WO2012173846A3 - Macrocycles peptidomimétiques - Google Patents

Macrocycles peptidomimétiques Download PDF

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Publication number
WO2012173846A3
WO2012173846A3 PCT/US2012/041181 US2012041181W WO2012173846A3 WO 2012173846 A3 WO2012173846 A3 WO 2012173846A3 US 2012041181 W US2012041181 W US 2012041181W WO 2012173846 A3 WO2012173846 A3 WO 2012173846A3
Authority
WO
WIPO (PCT)
Prior art keywords
peptidomimetic macrocycles
macrocycles
disease
peptidomimetic
treatment
Prior art date
Application number
PCT/US2012/041181
Other languages
English (en)
Other versions
WO2012173846A2 (fr
Inventor
Huw M. Nash
Noriyuki Kawahata
Carl Elkin
Original Assignee
Aileron Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aileron Therapeutics, Inc. filed Critical Aileron Therapeutics, Inc.
Publication of WO2012173846A2 publication Critical patent/WO2012173846A2/fr
Publication of WO2012173846A3 publication Critical patent/WO2012173846A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

La présente invention concerne de nouveaux macrocycles peptidomimétiques et des procédés d'utilisation de tels macrocycles dans le traitement de maladies.
PCT/US2012/041181 2011-06-06 2012-06-06 Macrocycles peptidomimétiques WO2012173846A2 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201161493979P 2011-06-06 2011-06-06
US61/493,979 2011-06-06
US201161494382P 2011-06-07 2011-06-07
US201161494377P 2011-06-07 2011-06-07
US61/494,382 2011-06-07
US61/494,377 2011-06-07

Publications (2)

Publication Number Publication Date
WO2012173846A2 WO2012173846A2 (fr) 2012-12-20
WO2012173846A3 true WO2012173846A3 (fr) 2013-03-21

Family

ID=47357671

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/041181 WO2012173846A2 (fr) 2011-06-06 2012-06-06 Macrocycles peptidomimétiques

Country Status (1)

Country Link
WO (1) WO2012173846A2 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7960506B2 (en) 2006-12-14 2011-06-14 Aileron Therapeutics, Inc. Bis-sulfhydryl macrocyclization systems
CN109627287A (zh) 2007-02-23 2019-04-16 爱勒让治疗公司 三唑大环系统
WO2008121767A2 (fr) 2007-03-28 2008-10-09 President And Fellows Of Harvard College Polypeptides cousus
BRPI0918948A2 (pt) 2008-09-22 2015-12-15 Aileron Therapeutics Inc macrociclos peptidomiméticos
US9458202B2 (en) 2008-11-24 2016-10-04 Aileron Therapeutics, Inc. Peptidomimetic macrocycles with improved properties
JP2012515172A (ja) 2009-01-14 2012-07-05 エルロン・セラピューティクス・インコーポレイテッド ペプチド模倣大環状分子
JP2013505300A (ja) 2009-09-22 2013-02-14 エルロン・セラピューティクス・インコーポレイテッド ペプチド模倣大環状分子
RU2582678C2 (ru) 2010-08-13 2016-04-27 Эйлерон Терапьютикс, Инк. Пептидомиметические макроциклы
TWI643868B (zh) 2011-10-18 2018-12-11 艾利倫治療公司 擬肽巨環化合物
JP6450191B2 (ja) 2012-02-15 2019-01-09 エイルロン セラピューティクス，インコーポレイテッド ペプチドミメティック大環状化合物
EP2819688A4 (fr) 2012-02-15 2015-10-28 Aileron Therapeutics Inc Macrocycles peptidomimétiques réticulés par triazole et par thioéther
WO2014071241A1 (fr) 2012-11-01 2014-05-08 Aileron Therapeutics, Inc. Acides aminés disubstitués et procédés de préparation et d'utilisation de ceux-ci
KR102570210B1 (ko) 2014-09-24 2023-08-23 에일러론 테라퓨틱스 인코포레이티드 펩티드모방 거대고리 및 이의 제제
KR20170058424A (ko) 2014-09-24 2017-05-26 에일러론 테라퓨틱스 인코포레이티드 펩티드모방 거대고리 및 이의 용도
JP2018516844A (ja) 2015-03-20 2018-06-28 エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． ペプチド模倣大環状分子およびその使用
WO2017004548A1 (fr) 2015-07-01 2017-01-05 Aileron Therapeutics, Inc. Macrocycles peptidomimétiques
US20170056352A1 (en) 2015-08-25 2017-03-02 Rgenix, Inc. PHARMACEUTICALLY ACCEPTABLE SALTS OF beta-GUANIDINOPROPIONIC ACID WITH IMPROVED PROPERTIES AND USES THEREOF
US10023613B2 (en) 2015-09-10 2018-07-17 Aileron Therapeutics, Inc. Peptidomimetic macrocycles as modulators of MCL-1
WO2018160178A1 (fr) 2017-03-01 2018-09-07 Rgenix, Inc. Sels pharmaceutiquement acceptables d'acide bêta-guanidinopropionique ayant des propriétés améliorées et utilisations de ceux-ci

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080262200A1 (en) * 2007-02-23 2008-10-23 Aileron Therapeutics, Inc., A Delaware Corporation Triazole Macrocycle Systems
US20100184047A1 (en) * 2007-03-30 2010-07-22 Oncotherapy Science, Inc. Screening and therapeutic method for nsclc targeting the cdca8-aurkb complex

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080262200A1 (en) * 2007-02-23 2008-10-23 Aileron Therapeutics, Inc., A Delaware Corporation Triazole Macrocycle Systems
US20100184047A1 (en) * 2007-03-30 2010-07-22 Oncotherapy Science, Inc. Screening and therapeutic method for nsclc targeting the cdca8-aurkb complex

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JEYAPRAKASH ET AL.: "Structure of a survivin-borealin-INCENP core complex reveals how chromosomal passengers travel together.", CELL, vol. 131, 2007, pages 271 - 285 *

Also Published As

Publication number Publication date
WO2012173846A2 (fr) 2012-12-20

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