which the product is unfit or undesirable for sale and/or consumption.
  • Numerical ranges as used herein are intended to include every number and subset of numbers within that range, whether specifically disclosed or not. Further, these numerical ranges should be construed as providing support for a claim directed to any number or subset of numbers in that range. For example, a disclosure of from 1 to 10 should be construed as supporting a range of from 2 to 8, from 3 to 7, from 5 to 6, from 1 to 9, from 3.6 to 4.6, from 3.5 to 9.9, and so forth.
  • the various embodiments of the ultrasonically-produced nutritional tablets of the present disclosure may also be substantially free of any optional or selected essential ingredient or feature described herein, provided that the remaining tablet still contains all of the required ingredients or features as described herein.
  • substantially free means that the selected tablet contains less than a functional amount of the optional ingredient, typically less than 0.1% by weight, and also including zero percent by weight of such optional or selected essential ingredient.
  • the nutritional tablets and corresponding manufacturing methods of the present disclosure can comprise, consist of, or consist essentially of the essential elements and limitations of the disclosure as described herein, as well as any additional or optional ingredients, components, or limitations described herein or otherwise useful in nutritional applications.
  • the nutritional tablets produced utilizing ultrasonic energy are solid nutritional tablets that resist breaking during handling.
  • the nutritional tablets may have a substantially uniform density throughout, or may have two or more distinct zones of density as described herein.
  • the inside (also referred to herein as the core) of the tablet is less dense than the outside (also referred to herein as the outer edge of the tablet); this produces a tablet that is resistant to breaking but has good dissolution properties.
  • These nutritional tablets are generally mixed with water or another liquid and dissolved prior to use.
  • the tablets of the present disclosure are prepared from dry nutritional powders generally having a moisture content (i.e., water) of no more than 3% (by weight), or even from about 1.75% to 3% (by weight), or even from about 2% to about 3% (by weight).
  • the dry nutritional powder includes water in an amount of from about 1.75% to about 2.75% (by weight).
  • the tablets of the present disclosure generally have a shelf life of at least about 3 months, or even at least about 4 months, or even at least about 5 months or even 12 months, or even 18 months, or even 24 months, or even 36 months including from 6 to 24 months.
  • the tablets of the present disclosure may be formulated with sufficient kinds and amounts of nutrients so as to provide a sole, primary, or supplemental source of nutrition, or to provide a specialized nutritional formulation for use in individuals afflicted with specific diseases or conditions.
  • the nutritional tablets of the present disclosure comprise at least one of fat, protein, and carbohydrate.
  • any source of fat, protein, and carbohydrate that is known or otherwise suitable for use in powdered nutritional products may also be suitable for use in the nutritional tablets herein, provided that such macronutrients are also compatible with the essential elements of the nutritional formulations as defined herein.
  • the ultrasonically-produced nutritional tablets of the present disclosure may comprise a carbohydrate source.
  • the carbohydrate component is present in an amount of from about 30% to about 85%, including from about 45% to about 60%, including from about 50% to about 55% by weight of the infant nutritional tablet.
  • the carbohydrate source may be any known or otherwise suitable source that is safe and effective for oral administration and is compatible with the essential and other ingredients in the tablet.
  • the carbohydrate component is present in an amount of from about 5% to about 60%), including from about 7% to about 30%>, including from about 10%> to about 25%, by weight of the adult nutritional tablet.
  • the carbohydrate source may be any known or otherwise suitable source that is safe and effective for oral administration and is compatible with the essential and other ingredients in the tablet.
  • Suitable carbohydrates or carbohydrate sources for use in the nutritional tablets include glycerin, sucrose, dextrins, maltodextrin, tapioca maltodexrin, corn syrup, tapioca syrup, isomaltulose, lactose, fructose, both unhydroyzed, partially hydrolyzed gums, gum Arabic, also known as gum acacia, xanthan gum, gum tragacanth, and guar gum, glycerin, vegetable fibers, glucose, maltose, cooked and uncooked waxy and non- waxy corn starch, cooked and uncooked waxy and non-waxy tapioca starch, cooked and uncooked waxy and non-waxy rice starch, tagatose, galacto-oligosaccharides (GOS), fructo-oligosaccharides (FOS) including short chain, moderate length chain, and long chain fructo-oligosaccharides, alpha-lactose
  • suitable carbohydrates include any dietary fiber or fiber source, non- limiting examples of which include insoluble dietary fiber sources such as oat hull fiber, pea hull fiber, soy hull fiber, soy cotyledon fiber, sugar beet fiber, cellulose, corn bran, and combinations thereof.
  • the carbohydrate for use in the nutritional tablet formulation may therefore include soluble and/or insoluble fiber, or other complex carbohydrate, preferably having a DE (dextrose equivalent) value of less than about 40, including less than 20, and also including from 1 to 10.
  • the ultrasonically-produced nutritional tablets of the present disclosure may comprise a fat or fat source.
  • the fat component is present in an amount of from about 10% to about 35%, including from about 25% to about 30%, and including from about 26% to about 28% by weight of the infant nutritional tablet.
  • the fat may be any known or otherwise suitable source that is safe and effective for oral administration and is compatible with the essential and other ingredients in the tablet.
  • the fat component is present in an amount of from about 0.5% to about 20%, including from about 1% to about 10%, and also including from about 2% to about 5% by weight of the adult nutritional tablet.
  • the fat may be any known or otherwise suitable source that is safe and effective for oral administration and is compatible with the essential and other ingredients in the tablet.
  • Suitable fat or fat sources include coconut oil, soy oil, high oleic safflower or sunflower oil, safflower oil, sunflower oil, corn oil, palm oil, palm kernel oil, canola oil, triheptanoin, milk fat including butter, any animal fat or fraction thereof, fish or crustacean oils containing docosahexaenoic acid (DHA) and/or eicosapentaenoic acid (EPA), phospholipids from fish or crustacean containing docosahexaenoic acid (DHA) and/or eicosapentaenoic acid (EPA), concentrates of DHA and/or EPA from marine, vegetable, or fugal sources, arachidonic acid (ARA) concentrate from fungal or other sources, a- linolenic acid concentrate (ALA), flax seed oil, phospholipids and fractions thereof, including soy lecithin and egg lecithin, both partially hydrolyzed and unhydrolyzed,
  • the ultrasonically-produced nutritional tablets of the present disclosure may comprise a protein or protein source.
  • the protein component is present in an amount of from about 5% to about 35%, including from about 8% to about 12%, and including from about 10%> to about 12% by weight of the infant nutritional tablet.
  • the protein may be any known or otherwise suitable source that is safe and effective for oral administration and is compatible with the essential and other ingredients in the tablet.
  • the protein component is present in an amount of from about 10% to about 90%, including from about 30% to about 80%>, and also including from about 40%> to about 75% by weight of the adult nutritional tablet.
  • the protein may be any known or otherwise suitable source that is safe and effective for oral administration and is compatible with the essential and other ingredients in the tablet.
  • Suitable protein or protein sources include either intact, partially hydro lyzed, or fully hydro lyzed, or a combination thereof, of lactase treated nonfat dry milk, milk protein isolate, milk protein concentrate, whey protein concentrate,
  • glycomacropeptides whey protein isolate, milk casemates such as sodium caseinate, calcium caseinate, or any combination of caseinate salts of any mineral, soy protein concentrate, soy protein isolate, soy protein flour, pea protein isolate, pea protein concentrate, any monocot or dicot protein isolate or protein concentrate, animal collagen, gelatin, all amino acids, taurine, milk protein peptides, whey protein peptides, bovine colostrum, human colostrum, other mammalian colostrum, genetic communication proteins found in colostrum and in mammalian milk such as, but not limited to, interleukin proteins, hydrolyzed animal collagen, hydrolyzed yeast, and combinations thereof.
  • Macronutrient Profile such as sodium caseinate, calcium caseinate, or any combination of caseinate salts of any mineral, soy protein concentrate, soy protein isolate, soy protein flour, pea protein isolate, pea protein concentrate, any monocot or dicot protein isolate or protein concentrate, animal collagen, gelatin, all amino acids, taurine, milk
  • the total amount or concentration of fat, carbohydrate, and protein in the ultrasonically-produced nutritional tablets of the present disclosure can vary considerably depending upon the selected formulation and dietary or medical needs of the intended user, Additional suitable examples of macronutrient concentrations are set forth below.
  • the total amount or concentration refers to all fat, carbohydrate, and protein sources in the nutritional tablet.
  • such total amounts or concentrations are most typically and preferably formulated within any of the embodied ranges described in the following table (all numbers have "about" in front of them).
  • the ultrasonically-produced nutritional tablets of the present disclosure may further comprise other optional components that may modify the physical, chemical, aesthetic or processing characteristics of the tablets or serve as pharmaceutical or additional nutritional components when used in the targeted population.
  • Many such optional ingredients are known or otherwise suitable for use in medical food or other nutritional products or pharmaceutical dosage forms and may also be used in the tablet formulations herein, provided that such optional ingredients are safe and effective for oral administration and are compatible with the essential and other ingredients in the tablets.
  • Non-limiting examples of such optional ingredients include preservatives, anti-oxidants, emulsifying agents, buffers, pharmaceutical actives, additional nutrients as described herein, vitamins, minerals, sweeteners including artificial sweeteners (e.g., saccharine, aspartame, acesulfame K, Stevia extract, and sucralose) colorants, flavorants in addition to those described herein, thickening agents and stabilizers, emulsifying agents, lubricants, probiotics (such as acidophilous and/or bifidus bacteria, both alive and inactive), prebiotics, beta-hydroxy beta-methylbutyrate (HMB), arginine, glutamine, and so forth.
  • sweeteners including artificial sweeteners (e.g., saccharine, aspartame, acesulfame K, Stevia extract, and sucralose) colorants, flavorants in addition to those described herein, thickening agents and stabilizers, emulsifying agents, lubricants, probiotics (
  • Non-limiting examples of suitable minerals for use herein include phosphorus, sodium, chloride, magnesium, manganese, iron, copper, zinc, iodine, calcium, potassium, chromium, molybdenum, selenium, and combinations thereof.
  • Non-limiting examples of suitable vitamins for use herein include carotenoids (e.g., beta-carotene, zeaxanthin, lutein, lycopene), biotin, choline, inositol, folic acid, pantothenic acid, choline, vitamin A, thiamine (vitamin Bi), riboflavin (vitamin B 2 ), niacin (vitamin B 3 ), pyridoxine (vitamin B 6 ), cyanocobalamine (vitamin Bi 2 ), ascorbic acid (vitamin C), vitamin D, vitamin E, vitamin K, and various salts, esters or other derivatives thereof, and combinations thereof.
  • carotenoids e.g., beta-carotene, zeaxanthin, lutein, lycopene
  • biotin choline
  • inositol folic acid
  • pantothenic acid choline
  • vitamin A thiamine
  • vitamin B 2 riboflavin
  • the methods of the present disclosure incorporating the use of ultrasonic energy provide for ultrasonically-produced nutritional tablets that are sufficiently hard such to resist breaking apart during shipping and/or handling, while being rapidly dissolvable when placed in water.
  • one or more tablets may be placed in water, such as in a baby bottle or cup, and the tablet begins to dissolve after a time period of from about ten seconds to about twenty seconds.
  • the ultrasonically-produced nutritional tablet completely dissolves when placed in room temperature water after a period of about 240 seconds.
  • the ultrasonically-produced nutritional tablet completely dissolves when placed in water having a temperature of about 105°F (40.6°C) after a period of about 210 seconds.
  • the ultrasonically-produced nutritional tablet is obtained from a dry nutritional powder.
  • Any dry nutritional powder such as is obtained by spray-drying, dryblending, and combinations thereof, as well as any other method known in the art for encapsulating and/or emulsifying fat such that there is very little free fat in the resulting dry powder, may be used as the starting dry nutritional powder for producing the tablets.
  • the dry nutritional powders include water in an amount of no more than about 3% (by weight), including from about 1.75% to 3% (by weight).
  • the dry nutritional powder is a spray-dried nutritional powder including water in an amount of no more than 3% (by weight).
  • the spray-dried nutritional powder may be a spray-dried infant nutritional powder or may be a spray-dried adult nutritional powder.
  • mold 2 includes die 4, which is circular in shape, having a diameter of about 1.838 inches + 0.031 inches. Mold 2 further has a thickness of about 1.25 inches.
  • a nutritional tablet having a diameter of from about 0.5 inches to about 3 inches, including a diameter of about 1.8 inches, and a thickness of from about 0.1 to about 0.5 inches, including a thickness of about 0.28 inches, is produced using die 4 as shown in Figure 1, or a die similar thereto. It should be understood by one skilled in the art, however, that the die can be readily made by one skilled in the art into any size or shape as suitable for nutritional tablets without departing from the scope of the present disclosure.
  • the ultrasonic system 1 includes power generator 3, transducer 5, and ultrasonic probe 7.
  • a suitable ultrasonic system 1 includes power generator 3 to provide energy to transducer 5, which further energizes ultrasonic probe 7 to mechanically vibrate ultrasonically.
  • Examples of suitable ultrasonic systems 1 include systems available from Hielscher Ultrasonics (e.g.,
  • Ultrasonic probe 7 is shaped such to have a flat bottom, which can be surface-to-surface pressed to mold 2, thereby contacting the dry nutritional powder in die 4. Further, ultrasonic probe 7 has a diameter of about 1.775 inches. It should be understood by one skilled in the art, however, that any size or shape of ultrasonic probe as suitable for use in making tablets can be used by one skilled in the art without departing from the scope of the present disclosure.
  • the ultrasonic system 1 is capable of operating the ultrasonic probe 7 at 100% amplitude and a frequency in the range of from about 15 kHz to about 100 kHz, more suitably in the range of from about 15 kHz to about 50 kHz, and even more suitably about 20 kHz.
  • the physical size, shape, and density of the nutritional tablets can be affected by the power level supplied by ultrasonic system 1 and the time period for which ultrasonic energy is contacted with the dry nutritional powder.
  • the power generator 3 provides transducer 5 and ultrasonic probe 7 power in the amount of at least about 75 watts, including from about 75 watts to about 170 watts, including from about 110 watts to about 150 watts, and including from about 110 watts to about 125 watts.
  • Ultrasonic probe 7 is energized for a period of from about 30 seconds to about 120 seconds, and including a period of from about 60 seconds to about 90 seconds.
  • the amount of dry nutritional powder in each ultrasonically- produced tablet will vary depending on the size and density of the tablet. Suitable nutritional tablets produced herein will include from about 1 gram to about 15 grams of dry nutritional powder, including from about 2 grams to about 12 grams of dry nutritional powder, including from about 5 grams to about 10 grams of dry nutritional powder. In one particularly suitable embodiment, the ultrasonically-produced nutritional tablet will include about 10 grams of dry nutritional powder. [0064] In some embodiments of the present disclosure, the ultrasonic energy is applied such to produce a tablet including at least two distinct zones of density. For example, in one embodiment, the tablet is produced such to include a loose, less dense powder in the core of the tablet and a more compacted shell of powder surrounding the loose powder. This allows the tablet to dissolve more rapidly in water.
  • an infant nutritional tablet is prepared by contacting commercially available spray-dried infant nutritional powder with ultrasonic energy.
  • Example 2 Commercially available from Hielscher Ultrasonics of Ringwood, New Jersey), was then turned on at 100% amplitude and a power level of 125 watts for 75 seconds. The tablet was then removed from the die. The resulting tablet maintained a solid shape and was dissolvable in room temperature water and warm (105°F (40.6°C)) water.
  • Example 2
  • Example 3 illustrates a spray-dried infant nutritional powder that could be contacted with ultrasonic energy as described in the methods of the present disclosure to produce an ultrasonically-produced infant nutritional tablet.
  • the starting ingredients of Example 3 are listed in the following Table.
  • Example 4 illustrates a spray-dried infant nutritional powder that could be contacted with ultrasonic energy as described in the methods of the present disclosure to produce an ultrasonically-produced infant nutritional tablet.
  • the starting ingredients of Example 4 are listed in the following Table.
  • Example 5 illustrates a spray-dried infant nutritional powder that could be contacted with ultrasonic energy as described in the methods of the present disclosure to produce an ultrasonically-produced infant nutritional tablet.
  • the starting ingredients of Example 5 are listed in the following Table.
  • Example 6 illustrates a spray-dried adult nutritional powder that could be contacted with ultrasonic energy as described in the methods of the present disclosure to produce an ultrasonically-produced adult nutritional tablet.
  • the starting ingredients of Example 6 are listed in the following Table.

Abstract

L'invention porte sur des comprimés nutritionnels produits par ultrasons et sur des procédés de fabrication des comprimés nutritionnels, comprenant des comprimés nutritionnels pour enfants produits par ultrasons et des comprimés nutritionnels pour adultes produits par ultrasons. Les procédés comprennent la mise en contact de poudres sèches nutritionnelles et, en particulier, de poudres nutritionnelles desséchées par pulvérisation, avec une énergie ultrasonore pour produire des comprimés nutritionnels.
PCT/US2012/050563 2011-08-16 2012-08-13 Utilisation d'énergie ultrasonore dans la production de produits nutritionnels WO2013025601A2 (fr)

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US201161524093P 2011-08-16 2011-08-16
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WO2013025601A3 WO2013025601A3 (fr) 2014-01-09

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3270900A4 (fr) * 2015-03-18 2018-03-28 Frederick S. Marius Comprimé de glucide et procédé de fabrication
WO2019023250A1 (fr) * 2017-07-26 2019-01-31 Abbott Laboratories Comprimés nutritionnels et leurs procédés de fabrication

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2664851B1 (fr) * 1990-07-20 1992-10-16 Oreal Procede de compactage d'un melange pulverulent permettant d'obtenir un produit compact absorbant ou partiellement delitable et produit obtenu par ce procede.
JP4592613B2 (ja) * 2006-02-13 2010-12-01 花王株式会社 崩壊性タブレット及びその製造方法
EP2230925A2 (fr) * 2007-12-18 2010-09-29 Diolaiti, Erminio Composition à base de produit et emballage correspondant

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
None

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3270900A4 (fr) * 2015-03-18 2018-03-28 Frederick S. Marius Comprimé de glucide et procédé de fabrication
WO2019023250A1 (fr) * 2017-07-26 2019-01-31 Abbott Laboratories Comprimés nutritionnels et leurs procédés de fabrication

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