WO2013001817A1 - 口腔内細菌の増殖抑制剤 - Google Patents

口腔内細菌の増殖抑制剤 Download PDF

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Publication number
WO2013001817A1
WO2013001817A1 PCT/JP2012/004187 JP2012004187W WO2013001817A1 WO 2013001817 A1 WO2013001817 A1 WO 2013001817A1 JP 2012004187 W JP2012004187 W JP 2012004187W WO 2013001817 A1 WO2013001817 A1 WO 2013001817A1
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WO
WIPO (PCT)
Prior art keywords
sorbitol
galactose
oral
bacteria
oral bacteria
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2012/004187
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English (en)
French (fr)
Japanese (ja)
Inventor
悠史 児玉
成瀬　敦
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Lotte Co Ltd
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Lotte Co Ltd
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Filing date
Publication date
Application filed by Lotte Co Ltd filed Critical Lotte Co Ltd
Priority to CN201280032036.7A priority Critical patent/CN104039304A/zh
Priority to KR1020147001513A priority patent/KR20140061349A/ko
Publication of WO2013001817A1 publication Critical patent/WO2013001817A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/52—Adding ingredients
    • A23L2/60—Sweeteners
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G1/00—Cocoa; Cocoa products, e.g. chocolate; Substitutes therefor
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G1/00—Cocoa; Cocoa products, e.g. chocolate; Substitutes therefor
    • A23G1/30—Cocoa products, e.g. chocolate; Substitutes therefor
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G9/00—Frozen sweets, e.g. ice confectionery, ice-cream; Mixtures therefor
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/52—Adding ingredients
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
    • A23L29/37—Sugar alcohols
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L9/00—Puddings; Cream substitutes; Preparation or treatment thereof
    • A23L9/10—Puddings; Dry powder puddings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L21/00—Marmalades, jams, jellies or the like; Products from apiculture; Preparation or treatment thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L9/00—Puddings; Cream substitutes; Preparation or treatment thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/92—Oral administration

Definitions

  • the present invention relates to a growth inhibitor of oral bacteria.
  • Fusobacterium nucleatum (hereinafter referred to as F. nucleatum) is a bacterial species that is frequently detected in plaques at both healthy and diseased sites in humans (Non-patent Documents 1 and 2). Since this ratio increases with the progression of periodontal disease, it is considered to contribute to the onset and progression of periodontal disease (Non-Patent Documents 3 to 5). In addition, it has the ability to adhere to many other bacteria, and in dental plaque, it plays a role of bridging to connect early colony-forming bacterial species and late colony-forming bacterial species including periodontal pathogens Known (Non-Patent Document 6).
  • Non-patent Document 7 a bacterium species producing volatile sulfur compounds that cause bad breath. Therefore, it is considered that an antibacterial agent having activity against F. nucleatum is effective in preventing periodontal disease, reducing bacteria in the oral cavity, and preventing and reducing bad breath. Research has also been conducted on substances that activate or suppress these activities. For example, saccharides are widely known to be causative substances when caries-causing bacteria produce acids. On the other hand, sugar alcohol is known to have a growth inhibitory action against caries-causing bacteria, and a growth inhibitory action against periodontal pathogens has also been reported in recent years.
  • Moore, W.E. and Moore, L.V. The bacteria of periodontal diseases, Periodontology 2000, 5, 66-77 (1994).
  • Dzink, J.L., Socransky, S.S. and Haffajee, A.D. The predominant cultivable microbiota of active and inactive lesions of destructive periodontal diseases, Journal of clinical periodontology, 15, 1988-316 Socransky, S.S., Haffajee, A.D.
  • a plurality of oral bacteria are known as periodontal pathogens and caries pathogens, and provision of substances that suppress the growth of these bacteria is required. Moreover, as such a substance, since it acts in the oral cavity, it is desirable that the substance be harmless even if ingested into the body.
  • an object of the present invention is to provide a substance that does not harm when ingested so as to suppress the growth of oral bacteria.
  • the usefulness of the combination of sugar and sugar alcohol has not yet been clarified, and the object is to provide a combination of sugar and sugar alcohol that suppresses the growth of oral bacteria. .
  • the present inventors have found that the growth of oral bacteria F. nucleatum is remarkably inhibited in a medium containing galactose and sorbitol, and thus completed the present invention. That is, the present invention relates to a growth inhibitor of oral bacteria characterized by containing galactose and sorbitol.
  • the oral bacterial growth inhibitor according to the present invention can be safely used or ingested daily by containing it in a food or oral composition, efficiently reducing oral bacteria, Periodontal disease can be improved and prevented, and furthermore, bad breath can be prevented and reduced.
  • FIG. 1 The graph showing the OD value obtained about each culture medium in Example 2.
  • FIG. 3 The graph showing the OD value obtained about each culture medium in Example 3.
  • FIG. 4 The graph showing the OD value obtained about each culture medium in Example 4.
  • the oral bacterial growth inhibitor containing galactose and sorbitol of the present invention has an effect of synergistically suppressing the growth of F. nucleatum.
  • F. nucleatum adheres to many other bacteria and forms dental plaque. By inhibiting the growth of this fungus, other bacteria in the oral cavity that cause periodontal disease and dental caries Can suppress the growth of bacteria.
  • F. nucleatum is one of the pathogens of periodontal disease
  • the present invention is useful for improvement and prevention of periodontal disease.
  • this bacterium produces a volatile sulfur compound that is a causative agent of bad breath, it is thought that inhibiting the growth of F. nucleatum is also effective in preventing and reducing bad breath.
  • the total molar concentration of galactose and sorbitol is preferably 0.5M or more and 0.9M or less.
  • ⁇ -D-galactose is preferably used.
  • sorbitol in this invention it is preferable to use D-sorbitol (D-sorbitol).
  • the growth inhibitor of the present invention includes oral compositions such as a mouthwash, toothpaste, inhalant and troche, chewing gum, candy, tablet confectionery, gummy jelly, chocolate, biscuits and snacks, ice cream, sorbet And frozen desserts such as ice confectionery, beverages, bread, hot cakes, dairy products, livestock meat products such as ham and sausage, fish products such as kamaboko and chikuwa, prepared foods such as side dishes, pudding, soup or jam It is possible to use.
  • oral compositions such as a mouthwash, toothpaste, inhalant and troche, chewing gum, candy, tablet confectionery, gummy jelly, chocolate, biscuits and snacks, ice cream, sorbet And frozen desserts such as ice confectionery, beverages, bread, hot cakes, dairy products, livestock meat products such as ham and sausage, fish products such as kamaboko and chikuwa, prepared foods such as side dishes, pudding, soup or jam It is possible to use.
  • Samples D (+)-galactose (Wako Pure Chemical: special grade) and D (-)-sorbitol (Wako Pure Chemical: first grade) were used.
  • F. nucleatum JCM12990 strain was used as a test strain oral bacterium.
  • TSB medium Tripticase soy broth (hereinafter TSB medium) supplemented with Yeast extract (3.0 g / l), Hemin (5.0 mg / l), Menadione (0.5 mg / l), anaerobic conditions (10% CO 2 and 10% H 2 , 80% N 2 ).
  • a TSB medium in which galactose and sorbitol were dissolved was prepared so that the final concentration when 3.0 ml was added to 7.0 ml of TSB medium was the set concentration. All media were sterilized with a filter (ADVANTEC, pore shape 0.20 ⁇ m). Measurement of Bacterial Count A preculture of the oral bacterium F. nucleatum JCM12990 was added to 7.0 ml of TSB medium and cultured until the logarithmic growth phase.
  • Example 1 a galactose-added TSB medium containing 0.1 M or 0.6 M galactose, a sorbitol-added TSB medium containing 0.2 M, 0.3 M or 0.6 M sorbitol Above, 0.4 M galactose and 0.2 M sorbitol, 0.3 M Tests were performed by preparing a TSB medium mixed with galactose and 0.3 M sorbitol or a mixed addition TSB containing 0.3 M galactose and 0.6 M sorbitol, and a control. The OD values obtained for each TSB medium are shown in FIG.
  • a mouthwash was prepared according to the following formulation. Ethanol 2.0% by weight Fragrance 1.0 Galactose 3.7 Sorbitol 7.4 Water remaining 100.0
  • a toothpaste was produced according to the following formulation. Calcium carbonate 40.0% by weight Glycerin 10.0 Carboxymethylcellulose 2.0 Sodium ralyl sulfate 2.0 Fragrance 1.0 Saccharin 0.1 Chlorhexidine 0.01 Galactose 5.5 Sorbitol 11.0 Water remaining 100.0
  • a spray for halitosis was produced according to the following formulation. Ethanol 10.0% by weight Glycerin 5.0 Fragrance 0.05 Coloring 0.001 Galactose 5.5 Sorbitol 11.0 Water remaining 100.0
  • a lozenge was produced according to the following formulation. Gum arabic 6.0% by weight Palatinit 75.8 Fragrance 1.0 Galactose 5.5 Sorbitol 11.0 Sodium monofluorophosphate 0.7 100.0
  • Chewing gum was manufactured according to the following formulation. Gum base 20.0% by weight Palatinit 61.5 Galactose 5.5 Sorbitol 11.0 Fragrance 2.0 100.0
  • Tablet confectionery was produced according to the following prescription. Sucrose fatty acid ester 0.2% by weight Palatinit 78.6 Fragrance 0.2 Galactose 5.5 Sorbitol 11.0 Water 4.5 100.0
  • Gummy jelly was manufactured according to the following prescription. Gelatin 60.0% by weight Reduced water candy 21.6 Vegetable oil 4.5 Malic acid 2.0 Galactose 3.8 Sorbitol 7.6 Fragrance 0.5 100.0
  • a beverage was produced according to the following formulation. Orange juice 30.0% by weight Citric acid 0.1 Vitamin C 0.04 Fragrance 0.1 Galactose 5.0 Sorbitol 10.0 Water remaining 100.0

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Nutrition Science (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Emergency Medicine (AREA)
  • Cosmetics (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Confectionery (AREA)
  • Non-Alcoholic Beverages (AREA)
PCT/JP2012/004187 2011-06-30 2012-06-28 口腔内細菌の増殖抑制剤 Ceased WO2013001817A1 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201280032036.7A CN104039304A (zh) 2011-06-30 2012-06-28 口腔内细菌的增殖抑制剂
KR1020147001513A KR20140061349A (ko) 2011-06-30 2012-06-28 구강 내 세균의 증식 억제제

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2011-145737 2011-06-30
JP2011145737A JP2013010724A (ja) 2011-06-30 2011-06-30 口腔内細菌の増殖抑制剤

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JP (1) JP2013010724A (https=)
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CN (1) CN104039304A (https=)
TW (1) TW201313234A (https=)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3466403A1 (de) * 2017-10-04 2019-04-10 Prisman GmbH Verwendung eines monosaccharids zur sub- und/oder supragingivalen zahnreinigung

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016048007A1 (ko) * 2014-09-24 2016-03-31 서울대학교 산학협력단 D-갈락토오스를 포함하는 쿼럼센싱 저해제

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0217120A (ja) * 1988-05-14 1990-01-22 Biodyn Ag 虫歯予防剤
JP2005520807A (ja) * 2001-10-25 2005-07-14 スフェリックス インコーポレイティッド 抗バイオフィルム剤としてのｄ−タガトース
JP2006182692A (ja) * 2004-12-27 2006-07-13 Kao Corp 口腔用組成物
JP2008303188A (ja) * 2007-06-08 2008-12-18 Univ Of Tokushima カンジダバイオフィルム除去剤

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101027034B (zh) * 2004-09-29 2013-01-23 花王株式会社 口腔用组合物

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0217120A (ja) * 1988-05-14 1990-01-22 Biodyn Ag 虫歯予防剤
JP2005520807A (ja) * 2001-10-25 2005-07-14 スフェリックス インコーポレイティッド 抗バイオフィルム剤としてのｄ−タガトース
JP2006182692A (ja) * 2004-12-27 2006-07-13 Kao Corp 口腔用組成物
JP2008303188A (ja) * 2007-06-08 2008-12-18 Univ Of Tokushima カンジダバイオフィルム除去剤

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3466403A1 (de) * 2017-10-04 2019-04-10 Prisman GmbH Verwendung eines monosaccharids zur sub- und/oder supragingivalen zahnreinigung

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CN104039304A (zh) 2014-09-10
JP2013010724A (ja) 2013-01-17
TW201313234A (zh) 2013-04-01
KR20140061349A (ko) 2014-05-21

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