WO2013022313A3 - 물질의 고집적 디스플레이를 토대로 에너지 전달 및 신호 변화를 이용해서 표적물질과의 상호작용을 정량적으로 감지 및 효과적으로 표지하는 방법 - Google Patents

물질의 고집적 디스플레이를 토대로 에너지 전달 및 신호 변화를 이용해서 표적물질과의 상호작용을 정량적으로 감지 및 효과적으로 표지하는 방법 Download PDF

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Publication number
WO2013022313A3
WO2013022313A3 PCT/KR2012/006399 KR2012006399W WO2013022313A3 WO 2013022313 A3 WO2013022313 A3 WO 2013022313A3 KR 2012006399 W KR2012006399 W KR 2012006399W WO 2013022313 A3 WO2013022313 A3 WO 2013022313A3
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WO
WIPO (PCT)
Prior art keywords
density
energy transfer
effectively
signal change
interaction
Prior art date
Application number
PCT/KR2012/006399
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English (en)
French (fr)
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WO2013022313A2 (ko
Inventor
김태국
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Kim Tae Kook
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kim Tae Kook filed Critical Kim Tae Kook
Priority to US14/237,840 priority Critical patent/US9759717B2/en
Publication of WO2013022313A2 publication Critical patent/WO2013022313A2/ko
Publication of WO2013022313A3 publication Critical patent/WO2013022313A3/ko

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

본 발명은 나노고단위복합체(nano-assembly matrix)에 고집적(high density)로 물질을 디스플레이(display)함으로써, 고집적 표지물질에서 효과적으로 발생하는 에너지 전달 및 신호 변화를 이용해서, 고집적 탐색물질들 사이에서 효과적으로 발생하는 상호작용을 정량적으로 감지 및 검출하고, 고집적 탐색물질과 효과적으로 상호작용하는 표적물질을 민감하게 표지 및 분리하는 방법에 관한 것이다. 즉, 고집적 디스플레이를 토대로 인 비트로(in vitro) 또는 인 비보(in vivo)에서 일어나는 다양한 생리활성물질들 사이의 상호작용을 정량적으로 감지하는 방법 그리고 이들과 상호작용하는 표적물질을 민감하게 표지하는 방법에 관한 것이다.
PCT/KR2012/006399 2011-08-10 2012-08-10 물질의 고집적 디스플레이를 토대로 에너지 전달 및 신호 변화를 이용해서 표적물질과의 상호작용을 정량적으로 감지 및 효과적으로 표지하는 방법 WO2013022313A2 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US14/237,840 US9759717B2 (en) 2011-08-10 2012-08-10 Method for quantitatively sensing and effectively marking interaction with target material by using energy transfer and signal change based on high-density display of material

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2011-0079888 2011-08-10
KR20110079888 2011-08-10

Publications (2)

Publication Number Publication Date
WO2013022313A2 WO2013022313A2 (ko) 2013-02-14
WO2013022313A3 true WO2013022313A3 (ko) 2013-06-13

Family

ID=47669112

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2012/006399 WO2013022313A2 (ko) 2011-08-10 2012-08-10 물질의 고집적 디스플레이를 토대로 에너지 전달 및 신호 변화를 이용해서 표적물질과의 상호작용을 정량적으로 감지 및 효과적으로 표지하는 방법

Country Status (3)

Country Link
US (1) US9759717B2 (ko)
KR (1) KR20130018194A (ko)
WO (1) WO2013022313A2 (ko)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007058454A1 (en) * 2005-11-15 2007-05-24 Cgk Co., Ltd. System for detecting molecular interactions
KR20090018585A (ko) * 2007-08-17 2009-02-20 한국과학기술원 물질의 상호작용 검출 방법

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004001019A2 (en) 2002-02-01 2003-12-31 Montana State University Novel nanoparticles and use thereof
AU2003215280A1 (en) 2002-02-15 2003-09-09 Northwestern University Self-assembly of peptide-amphiphile nanofibers under physiological conditions

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007058454A1 (en) * 2005-11-15 2007-05-24 Cgk Co., Ltd. System for detecting molecular interactions
KR20090018585A (ko) * 2007-08-17 2009-02-20 한국과학기술원 물질의 상호작용 검출 방법

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
LI, M. ET AL.: "Organization of Inorganic Nanoparticles Using Biotin Streptavidin Connectors.", CHEM. MATER., vol. 11, 1999, pages 23 - 26, XP055071209 *
SEKAR, R.B. ET AL.: "Fluorescence resonance energy transfer (FRET) microscopy imaging of live cell protein localizations.", THE JOURNAL OF CELL BIOLOGY, vol. 160, no. 5, 3 March 2003 (2003-03-03), pages 629 - 633, XP055071207 *
WOUTERS, F.S.: "Imaging biochemistry inside cells.", TRENDS IN CELL BIOLOGY., vol. 11, no. 5, May 2001 (2001-05-01), pages 203 - 211, XP009098796 *

Also Published As

Publication number Publication date
KR20130018194A (ko) 2013-02-20
US20140309132A1 (en) 2014-10-16
WO2013022313A2 (ko) 2013-02-14
US9759717B2 (en) 2017-09-12

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