WO2012150408A1 - Method for marking a small-volume single-dose container, and container thus marked - Google Patents

Method for marking a small-volume single-dose container, and container thus marked Download PDF

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Publication number
WO2012150408A1
WO2012150408A1 PCT/FR2012/050961 FR2012050961W WO2012150408A1 WO 2012150408 A1 WO2012150408 A1 WO 2012150408A1 FR 2012050961 W FR2012050961 W FR 2012050961W WO 2012150408 A1 WO2012150408 A1 WO 2012150408A1
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WO
WIPO (PCT)
Prior art keywords
marking
label
foot
vial
container
Prior art date
Application number
PCT/FR2012/050961
Other languages
French (fr)
Inventor
Patrick Colin
Original Assignee
Unither Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unither Pharmaceuticals filed Critical Unither Pharmaceuticals
Priority to ES12725074.4T priority Critical patent/ES2611677T3/en
Priority to US14/115,145 priority patent/US20140069839A1/en
Priority to JP2014508858A priority patent/JP2014515687A/en
Priority to EP12725074.4A priority patent/EP2704955B1/en
Publication of WO2012150408A1 publication Critical patent/WO2012150408A1/en

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D25/00—Details of other kinds or types of rigid or semi-rigid containers
    • B65D25/34—Coverings or external coatings
    • B65D25/36—Coverings or external coatings formed by applying sheet material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/06—Ampoules or carpules
    • A61J1/067—Flexible ampoules, the contents of which are expelled by squeezing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D1/00—Containers having bodies formed in one piece, e.g. by casting metallic material, by moulding plastics, by blowing vitreous material, by throwing ceramic material, by moulding pulped fibrous material, by deep-drawing operations performed on sheet material
    • B65D1/09—Ampoules
    • B65D1/095—Ampoules made of flexible material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J2205/00—General identification or selection means
    • A61J2205/30—Printed labels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2203/00—Decoration means, markings, information elements, contents indicators
    • B65D2203/02—Labels
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
    • Y10T156/10—Methods of surface bonding and/or assembly therefor

Definitions

  • the present invention relates to a method of marking a single - dose container of small capacity.
  • the invention also covers the container thus marked.
  • low volume single dose container means a container intended to contain volumes of the order of 0.1 to 5.0 ml.
  • the fact of using single dose vials allows to have a sterile product, effective for each application on the same patient or for treatments of different patients without transmitting anything and ensuring the effectiveness of the active ingredient.
  • each vial allows to deliver the product contained therein in small quantities, precisely because of a suitable form of said vials which comprise a generally conical neck and a very small diameter orifice.
  • the opening is obtained by removing a shutter, generally welded, very easily, thanks to a rotation of said shutter relative to the body of the container.
  • This shutter is thus very resistant to accidental pulling and can be easily removed. It is also noted that these containers, because of their very small volume, retain by the play of capillarity phenomena, the liquid in the body of the container when it is fluid and all the more so that the fluid is viscous.
  • the user must exert a slight pressure on the body of the vial to release the product and adjust exactly the moment of said release.
  • vials are manufactured in line and in large numbers and are generally presented in batches of juxtaposed jars and linked together detachably by their sides.
  • the first is the seizure of the container with the fingers which is delicate, especially with adult fingers and especially as these fingers will be big.
  • this tab offers another advantage relative to marking.
  • the body of the container is generally with more or less curved shapes that make it difficult to affix a label.
  • the tongue thus added can be reported by welding during the manufacture of the vial or come from manufacture with the vial by flattening the faces to form a flat tongue, arranged in the extension of the body of the vial, in the lower part.
  • the vials can receive a label reported by gluing for example.
  • This label can therefore bear a logo, a mark, a product identification.
  • marking with ink by means of a print head.
  • the marking is affixed to the tongue, on the opposite side of the one carrying the label.
  • This arrangement has a disadvantage, that of subjecting the marking to external aggressions such as contact with liquids, especially moisture, temperature variations, mechanical friction, for example the friction of the fingers and therefore the risk of erasure at least partial marking.
  • the present invention relates to a marking method which makes it possible to overcome the problems raised by the products of the prior art and ensures a reading of the marked information as well as the necessary durability.
  • FIG. 1 a perspective view of a set of vials according to the invention
  • FIG. 2A a perspective view of a vial according to the present invention, after marking and before affixing a label, marking side,
  • FIG. 2B a perspective view of a vial according to the present invention, after marking, before affixing a label, opposite side to the marking,
  • FIG. 3A a perspective view of a vial according to the present invention, after marking and after affixing a label, marking side,
  • FIG. 3B a perspective view of a vial according to the present invention after marking, after affixing the label, opposite side marking.
  • FIG. 1 shows vials 10 according to the present invention, generally made by extrusion blowing, filling in a parade and filling, in a sterile environment when the product requires it.
  • the method and the device being known, the description is not more exemplified.
  • the flasks are generally presented in strips as in Figure 1 comprising several flasks.
  • each vial comprises a foot 12, a body 14 and a head 16.
  • the foot 12 forms a tongue and generally results from hot plating of the walls of the container so as to produce a surface, in this case flat, rectangular, of a thickness substantially equal to twice the thickness of the wall of the container. containing or of a smaller thickness depending on the initial volume used and the area generated from this volume.
  • These vials 10 are bonded to form a strip 18, in this case they are bonded at their sides by connecting means 20.
  • These connecting means 20 are adapted to make the connection detachable by breaking the link to the right of the connecting means, thus allowing to take one of the end vials, the remaining remaining connected.
  • the body 14, of small volume, is hollow to receive the product 22, in the form of liquid, gel or solution, for example.
  • the volume is preferably adapted to the general shape of the container and it is found that the geometry of the body is a little flattened in the embodiment shown.
  • the head 16 is manufactured after filling and results from a hot deformation of the upper part of the container.
  • This head 16 has a neck 24, a cap 26 and a weakening point 28 between the two to ensure easy removal of said head and to access the product.
  • This weakening point 28 is broken, often by rotating the cap 26 relative to the neck 24.
  • the neck is then opened to the right of the point of weakness and allows the flow of the product by inverting the vial and generally by pressure on the body because the liquid can be retained by capillarity in said body due to the small volume and the small diameter of the outlet orifice.
  • the vial 10 is held by the user by his foot 12.
  • a marking 30 of the type corresponding to the expiry date, at the date of manufacture, is provided. to the lot number.
  • This marking is carried out on the front face for example by a commercial inkjet printing head, the ink preferably being an ink in an aqueous medium.
  • the marking is ensured parade on the pallet constituted by the foot of the vial.
  • the marking which is made on the front face is a mirror marking that is to say with characters such that they would appear in a mirror from a normal writing.
  • the material used is generally polypropylene or polyethylene which both have the property of being transparent or at least translucent.
  • FIG. 2B it can be seen that the back side of the tongue constituted by the foot 12 makes the marking appear transparent and is directly readable, writing at the point, making it possible to immediately apprehend the information.
  • the vial 10 is shown with its marking 30 but the front face has received a label 32 which masks the marking and covers it, thus ensuring its protection against mechanical aggression or moisture or contact with liquids such as water and UV radiation exposures that may degrade V marking ink.
  • These labels are generally also made in polymeric materials such as polyethylene so that these labels are very mechanically resistant, resistant to moisture and the adhesive that allows adhesion on the foot of the vial is very strongly adhesive. These labels are therefore preferably made of a material comprising a high tack polymer.
  • the label is also of interest for enhancing readability.
  • the background of the labels is generally opaque, white so that the marking 30, usually black, is all the more readable.
  • the label bears indications which are also useful but the marking is made in a printing machine with suitable inks and a possibility of polymerization by heat or UV, which makes these prints very resistant to both wear and tear. in general, any degradation by moisture or friction.
  • the content of the label literature does not pose the same problem as that of vial labeling and degradation is not a problem, at least under the normal conditions of use of these generally pharmaceutical or cosmetic products.
  • the method of marking a vial comprising a foot 12, a body 14 and a head 16, said tongue - shaped foot with two faces, one of these faces receiving a label 32 is characterized in that one affixes a marking 30 on the face of the foot 12 receiving the label, prior to the affixation of said label and in that the label is affixed to said face, covering said marking, once it has been done.
  • Said writing in the method according to the invention consists more particularly of affixing the mirror marking on the face which bears the label.

Abstract

The invention relates to a method for marking a vial made from a material that is transparent or at least translucent, intended, in particular, for pharmaceutical and/or cosmetic use. The container comprises a foot (12), a body (14) and a head (16), said foot taking the form of a tongue having two faces, one of which receives a label (32). The container is characterized in that a mark (30) is made on the face of the foot (12) that receives the label, prior to the affixing of the label, and in that the label is affixed to the face once the mark has been made, such that the label covers the mark.

Description

PROCEDE DE MARQUAGE D'UN CONTENANT UNIDOSE DE FAIBLE VOLUME, CONTENANT AINSI MARQUE  PROCESS FOR MARKING A LOW VOLUME UNIDOSE CONTAINER, CONTAINING THE SAME
La présente invention concerne un procédé de marquage d' un contenant unidose de faible contenance. The present invention relates to a method of marking a single - dose container of small capacity.
L' invention couvre aussi le contenant ainsi marqué.  The invention also covers the container thus marked.
On entend par contenant unidose de faible volume, un contenant destiné à contenir des volumes de l 'ordre de 0,1 à 5,0 ml.  The term "low volume single dose container" means a container intended to contain volumes of the order of 0.1 to 5.0 ml.
Ces contenants appelés également fioles sont donc à usage unique. Le faible volume permet de ne pas gaspiller de produit actif. En effet, certains produits se dégradent au contact de l 'air et peuvent être pollués après ouverture ou lors de l 'utilisation.  These containers, also called vials, are therefore for single use only. The small volume makes it possible not to waste active product. Indeed, some products degrade in contact with air and can be polluted after opening or during use.
Aussi, le fait d'utiliser des fioles unidoses permet de disposer d' un produit stérile, efficace pour chaque application sur un même patient ou pour des traitements de différents patients sans transmettre quoi que ce soit et en garantissant l 'efficacité du principe actif. Also, the fact of using single dose vials allows to have a sterile product, effective for each application on the same patient or for treatments of different patients without transmitting anything and ensuring the effectiveness of the active ingredient.
De plus, la manipulation est simple car chaque fiole permet de délivrer du produit qui y est contenu en petites quantités, avec précision du fait d'une forme adaptée desdites fioles qui comprennent un col de forme conique généralement et un orifice de très faible diamètre.  In addition, the handling is simple because each vial allows to deliver the product contained therein in small quantities, precisely because of a suitable form of said vials which comprise a generally conical neck and a very small diameter orifice.
L'ouverture est obtenue par retrait d'un obturateur, généralement soudé, de façon très aisée, grâce à une rotation dudit obturateur par rapport au corps du contenant. Cet obturateur est ainsi très résistant à l'arrachage accidentel et peut être retiré facilement. On note aussi que ces contenants, du fait de leur très faible volume, retiennent par le jeu des phénomènes de capillarité, le liquide dans le corps du contenant lorsque celui-ci est fluide et ce d'autant plus que le fluide est visqueux. The opening is obtained by removing a shutter, generally welded, very easily, thanks to a rotation of said shutter relative to the body of the container. This shutter is thus very resistant to accidental pulling and can be easily removed. It is also noted that these containers, because of their very small volume, retain by the play of capillarity phenomena, the liquid in the body of the container when it is fluid and all the more so that the fluid is viscous.
L'utilisateur doit exercer une légère pression sur le corps de la fiole pour libérer le produit et ajuster exactement le moment de ladite libération. The user must exert a slight pressure on the body of the vial to release the product and adjust exactly the moment of said release.
Les applications sont nombreuses par exemple pour: The applications are numerous for example for:
- des collyres  - eye drops
- des produits en rhinologie,  - products in rhinology,
- du sérum physiologique,  physiological saline,
- des antiseptiques,  - antiseptics,
- des produits pour le traitement de l 'asthme,  - products for the treatment of asthma,
- des produits cosmétiques.  - cosmetics
Ces fioles sont fabriquées en ligne et en très grand nombre et sont généralement présentées par lots de fioles juxtaposées et liées entre elles de façon détachable par leur côtés.  These vials are manufactured in line and in large numbers and are generally presented in batches of juxtaposed jars and linked together detachably by their sides.
Du fait du très faible volume de telles fioles, on comprend aussi que cela engendre des contraintes.  Because of the very small volume of such vials, it is also understood that this generates constraints.
La première est la saisie du contenant avec les doigts qui est délicate, surtout avec des doigts adultes et d'autant plus que ces doigts seront gros.  The first is the seizure of the container with the fingers which is delicate, especially with adult fingers and especially as these fingers will be big.
Aussi, il a été imaginé d'adjoindre au corps de la fiole une languette en partie inférieure pour augmenter dimensionnellement la taille du contenant unidose sans pour autant augmenter le volume utile. Also, it has been imagined to add to the body of the vial a tab in the lower part to dimensionally increase the size of the single dose container without increasing the useful volume.
En plus d'améliorer grandement la préhension et la manipulation, cette languette offre un autre avantage relatif au marquage.  In addition to greatly improving the grip and handling, this tab offers another advantage relative to marking.
En effet, le corps du contenant est généralement avec des formes plus ou moins courbes qui rendent difficile l 'apposition d'une étiquette. Indeed, the body of the container is generally with more or less curved shapes that make it difficult to affix a label.
La languette ainsi ajoutée peut être rapportée par soudage au cours de la fabrication de la fiole ou venue de fabrication avec la fiole par aplatissage des faces afin de constituer une languette plate, disposée dans le prolongement du corps de la fiole, en partie inférieure. The tongue thus added can be reported by welding during the manufacture of the vial or come from manufacture with the vial by flattening the faces to form a flat tongue, arranged in the extension of the body of the vial, in the lower part.
Ainsi, les fioles peuvent recevoir une étiquette rapportée par collage par exemple.  Thus, the vials can receive a label reported by gluing for example.
Cette étiquette peut donc porter un logo, une marque, une identification de produit. This label can therefore bear a logo, a mark, a product identification.
Néanmoins, il subsiste un problème, celui du marquage, en cours de fabrication sur la chaîne de production, d' informations liées à la production même c'est-à- dire le numéro de lot, la date de fabrication, la date de péremption pour ne citer que ces informations.  Nevertheless, there remains a problem, that of marking, during production on the production line, information related to the production itself, that is to say the batch number, the date of manufacture, the expiry date. to name just this information.
Or ces informations doivent être marquées au défilé sur les contenants.  However, this information must be marked on parade containers.
Il existe plusieurs méthodes de marquage mais la plus simple et la plus répandue est le marquage à l 'encre au moyen d' une tête d' impression. Le marquage est apposé sur la languette, sur la face opposée de celle qui porte l 'étiquette. There are several methods of marking but the simplest and most widespread is the marking with ink by means of a print head. The marking is affixed to the tongue, on the opposite side of the one carrying the label.
Ainsi, dans les agencements de l'art antérieur, on dispose d'une fiole qui est équipée d'une prolongation sous forme d'une languette dont l' une des faces porte une étiquette et l 'autre face porte un marquage directement lisible, imprimé à l'endroit. Thus, in the arrangements of the prior art, there is a vial which is equipped with an extension in the form of a tongue, one of whose faces bears a label and the other side bears a directly readable marking, printed on the spot.
Cet agencement présente un inconvénient, celui de soumettre le marquage aux agressions extérieures telles que contact avec des liquides, notamment l' humidité, aux variations de température, aux frottements mécaniques, par exemple le frottement des doigts et donc aux risques d'effacement au moins partiel du marquage.  This arrangement has a disadvantage, that of subjecting the marking to external aggressions such as contact with liquids, especially moisture, temperature variations, mechanical friction, for example the friction of the fingers and therefore the risk of erasure at least partial marking.
Or il convient de garantir la pérennité du marquage puisque sans l ' information, le contenu de la fiole ne doit pas être utilisé. Le problème est d'autant plus important lorsque les fioles contiennent des liquides à longue date de péremption laissant d'autant plus d'occasions de conduire à une dégradation dudit marquage. La présente invention concerne un procédé de marquage qui permet de pallier les problèmes soulevés par les produits de l 'art antérieur et assure une lecture des informations marquées ainsi que la pérennisé nécessaire. However, it is necessary to guarantee the durability of the marking since without the information, the contents of the vial must not be used. The problem is all the more important when the vials contain liquids with a long shelf life, leaving all the more opportunities to lead to a degradation of said marking. The present invention relates to a marking method which makes it possible to overcome the problems raised by the products of the prior art and ensures a reading of the marked information as well as the necessary durability.
L' invention est maintenant décrite en détail suivant un mode de réalisation particulier, non limitatif, ceci en regard de dessins explicatifs sur lesquels les différentes figures représentent :  The invention is now described in detail according to a particular, non-limiting embodiment, with reference to explanatory drawings in which the different figures represent:
- Figure 1 : une vue en perspective d'un ensemble de fioles selon l ' invention, - Figure 1: a perspective view of a set of vials according to the invention,
- Figure 2A : une vue en perspective d'une fiole selon la présen e invention, après marquage et avant apposition d'étiquette, côté marquage, 2A: a perspective view of a vial according to the present invention, after marking and before affixing a label, marking side,
- Figure 2B : une vue en perspective d'une fiole selon la présente invention, après marquage, avant apposition d'étiquette, côté opposé au marquage, FIG. 2B: a perspective view of a vial according to the present invention, after marking, before affixing a label, opposite side to the marking,
- Figure 3 A : une vue en perspective d'une fiole selon la présente invention, après marquage et après apposition d'étiquette, côté marquage, FIG. 3A: a perspective view of a vial according to the present invention, after marking and after affixing a label, marking side,
- Figure 3B : une vue en perspective d'une fiole selon la présente invention, après marquage, après apposition d'étiquette, côté opposé au marquage. - Figure 3B: a perspective view of a vial according to the present invention after marking, after affixing the label, opposite side marking.
Sur la figure 1, on a représenté des fioles 10 selon la présente invention, généralement réalisées par extrusion soufflage, remplissage au défilé et obturation à la suite, en ambiance stérile lorsque le produit le nécessite. Le procédé et le dispositif étant connus, la description n'est pas plus exemplif iée. Les fioles sont généralement présentées en bande comme sur la figure 1 comportant plusieurs fioles. FIG. 1 shows vials 10 according to the present invention, generally made by extrusion blowing, filling in a parade and filling, in a sterile environment when the product requires it. The method and the device being known, the description is not more exemplified. The flasks are generally presented in strips as in Figure 1 comprising several flasks.
Comme montré sur les figures 2A, 2B, 3A et 3B, chaque fiole comprend un pied 12, un corps 14 et une tête 16.  As shown in FIGS. 2A, 2B, 3A and 3B, each vial comprises a foot 12, a body 14 and a head 16.
Le pied 12 forme une languette et résulte généralement d'un placage à chaud des parois du contenant de façon à réaliser une surface, en l'occurrence plane, rectangulaire, d'une épaisseur égale sensiblement au double de l 'épaisseur de la paroi du contenant ou d'une épaisseur plus réduite en fonction du volume initial utilisé et de la surface générée à partir de ce volume. Ces fioles 10 sont liées pour former une bande 18, en l 'occurrence elles sont liées par leurs côtés, par des moyens 20 de liaison. The foot 12 forms a tongue and generally results from hot plating of the walls of the container so as to produce a surface, in this case flat, rectangular, of a thickness substantially equal to twice the thickness of the wall of the container. containing or of a smaller thickness depending on the initial volume used and the area generated from this volume. These vials 10 are bonded to form a strip 18, in this case they are bonded at their sides by connecting means 20.
Ces moyens 20 de liaison sont adaptés pour rendre la liaison détachable, par rupture du lien au droit des moyens de liaison, permettant ainsi de prélever une des fioles d'extrémité, les autres restant liées.  These connecting means 20 are adapted to make the connection detachable by breaking the link to the right of the connecting means, thus allowing to take one of the end vials, the remaining remaining connected.
Le corps 14, de faible volume, est creux pour recevoir le produit 22, sous forme de liquide, de gel ou de solution par exemple.  The body 14, of small volume, is hollow to receive the product 22, in the form of liquid, gel or solution, for example.
Le volume est, de préférence, adapté à la forme générale du contenant et on constate que la géométrie du corps est un peu aplatie, dans le mode de réalisation représenté.  The volume is preferably adapted to the general shape of the container and it is found that the geometry of the body is a little flattened in the embodiment shown.
La tête 16 est venue de fabrication après remplissage et résulte d'une déformation à chaud de la partie supérieure du contenant.  The head 16 is manufactured after filling and results from a hot deformation of the upper part of the container.
Cette tête 16 comporte un col 24, un capuchon 26 et un point 28 de fragilisation entre les deux pour assurer un retrait aisé de ladite tête et pour accéder au produit. Ce point 28 de fragilisation est cassé, souvent par rotation du capuchon 26 par rapport au col 24. Le col est alors ouvert au droit du point de fragilisation et autorise l 'écoulement du produit par renversement de la fiole et généralement par pression sur le corps car le liquide peut être retenu par capillarité dans ledit corps du fait du faible volume et du faible diamètre de l'orifice de sortie.  This head 16 has a neck 24, a cap 26 and a weakening point 28 between the two to ensure easy removal of said head and to access the product. This weakening point 28 is broken, often by rotating the cap 26 relative to the neck 24. The neck is then opened to the right of the point of weakness and allows the flow of the product by inverting the vial and generally by pressure on the body because the liquid can be retained by capillarity in said body due to the small volume and the small diameter of the outlet orifice.
Durant cette opération, la fiole 10 est tenue par l 'utilisateur par son pied 12. Sur ce pied 12, comme montré sur la figure 2A, on assure un marquage 30 du type correspondant à la date de péremption, à la date de fabrication, au numéro de lot.  During this operation, the vial 10 is held by the user by his foot 12. On this foot 12, as shown in FIG. 2A, a marking 30 of the type corresponding to the expiry date, at the date of manufacture, is provided. to the lot number.
Ce marquage est réalisé sur la face recto par exemple par une tête d' impression à jet d'encre, de type du commerce, l 'encre étant de préférence une encre en milieu aqueux. La marquage est donc assuré au défilé sur la palette constituée par le pied de la fiole. This marking is carried out on the front face for example by a commercial inkjet printing head, the ink preferably being an ink in an aqueous medium. The marking is ensured parade on the pallet constituted by the foot of the vial.
On note que le marquage qui est réalisé sur la face recto est un marquage miroir c'est-à-dire avec des caractères tels qu' ils se présenteraient dans un miroir à partir d'une écriture normale.  It is noted that the marking which is made on the front face is a mirror marking that is to say with characters such that they would appear in a mirror from a normal writing.
On note que la matériau utilisé est généralement du polypropylène ou du polyéthylène qui ont tous deux la propriété d'être transparents ou du moins translucides.  It is noted that the material used is generally polypropylene or polyethylene which both have the property of being transparent or at least translucent.
Sur cette face recto, l 'utilisateur aurait du mal à lire le marquage ou du moins à déterminer immédiatement le contenu des informations portées.  On this front face, the user would have difficulty reading the marking or at least immediately determine the content of the information carried.
Par contre, sur la figure 2B, on constate que la face verso de la languette constituée du pied 12, fait apparaître en transparence le marquage et se trouve directement lisible, écriture à l 'endroit, permettant d'appréhender immédiatement les informations.  On the other hand, in FIG. 2B, it can be seen that the back side of the tongue constituted by the foot 12 makes the marking appear transparent and is directly readable, writing at the point, making it possible to immediately apprehend the information.
Sur la figure 3 A, on a représenté la fiole 10 avec son marquage 30 mais la face recto a reçu une étiquette 32 qui masque le marquage et le recouvre, assurant ainsi sa protection contre les agressions mécaniques ou l ' humidité ou le contact avec des liquides comme de l 'eau et les expositions aux rayonnements UV susceptibles de dégrader V encre du marquage. In FIG. 3A, the vial 10 is shown with its marking 30 but the front face has received a label 32 which masks the marking and covers it, thus ensuring its protection against mechanical aggression or moisture or contact with liquids such as water and UV radiation exposures that may degrade V marking ink.
Ces étiquettes sont généralement réalisées également dans des matériaux polymères comme du polyéthylène si bien que ces étiquettes sont très résistantes mécaniquement, résistantes à l ' humidité et la colle qui permet l'adhésion sur le pied de la fiole est très fortement adhésive. Ces étiquettes sont donc préférentiellement réalisées en un matériau comportant un polymère à forte adhésivité. These labels are generally also made in polymeric materials such as polyethylene so that these labels are very mechanically resistant, resistant to moisture and the adhesive that allows adhesion on the foot of the vial is very strongly adhesive. These labels are therefore preferably made of a material comprising a high tack polymer.
On constate aussi un des avantages tirés de la présente invention concernant les éventuelles contrefaçons car si un tiers venait à retirer l 'étiquette du pied en vue d'un reconditionnement ou d'une falsification des informations imprimées, le marquage serait fortement endommagé par le retrait de ladite étiquette. There is also one of the advantages derived from the present invention concerning possible counterfeits because if a third party were to remove the label of the foot in the repackaging or falsification of the printed information, the marking would be strongly damaged by the removal of the said label.
L'étiquette présente également un intérêt pour renforcer la lisibilité. The label is also of interest for enhancing readability.
En effet, le fond des étiquettes est généralement opaque, blanc si bien que le marquage 30, généralement noir, est d'autant plus lisible. Indeed, the background of the labels is generally opaque, white so that the marking 30, usually black, is all the more readable.
L'étiquette porte des mentions qui sont également utiles mais le marquage est fait en machine d' impression avec des encres adaptées et une possibilité de polymérisation par la chaleur ou par les UV, ce qui rend ces impressions très résistantes tant à l' usure que de façon générale à toute dégradation par l' humidité ou par frottement.  The label bears indications which are also useful but the marking is made in a printing machine with suitable inks and a possibility of polymerization by heat or UV, which makes these prints very resistant to both wear and tear. in general, any degradation by moisture or friction.
Aussi, le contenu des écrits des étiquettes ne pose pas le même problème que celui du marquage sur fiole et la dégradation n'est pas un problème, du moins dans les conditions d' utilisation normales de ces produits généralement pharmaceutiques ou cosmétiques.  Also, the content of the label literature does not pose the same problem as that of vial labeling and degradation is not a problem, at least under the normal conditions of use of these generally pharmaceutical or cosmetic products.
Le procédé de marquage d' une fiole comprenant un pied 12, un corps 14 et une tête 16, ledit pied en forme de languette avec deux faces, l' une de ces faces recevant une étiquette 32 est caractérisé en ce que l 'on appose un marquage 30 sur la face du pied 12 recevant l'étiquette, préalablement à l 'apposition de ladite étiquette et en ce que l 'on appose l 'étiquette sur ladite face, en recouvrant ledit marquage, une fois celui-ci effectué. The method of marking a vial comprising a foot 12, a body 14 and a head 16, said tongue - shaped foot with two faces, one of these faces receiving a label 32 is characterized in that one affixes a marking 30 on the face of the foot 12 receiving the label, prior to the affixation of said label and in that the label is affixed to said face, covering said marking, once it has been done.
Ladite écriture dans le procédé selon l' invention consiste plus particulièrement à apposer le marquage en miroir sur la face qui porte l'étiquette.  Said writing in the method according to the invention consists more particularly of affixing the mirror marking on the face which bears the label.

Claims

REVENDICATIONS
1. Procédé de marquage d'une fiole en matériau transparent ou au moins translucide, notamment à visée pharmaceutique et/ou cosmétique, comprenant un pied (12), un corps (14) et une tête (16), ledit pied en forme de languette avec deux faces, l 'une de ces faces recevant une étiquette (32), caractérisé en ce que l'on appose un marquage (30) sur la face du pied (12) recevant l 'étiquette, préalablement à l 'apposition de ladite étiquette et en ce que l 'on appose l'étiquette sur ladite face, en recouvrant ledit marquage, une fois celui-ci effectué. 1. A method of marking a vial of transparent or at least translucent material, especially for pharmaceutical and / or cosmetic purposes, comprising a foot (12), a body (14) and a head (16), said foot in the form of tongue with two faces, one of these faces receiving a label (32), characterized in that a marking (30) is affixed to the face of the foot (12) receiving the label, prior to the affixing of said label and that the label is affixed to said face, covering said marking, once it has been done.
2. Procédé de marquage d'une fiole selon la revendication l,caractérisé en ce que le marquage (30) est réalisé en miroir.  2. A method of marking a vial according to claim 1, characterized in that the marking (30) is carried out in mirror.
3. Procédé de marquage d'une fiole selon la revendication 1 ou 2, caractérisé en ce que le marquage (30) est réalisé par impression d'encre.  3. A method of marking a vial according to claim 1 or 2, characterized in that the marking (30) is achieved by printing ink.
4. Procédé de marquage d' une fiole selon l ' une quelconque des revendications précédentes, caractérisé en ce que l'étiquette est réalisée en un matériau comportant un polymère à forte adhésivité.  4. Process for marking a vial according to any one of the preceding claims, characterized in that the label is made of a material comprising a high tack polymer.
5. Fiole réalisée en matériau polymère transparent ou translucide comprenant un pied (12), un corps (14) et une tête (16), ledit pied en forme de languette avec deux faces, l 'une de ces faces recevant une étiquette (32), caractérisée en ce qu'elle comprend sur l 'une des faces du pied (12) en forme de languette un marquage (30) miroir sur lequel est superposée ladite étiquette, ledit marquage étant lisible à l 'endroit uniquement par transparence sur la face opposée de celle recevant l'étiquette. 5. A vial made of transparent or translucent polymer material comprising a foot (12), a body (14) and a head (16), said tongue-like foot with two faces, one of these faces receiving a label (32). ), characterized in that it comprises on one of the faces of the tongue - shaped foot (12) a mirror marking (30) on which said label is superimposed, said marking being legible at the point only by transparency on the opposite side of the one receiving the label.
6. Fiole réalisée en matériau polymère transparent ou translucide selon la revendication 5, caractérisée en ce que le volume est compris entre 0,1 et 5 millilitres. 6. Vial made of transparent or translucent polymer material according to claim 5, characterized in that the volume is between 0.1 and 5 milliliters.
PCT/FR2012/050961 2011-05-04 2012-04-30 Method for marking a small-volume single-dose container, and container thus marked WO2012150408A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
ES12725074.4T ES2611677T3 (en) 2011-05-04 2012-04-30 Procedure for marking a vial, vial so marked
US14/115,145 US20140069839A1 (en) 2011-05-04 2012-04-30 Method for marking a small-volume single-dose container, and container thus marked
JP2014508858A JP2014515687A (en) 2011-05-04 2012-04-30 How to mark low dose single dose containers, containers marked in that way
EP12725074.4A EP2704955B1 (en) 2011-05-04 2012-04-30 Method for marking a small-volume single-dose container, and container thus marked

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1153786A FR2974755B1 (en) 2011-05-04 2011-05-04 PROCESS FOR MARKING A LOW VOLUME UNIDOSE CONTAINER, CONTAINING THE SAME
FR1153786 2011-05-04

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WO2012150408A1 true WO2012150408A1 (en) 2012-11-08

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EP (1) EP2704955B1 (en)
JP (1) JP2014515687A (en)
ES (1) ES2611677T3 (en)
FR (1) FR2974755B1 (en)
WO (1) WO2012150408A1 (en)

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TWI794137B (en) * 2014-06-17 2023-03-01 美商脫其泰有限責任公司 Affixed groups of pharmaceutical vials including frangible connectors
CN111615409A (en) 2017-11-17 2020-09-01 科斯卡家族有限公司 System and method for fluid delivery manifold
JP7152776B2 (en) * 2019-04-16 2022-10-13 株式会社タカゾノ Method for writing information on medicine packaging device, packaging bag, and packaging material
US20220387256A1 (en) * 2021-06-03 2022-12-08 Kent Byron Vial With Metered Dispenser
USD992110S1 (en) 2021-08-10 2023-07-11 Koska Family Limited Sealed fluid container

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EP2704955B1 (en) 2016-10-26
FR2974755B1 (en) 2014-03-21
ES2611677T3 (en) 2017-05-09
JP2014515687A (en) 2014-07-03
EP2704955A1 (en) 2014-03-12
US20140069839A1 (en) 2014-03-13
FR2974755A1 (en) 2012-11-09

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