WO2012095651A1 - Appareil et méthode d'analyse - Google Patents

Appareil et méthode d'analyse Download PDF

Info

Publication number
WO2012095651A1
WO2012095651A1 PCT/GB2012/050032 GB2012050032W WO2012095651A1 WO 2012095651 A1 WO2012095651 A1 WO 2012095651A1 GB 2012050032 W GB2012050032 W GB 2012050032W WO 2012095651 A1 WO2012095651 A1 WO 2012095651A1
Authority
WO
WIPO (PCT)
Prior art keywords
sample
radiation
integrating sphere
analysis
light
Prior art date
Application number
PCT/GB2012/050032
Other languages
English (en)
Inventor
Christopher Glynn
Original Assignee
Murwillumbah Manufacturing Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Murwillumbah Manufacturing Limited filed Critical Murwillumbah Manufacturing Limited
Publication of WO2012095651A1 publication Critical patent/WO2012095651A1/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/4738—Diffuse reflection, e.g. also for testing fluids, fibrous materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
    • G01N21/51—Scattering, i.e. diffuse reflection within a body or fluid inside a container, e.g. in an ampoule
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
    • G01N21/53—Scattering, i.e. diffuse reflection within a body or fluid within a flowing fluid, e.g. smoke
    • G01N21/532—Scattering, i.e. diffuse reflection within a body or fluid within a flowing fluid, e.g. smoke with measurement of scattering and transmission
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/4738—Diffuse reflection, e.g. also for testing fluids, fibrous materials
    • G01N21/474—Details of optical heads therefor, e.g. using optical fibres
    • G01N2021/4742—Details of optical heads therefor, e.g. using optical fibres comprising optical fibres
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6484—Optical fibres
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G01N21/3581—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using far infrared light; using Terahertz radiation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/065—Integrating spheres
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/12—Circuits of general importance; Signal processing
    • G01N2201/129—Using chemometrical methods

Definitions

  • the present invention relates to an apparatus for analysis and in particular, but not exclusively, to an apparatus for spectral analysis of a sample, whether a liquid, solid or particulate sample and the invention also relates to a method of performing spectral analysis.
  • transmission or reflection spectroscopy analysis by either transmission or reflection spectroscopy.
  • transmission or reflection spectroscopy systems are limited to one or other of transmission or reflection techniques.
  • known reflection spectrum systems use mathematical predictions to determine the transmission spectra based on a statistical prediction of the absorption in the sample.
  • transmission spectrum systems can also mathematically predict the reflection spectra based on a statistical prediction of the reflection at a surface of the sample.
  • numerous assumptions are required in such predictive techniques which could lead to incorrect results for particular sample types.
  • the constitution of the sample or the materials within the sample may be unknown at the time of performing the spectral analysis, in which case statistical prediction becomes more difficult to achieve with any certainty due to the unknown nature of the sample and/or its constituent material.
  • the present invention was devised with the foregoing in mind and seeks to provide a new apparatus for spectral analysis of a liquid sample and a method for performing spectral analysis of a sample.
  • an apparatus for performing analysis of a sample comprising: sample container means, a first integrating sphere, and a second integrating sphere, the first and second integrating spheres and the sample container means being arranged such that the first integrating sphere performs reflectance analysis of the sample, and the second integrating sphere performs transmission analysis of the sample, and preferably the same sample at the same time.
  • the present invention may allow for simultaneous measurement of both diffuse reflection and diffuse transmission for a particular sample which addresses one or more of the above mentioned problems.
  • the present invention may also allow for direct reflectance analysis with diffuse transmission analysis as well as diffuse reflectance analysis with direct transmission analysis.
  • diffuse reflection means that light is reflected from the sample onto the internal surface of the sphere and then reflected from the surface of the sphere.
  • Diffuse transmission means that light transmitted through the sample is transmitted onto the internal surface of the sphere and then reflected from the surface of the sphere,
  • direct reflection means that light is directly reflected from the sample without reflecting from the surface of the sphere.
  • Direct transmission means that transmitted light directly transmitted without reflecting from the surface of the sphere.
  • the first and second integrating spheres each comprise both a light inlet and a light outlet and the light outlet of the first integrating sphere is optically coupled to the light inlet of the second integrating sphere.
  • the invention includes a transparent sample holder, wherein the sample holder is arranged at the outlet of the first integrating sphere and at the inlet of the second integrating sphere.
  • Light directed onto the transparent sample holder is transmitted through the sample hoider to the inlet of the second integrating sphere and the sample holder is arranged between the outlet of the first integrating sphere and the inlet of the second integrating sphere.
  • a fibre-optic cable can be arranged to guide light directly reflected from a sample directly to a detector.
  • a fibre-optic cable can alternatively or in addition also be arranged to guide light transmitted through the sample directly to a detector. It will be appreciated therefore that the converse of this arrangement is also appropriate.
  • the present invention provides an apparatus for performing spectral analysis that can allow for both measurement of diffuse and direct reflectance and transmission simultaneously on the same sample.
  • the present invention provides an apparatus and method which can measure or detect different substances in a sample simultaneously.
  • Light directed into the first integrating sphere can be amoduled Sight wave form or continuous light.
  • pulsed light measurements of reflectance transmission and/or absorption can be initiated at the start of the first pulse or at the end of a pulse, or at a predetermined time after an initialmodule.
  • pulsed light the same amount of light can be used each time a particular type of measurement is made and it is therefore possible to measure the amount of reflectance and/or absorbance from a specified substance to ensure that the illumination conditions are repeatabie. It is also possible to carry out any number of separate measurements and then do an analysis to give a mean and standard deviation based on the results of the separate measurements. It is also possible to measure the reflectance and or absorbance at different time intervals after the pulse has started or ended.
  • Sample holder can be formed in a pipeline, thus allowing for real-time and in-situ measurements without the need for a separate step of extracting a sample from the pipeline.
  • polarised light may be used in the first sphere or it may be used separately between the sample and the second sphere so that the measurement of the absorbance is polarised.
  • the present invention can be implemented in all aspects of spectroscopy, such as for example Raman, or Terahertz spectroscopy, absorption spectroscopy.
  • a method of performing spectral analysis on a liquid sample comprising: directing light from a light source into a first integrating sphere to perform reflectance analysis of the sample; and directing light from the Sight source into a second integrating sphere to perform transmission analysis of the sample.
  • the method can be arranged to determine the concentration of at least one component of the liquid sample.
  • Fig 1 is a schematic cross-section view of the apparatus according to an embodiment of the present invention.
  • Figs 2 to 5 are diagrammatic views showing the relative intensity of Iight of each selected wavelength measured.
  • Fig 1 an apparatus is provided for performing a spectral analysis of a liquid sample, in order to determine the concentration of specific chemicals or other components present in the sample.
  • the apparatus illustrated in Fig 1 comprises a radiation energy source such as, for example, a light source 1 although it should be appreciated that other sources of energy and, in particular, radiated energy can be employed.
  • the Iight source 1 may be any convenient Iight source providing constant uniform intensity Iight within the visible spectrum, the ultraviolet and/or the infrared .
  • the word "light" as used in this Specification is intended to include Iight in the spectral range of ultraviolet to. infrared.
  • the light source 1 may be provided with a filter 2, the filter 2 serving to limit the spectral range of the light from the Iight source 1.
  • the Iight passing through the filter may only be in the infrared part of the spectrum, or in the infrared and the "red" end of the visible spectrum, or any selected part of the spectrum depending on the spectral transmission characteristics of the filter.
  • the Iight source may be LEDs or lasers.
  • the iight from the Iight source 1 is directed into a first integrating sphere 3.
  • the integrating sphere 3 is provided with a spherical body 4 formed from two hemispherical parts interconnected by means of a flange 5.
  • the interior surface of the sphere is reflective to the Iight which is introduced to the integrating sphere.
  • the interior of the sphere may be coated with a stable barium sulphate based white coating, or the sphere may be formed from a thermoplastic material which may be reflective to light of a wide range of wavelengths, including very low wavelengths.
  • a first aperture 8 is provided in the first integrating sphere which serves as a light inlet for light from the source 1.
  • the aperture 8 may be configured to accommodate a mounting flange 8 which is used, for example, to mount a fibre optic bundle 9 which extends from the light source, so that light is directed through the aperture 8 into the interior of the integrating sphere 3.
  • the first aperture 8 may also be provided with a focusing arrangement such as a lens system (not shown).
  • a second aperture 10 is provided in the first integrating sphere which serves as a light outlet.
  • the second aperture 10 may be located directly opposite to the first aperture 6, but the second aperture 10 could have any convenient location within the sphere which is spaced from the first aperture 8.
  • the second aperture 10 is configured to receive a sample holder 1 1. Light directed into the first integrating sphere can pass through the sample holder 11 into a first aperture 6' of a second integrating sphere 3'.
  • the first aperture of the second integrating sphere serves as a light inlet.
  • the structural arrangement of the second integrating sphere 3' is substantially the same as the first integrating sphere and like reference numerals for the first integrating sphere 3 correspond to like features for the second integrating sphere 3'.
  • the sample holder 11 is arranged at the first aperture 8' of the second integrating sphere.
  • the size of the spheres may be variable depending on the substances to be measured and both spheres do not have to be the same size.
  • the sphere for reflectance and transmission may be different sizes for the same substances.
  • the sample holder 11 is arranged between the second aperture 10 of the first integrating sphere 3 and the first aperture 8 ! of the second integrating sphere 3' such that Sight exiting the second aperture 10 of the first integrating sphere 3 is transmitted through the sample holder and enters the second integrating sphere 3 ! through the first aperture 6',
  • the first aperture 6' of the second integrating sphere is configured to receive a sample holder 11.
  • the sample holder 11 can comprise a base 12, from which two spaced apart upstanding walls 13, 14 extend.
  • the upstanding walls 13, 14 can be provided with apertures 15, 15 ! .
  • Aperture 15 is arranged to engage with the second aperture 10 formed in the first integrating sphere 3.
  • Aperture 15' is arranged to engage with the first aperture 6 ! formed in the second integrating sphere 3 ⁇
  • the space defined between the two upstanding wails 13, 14 can be dimensioned to receive a sample bottle or cuvette.
  • the sample bottle may contain a liquid.
  • the sample bottle is, of course, formed of a materia! which is transparent to light having wavelengths within the spectral band being supplied by the light source to the interior of the first integrating sphere 3.
  • the sampie ho!der may be held at a position where light from the light source is focussed, so that the sample is exposed to a precisely predetermined amount of light.
  • the upstanding walls of sample holder can have respective radii of curvatures such the upstanding walls conform to the radii of curvatures of the integrating spheres.
  • the sampie holder can be mounted to the first and second integrating spheres by means of a mounting collar 35, the mounting collar 35 having an internally threaded ring to engage threading provided on the exterior of the apertures of the integrating spheres.
  • the sample holder may be associated with a removable element in the form of a spectral filter.
  • the spectral filter will allow Sight of selected wavelengths to be transmitted or partially transmitted through the filter and/or reflected or partially reflected back into the sample holder.
  • the filter can be on either side of the sample holder to filter the transmitted light into sphere 3'
  • the sample holder can comprise any appropriate means for containing a sample to be analysed, irrespective of form taken and whether fluid, liquid, solid or particulate in nature, relative to the first and second integrating spheres 3, 3'.
  • the sample need not be static and so the sample container can comprise a pipeline or portion of a pipeline or conduit through which sample liquid can be passed. The portion is shaped to engage with the second aperture of the first integrating sphere and the first aperture of the second integrating sphere.
  • the conduit or pipeline may comprise a bypass line of any appropriate system/apparatus in any required environment such as, for example, but not limited to, industrial environments e.g. an oil refinery; medical environments e.g. for renal or cardiac bypass; or agricultural of manufacturing environments e.g. grain assessment or paint production.
  • the third aperture 17 being associated, in this case, with an aperture reducer 18 on which is mounted an accessory adapter 19, the accessory adapter 19 supporting a light trap 20.
  • the light trap 20 is connected to a spectroscope 21 configured to conduct a spectral analysis of light received in the light trap, to determine the intensity of the light received at each wavelength.
  • the spectroscope may be a "selective" spectroscope and may only determine the intensity of light at specific predetermined wavelengths.
  • a second aperture 10' At a further position on the second integrating sphere 3' aiso there is provided a second aperture 10'.
  • the second aperture associated, in this case, with an aperture reducer 18 ! on which is mounted an accessory adapter 19', the accessory adapter 19' supporting a Sight trap 20'.
  • the light trap 20' is connected to a spectroscope 21 ' configured to conduct a spectra! analysis of light received in the light trap, to determine the intensity of the light received at each wavelength.
  • the spectroscope may be a "selective'' spectroscope.
  • the output of the respective spectroscopes can be passed to one or more processors 22, configured to perform an analysts of the data provided by the spectroscopes, and the processors associated with one or more displays/printers 23 configured to display or print results determined by the processors.
  • the interior of the integrating spheres maybe provided with one or more baffles to present light passing directly from the first apertures 8. 8' to the light traps and/or to prevent light passing directly from the sample holder 11 to the light trap.
  • the skilled person wiii recognise that the first integrating sphere 3 is used in a reflection mode, that is Sight reflected from the sample, whereas the second integrating sphere is used in transmission mode, that is light transmitted through the sample, in the case of the first integrating sphere a sample in the sample holder is exposed to the interior of the sphere, and will thus be exposed to the light that is directed into the first integrating sphere. In the case of the second integrating sphere, light will transmitted through the sample will be directed into the second integrating sphere. Light from the light source 1 , passing through the filter 2 and the fibre optic bundle 9 is directed into the first integrating sphere.
  • the light may be focussed on to the sample within the sample holder, and a percentage of that light is effectively "reflected" into the interior of the first sphere. A percentage of the light will be transmitted by the sample into the second sphere. Some wavelengths of light are reflected aimost totally, but other wavelengths of light are partially, or sometimes completely, absorbed by the blood or other fluid to be examined. The light that is reflected from or transmitted through the sample is consequently not of the same spectral content as the light entering the first integrating sphere.
  • the integrating spheres are known components. Light within the integrating spheres can be uniformly reflected and scattered around the interior of the sphere, with the light sometimes effecting many multiple reflections and re- reflections.
  • the interior of the spheres, whilst being “reflective” of light are not a “mirror” finish, but instead reflect light in a “diffuse” manner.
  • the whole of the interior of a sphere is thus exposed to a substantially uniform illumination, and at any point on the surface of the sphere light will be present which has a spectral content which is determined by the light reflection/transmission characteristics of the sample. Light having a specific spectral content will thus emerge from the integrating spheres.
  • the spectral content will depend on the reflection characteristics of the sample, whereas in the case of the second integrating sphere the spectral content will depend on the transmission characteristics of the sample.
  • Light emerging from the spheres will then pass through the apertures 17 and will pass into the light traps 20.
  • the light passes to the spectroscopes 21 , which performs a spectral analysis to provide data related to the intensity of light at a plurality of wavelengths.
  • the light source is a source which provides a constant uniform intensity light.
  • the source may be a pulsed source.
  • the spectroscopic analysis may be performed shortly after the end of each input pulse of light. Successive input pulses may have different spectral contents. Some pulses may be substantially monochromatic, but other pulses may contain specific selected wavelengths of light.
  • the light may be polarised, being either plane polarised or circular polarised. It has now been found that it is possible to make qualitative or quantitative measurements with regards to specific components of a liquid sample using ultra-violet, visible and near-infrared spectrometry.
  • chemometrics involve many steps and methods, depending upon the nature of the data and how one step or method works over the other.
  • principal component analysis which can be performed by analysing the intensities of light at a few selected wavelengths, the wavelengths being selected, of course, in dependence upon the nature of the specific component or chemical in the sample that is to be identified, and whose concentration is to be determined.
  • the wavelengths are selected so that there will be no "interference" from other constituents of the liquid, such as water.
  • the wavelengths selected are wavelengths where a "peak” is expected to be if, and only if, a specific component or chemical is present.
  • each of the wavelengths to be analysed is represented as a separate "dimension" in a notional poly-dimensional space.
  • the relative intensity of light of each selected wavelength is measured, as shown in Fig 2.
  • the three intensities of light and three wavelengths may be shown on three separate lines, as shown in Fig 3.
  • the three separate lines may form three orthogonal axes, as shown in Fig 4, and consequently, a single point, identified as the point O in Fig 5 can be defined, from the three measurements which have been taken. It is to be appreciated that if subsequent measurements of the further sample lead to a point line on the line 24 shown in Fig 5 which passes from the origin of the orthogonai space, and which passes through the point O than the present of a point on that line indicates the presence of the same substance that was in the sample initially tested, and the position on the line 24 indicates the concentration of the sample.
  • a further technique that may be utilised involves Fourier analysis of the sometimes complex initial output of the spectroscope, the Fourier analysis being intended to identify underlying "wave forms" which make up the complex "wave form” of the spectroscope output.
  • the Fourier analysis may identify several underlying "wave forms", each with a different amplitude. Each of those "wave forms” may be representative of a particular component of the sample and the amplitude of the wave form is representative of the concentration of that component within the sample.
  • the processor 20 may utilise many different techniques to process the data from the spectral analysis, and the processor will operate to determine the presence of, and also the concentration of, at least one predetermined component within the sample.
  • the processor may be programmed to determine the concentration of alcohol in the blood or the concentration of glucose in the blood or the concentration of any other blood component that is of interest.
  • the processor may therefore perform the necessary processing steps to produce an output which is indicative of the presence of and the concentration of a large number of potential components in the sample.
  • the processor provides an output to a display device or printer 23 which gives a visible indication of the results produced by the processor.
  • a "screen" or printout may be provided which indicates the presence of one or more components in the blood, giving the concentration of each component,
  • the components may be alcohol, glucose, haemoglobin, sodium, potassium or other components that may be of interest.
  • a sample of a liquid which may be opaque, such as blood
  • the sample holder may be mounted to the integrating spheres 3, 3', and subsequently the spectroscope will analyse light emerging from the integrating sphere with the output of the spectroscope being processed by a processor to determine the light absorption/reflection characteristics to be determined and processed to enable a display to display information (or a printer to print information), that information including an indication of the presence of and the concentration of specific components in the blood.
  • the entire process may be complete within a few milliseconds and with great repeatability and high accuracy.
  • the chemicals or the components in the liquid sample may be normally present in the liquid (such as glucose in blood) or may be temporarily present on certain occasions (such as a!coho! or drugs in biood).
  • the liquid may be an opaque liquid, such as blood or transparent
  • An opaque liquid is a liquid which will not let visible light pass through it, or which will not let light in a significant part of the spectrum (including ultra violet and infrared) pass through it.
  • the sample is provided at an aperture which is spaced from the light inlet.
  • the sample may be provided at the light inlet, thus being positioned between the light source and the integrating sphere so that the light passes through the sample before entering the integrating sphere. If the sample is provided at the light inlet it may need to be in a sample holder with parallel straight walls to avoid unwanted reflections from, for example, a concave wall.
  • fibre optic cable to return the light directly reflected from the sample to the spectroscope 21 .
  • a fibre optic cable to return the light directly transmitted through the sample to the spectroscope 21 '.

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

Cette invention concerne un appareil, et une méthode afférente, pour effectuer l'analyse spectrale d'un échantillon, ledit appareil comprenant un moyen de récipient pour échantillon qui positionne l'échantillon en association avec une première sphère d'intégration, et une seconde sphère d'intégration. Les première et seconde sphères d'intégration et le moyen de récipient pour échantillon sont placés de façon que la première sphère d'intégration effectue une analyse de réflectance diffuse de l'échantillon, et que la seconde sphère d'intégration effectue une analyse de transmission diffuse de l'échantillon. Cette invention peut, en outre, effectuer une analyse de réflectance directe avec analyse de transmission diffuse ainsi qu'une analyse de réflectance diffuse avec analyse de transmission directe.
PCT/GB2012/050032 2011-01-10 2012-01-09 Appareil et méthode d'analyse WO2012095651A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB201100279A GB201100279D0 (en) 2011-01-10 2011-01-10 Spectral analysis apparatus and method
GB1100279.7 2011-01-10

Publications (1)

Publication Number Publication Date
WO2012095651A1 true WO2012095651A1 (fr) 2012-07-19

Family

ID=43663950

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2012/050032 WO2012095651A1 (fr) 2011-01-10 2012-01-09 Appareil et méthode d'analyse

Country Status (2)

Country Link
GB (1) GB201100279D0 (fr)
WO (1) WO2012095651A1 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9431301B1 (en) 2015-12-10 2016-08-30 International Business Machines Corporation Nanowire field effect transistor (FET) and method for fabricating the same
EP3211400A1 (fr) * 2016-02-24 2017-08-30 TOMRA Sorting NV Procédé et appareil pour la détection de la présence de mycotoxines dans des céréales
JP2018077206A (ja) * 2016-11-11 2018-05-17 ビーダブリュティー・プロパティー・インクＢＷＴ Ｐｒｏｐｅｒｔｙ， Ｉｎｃ． 試料のラマン散乱を測定するための光伝送及び収集装置並びに方法
CN110132887A (zh) * 2019-04-30 2019-08-16 深圳市太赫兹科技创新研究院有限公司 一种光学积分球和样品太赫兹透射光谱采集装置
CN112161942A (zh) * 2020-09-08 2021-01-01 深圳世绘林科技有限公司 一种液质在线测试方法
CN112285124A (zh) * 2020-11-09 2021-01-29 南京财经大学 植物油中黄曲霉毒素b1污染程度的判别方法、装置及光学判别装置
CN112611736A (zh) * 2020-12-23 2021-04-06 西安应用光学研究所 太赫兹波段光谱漫反射比校准装置

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2757196A1 (de) * 1977-12-22 1979-06-28 Vladimir Dipl Ing Blazek Photometrische anordnung
EP0026885A1 (fr) * 1979-10-09 1981-04-15 Miles Laboratories, Inc. Photomètre à filtre
EP0670143A1 (fr) * 1993-08-12 1995-09-06 Kurashiki Boseki Kabushiki Kaisha Procede non-invasif de mesure du taux de sucre sanguin et instrument de mesure utilise a cet effet
EP1949080A1 (fr) 2005-06-27 2008-07-30 H-icheck Ltd. Procede d'analyse spectrale et appareil permettant d'appliquer ce procede

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2757196A1 (de) * 1977-12-22 1979-06-28 Vladimir Dipl Ing Blazek Photometrische anordnung
EP0026885A1 (fr) * 1979-10-09 1981-04-15 Miles Laboratories, Inc. Photomètre à filtre
EP0670143A1 (fr) * 1993-08-12 1995-09-06 Kurashiki Boseki Kabushiki Kaisha Procede non-invasif de mesure du taux de sucre sanguin et instrument de mesure utilise a cet effet
EP1949080A1 (fr) 2005-06-27 2008-07-30 H-icheck Ltd. Procede d'analyse spectrale et appareil permettant d'appliquer ce procede

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9887264B2 (en) 2015-12-10 2018-02-06 International Business Machines Corporation Nanowire field effect transistor (FET) and method for fabricating the same
US9431301B1 (en) 2015-12-10 2016-08-30 International Business Machines Corporation Nanowire field effect transistor (FET) and method for fabricating the same
US10429295B2 (en) 2016-02-24 2019-10-01 Tomra Sorting N.V. Method and apparatus for the detection of the presence of mycotoxins in cereals
WO2017144608A1 (fr) * 2016-02-24 2017-08-31 Tomra Sorting N.V. Procédé et appareil pour la détection de présence de mycotoxines dans des céréales
EP3211400A1 (fr) * 2016-02-24 2017-08-30 TOMRA Sorting NV Procédé et appareil pour la détection de la présence de mycotoxines dans des céréales
JP2018077206A (ja) * 2016-11-11 2018-05-17 ビーダブリュティー・プロパティー・インクＢＷＴ Ｐｒｏｐｅｒｔｙ， Ｉｎｃ． 試料のラマン散乱を測定するための光伝送及び収集装置並びに方法
JP2021144033A (ja) * 2016-11-11 2021-09-24 ビーアンドダブリュ・ティーイーケー・エルエルシーB&W Tek Llc 対象物の分光分析を行う装置及び方法
JP7159378B2 (ja) 2016-11-11 2022-10-24 ビーアンドダブリュ・ティーイーケー・エルエルシー 対象物の分光分析を行う装置及び方法
CN110132887A (zh) * 2019-04-30 2019-08-16 深圳市太赫兹科技创新研究院有限公司 一种光学积分球和样品太赫兹透射光谱采集装置
CN112161942A (zh) * 2020-09-08 2021-01-01 深圳世绘林科技有限公司 一种液质在线测试方法
CN112285124A (zh) * 2020-11-09 2021-01-29 南京财经大学 植物油中黄曲霉毒素b1污染程度的判别方法、装置及光学判别装置
CN112611736A (zh) * 2020-12-23 2021-04-06 西安应用光学研究所 太赫兹波段光谱漫反射比校准装置
CN112611736B (zh) * 2020-12-23 2023-03-14 西安应用光学研究所 太赫兹波段光谱漫反射比校准装置

Also Published As

Publication number Publication date
GB201100279D0 (en) 2011-02-23

Similar Documents

Publication Publication Date Title
WO2012095651A1 (fr) Appareil et méthode d'analyse
US9182282B2 (en) Multi-analyte optical computing system
US8213006B2 (en) Multi-analyte optical computing system
US6137108A (en) Instrument and method for spectroscopic analysis by reflectance and transmittance
US7623233B2 (en) Optical analysis systems and methods for dynamic, high-speed detection and real-time multivariate optical computing
US7990538B2 (en) Signal processing for optical computing system
US5258825A (en) Optical compositional analyzer apparatus and method for detection of ash in wheat and milled wheat products
WO2008121692A1 (fr) Système d'analyse et de mesure à tablette
AU769362B2 (en) Method and apparatus for detecting mastitis by using visible light and/or near infrared light
JP6336710B2 (ja) 試料内の不均質性を検知するための光学装置、特に偏光計
WO2007061437A1 (fr) Système d'analyse optique permettant d'effectuer en temps réel une détection et une mesure dynamiques
JPH0141934B2 (fr)
US11137290B2 (en) Accessory for infrared spectrophotometer
US7324188B1 (en) Characterization of color and clarity enhancement agents in gems
JPH1054761A (ja) 分光分析方法および分光分析装置
CA2565172C (fr) Dispositif portable et procede de detection et de quantification de medicaments sur place
CN208255048U (zh) 光纤探头和水质检测装置
US7105822B1 (en) Characterization of clarity and color enhancement agents in gems
EP1949080A1 (fr) Procede d'analyse spectrale et appareil permettant d'appliquer ce procede
US6147350A (en) Spectroscopic residue detection system and method
CN208283265U (zh) 多功能光纤探头和水质检测装置
CN218382403U (zh) 一种pcr光学检测组件
EP0574601A1 (fr) Méthode et appareil perfectionnés pour des mesures d'interactance et de transmittance optiques
CN212255059U (zh) 一种多合一光源的分光光度检测系统
Yoon et al. Spectrophotometry

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 12700245

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 12700245

Country of ref document: EP

Kind code of ref document: A1