WO2012154018A1 - Zéolite activé et micronisée, procédé permettant son activation et sa micronisation et utilisation de celle-ci en tant qu'exicipient dans des préparations pharmaceutiques et des compléments alimentaires - Google Patents

Zéolite activé et micronisée, procédé permettant son activation et sa micronisation et utilisation de celle-ci en tant qu'exicipient dans des préparations pharmaceutiques et des compléments alimentaires Download PDF

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Publication number
WO2012154018A1
WO2012154018A1 PCT/MX2011/000053 MX2011000053W WO2012154018A1 WO 2012154018 A1 WO2012154018 A1 WO 2012154018A1 MX 2011000053 W MX2011000053 W MX 2011000053W WO 2012154018 A1 WO2012154018 A1 WO 2012154018A1
Authority
WO
WIPO (PCT)
Prior art keywords
activated
micronized
zeolite
natural zeolite
carrier
Prior art date
Application number
PCT/MX2011/000053
Other languages
English (en)
Spanish (es)
Inventor
Javier Isaías ALANÍS ORTEGA
Original Assignee
Alanis Ortega Javier Isaias
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alanis Ortega Javier Isaias filed Critical Alanis Ortega Javier Isaias
Priority to PCT/MX2011/000053 priority Critical patent/WO2012154018A1/fr
Priority to MX2012005979A priority patent/MX351668B/es
Priority to MX2013005263A priority patent/MX364313B/es
Priority to PCT/MX2012/000020 priority patent/WO2012154019A1/fr
Publication of WO2012154018A1 publication Critical patent/WO2012154018A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/70—Fixation, conservation, or encapsulation of flavouring agents
    • A23L27/77—Use of inorganic solid carriers, e.g. silica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/45—Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry

Definitions

  • the invention relates to a natural activated and micronized zeolite and its use as a carrier of herbal, fruit extracts, vitamins, organic and synthetic molecules and animal derivatives.
  • the activated and micronized natural zeolite has a particle size of 1 to 15 microns and a surface area of 20 to 30 m2 / g.
  • natural zeolite is not mentioned at any time activated and micronized as carrier of herbal, fruit, vitamins, organic and synthetic molecules and animal derivatives etc. nor is a particle size of 1 to 15 microns mentioned, nor a surface area of 20 to 30 m2 / g; nor is a tribochemical reaction process treated in a high intensity dry turbo mixer treated and a tribochemical reaction process treated in a wet condition in a multiple colloid mill.
  • the erythromycin charge was carried out by evaporation of a solution of erythromycin in ethanol, in which the micronized carrier had previously been dispersed and loaded with zinc.
  • this patent exclusively describes the use of chemically activated zeolites with zinc and loaded with erythromycin for the preparation of pharmaceutical compositions for topical application.
  • U.S. Patent No. 20090098208 describes synthetic zeolites from the group of faujasites of type X or ALSX, which are used in pharmaceutical compositions as carriers for pharmacologically active molecules such as: diclofenac, ketorolac, ibopruphene, naproxen, ketoprofen and comprising:
  • An activation treatment comprising heating the synthetic zeolite X or ALSX at a temperature of 200 to 600 ° C.
  • the loading of the synthetic zeolites X or ALSX with the pharmacologically active molecules is effected by impregnating the zeolites with solutions of these molecules in one or more solvents and the subsequent evaporation of the solvent (s).
  • the impregnation is effected by dispersion under stirring at a temperature of 25 to 30 ° C for a time of 36 to 48 hours.
  • this patent exclusively describes the use of zeolites Synthetic X or ALSX as carriers for pharmacologically active molecules such as: diclofenac, ketorolac, ibopteur, naproxen, ketoprofen, etc.
  • zeolites Synthetic X or ALSX are carriers for pharmacologically active molecules such as: diclofenac, ketorolac, ibopteur, naproxen, ketoprofen, etc.
  • the activated and micronized natural zeolite mentioned as a carrier of herbal extracts, fruit, vitamins, organic and synthetic molecules and animal derivatives, etc .; nor is a particle size of 1 to 15 microns mentioned, nor a surface area of 20 to 30 m2 / g; nor is a tribochemical reaction process treated in a high intensity dry turbo mixer treated and a tribochemical reaction process treated in a wet condition in a multiple colloid mill.
  • the invention relates to an activated and micronized natural zeolite and its use as a carrier of herbal, fruit extracts, vitamins, organic and synthetic molecules and animal derivatives and its application in pharmaceutical preparations and food supplements comprising: a) .- Micronization of the natural zeolite,
  • the invention relates to an activated and micronized natural zeolite and its use as a carrier of herbal, fruit, vitamin, organic and synthetic extracts and derived from animals selected from: Standardized herbal extracts of: Echinacea, Ginkgo biloba, Astragalus, Nettle, Te green, etc .; Standardized fruit extracts of: Blackberry, grape seed, red raspberry, plum, cherry, strawberry, lycopene, etc .; Vitamins: A, B1, B2, B6, B8, B12, C, D3, E, etc .; Organic molecules: Amino acids, etc. Synthetic molecules: PEAK ATP® (5 'adenosine triphosphate) Animal derivatives: Royal jelly, propolis, bovine colostrum, whey protein, etc. and his Application in pharmaceutical preparations and food supplements comprising:
  • the natural zeolite is micronized in a micronizer mill, whose rotors are propelled at high revolutions and countercurrent, conditions that are desirable for a fine grinding of the material. Subsequently, the micronized material is classified by means of a turbo classifier until a particle size of 1 to 15 microns and a surface area of 20 to 30 m2 / g is obtained.
  • a natural zeolite of the clinoptilolite / heulandite type was used with the following composition:
  • AI203 1 1.50 to 13.50%
  • the final product obtained through the tribochemical process shows a homogeneous powder of a "zeolite” with herbal extracts, fruit, vitamins, organic and synthetic molecules and animal derivatives, encapsulated within the pores of the activated zeolite and micronized and / or in its surface
  • the tribochemical reaction is carried out by means of the turbo mixing of the components at a speed of 3500 rpm for 15 minutes.
  • the final product obtained through the tribochemical process shows a homogeneous suspension of a "zeolite” with herbal extracts, fruit, vitamins, organic and synthetic molecules and animal derivatives, encapsulated within the pores of the activated zeolite and micronized and / or on its surface.
  • the main advantage of the process of the invention is that a pharmaceutical preparation and / or nutritional supplement can be obtained with the encapsulated assets and / or on the surface of the zeolite quickly and effectively.
  • the conditions in the turbo mixer and in the multiple colloid mill provide good contact between herbal, fruit extracts, vitamins, organic and synthetic molecules and animal derivatives and the interchangeable cations in the hydration zone that begin the chemical reaction of the mineral, forming a zeolite with assets encapsulated within the pores of the activated and micronized zeolite and / or on its surface.
  • the high intensity mechanical energy released by the turbo mixer and the multiple colloid mill activates layers of hydrated molecules of water around the exchangeable cation, promoting good Conditions for the chemical reaction between activated and micronized zeolite and herbal, fruit, vitamin, organic and synthetic molecules and animal derivatives.
  • ZAM activated and micronized zeolite

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Microbiology (AREA)
  • Nutrition Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Food Science & Technology (AREA)
  • Mycology (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Fertilizers (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

L'invention concerne une zéolite naturelle activée et micronisée et son utilisation en tant qu'excipient d'extraits de plantes, de fruits, de vitamines, de molécules organiques et de synthèse et de dérivés d'origines animales et leur application dans des préparations pharmaceutiques et des compléments alimentaires. En particulier, l'invention concerne une zéolite naturelle activée et micronisée présentant une taille de particule comprise entre 1 et 15 microns, une surface utile de 20 à 30 m2/g et une activation thermique à une température comprise entre 250°C et 400°C pendant 2 à 4 heures. En outre, la charge des extraits de plantes, de fruits, de vitamines, de molécules organiques et de synthèse et celle des dérivés d'origines animales, encapsulés dans les pores de la zéolite activée et micronisée et/ou sur sa surface est exécutée par un processus de réaction tribochimique mis en oeuvre dans un turbo-mélangeur de haute intensité par voie sèche et/ou par un processus de réaction tribochimique mis en oeuvre par voie humide dans un moulin colloïdal. L'excipient selon la présente invention peut être utilisé pour l'élaboration de préparations pharmaceutiques et de compléments alimentaires sous forme de comprimés, de capsules dures, de capsules molles, de suspensions, etc.
PCT/MX2011/000053 2011-05-11 2011-05-11 Zéolite activé et micronisée, procédé permettant son activation et sa micronisation et utilisation de celle-ci en tant qu'exicipient dans des préparations pharmaceutiques et des compléments alimentaires WO2012154018A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
PCT/MX2011/000053 WO2012154018A1 (fr) 2011-05-11 2011-05-11 Zéolite activé et micronisée, procédé permettant son activation et sa micronisation et utilisation de celle-ci en tant qu'exicipient dans des préparations pharmaceutiques et des compléments alimentaires
MX2012005979A MX351668B (es) 2011-05-11 2012-01-27 Zeolitica activada y micronizada, proceso para su activacion y micronizacion y su utilizacion como acarreador en preparaciones farmaceuticas y suplementos alimenticios.
MX2013005263A MX364313B (es) 2011-05-11 2012-02-23 Suspensión de zeolita micronizada, proceso para su preparación y su utilización como acarreador en preparaciones agrícolas.
PCT/MX2012/000020 WO2012154019A1 (fr) 2011-05-11 2012-02-23 Suspension de zéolite micronisée, procédé permettant de la préparer et de l'utiliser en tant qu'excipient dans des préparations agricoles

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/MX2011/000053 WO2012154018A1 (fr) 2011-05-11 2011-05-11 Zéolite activé et micronisée, procédé permettant son activation et sa micronisation et utilisation de celle-ci en tant qu'exicipient dans des préparations pharmaceutiques et des compléments alimentaires

Publications (1)

Publication Number Publication Date
WO2012154018A1 true WO2012154018A1 (fr) 2012-11-15

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/MX2011/000053 WO2012154018A1 (fr) 2011-05-11 2011-05-11 Zéolite activé et micronisée, procédé permettant son activation et sa micronisation et utilisation de celle-ci en tant qu'exicipient dans des préparations pharmaceutiques et des compléments alimentaires
PCT/MX2012/000020 WO2012154019A1 (fr) 2011-05-11 2012-02-23 Suspension de zéolite micronisée, procédé permettant de la préparer et de l'utiliser en tant qu'excipient dans des préparations agricoles

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/MX2012/000020 WO2012154019A1 (fr) 2011-05-11 2012-02-23 Suspension de zéolite micronisée, procédé permettant de la préparer et de l'utiliser en tant qu'excipient dans des préparations agricoles

Country Status (2)

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MX (2) MX351668B (fr)
WO (2) WO2012154018A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015076652A1 (fr) * 2013-11-21 2015-05-28 Alanís Ortega Javier Isaías Zéolite activée et micronisée, son procédé de préparation et son utlisation en tant que modulateur du stress oxydatif et détoxifiant

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102976867B (zh) * 2012-12-17 2016-01-20 北京清迈华清控股(集团)有限公司 磁化高硅铁尾矿复合土壤修复肥的生产方法及产品
CN107793196A (zh) * 2016-08-30 2018-03-13 苏州丰倍生物科技有限公司 一种高浓度悬浮水溶肥的制备方法
WO2019241501A1 (fr) * 2018-06-15 2019-12-19 W. R. Grace & Co.-Conn Agent antimousse actif, son procédé de fabrication et formulation de démoussage

Citations (2)

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Publication number Priority date Publication date Assignee Title
US20050031708A1 (en) * 2003-08-06 2005-02-10 Portney Micah S. Composition comprising a zeolite compound for treatment of diseases
WO2010018418A1 (fr) * 2008-08-12 2010-02-18 Novatech D.O.O. Formulation à base de clinoptilolite micronisée utilisée en tant qu’agent thérapeutique produisant un silicium extrêmement biodisponible

Family Cites Families (3)

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Publication number Priority date Publication date Assignee Title
JP4073001B2 (ja) * 2002-03-27 2008-04-09 クミアイ化学工業株式会社 顆粒状水和剤
EP1720957A4 (fr) * 2004-02-09 2011-07-06 Ballance Agri Nutrients Ltd Compositions d'engrais
EP2442643A4 (fr) * 2009-06-17 2014-08-06 Isp Investments Inc Procédé de préparation de substances actives biocides stables, microencapsulées et à libération lente et composition apparentée

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050031708A1 (en) * 2003-08-06 2005-02-10 Portney Micah S. Composition comprising a zeolite compound for treatment of diseases
WO2010018418A1 (fr) * 2008-08-12 2010-02-18 Novatech D.O.O. Formulation à base de clinoptilolite micronisée utilisée en tant qu’agent thérapeutique produisant un silicium extrêmement biodisponible

Non-Patent Citations (2)

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Title
A. RIVERA ET AL.: "Preliminary characterization of drug support systems based on natural clinoptilolite", MICROPOROUS AND MESOPOROUS MATERIALS., vol. 61, 2003, pages 249 - 259 *
SELDA GOKTAS ET AL.: "Clinoptilolite-rich mineral as a novel carrier for the active constituents present in Ginkgo biloba leaf extract", APPLIED CLAY SCIENCE, vol. 40, 5 July 2007 (2007-07-05), pages 6 - 14 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015076652A1 (fr) * 2013-11-21 2015-05-28 Alanís Ortega Javier Isaías Zéolite activée et micronisée, son procédé de préparation et son utlisation en tant que modulateur du stress oxydatif et détoxifiant

Also Published As

Publication number Publication date
MX364313B (es) 2019-04-17
MX351668B (es) 2017-10-24
MX2012005979A (es) 2012-10-29
WO2012154019A1 (fr) 2012-11-15
MX2013005263A (es) 2013-06-28

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