WO2012052562A1 - Compositions comprenant un produit de charge et une tétracycline chimiquement modifiée - Google Patents

Compositions comprenant un produit de charge et une tétracycline chimiquement modifiée Download PDF

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Publication number
WO2012052562A1
WO2012052562A1 PCT/EP2011/068516 EP2011068516W WO2012052562A1 WO 2012052562 A1 WO2012052562 A1 WO 2012052562A1 EP 2011068516 W EP2011068516 W EP 2011068516W WO 2012052562 A1 WO2012052562 A1 WO 2012052562A1
Authority
WO
WIPO (PCT)
Prior art keywords
dedimethylamino
composition
tetracycline
chemically modified
combination product
Prior art date
Application number
PCT/EP2011/068516
Other languages
English (en)
Inventor
Guy Bouvier
Original Assignee
Galderma Research & Development
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galderma Research & Development filed Critical Galderma Research & Development
Publication of WO2012052562A1 publication Critical patent/WO2012052562A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/91—Injection

Definitions

  • the present invention relates to compositions for topical and/or parenteral application comprising, in a physiologically acceptable medium, at least one filler product and at least one chemically modified tetracycline.
  • the invention also relates to the use of these compositions especially for treating skin aging, in particular for treating by filling wrinkles, fine lines, fibroblast depletions, dehydration of the skin and any scars.
  • composition B comprising at least one chemically modified tetracycline
  • physiologically acceptable medium is intended to mean a medium that is compatible with the skin, the mucous membranes and/or the skin appendages.
  • the filler product may also contain another active ingredient, for instance an anaesthetic such as lidocaine.
  • an anaesthetic such as lidocaine.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne une combinaison de produits comprenant : - une composition A comprenant au moins un produit de charge et - une composition B comprenant au moins une tétracycline chimiquement modifiée, pour le traitement du vieillissement cutané et des cicatrices, les compositions A et B étant utilisés simultanément, séparément ou séquentiellement au cours du temps. L'invention concerne également une composition pharmaceutique unique, ou un produit d'association médicamenteuse fixe pouvant être injecté, comprenant, dans le même support physiologiquement acceptable, au moins un produit de charge et au moins une tétracycline chimiquement modifiée.
PCT/EP2011/068516 2010-10-22 2011-10-24 Compositions comprenant un produit de charge et une tétracycline chimiquement modifiée WO2012052562A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US34484710P 2010-10-22 2010-10-22
FR1058648A FR2966348B1 (fr) 2010-10-22 2010-10-22 Compositions comprenant un produit de comblement des rides et une tetracycline modifiee chimiquement
US61/344,847 2010-10-22
FR1058648 2010-10-22

Publications (1)

Publication Number Publication Date
WO2012052562A1 true WO2012052562A1 (fr) 2012-04-26

Family

ID=43939886

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2011/068516 WO2012052562A1 (fr) 2010-10-22 2011-10-24 Compositions comprenant un produit de charge et une tétracycline chimiquement modifiée

Country Status (2)

Country Link
FR (1) FR2966348B1 (fr)
WO (1) WO2012052562A1 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017078532A1 (fr) 2015-11-05 2017-05-11 Tsk Laboratory Europe B.V. Procédé permettant de relier deux objets à l'aide d'une composition polymère, et système, pour une utilisation lors d'une procédure cosmétique
WO2018021331A1 (fr) * 2016-07-27 2018-02-01 東レ株式会社 Composition de résine
RU2743746C2 (ru) * 2016-03-02 2021-02-25 Мерц Фарма Гмбх Энд Ко. Кгаа Композиция, содержащая ботулинический токсин
US11155802B2 (en) 2017-07-06 2021-10-26 Merz Pharma Gmbh & Co. Kgaa Recombinant botulinum neurotoxins with increased duration of effect
US11952601B2 (en) 2017-06-20 2024-04-09 Merz Pharma Gmbh & Co. Kgaa Recombinant botulinum toxin with increased duration of effect

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5332802A (en) * 1988-02-18 1994-07-26 Autogenesis Technologies, Inc. Human collagen processing and autoimplant use
US20030082120A1 (en) * 2001-10-26 2003-05-01 Milstein Harold J. Method for reducing systemic effects of aging, effects of aging on the skin, and incidence of skin damage from sun exposure using antibiotics of the tetracycline family
US20030203008A1 (en) * 1997-01-13 2003-10-30 Subramanian Gunasekaran Preparation of collagen
US20070067045A1 (en) * 2005-09-19 2007-03-22 Ar2 Partners, Inc. Systems and methods for skin wrinkle removal
US7211267B2 (en) 2001-04-05 2007-05-01 Collagenex Pharmaceuticals, Inc. Methods of treating acne

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5332802A (en) * 1988-02-18 1994-07-26 Autogenesis Technologies, Inc. Human collagen processing and autoimplant use
US20030203008A1 (en) * 1997-01-13 2003-10-30 Subramanian Gunasekaran Preparation of collagen
US7211267B2 (en) 2001-04-05 2007-05-01 Collagenex Pharmaceuticals, Inc. Methods of treating acne
US20030082120A1 (en) * 2001-10-26 2003-05-01 Milstein Harold J. Method for reducing systemic effects of aging, effects of aging on the skin, and incidence of skin damage from sun exposure using antibiotics of the tetracycline family
US20070067045A1 (en) * 2005-09-19 2007-03-22 Ar2 Partners, Inc. Systems and methods for skin wrinkle removal

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BERGE ET AL., J. PHARM. SCI., vol. 66, 1977, pages 1 - 19
FISHER ET AL.: "Looking older", ARCH DERMATOL., vol. 144, no. 5, 2008, pages 666 - 672, XP002749024
KAPOOR, VIJAY K. (CORRESPONDENCE) ET AL CHADHA, RENU: "Synthetic drugs with anti-ageing effects.", DRUG DISCOVERY TODAY, vol. 14, no. 17-18, September 2009 (2009-09-01), pages 899 - 904, XP002637081 *
NAOUM C, DASIOU-PLAKIDA D: "Dermal filler materials and botulin toxin", INT J DERMATOL., vol. 40, no. 10, October 2001 (2001-10-01), pages 609 - 21, XP009085797, DOI: doi:10.1046/j.1365-4362.2001.01111.x
SAARI H ET AL.: "Differential effects of reactive oxygen species on native synovial fluid and purified human umbilical cord hyaluronate", INFLAMMATION, vol. 17, 1993, pages 403 - 415
SHERMAN, RICHARD N., DR. (CORRESPONDENCE): "Avoiding dermal filler complications.", CLINICS IN DERMATOLOGY, vol. 27, no. 3 Suppl, June 2009 (2009-06-01), pages S23 - S32, XP002637080 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017078532A1 (fr) 2015-11-05 2017-05-11 Tsk Laboratory Europe B.V. Procédé permettant de relier deux objets à l'aide d'une composition polymère, et système, pour une utilisation lors d'une procédure cosmétique
US11091670B2 (en) 2015-11-05 2021-08-17 Tsk Laboratory Europe B.V. Method for connecting two objects using a polymer composition and a system, for use in a cosmetic procedure
RU2743746C2 (ru) * 2016-03-02 2021-02-25 Мерц Фарма Гмбх Энд Ко. Кгаа Композиция, содержащая ботулинический токсин
US11969461B2 (en) 2016-03-02 2024-04-30 Merz Pharma Gmbh & Co. Kgaa Composition comprising botulinum toxin
WO2018021331A1 (fr) * 2016-07-27 2018-02-01 東レ株式会社 Composition de résine
US11199776B2 (en) 2016-07-27 2021-12-14 Toray Industries, Inc. Resin composition
US11952601B2 (en) 2017-06-20 2024-04-09 Merz Pharma Gmbh & Co. Kgaa Recombinant botulinum toxin with increased duration of effect
US11155802B2 (en) 2017-07-06 2021-10-26 Merz Pharma Gmbh & Co. Kgaa Recombinant botulinum neurotoxins with increased duration of effect

Also Published As

Publication number Publication date
FR2966348B1 (fr) 2012-11-09
FR2966348A1 (fr) 2012-04-27

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