WO2012084216A1 - Hochdichte einzeldosisverpackung - Google Patents
Hochdichte einzeldosisverpackung Download PDFInfo
- Publication number
- WO2012084216A1 WO2012084216A1 PCT/EP2011/006459 EP2011006459W WO2012084216A1 WO 2012084216 A1 WO2012084216 A1 WO 2012084216A1 EP 2011006459 W EP2011006459 W EP 2011006459W WO 2012084216 A1 WO2012084216 A1 WO 2012084216A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- packaging
- tear
- packaging material
- layer
- dose
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/03—Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
- A61J1/035—Blister-type containers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
- B65D75/52—Details
- B65D75/58—Opening or contents-removing devices added or incorporated during package manufacture
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
- B65D75/52—Details
- B65D75/58—Opening or contents-removing devices added or incorporated during package manufacture
- B65D75/5805—Opening or contents-removing devices added or incorporated during package manufacture for tearing a side strip parallel and next to the edge, e.g. by means of a line of weakness
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D65/00—Wrappers or flexible covers; Packaging materials of special type or form
- B65D65/02—Wrappers or flexible covers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
- B65D75/40—Packages formed by enclosing successive articles, or increments of material, in webs, e.g. folded or tubular webs, or by subdividing tubes filled with liquid, semi-liquid, or plastic materials
- B65D75/42—Chains of interconnected packages
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
- B65D75/52—Details
- B65D75/58—Opening or contents-removing devices added or incorporated during package manufacture
- B65D75/5855—Peelable seals
Definitions
- the present invention relates to high-density single-dose packaging for film-shaped or film-shaped dosage forms and transdermal therapeutic systems (TTS), which are largely inert to the active ingredients in the enclosed dosage form, but still can be opened easily without aids and are nevertheless kinderersi- rather.
- TTS transdermal therapeutic systems
- the present invention also encompasses a method for producing the single-dose packages according to the invention, which is characterized by an economical use of materials, and their use.
- Pharmaceutical packaging has several tasks to accomplish. On the one hand, packing as a single dose should ensure, for example, that only one particular dose is taken at a time and multiple dosing is avoided. On the other hand, the packaging should prevent the medicines being made available to children for accidental ingestion or self-medication.
- CONFIRMATION COPY confused with candies or other sweets and take or apply the included TTS in the game.
- the size of the film thus determines the size of the package. Furthermore, due to the already discussed sensitivity of the films, the use of expensive high barrier films is (High barrier films), which are mechanically strong and at best allow low permeation of gases and moisture, indicated to ensure the necessary protection of the dosage form.
- both the top and the bottom of the large-scale dosage form must be covered with a film, which is associated with a high cost of materials and leads to high packaging costs due to the expensive films, which significantly increase the cost of the single dose and an extremely unfavorable ratio of packaging costs to product costs.
- single-dose packaging In addition, there is a particular problem with the requirements of single-dose packaging that they should protect not only medicines from environmental influences such as light and moisture, which often lead to drug breakdown and thus the uselessness of the drug. Rather, single-dose packaging must also ensure that the dosage forms packaged in them do not interfere with the inner coating and, by diffusion and migration of drugs into that layer, reduce the drug content and thus the effectiveness of the medication.
- the aspect of the inertness of the inner contact layer of the single-dose packaging deserves special attention due to the large contact surface of the coating and dosage form.
- Another aspect of the selection of the films is that just because of the large contact surface components of the réellebeSchichtung can diffuse into the dosage form, the z. B.
- oral dosage forms affect the taste or even be harmful to health.
- transdermal dosage forms there is the possibility that plasticizers enter the dosage form, which can change, for example, the permeation rate of the drug through the skin due to their diverse mode of action.
- German Patent Disclosure DE 10 2004 047 445 A1 discloses a non-resealable packaging for hazardous products comprising two superimposed packaging material elements, a first surface section, at the edge or edges of which the two packaging material elements are detachably connected to one another, wherein at least between the two packaging material elements a cavity enclosed on all sides for receiving the packaged product is formed, and has a second, lying outside the first surface portion or adjacent to this surface portion at the edge or edges of the two packaging material elements are releasably connected together.
- At least one of the two packaging material elements is provided with at least one structure that extends within the second surface portion and that allows the tearing of the / the packing material elements.
- US 2006/0023976 A1 discloses retractable pouches for one or more doses of a drug in which two packaging material webs are marginally sealed to one another, and which are provided in the region of the sealing rim with a tear-open surface structure which depends on a fold line is crossed. The edge of the bag must be folded along the fold line so that it can be torn and opened at the surface structure.
- German patent application DE 10 2006 041 921 A1 describes a child-resistant package for active substance-containing films which comprises a carrier layer and a cover layer releasably connected thereto and has in a paired arrangement two opposite surface regions which are separated from one another by a web, within which the Cover layer is not connected to the carrier layer, whereby two separate, mutually enclosed spaces for pairwise recording of said films are formed. Within this web, there is another surface area in which the carrier layer is not connected to the cover layer, whereby a cavity enclosed on all sides is formed. There is at least one perforation line inside the bridge.
- the top and bottom of the packaging must be easily peeled apart to expose the dosage form.
- sealing layers based on polyolefin, z.
- polyethylene which have a good peel behavior with peel forces between 3 and 20 N.
- the disadvantage of this choice of material lies in the fact that the sealing seams, which, in contrast to the outer surfaces, are not additionally provided with another layer, e.g. a metal layer, can be acted upon to increase the tightness, have no high tightness to water vapor.
- the minimal water vapor permeability of the single-dose packaging is therefore limited by the choice of seed material.
- sealing surfaces which form the inner layer of the unit dose package and which are in contact with the product, so that the material of the sealing surfaces should be compatible with the packaged product and ideally inert to the product.
- a further problem is that the material consumption for producing child-resistant packaging is often increased by the fact that there must be unpacked sections to open the packaging, which serve as an aid to "peel", wherein the minimum size of the Anjanhoffn is limited by anatomical conditions .
- the child-resistant packaging of film-shaped or film-shaped pharmaceuticals / dosage forms thus represents a particular challenge since films and films are sensitive to physico-chemical (eg light, moisture, oxygen) and mechanical stresses.
- the object of the present invention is therefore to provide a high-density, easy-to-open but nevertheless child-proof individual packaging which minimizes the consumption of packaging material per single dose and is inert to drug migration from the dosage form into the contact layer or vice versa to migration of constituents of the contact layers is in the dosage form.
- TTS transdermal therapeutic systems
- the object is achieved by a single-dose packaging according to claim 1 of the present invention and a corresponding method for producing the sealed single doses according to claim 12.
- the single-dose packaging of the present invention is a tearable end-sealable bag having a completely circumferential and continuous, ie non-interrupted, non-peelable sealing surface, the upper and lower sides of the sealed-edge bag being formed by two packaging material elements which are arranged one above the other and form a receptacle for the packaged product and wherein at least one layer of the packaging material elements which determines the tear strength has an anisotropic tear strength and is preferably monoaxially stretched.
- the sealing surface preferably forms the outer boundaries of the packaging, so that there is no gripping possibility for a possible opening of the bag by "peeling", ie the opening of the bag by loosening the sealing seams from each other or from the adjacent laminate layers given. In this way, the opening of the bag is prevented by a weakened sealing seam, which is not peelable actually.
- the packaging material elements for the production of single-dose packages according to the present invention are preferably of multilayer construction. In this case, at least one layer of the packaging material elements is particularly preferably a metal layer in order to ensure the sorted high density of the single-dose packaging.
- At least one packaging material element is a film laminate having an at least three-layered structure, the outermost, i. the product facing away layer has a minimum tensile strength of 50 N, so that opening the package by a simple tearing without tools is not possible.
- At least three-ply Packstoff Mrs can optionally be used as a second packaging material element a cheaper film laminate with a lower tensile strength to save costs.
- Tear strength-based layer of an anisotropically tear-resistant polymer eg. As a monoaxially stretched polypropylene (PP) or polyethylene terephthalate (PET), in which the ani- sotropic tear strength is achieved by a suitable composition, so that the crack propagation in one direction is preferred.
- PP polypropylene
- PET polyethylene terephthalate
- the packaging has a linear weakening (weakening line) in the sealing area, which does not touch the edge of the packaging.
- This weakening line can be a cut, a perforation or another suitable weakening of the tear-resistant known to the person skilled in the art
- the line of weakness is preferably produced by the fact that the outer, the packaged material facing away anisotropically tear-resistant polymer layer of the film laminate is removed or greatly lent reduced in the thickness, so that the tensile strength is reduced, this reduction or removal of the outermost, tear-resistant layer of the film laminates Laser ablation or laser scoring (scoring by lasers) takes place.
- the advantage of the embodiment of the weakening line only in the outermost layer of the laminate is that the highly gas-tight metal layer is not damaged and thus maximum protection of the packaged goods from moisture and oxygen is made possible.
- the packaging By tearing the packaging at the weakening line is a tearing of the anisotropic tear-resistant layer possible.
- the packaging can be opened without additional aids.
- the weakening line is arranged such that the weakening line runs along the direction of the lower tear strength of the anisotropically tear-resistant polymer, in which tear propagation is possible.
- the predetermined orientation of the tear strength-determining layer not only allows the further tearing, but also the crack profile is determined, so that damage to the product in the product receiving area is prevented.
- the orientation of the stretched polymer layer controls the course of the crack, and the maximum lateral deviation of the crack profile relative to the orientation of the initial weakening line is a maximum of ⁇ 2 mm, preferably ⁇ 1 mm.
- Weakness in the adjacent non-sealed product receiving area, wherein the distance of the crack in parallel course to the sealing surface is less than 5 mm, preferably less than 3 mm, more preferably less than 2 mm, and most preferably less than 1 mm.
- the safety zone of the packaging in which no product may be present so that it is not damaged when opened, can be correspondingly limited and the material requirements for the packaging minimized.
- the package since the beginning of the line of weakness does not affect the circumference of the package, the package must first be kinked to expose the beginning of the line of weakness along which the package can be torn open and which dictates the course of the tear. Thus, only a slightly enlarged sealing area is required in which the line of weakness is arranged and which can be bent to expose the line of weakness orthogonal to this.
- a particularly preferred embodiment therefore provides only to remove the outermost, tear-resistant layer at the level of the marked bend region which extends orthogonally to the weakening line, so that no obvious incision can be seen in the individual packaging, which has the imagination of children to open the Can stimulate packaging.
- the anisotropically tear-resistant polymer is laminated at an angle to the direction of stretching, preferably 45 °, relative to the carrier web so that the tear direction is not parallel to the edge of the package and a corner is exposed.
- the line of weakness is in the form of a
- the single-dose packaging has position restrictors for the product in the product-receiving region, which are preferably produced by heat-sealing.
- the Positionrestrlktoren could be designed as a narrow ArdsStege between the upper and lower film layer, or as a flat structure, for example, arranged in the edges triangles.
- the line of weakness may be
- the sealed-edge bag of the present invention consists of two packaging material elements arranged one above the other, a first packaging material element and a second packaging material element, wherein at least one of the packaging elements comprises a tear-resistant layer of an anisotropically tear-resistant, in particular monoaxially stretched, polymer.
- the packaging material for the production of the sealed-edge pouches is preferably a packaging material which has low permeation rates for gases and moisture.
- packaging materials with an at least three-layer structure are particularly well suited, the individual layers or layers of the packaging material being joined together to form a composite, preferably in the form of a laminate.
- the individual layers of the packaging material perform one or more functions that are essential for the achievement of the object of the present invention.
- at least one layer, preferably the outermost layer, of the packaging material element is distinguished by a high, anisotropic tensile strength. This layer can not be destroyed manually without additional tools.
- an existing crack generated at a predetermined weakened point can be widened and crack propagation in the direction of weaker tear strength, ie in the direction of stretching of the polymer, can be achieved so that manual tearing without aids is possible.
- Such a layer is particularly preferably a monoaxially stretched polyethylene terephthalate or polypropylene layer with a layer thickness of 10-100 ⁇ m, preferably 20-50 ⁇ m, and particularly preferably 12-25 ⁇ m.
- a layer thickness of 10-100 ⁇ m, preferably 20-50 ⁇ m, and particularly preferably 12-25 ⁇ m.
- other materials familiar to the person skilled in the art with anisotropic tear strengths in suitable layer thicknesses.
- these materials have been prepared by monoaxial stretching.
- the outer layer is further preferably printable, so that e.g. Product labels and tear-open aids can be attached.
- the middle layer consists of a metal foil, preferably aluminum, with a thickness of 9-25 ⁇ m.
- This metal layer ensures the tightness of the packaging against moisture and air.
- the inner layer is a sealable plastic layer, wherein the sealed seam produced by this layer can not be opened again.
- the laminates are preferably bonded by heat sealing, but can also be effected by any other suitable sealing method, such as cold sealing, ultrasonic sealing, laser sealing or comparable film welding methods known to the person skilled in the art, as long as a non-detachable sealing seam is obtained.
- the sealing seams or sealing surfaces preferably have a width of 0.1 mm to 10 cm, particularly preferably a width of 1 mm to 2 cm, and very particularly preferably a width of 2 mm to 8 mm, and they preferably extend over the entire length and width of the packaging material elements. At particularly exposed locations, the seal seam width may also be greater, e.g. to allow a kinking to expose the line of weakness. On the other hand, at least one of the sealing seams may be made stronger and wider than the other sealing seams, in order to further complicate the opening of the packaging at this point.
- Plastics used for the seal surfaces include materials known to those skilled in the art, such as polyvinyl chloride (PVC), polyvinylidene chloride (PVDC), Barex® (BP Chemicals, copolymer of acrylonitrile and butadiene), Surlyn®, Aclar TM (Honeywell, high barrier polychlorofluoroethylene films [PCTFE]) and Topas®-COC (Ticona, cyclo-olefin copolymer films), the layer thickness typically being 10-100 ⁇ m, preferably 10-50 ⁇ m, and particularly suitable are plastics which are highly dense , inert to the active ingredient of the packaged dosage form and / or adsorb it only slightly.
- a particularly preferred high barrier film laminate for use as a packaging element consists of a Barex® layer (20-40 ⁇ m), an aluminum foil (9-25 ⁇ m) and a PET layer (10-30 ⁇ m).
- the thickness of the multilayered film laminate is preferably in the range of 35 to 300 ⁇ m, more preferably 50 to 200 ⁇ m.
- the tensile strength and the tear propagation resistance of the packaging material can be reduced by means of known tensile testing machines
- sample holder for tearing tests (type No. 00740) can be determined (for example, available from FRANK für für tearing tests (type No. 00740) (for example, available from FRANK für tearing tests (type No. 00740) can be determined (for example, available from FRANK für tearing tests (type No. 00740).
- the weaker, anisotropic tear strength of the packaging material is at least 50 N, preferably at least 60 N, and particularly preferably at least 70 N, measured on the two interconnected packaging material elements, which
- the minimum tearability of the second film laminate is below that of the first film laminate, preferably in the range from 10 N to 50 N, particularly preferably in the range from 20 N to 40 N.
- the weaker tear propagation resistance of the anisotropic packaging material must not be too low, because then sufficient protection of the packaged goods can no longer be ensured and there is the risk that the packaging will be opened unintentionally and / or the packaged goods will be damaged. This can be determined by simple experiments.
- the weaker Tear strength of the packaging material is preferably less than 10 N, measured on the two interconnected packaging material elements forming the package. In order to enable or facilitate the tearing of the packaging material, the tear strength is a multiple of the tear propagation resistance.
- the ratio of tear strength to tear propagation resistance is preferably in the range from 50: 1 to 150: 1, based on the tear resistance and tear resistance of the two interconnected packaging material elements.
- FIG. 1 shows a preferred embodiment of the single-dose packaging according to the invention in plan view with a weakening point arranged in the upper edge.
- FIG. 2 shows a single-dose packaging with position restrictors.
- FIG. 3 shows a strand with paired individual dose packages for waste-free production.
- the packaging (1) according to the invention is a sealed-edge bag made of two superimposed packaging material elements, of which one packaging material element forms the cover layer and the other packaging material element the intermediate layer between which the product (5), preferably a transdermal therapeutic system or a film or sheet-shaped dosage form, is arranged.
- the two packaging material elements are sealed to one another in such a way that the product (5) is surrounded by a circumferential, continuous sealing edge (3) which is not peelable.
- the sealed-edge bag (1) has a front edge (8), a trailing edge (9) and two preferably parallel side edges (10, 10 ').
- the sealed-edge bag has a weakening line (20) in the direction of which the packaging material elements can be torn open.
- the sealed-edge bag in FIG. 2 has a weakening line (20) in the direction of which the packaging material elements can be torn open.
- Position restrictors (35, 35 ') which prevent displacement of the product in the crack region.
- the parental control of the packaging is achieved in that the lines of weakness for tearing the package can be exposed only by overcoming a child safety device.
- This backup is that the lines of weakness do not extend to the edge and tear the otherwise tear-resistant material of the packaging material only after exposing the beginning of the weakening line by folding the package along a crease line, which may be optional, torn and the product can be removed.
- the weakening line for tearing the packaging material should according to the invention have no edge contact with the packaging, so that this structure does not occur until the packaging has been folded. for a long line passing through this structure, for example along the line AA '(FIG. 1), the beginning of the weakened region is exposed for tearing.
- Packaging material elements may be present in one of the two packaging material elements, for example, if the second packaging material element has a lower tensile strength, or in both, with the latter embodiment being preferred.
- the weakening line for tearing the packaging material is arranged congruently in both packaging material elements.
- the weakening line can also be a cut or a perforation.
- the single-dose packaging is childproof according to DIN EN 14375 and / or according to ASTM D3475-03a.
- the present invention also relates to a method for producing a single-dose packaging for transdermal therapeutic systems or film-shaped dosage forms. This method is characterized by the fact that it is particularly material-saving in comparison to the known methods.
- the method of manufacturing a unit dose package according to any one of the preceding claims comprises the steps of:
- the weakening lines for tearing the packaging material can also be attached only in a later step.
- the insoluble bond between the packaging material elements is preferably produced by heat sealing at temperatures in the range between 50 ° C. and 200 ° C., in particular 100 ° C. to 200 ° C.
- the intractable connection between the two packaging material webs can also be produced by other heat-sealing or cold-sealing methods, such as ultrasonic sealing, laser sealing or the like.
- the packaging can be efficiently manufactured from ribbon by series production on rotary sealing machines.
- the line of weakness in manufacture by laser ablation or Laserscoring is generated, with the use of tear-resistant film laminates for the first and second packaging material element, the lines of weakness are mounted directly opposite congruent.
- Another embodiment provides that in the product receiving area position restrictors, preferably by heat sealing, are arranged.
- the individual packagings are produced as a waste-free strand (40), packaging pairs being formed.
- Two single-dose packages of a packaging package are each connected point-symmetrically via tabs.
- the present invention further relates to the use of the unit dose packages as described above for packaging transdermal therapeutic systems or pharmaceutical dosage forms.
Abstract
Description
Claims
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11817269.1A EP2655211A1 (de) | 2010-12-23 | 2011-12-21 | Hochdichte einzeldosisverpackung |
RU2013134145A RU2635475C2 (ru) | 2010-12-23 | 2011-12-21 | Единичная дозовая упаковка высокой герметичности |
KR1020137018850A KR101899616B1 (ko) | 2010-12-23 | 2011-12-21 | 기밀 밀봉 단회 용량 포장재 |
CN201180065933.3A CN103339040B (zh) | 2010-12-23 | 2011-12-21 | 高密封的单剂量包装件 |
AU2011348432A AU2011348432B2 (en) | 2010-12-23 | 2011-12-21 | Tightly sealing single dose packaging |
CA2822522A CA2822522C (en) | 2010-12-23 | 2011-12-21 | Tightly sealing single dose packaging |
BR112013015756A BR112013015756A2 (pt) | 2010-12-23 | 2011-12-21 | embalagem de dose única altamente hermética |
JP2013545106A JP6226747B2 (ja) | 2010-12-23 | 2011-12-21 | 堅く密封された単回用量剤パッケージング |
MX2013007289A MX354293B (es) | 2010-12-23 | 2011-12-21 | Empaque de una sola dosis que sella de manera hermética. |
US13/922,316 US11045387B2 (en) | 2010-12-23 | 2013-06-20 | Tightly sealing single dose packaging |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201061460022P | 2010-12-23 | 2010-12-23 | |
US61/460,022 | 2010-12-23 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US13/922,316 Continuation-In-Part US11045387B2 (en) | 2010-12-23 | 2013-06-20 | Tightly sealing single dose packaging |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2012084216A1 true WO2012084216A1 (de) | 2012-06-28 |
Family
ID=45571485
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2011/006459 WO2012084216A1 (de) | 2010-12-23 | 2011-12-21 | Hochdichte einzeldosisverpackung |
Country Status (13)
Country | Link |
---|---|
US (1) | US11045387B2 (de) |
EP (1) | EP2655211A1 (de) |
JP (1) | JP6226747B2 (de) |
KR (1) | KR101899616B1 (de) |
CN (1) | CN103339040B (de) |
AR (1) | AR084452A1 (de) |
AU (1) | AU2011348432B2 (de) |
BR (1) | BR112013015756A2 (de) |
CA (1) | CA2822522C (de) |
MX (1) | MX354293B (de) |
RU (1) | RU2635475C2 (de) |
TW (1) | TWI546230B (de) |
WO (1) | WO2012084216A1 (de) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2687458A1 (de) * | 2012-07-17 | 2014-01-22 | LTS LOHMANN Therapie-Systeme AG | Verpackung für einzeldosierte wirkstoffhaltige Filme |
DE102014104692A1 (de) * | 2014-04-02 | 2015-10-08 | Huhtamaki Flexible Packaging Germany, Zweigniederlassung Der Huhtamaki Flexible Packaging Germany Gmbh & Co. Kg | Verpackung |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
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DE102009008217A1 (de) * | 2009-02-10 | 2010-08-19 | Lts Lohmann Therapie-Systeme Ag | Kindergesicherte, hochinerte Einzelverpackung |
EP2655211A1 (de) * | 2010-12-23 | 2013-10-30 | LTS LOHMANN Therapie-Systeme AG | Hochdichte einzeldosisverpackung |
ITMI20120031A1 (it) * | 2012-01-13 | 2013-07-14 | Altergon Sa | Struttura di confezionamento per film biomedicali |
CN105026283A (zh) * | 2013-01-18 | 2015-11-04 | 比密斯公司 | 用于易碎性薄材料的撕开式小袋 |
GB2516890A (en) * | 2013-08-05 | 2015-02-11 | Kraft Foods R & D Inc | A package for a plurality of articles |
US9938075B2 (en) * | 2014-11-26 | 2018-04-10 | The Procter & Gamble Company | Beverage cartridge containing pharmaceutical actives |
US11542060B2 (en) | 2017-03-21 | 2023-01-03 | Altria Client Services Llc | Package for consumer goods and method for manufacturing a tear-open package |
CA3049742A1 (en) * | 2017-03-21 | 2018-09-27 | Philip Morris Products S.A. | Method for opening a package for consumer goods and package for consumer goods as well as a method for manufacturing such a package |
WO2018226612A1 (en) * | 2017-06-07 | 2018-12-13 | Automated Packaging Systems, Inc. | Tear open bag |
KR102491484B1 (ko) | 2021-08-13 | 2023-01-20 | 박우진 | 포장 케이스 제조장치 및 이를 이용한 포장 케이스 제조방법 |
WO2023183424A1 (en) * | 2022-03-23 | 2023-09-28 | Bayer Healthcare Llc | Child-proof stick pack |
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- 2011-12-21 EP EP11817269.1A patent/EP2655211A1/de not_active Withdrawn
- 2011-12-21 KR KR1020137018850A patent/KR101899616B1/ko active IP Right Grant
- 2011-12-21 AR ARP110104839A patent/AR084452A1/es active IP Right Grant
- 2011-12-21 CA CA2822522A patent/CA2822522C/en active Active
- 2011-12-21 JP JP2013545106A patent/JP6226747B2/ja active Active
- 2011-12-21 RU RU2013134145A patent/RU2635475C2/ru active
- 2011-12-21 BR BR112013015756A patent/BR112013015756A2/pt not_active Application Discontinuation
- 2011-12-21 WO PCT/EP2011/006459 patent/WO2012084216A1/de active Application Filing
- 2011-12-21 MX MX2013007289A patent/MX354293B/es active IP Right Grant
- 2011-12-21 TW TW100147741A patent/TWI546230B/zh active
- 2011-12-21 CN CN201180065933.3A patent/CN103339040B/zh active Active
- 2011-12-21 AU AU2011348432A patent/AU2011348432B2/en active Active
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2013
- 2013-06-20 US US13/922,316 patent/US11045387B2/en active Active
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US20060023976A1 (en) | 2004-08-02 | 2006-02-02 | Alvater Paul H | Peelable pouch containing a single or multiple dosage forms and process of making same |
DE102004047445A1 (de) | 2004-09-30 | 2006-04-13 | Lts Lohmann Therapie-Systeme Ag | Nichtwiederverschließbare Verpackung für gesundheitsgefährdende Erzeugnisse, sowie Verfahren zu deren Herstellung |
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---|---|---|---|---|
EP2687458A1 (de) * | 2012-07-17 | 2014-01-22 | LTS LOHMANN Therapie-Systeme AG | Verpackung für einzeldosierte wirkstoffhaltige Filme |
WO2014012787A1 (de) * | 2012-07-17 | 2014-01-23 | Lohmann Therapie-Systeme Ag | Verpackung für einzeldosierte wirkstoffhaltige filme und verfahren zur herstellung dieser verpackung |
CN104640781A (zh) * | 2012-07-17 | 2015-05-20 | Lts勒曼治疗系统股份公司 | 用于单剂的含活性物质的膜的封装件和用于制造该封装件的方法 |
JP2015524290A (ja) * | 2012-07-17 | 2015-08-24 | エルテーエス ローマン テラピー−ジステーメ アーゲー | 新規な単回用量パッケージング |
RU2633954C2 (ru) * | 2012-07-17 | 2017-10-19 | Лтс Ломанн Терапи-Системе Аг | Упаковка для пленок, содержащих однократно дозируемое действующее вещество, и способ ее изготовления |
DE102014104692A1 (de) * | 2014-04-02 | 2015-10-08 | Huhtamaki Flexible Packaging Germany, Zweigniederlassung Der Huhtamaki Flexible Packaging Germany Gmbh & Co. Kg | Verpackung |
Also Published As
Publication number | Publication date |
---|---|
US11045387B2 (en) | 2021-06-29 |
BR112013015756A2 (pt) | 2018-05-22 |
CN103339040B (zh) | 2016-01-13 |
AU2011348432A1 (en) | 2013-07-11 |
CA2822522A1 (en) | 2012-06-28 |
KR101899616B1 (ko) | 2018-09-17 |
RU2013134145A (ru) | 2015-01-27 |
CA2822522C (en) | 2019-07-30 |
KR20130140825A (ko) | 2013-12-24 |
MX354293B (es) | 2018-02-21 |
US20130341237A1 (en) | 2013-12-26 |
MX2013007289A (es) | 2013-08-26 |
JP6226747B2 (ja) | 2017-11-08 |
TW201242849A (en) | 2012-11-01 |
AR084452A1 (es) | 2013-05-15 |
RU2635475C2 (ru) | 2017-11-13 |
TWI546230B (zh) | 2016-08-21 |
EP2655211A1 (de) | 2013-10-30 |
JP2014506857A (ja) | 2014-03-20 |
AU2011348432B2 (en) | 2016-09-22 |
CN103339040A (zh) | 2013-10-02 |
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