WO2012163806A1 - Procédé de production d'un produit antimicrobien en matière plastique - Google Patents

Procédé de production d'un produit antimicrobien en matière plastique Download PDF

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Publication number
WO2012163806A1
WO2012163806A1 PCT/EP2012/059763 EP2012059763W WO2012163806A1 WO 2012163806 A1 WO2012163806 A1 WO 2012163806A1 EP 2012059763 W EP2012059763 W EP 2012059763W WO 2012163806 A1 WO2012163806 A1 WO 2012163806A1
Authority
WO
WIPO (PCT)
Prior art keywords
silver
salt
plastic
aqueous solution
orthophosphate
Prior art date
Application number
PCT/EP2012/059763
Other languages
German (de)
English (en)
Inventor
Christoph Cichos
Irmgard Cichos
Original Assignee
Spiegelberg (Gmbh & Co.) Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Spiegelberg (Gmbh & Co.) Kg filed Critical Spiegelberg (Gmbh & Co.) Kg
Publication of WO2012163806A1 publication Critical patent/WO2012163806A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A01N59/16—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/005—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters containing a biologically active substance, e.g. a medicament or a biocide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A61L2300/104—Silver, e.g. silver sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K3/00—Use of inorganic substances as compounding ingredients
    • C08K3/01—Use of inorganic substances as compounding ingredients characterized by their specific function
    • C08K3/015—Biocides

Definitions

  • All process variants according to WO 2009/013016 have a two-step procedure in common.
  • silver orthophosphate is precipitated by addition of phosphoric acid to an ammoniacal silver salt solution.
  • the silver orthophosphate is isolated as an intermediate and partially reduced in a second stage.
  • the reaction rate of reduction by the polybasic hydroxycarboxylic acid at room temperature is very low.
  • the reaction rate of the reduction is increased by raising the temperature.
  • the skilled person can set the reaction rate by selecting the temperature so that he can control the extent of reduction for the preparation of the partially reduced silver orthophosphate over the reaction time.
  • the temperature and reaction time in step b) are selected to produce a partially reduced silver orthophosphate having a weight ratio of silver ions of the silver orthophosphate to silver atoms of the metallic silver in the range of 95: 5 to 55:45.
  • the precursor may comprise additives.
  • Additives may be, for example, inorganic or organic substances.
  • the precursor may in particular comprise all inorganic and organic substances that are inert and medically safe. These include, in particular, sparingly water-soluble materials such as zirconium dioxide, zirconium silicate, titanium dioxide, zinc oxide, calcium fluoride, calcium carbonate, aluminosilicates, hydroxyapatite, fluorapatite, barium sulfate, calcium sulfate and carbon in its various forms.
  • sparingly water-soluble materials such as zirconium dioxide, zirconium silicate, titanium dioxide, zinc oxide, calcium fluoride, calcium carbonate, aluminosilicates, hydroxyapatite, fluorapatite, barium sulfate, calcium sulfate and carbon in its various forms.
  • Such substances can already be used as fillers in a commercially available
  • the partially reduced silver orthophosphate preferably has a ratio of silver ions of the silver orthophosphate to silver atoms of the metallic silver in the range of 95: 5 to 55:45, i. the silver ions are in excess compared to the silver atoms.
  • 95% by weight, especially 98% by weight and most preferably 99% by weight of the particles have a size of less than 5 ⁇ m. This is the absolute size of the particles (and not averages).
  • the separated solid was then dried at 105 ° C.
  • a 600 ml beaker is filled with 300 ml of deionized water. Therein, 8.3 g of K2HPO4, 24.3 g of trisodium citrate dihydrate and 1.5 g of NaOH are dissolved.
  • the solids / liquid ratio was 1:20. Measurement of particle size distribution
  • Examples 1 to 3 show that a shift of the particle size distribution to smaller particle sizes, except by using a suitable dispersing agent, e.g. Tri-sodium citrate, also by using a mechanical intensive stirrer (high energy input) in combination with the dispersing agent and also by choosing a small solid / liquid ratio.
  • a suitable dispersing agent e.g. Tri-sodium citrate
  • a mechanical intensive stirrer high energy input

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Materials Engineering (AREA)
  • Biomedical Technology (AREA)
  • Agronomy & Crop Science (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Inorganic Chemistry (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

L'invention concerne un procédé pour produire un produit en matière plastique à action antimicrobienne, qui contient comme agent à action antimicrobienne de l'orthophosphate d'argent partiellement réduit. Selon ce procédé, de l'orthophosphate d'argent est précipité comme agent dispersant, à partir d'une solution aqueuse, par réaction d'un phosphate d'hydrogène avec un sel d'argent en présence d'un acide hydrocarboxylique ou d'un sel dudit acide. Pour finir, la température est augmentée afin de réduire au moins en partie en argent métallique les particules d'orthophosphate d'argent, par utilisation comme agent de réduction, d'acide hydrocarboxylique ou de son sel.
PCT/EP2012/059763 2011-05-27 2012-05-24 Procédé de production d'un produit antimicrobien en matière plastique WO2012163806A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102011102636.7 2011-05-27
DE102011102636A DE102011102636B3 (de) 2011-05-27 2011-05-27 Verfahren zur Herstellung eines antimikrobiellen Kunststoffproduktes

Publications (1)

Publication Number Publication Date
WO2012163806A1 true WO2012163806A1 (fr) 2012-12-06

Family

ID=46201594

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2012/059763 WO2012163806A1 (fr) 2011-05-27 2012-05-24 Procédé de production d'un produit antimicrobien en matière plastique

Country Status (2)

Country Link
DE (1) DE102011102636B3 (fr)
WO (1) WO2012163806A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2614284A (en) * 2021-12-23 2023-07-05 Matthew Thorn Daniel Anitmicrobial compositions and eyewear

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB759950A (en) * 1954-03-26 1956-10-24 Hans Johann Bardt Production of silver of bactericidal and catalytic activity
EP0251783A2 (fr) 1986-07-03 1988-01-07 Johnson Matthey Public Limited Company Composition antimicrobienne
WO1995020878A1 (fr) 1994-02-01 1995-08-10 Theodor Krall Procede de fabrication de corps plastiques bactericides/fongicides
WO2001009229A1 (fr) 1999-07-30 2001-02-08 Guggenbichler J Peter Procede de fabrication de corps en plastique anti-microbiens a comportement ameliore sur la duree
WO2004024205A1 (fr) 2002-09-10 2004-03-25 Prof. Dr. Josef-Peter Guggenbichler, Dr. Christoph Cichos Gbr Procede de fabrication d'un produit antimicrobien en matiere plastique
WO2009013016A1 (fr) 2007-07-26 2009-01-29 Spiegelberg (Gmbh & Co.) Kg Produits antimicrobiens en matière plastique et leur procédé de réalisation

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB759950A (en) * 1954-03-26 1956-10-24 Hans Johann Bardt Production of silver of bactericidal and catalytic activity
EP0251783A2 (fr) 1986-07-03 1988-01-07 Johnson Matthey Public Limited Company Composition antimicrobienne
WO1995020878A1 (fr) 1994-02-01 1995-08-10 Theodor Krall Procede de fabrication de corps plastiques bactericides/fongicides
WO2001009229A1 (fr) 1999-07-30 2001-02-08 Guggenbichler J Peter Procede de fabrication de corps en plastique anti-microbiens a comportement ameliore sur la duree
WO2004024205A1 (fr) 2002-09-10 2004-03-25 Prof. Dr. Josef-Peter Guggenbichler, Dr. Christoph Cichos Gbr Procede de fabrication d'un produit antimicrobien en matiere plastique
WO2009013016A1 (fr) 2007-07-26 2009-01-29 Spiegelberg (Gmbh & Co.) Kg Produits antimicrobiens en matière plastique et leur procédé de réalisation

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BI YINGPU ET AL: "Facet Effect of Single-Crystalline Ag3PO4 Sub-microcrystals on Photocatalytic Properties", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - SUPPORTING INFORMATION, 12 July 2011 (2011-07-12), XP055034034, Retrieved from the Internet <URL:http://pubs.acs.org/doi/suppl/10.1021/ja2002132/suppl_file/ja2002132_si_001.pdf> [retrieved on 20120727] *
H. REMY: "Lehrbuch der anorganischen Chemie", vol. 2, 1959, AKADEMISCHE VERLAGSGESELLSCHAFT GEEST & PORTIG K.-G., pages: 481
YINGPU BI ET AL: "Facet Effect of Single-Crystalline Ag 3 PO 4 Sub-microcrystals on Photocatalytic Properties", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 133, no. 17, 12 April 2011 (2011-04-12), pages 6490 - 6492, XP055033983, ISSN: 0002-7863, DOI: 10.1021/ja2002132 *
ZHIGUO YI ET AL: "An orthophosphate semiconductor with photooxidation properties under visible-light irradiation", NATURE MATERIALS, vol. 9, no. 7, 1 July 2010 (2010-07-01), pages 559 - 564, XP055026886, ISSN: 1476-1122, DOI: 10.1038/nmat2780 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2614284A (en) * 2021-12-23 2023-07-05 Matthew Thorn Daniel Anitmicrobial compositions and eyewear

Also Published As

Publication number Publication date
DE102011102636B3 (de) 2012-11-22

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