WO2013001817A1 - Inhibiteur de la prolifération bactérienne dans la bouche - Google Patents
Inhibiteur de la prolifération bactérienne dans la bouche Download PDFInfo
- Publication number
- WO2013001817A1 WO2013001817A1 PCT/JP2012/004187 JP2012004187W WO2013001817A1 WO 2013001817 A1 WO2013001817 A1 WO 2013001817A1 JP 2012004187 W JP2012004187 W JP 2012004187W WO 2013001817 A1 WO2013001817 A1 WO 2013001817A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- sorbitol
- galactose
- oral
- bacteria
- oral bacteria
- Prior art date
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
- A23L2/60—Sweeteners
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G1/00—Cocoa; Cocoa products, e.g. chocolate; Substitutes therefor
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G1/00—Cocoa; Cocoa products, e.g. chocolate; Substitutes therefor
- A23G1/30—Cocoa products, e.g. chocolate; Substitutes therefor
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G9/00—Frozen sweets, e.g. ice confectionery, ice-cream; Mixtures therefor
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
- A23L29/37—Sugar alcohols
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L9/00—Puddings; Cream substitutes; Preparation or treatment thereof
- A23L9/10—Puddings; Dry powder puddings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L21/00—Marmalades, jams, jellies or the like; Products from apiculture; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L9/00—Puddings; Cream substitutes; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/92—Oral administration
Definitions
- the present invention relates to a growth inhibitor of oral bacteria.
- Fusobacterium nucleatum (hereinafter referred to as F. nucleatum) is a bacterial species that is frequently detected in plaques at both healthy and diseased sites in humans (Non-patent Documents 1 and 2). Since this ratio increases with the progression of periodontal disease, it is considered to contribute to the onset and progression of periodontal disease (Non-Patent Documents 3 to 5). In addition, it has the ability to adhere to many other bacteria, and in dental plaque, it plays a role of bridging to connect early colony-forming bacterial species and late colony-forming bacterial species including periodontal pathogens Known (Non-Patent Document 6).
- Non-patent Document 7 a bacterium species producing volatile sulfur compounds that cause bad breath. Therefore, it is considered that an antibacterial agent having activity against F. nucleatum is effective in preventing periodontal disease, reducing bacteria in the oral cavity, and preventing and reducing bad breath. Research has also been conducted on substances that activate or suppress these activities. For example, saccharides are widely known to be causative substances when caries-causing bacteria produce acids. On the other hand, sugar alcohol is known to have a growth inhibitory action against caries-causing bacteria, and a growth inhibitory action against periodontal pathogens has also been reported in recent years.
- Moore, W.E. and Moore, L.V. The bacteria of periodontal diseases, Periodontology 2000, 5, 66-77 (1994).
- Dzink, J.L., Socransky, S.S. and Haffajee, A.D. The predominant cultivable microbiota of active and inactive lesions of destructive periodontal diseases, Journal of clinical periodontology, 15, 1988-316 Socransky, S.S., Haffajee, A.D.
- a plurality of oral bacteria are known as periodontal pathogens and caries pathogens, and provision of substances that suppress the growth of these bacteria is required. Moreover, as such a substance, since it acts in the oral cavity, it is desirable that the substance be harmless even if ingested into the body.
- an object of the present invention is to provide a substance that does not harm when ingested so as to suppress the growth of oral bacteria.
- the usefulness of the combination of sugar and sugar alcohol has not yet been clarified, and the object is to provide a combination of sugar and sugar alcohol that suppresses the growth of oral bacteria. .
- the present inventors have found that the growth of oral bacteria F. nucleatum is remarkably inhibited in a medium containing galactose and sorbitol, and thus completed the present invention. That is, the present invention relates to a growth inhibitor of oral bacteria characterized by containing galactose and sorbitol.
- the oral bacterial growth inhibitor according to the present invention can be safely used or ingested daily by containing it in a food or oral composition, efficiently reducing oral bacteria, Periodontal disease can be improved and prevented, and furthermore, bad breath can be prevented and reduced.
- FIG. 1 The graph showing the OD value obtained about each culture medium in Example 2.
- FIG. 3 The graph showing the OD value obtained about each culture medium in Example 3.
- FIG. 4 The graph showing the OD value obtained about each culture medium in Example 4.
- the oral bacterial growth inhibitor containing galactose and sorbitol of the present invention has an effect of synergistically suppressing the growth of F. nucleatum.
- F. nucleatum adheres to many other bacteria and forms dental plaque. By inhibiting the growth of this fungus, other bacteria in the oral cavity that cause periodontal disease and dental caries Can suppress the growth of bacteria.
- F. nucleatum is one of the pathogens of periodontal disease
- the present invention is useful for improvement and prevention of periodontal disease.
- this bacterium produces a volatile sulfur compound that is a causative agent of bad breath, it is thought that inhibiting the growth of F. nucleatum is also effective in preventing and reducing bad breath.
- the total molar concentration of galactose and sorbitol is preferably 0.5M or more and 0.9M or less.
- ⁇ -D-galactose is preferably used.
- sorbitol in this invention it is preferable to use D-sorbitol (D-sorbitol).
- the growth inhibitor of the present invention includes oral compositions such as a mouthwash, toothpaste, inhalant and troche, chewing gum, candy, tablet confectionery, gummy jelly, chocolate, biscuits and snacks, ice cream, sorbet And frozen desserts such as ice confectionery, beverages, bread, hot cakes, dairy products, livestock meat products such as ham and sausage, fish products such as kamaboko and chikuwa, prepared foods such as side dishes, pudding, soup or jam It is possible to use.
- oral compositions such as a mouthwash, toothpaste, inhalant and troche, chewing gum, candy, tablet confectionery, gummy jelly, chocolate, biscuits and snacks, ice cream, sorbet And frozen desserts such as ice confectionery, beverages, bread, hot cakes, dairy products, livestock meat products such as ham and sausage, fish products such as kamaboko and chikuwa, prepared foods such as side dishes, pudding, soup or jam It is possible to use.
- Samples D (+)-galactose (Wako Pure Chemical: special grade) and D (-)-sorbitol (Wako Pure Chemical: first grade) were used.
- F. nucleatum JCM12990 strain was used as a test strain oral bacterium.
- TSB medium Tripticase soy broth (hereinafter TSB medium) supplemented with Yeast extract (3.0 g / l), Hemin (5.0 mg / l), Menadione (0.5 mg / l), anaerobic conditions (10% CO 2 and 10% H 2 , 80% N 2 ).
- a TSB medium in which galactose and sorbitol were dissolved was prepared so that the final concentration when 3.0 ml was added to 7.0 ml of TSB medium was the set concentration. All media were sterilized with a filter (ADVANTEC, pore shape 0.20 ⁇ m). Measurement of Bacterial Count A preculture of the oral bacterium F. nucleatum JCM12990 was added to 7.0 ml of TSB medium and cultured until the logarithmic growth phase.
- Example 1 a galactose-added TSB medium containing 0.1 M or 0.6 M galactose, a sorbitol-added TSB medium containing 0.2 M, 0.3 M or 0.6 M sorbitol Above, 0.4 M galactose and 0.2 M sorbitol, 0.3 M Tests were performed by preparing a TSB medium mixed with galactose and 0.3 M sorbitol or a mixed addition TSB containing 0.3 M galactose and 0.6 M sorbitol, and a control. The OD values obtained for each TSB medium are shown in FIG.
- a mouthwash was prepared according to the following formulation. Ethanol 2.0% by weight Fragrance 1.0 Galactose 3.7 Sorbitol 7.4 Water remaining 100.0
- a toothpaste was produced according to the following formulation. Calcium carbonate 40.0% by weight Glycerin 10.0 Carboxymethylcellulose 2.0 Sodium ralyl sulfate 2.0 Fragrance 1.0 Saccharin 0.1 Chlorhexidine 0.01 Galactose 5.5 Sorbitol 11.0 Water remaining 100.0
- a spray for halitosis was produced according to the following formulation. Ethanol 10.0% by weight Glycerin 5.0 Fragrance 0.05 Coloring 0.001 Galactose 5.5 Sorbitol 11.0 Water remaining 100.0
- a lozenge was produced according to the following formulation. Gum arabic 6.0% by weight Palatinit 75.8 Fragrance 1.0 Galactose 5.5 Sorbitol 11.0 Sodium monofluorophosphate 0.7 100.0
- Chewing gum was manufactured according to the following formulation. Gum base 20.0% by weight Palatinit 61.5 Galactose 5.5 Sorbitol 11.0 Fragrance 2.0 100.0
- Tablet confectionery was produced according to the following prescription. Sucrose fatty acid ester 0.2% by weight Palatinit 78.6 Fragrance 0.2 Galactose 5.5 Sorbitol 11.0 Water 4.5 100.0
- Gummy jelly was manufactured according to the following prescription. Gelatin 60.0% by weight Reduced water candy 21.6 Vegetable oil 4.5 Malic acid 2.0 Galactose 3.8 Sorbitol 7.6 Fragrance 0.5 100.0
- a beverage was produced according to the following formulation. Orange juice 30.0% by weight Citric acid 0.1 Vitamin C 0.04 Fragrance 0.1 Galactose 5.0 Sorbitol 10.0 Water remaining 100.0
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Polymers & Plastics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Mycology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Emergency Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Confectionery (AREA)
- Non-Alcoholic Beverages (AREA)
Abstract
La présente invention concerne une substance pouvant inhiber la prolifération de bactéries dans la bouche et qui peut être ingérée sans risque. En particulier, l'utilité de l'utilisation combinée d'un saccharide et d'un alcool de sucre n'est toujours pas clairement avérée. L'invention concerne ainsi une combinaison d'un saccharide et d'un alcool de sucre, qui peut inhiber la prolifération de bactéries dans la bouche. L'invention concerne en outre un inhibiteur de la prolifération de bactéries dans la bouche caractérisé en ce qu'il comprend du galactose et du sorbitol. Cet inhibiteur de la prolifération de bactéries dans la bouche est efficace pour améliorer et prévenir les maladies parodontales.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201280032036.7A CN104039304A (zh) | 2011-06-30 | 2012-06-28 | 口腔内细菌的增殖抑制剂 |
KR1020147001513A KR20140061349A (ko) | 2011-06-30 | 2012-06-28 | 구강 내 세균의 증식 억제제 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2011145737A JP2013010724A (ja) | 2011-06-30 | 2011-06-30 | 口腔内細菌の増殖抑制剤 |
JP2011-145737 | 2011-06-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2013001817A1 true WO2013001817A1 (fr) | 2013-01-03 |
Family
ID=47423736
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2012/004187 WO2013001817A1 (fr) | 2011-06-30 | 2012-06-28 | Inhibiteur de la prolifération bactérienne dans la bouche |
Country Status (5)
Country | Link |
---|---|
JP (1) | JP2013010724A (fr) |
KR (1) | KR20140061349A (fr) |
CN (1) | CN104039304A (fr) |
TW (1) | TW201313234A (fr) |
WO (1) | WO2013001817A1 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3466403A1 (fr) * | 2017-10-04 | 2019-04-10 | Prisman GmbH | Utilisation d'un monosaccharide pour le nettoyage de dents subgingival et/ou supragingival |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10292993B2 (en) * | 2014-09-24 | 2019-05-21 | Seoul National University R&Db Foundation | Method of inhibiting quorum sensing using D-galactose |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0217120A (ja) * | 1988-05-14 | 1990-01-22 | Biodyn Ag | 虫歯予防剤 |
JP2005520807A (ja) * | 2001-10-25 | 2005-07-14 | スフェリックス インコーポレイティッド | 抗バイオフィルム剤としてのd−タガトース |
JP2006182692A (ja) * | 2004-12-27 | 2006-07-13 | Kao Corp | 口腔用組成物 |
JP2008303188A (ja) * | 2007-06-08 | 2008-12-18 | Univ Of Tokushima | カンジダバイオフィルム除去剤 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080255058A1 (en) * | 2004-09-29 | 2008-10-16 | Kao Corporation | Composition for Oral Cavity |
-
2011
- 2011-06-30 JP JP2011145737A patent/JP2013010724A/ja active Pending
-
2012
- 2012-06-28 WO PCT/JP2012/004187 patent/WO2013001817A1/fr active Application Filing
- 2012-06-28 CN CN201280032036.7A patent/CN104039304A/zh active Pending
- 2012-06-28 KR KR1020147001513A patent/KR20140061349A/ko not_active Application Discontinuation
- 2012-06-29 TW TW101123499A patent/TW201313234A/zh unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0217120A (ja) * | 1988-05-14 | 1990-01-22 | Biodyn Ag | 虫歯予防剤 |
JP2005520807A (ja) * | 2001-10-25 | 2005-07-14 | スフェリックス インコーポレイティッド | 抗バイオフィルム剤としてのd−タガトース |
JP2006182692A (ja) * | 2004-12-27 | 2006-07-13 | Kao Corp | 口腔用組成物 |
JP2008303188A (ja) * | 2007-06-08 | 2008-12-18 | Univ Of Tokushima | カンジダバイオフィルム除去剤 |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3466403A1 (fr) * | 2017-10-04 | 2019-04-10 | Prisman GmbH | Utilisation d'un monosaccharide pour le nettoyage de dents subgingival et/ou supragingival |
Also Published As
Publication number | Publication date |
---|---|
KR20140061349A (ko) | 2014-05-21 |
TW201313234A (zh) | 2013-04-01 |
CN104039304A (zh) | 2014-09-10 |
JP2013010724A (ja) | 2013-01-17 |
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