WO2012039452A1 - 歯の汚れを除去するための口腔用組成物 - Google Patents
歯の汚れを除去するための口腔用組成物 Download PDFInfo
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- WO2012039452A1 WO2012039452A1 PCT/JP2011/071601 JP2011071601W WO2012039452A1 WO 2012039452 A1 WO2012039452 A1 WO 2012039452A1 JP 2011071601 W JP2011071601 W JP 2011071601W WO 2012039452 A1 WO2012039452 A1 WO 2012039452A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/22—Peroxides; Oxygen; Ozone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C19/00—Dental auxiliary appliances
- A61C19/06—Implements for therapeutic treatment
- A61C19/063—Medicament applicators for teeth or gums, e.g. treatment with fluorides
- A61C19/066—Bleaching devices; Whitening agent applicators for teeth, e.g. trays or strips
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/75—Anti-irritant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/81—Preparation or application process involves irradiation
Definitions
- the present invention relates to an oral composition for removing dirt on teeth.
- the present invention relates to an oral composition capable of powerfully removing tooth dirt by containing a predetermined concentration of peroxide and condensed phosphoric acid.
- Patent Document 1 discloses a stain remover for oral cavity containing ultraphosphate.
- the acidity of this stain remover is set to pH 5 or more and 6.5 or less (paragraphs [0024] and [0033] of the same document).
- Patent Document 2 discloses a whitening agent containing hydrogen peroxide or urea peroxide as a radical accelerator.
- Patent Document 3 discloses a chewing gum composition for removing dirt from a tooth surface containing a peroxide and a polyphosphate.
- Patent Document 4 JP-T-2006-504776 discloses a composition for removing dirt from a tooth surface containing a peroxide and a polyphosphate.
- Patent Document 5 discloses a liquid oral composition having a pH of 7 to 9 and containing a polyphosphate, an acyl taurine salt, and polyethylene glycol having an average molecular weight of 600.
- an object of the present invention is to provide an oral composition that can effectively remove dental stains.
- an object of this invention is to provide the composition for oral cavity with few damage to a tooth
- Another object of the present invention is to provide an oral composition that can prevent dissolution of dental enamel.
- the present invention is basically based on the knowledge that tooth dirt can be strongly removed by containing a predetermined concentration of peroxide and condensed phosphoric acid (particularly ultraphosphate) or a salt thereof.
- the present invention is based on the knowledge that tooth dirt can be effectively removed even under neutral conditions by containing a predetermined concentration of peroxide and condensed phosphate.
- the first aspect of the present invention relates to an oral composition for removing dirt on teeth.
- This oral composition contains 3.5 wt% or more and 30 wt% or less of peroxide and 5 wt% or more and 20 wt% or less of condensed phosphoric acid (preferably ultraphosphoric acid).
- the ultraphosphoric acid preferably has an average phosphoric acid polymerization degree of 10 or more and 30 or less.
- this intraoral composition exhibits a remarkably high cleaning effect compared to peroxide alone or ultraphosphoric acid alone.
- the cleaning effect is extremely high compared to the case of using condensed phosphoric acid.
- this oral composition exhibits a high cleaning effect in a neutral region, it has high biocompatibility and is extremely easy to handle.
- peroxides examples include hydrogen peroxide, urea peroxide, or calcium peroxide.
- This intraoral composition is effective even in a neutral region where the acidity is 6.5 or more and 8 or less (or the acidity is 6.9 or more and 7.5 or less).
- This intraoral composition preferably contains an infrared heat-generating substance and is irradiated with infrared rays during use.
- An example of an infrared heating material is black.
- black ink are bamboo sumi, eggplant charcoal, and activated carbon. The use of eggplant charcoal is preferable because it not only has high biocompatibility, but also exhibits a synergistic effect with peroxide and ultraphosphoric acid to obtain a high bleaching effect.
- This oral composition is preferably used at 37 ° C. or more and 50 ° C. or less. If it is this temperature, since the activity of peroxide will increase, the cleaning effect can be enhanced. However, the temperature at which the lip, pulp, and gums are not damaged by heat is more preferably 37 ° C. or higher and 45 ° C. or lower.
- the oral composition preferably further comprises polyethylene glycol.
- examples of the average molecular weight of polyethylene glycol are 4000 or more and 10,000 or less.
- the concentration of polyethylene glycol is preferably 0.25 wt% or more and 2 wt% or less. Note that the above-described configurations can be appropriately combined.
- an oral composition capable of powerfully removing tooth dirt by containing a predetermined concentration of peroxide and condensed phosphoric acid (ultraphosphate).
- an oral composition capable of preventing damage to teeth and gums due to peroxide by containing condensed phosphoric acid (particularly ultraphosphate).
- the oral composition of the present invention exhibits a high cleaning effect even in a neutral region. For this reason, the composition for oral cavity of this invention has little damage to a biological body. Therefore, tooth cleaning using the composition for oral cavity of the present invention can be easily performed.
- composition for oral cavity of the present invention has an action of preventing the action of the peroxide from dissolving the calcium phosphate-based substance by the ultraphosphate. For this reason, the composition for oral cavity of this invention can prevent effectively that the enamel of a tooth
- FIG. 1A is a photograph of teeth left at 42 ° C. for 3.5 hours under 3.5% H 2 O 2 alkaline conditions (pH 10).
- FIG. 1B is a photograph of a tooth left at 42 ° C. for 3.5 hours under 3.5% H 2 O 2 alkaline condition (pH 10).
- FIG. 2A is a photograph of teeth left at 42 ° C. for each time under 3.5% H 2 O 2 and 10% ultraphosphoric acid (pH 7).
- FIG. 2B is a photograph of teeth left at 42 ° C. for each time under 3.5% H 2 O 2 and 10% ultraphosphoric acid (pH 7).
- FIG. 3 shows photographs of teeth left at 42 ° C. for 5 hours under 5% H 2 O 2 (pH 10).
- FIG. 10 shows photographs of teeth left at 42 ° C. for 5 hours under 5% H 2 O 2 (pH 10).
- FIG. 4 shows photographs of teeth left at 42 ° C. for 5 hours under 5% H 2 O 2 and 10% ultraphosphoric acid (pH 7).
- FIG. 5 shows the bleaching effect of teeth when an alkali-conditioned 10% H 2 O 2 -containing polymer and neutral 10% H 2 O 2 and 10% ultraphosphoric acid-containing polymer are applied to the same extracted tooth. It is a photograph shown.
- FIG. 6A shows photographs of teeth left for 20 hours at 42 ° C. under 20% H 2 O 2 (pH 10).
- FIG. 6B shows photographs of teeth left for 20 hours at 42 ° C. under 20% H 2 O 2 (pH 10).
- FIG. 7A shows photographs of teeth left for 20 hours at 42 ° C. under 20% H 2 O 2 and 10% ultraphosphoric acid (pH 7).
- FIG. 7B shows photographs of teeth left at 42 ° C. for each time under 20% H 2 O 2 and 10% ultraphosphoric acid (pH 7).
- the oral composition of the present invention is an oral composition for removing dirt on teeth. That is, the intraoral composition is a composition that is used mainly in the oral cavity to remove dental stains. However, the oral cavity composition of the present invention can also be used for cleaning complete dentures and dentures. An example of such an oral composition is a stain remover.
- This intraoral composition may be included in toothpaste and mouthwash. In addition, the oral composition may be liquid or gel. And it may be used in the case of whitening by a dentist.
- This intraoral composition contains 3.5 wt% or more and 30 wt% or less of peroxide and 5 wt% or more and 20 wt% or less of condensed phosphoric acid (preferably ultraphosphoric acid) or a salt thereof.
- peroxides are hydrogen peroxide, urea peroxide, or calcium peroxide.
- concentration of the peroxide is preferably 3.5% by weight to 20% by weight, preferably 3.5% by weight to 15% by weight, more preferably 3.5% by weight to 10% by weight, and 5% by weight. It may be 10% by weight or less. This is because the cleaning effect of the oral composition of the present invention is enhanced in these ranges as shown in the examples.
- the oral composition of the present invention contains condensed phosphoric acid.
- condensed phosphoric acid is so-called polyphosphoric acid.
- polyphosphoric acid Of the polyphosphoric acids, ultraphosphoric acid is preferred.
- ultraphosphoric acid are as disclosed in Patent Document 1.
- a preferred example of ultraphosphoric acid is ultraphosphoric acid having an average degree of polymerization of phosphoric acid of 10 to 30.
- the average degree of polymerization of ultraphosphoric acid may be 15 or more and 30 or less, or 15 or more and 25 or less.
- a high bleaching effect can be obtained due to a synergistic effect with the peroxide.
- the concentration of the condensed phosphoric acid is preferably 3.5% by weight to 20% by weight, preferably 3.5% by weight to 15% by weight, more preferably 7.5% by weight to 12.5% by weight, It is more preferably 5% by weight or more and 10% by weight or less, and may be 5% by weight or more and 10% by weight or less.
- Polyphosphoric acid may be added to the composition in the form of a salt.
- the salt of polyphosphoric acid are salts of polyphosphoric acid and alkali metal including polyphosphoric acid sodium salt and polyphosphoric acid potassium salt.
- This intraoral composition is effective even in a neutral region where the acidity is 6.5 or more and 8 or less (or the acidity is 6.9 or more and 7.5 or less).
- This intraoral composition preferably contains an infrared heat-generating substance and is irradiated with infrared rays during use.
- An example of an infrared heating material is black.
- examples of infrared heat generating materials other than black are titanium oxide, aluminum, gold, or silver.
- In the dental clinic there are infrared lasers for treatment and lights for whitening. Infrared lasers have less adverse effects on living bodies than ultraviolet lasers.
- the ink contained in the oral composition is irradiated with an infrared laser, infrared light, or visible light containing the infrared laser, the ink has heat, and as a result, the oral composition itself becomes warm. Then, the whitening effect of the oral composition is enhanced. For this reason, the intraoral composition of this invention can be used effectively in a dental clinic.
- Infrared heat-generating substance means a substance that generates heat when irradiated with infrared rays. Examples of infrared wavelengths are 750 nm to 2000 nm, 800 nm to 1500 nm, 800 nm to 1300 nm, and 850 nm to 1050 nm.
- the present invention also provides an intraoral composition that is applied to a tooth for which bleaching is intended and that exerts a bleaching effect on the tooth by irradiating the coated portion with infrared rays. Examples of the intensity of the irradiated infrared rays are 1 W or more and 50 W or less, 3 W or more and 20 W or less, and 5 W or more and 10 W or less.
- the present invention also includes an intraoral composition that contains a peroxide at a predetermined concentration and that is applied to a tooth intended for bleaching and that exerts a bleaching effect on the tooth by irradiating the applied part with infrared rays. provide.
- This oral composition is preferably used at 37 ° C. or more and 50 ° C. or less. Furthermore, 37 degreeC or more and 45 degrees C or less are more preferable in order to avoid the damage by the heat
- the oral composition preferably further comprises polyethylene glycol.
- examples of the average molecular weight (number average molecular weight) of polyethylene glycol are 4000 or more and 10,000 or less. When the average molecular weight is 4000 or more, the stain residual ratio can be reduced.
- the average molecular weight of polyethylene glycol is preferably 6000 or more.
- Table 6 it can be seen that when peroxide, polyphosphoric acid and PEG are present, an extremely high synergistic effect is obtained and the stain residual ratio can be drastically reduced.
- the concentration of polyethylene glycol is preferably 0.25 wt% or more and 2 wt% or less.
- the concentration of polyethylene glycol may be 0.5 wt% or more and 1.5 wt% or less, or 0.75 wt% or more and 1.25 wt% or less.
- This oral composition is an oral composition except that it contains 3.5 wt% or more and 30 wt% or less peroxide and 5 wt% or more and 20 wt% or less polyphosphoric acid (preferably ultraphosphoric acid).
- the composition normally used for may be included as appropriate.
- the oral composition may contain glycerin, a fragrance, a coloring agent, a flavoring agent, and a binder.
- the paste-like intraoral composition can be produced by kneading the raw materials. Alternatively, it may be dissolved in a solvent containing water and physiological saline to form a liquid oral composition.
- the apatite was suspended in 200 ⁇ L of water, and the suspension was transferred to one well of a 96-well microtiter plate.
- a 96-well microtiter plate was scanned from the bottom with a scanner (Epson GT8300), the obtained image was inverted in gradation, the light intensity was measured with Image J (free software), and the stain residual ratio was calculated.
- Table 1 summarizes the results of improvement of the bleaching effect of hydrogen peroxide by various condensed phosphoric acids.
- Table 1 shows the results of comparing the ability to improve the bleaching effect of hydrogen peroxide between sodium polyphosphate (average phosphoric acid polymerization degree 80: manufactured by Ligentis Co., Ltd.) and sodium ultraphosphate (manufactured by Mitejima Chemical Co., Ltd.).
- Sodium ultraphosphate was capable of improving more than twice as much as sodium polyphosphate.
- Table 5 shows that at a hydrogen peroxide concentration of 3.5%, the higher the temperature, the higher the effect of increasing the bleaching effect at 5% and 10% of ultraphosphoric acid, and the effect increases dramatically at 45 ° C. I understood. In addition, with 5% hydrogen peroxide, the effect of 45 ° C. treatment was higher than that of 37 ° C. treatment. From the above results, it can be said that the oral composition of the present invention is particularly preferably treated at a temperature of 42 ° C. or higher.
- Tables 7 and 8 show that the amount of polyethylene glycol added to enhance the bleaching effect is 0.25% to a maximum of 1%, and blending 1% or more has little effect on the bleaching effect. It was done. From the above results, it was found that, under neutral conditions and a processing temperature of 42 ° C., when a polyethylene glycol having a molecular weight of 6000 or more was blended at a concentration of 0.25 to 1%, a remarkable bleaching acceleration effect was exhibited.
- Table 9 shows that when 1% of polyethylene glycol having a molecular weight of 6000 is added and the concentration of ultraphosphoric acid is changed from 0 to 20%, the bleaching effect is compared.
- the residual rate was 25% or less, but the stain residual rate was the lowest when the concentration of ultraphosphoric acid was 10%.
- the concentration of ultraphosphoric acid was fixed at 10% for confirmation, and the bleaching effect when polyethylene glycols of various molecular weights were added at a concentration of 1% was compared.
- the effect of accelerating bleaching increased, and the effect was maximized at a molecular weight of 6000.
- tea tea juice 5 g of instant coffee, 2 bags of Lipton tea bags, 2 bags of Oi tea (registered trademark) tea bags, 110 mL of distilled water are added, heated in a microwave oven for about 2 minutes, filtered after natural heat dissipation was used.
- the artificial saliva is 20 mM HEPES-KOH
- the composition having pH 7.0, 1.5 mM CaCl 2 and 0.9 mM KH 2 PO 4 was used.
- pH 10 control experiment
- the other 10% A solution prepared by adding reticulated polyphosphoric acid to pH 7 was applied (Example 1) and allowed to stand at 42 ° C. for a maximum of 30 minutes to examine the color removal effect.
- FIG. 1A and FIG. 1B are photographs of teeth left at 42 ° C. for each time under 3.5% H 2 O 2 alkaline conditions (pH 10) (control experiment). 2A and 2B show 3.5. % H 2 O 2 and 10% Ultra phosphate (pH 7) is a photograph of a tooth was left each time 42 ° C. at the bottom (Example 1). Comparing FIG. 1A and FIG. 1B with FIG. 2A and FIG. 2B, the combined use of 10% ultraphosphoric acid and hydrogen peroxide solution under neutral conditions compared to hydrogen peroxide solution under alkaline conditions Is high.
- FIG. 3 shows photographs of teeth left at 42 ° C. for 5 hours under 5% H 2 O 2 (pH 10).
- FIG. 4 shows 5% H 2 O 2 and 10% ultraphosphoric acid (pH 7) Below are photographs of teeth left at 42 ° C for each time.
- the bleaching effect of the combination of ultraphosphoric acid and 5% hydrogen peroxide was higher than that of 5% hydrogen peroxide alone in bleaching with 5% hydrogen peroxide.
- FIG. 5 shows the bleaching effect of teeth when an alkali-conditioned 10% H 2 O 2 -containing polymer and neutral 10% H 2 O 2 and 10% ultraphosphoric acid-containing polymer are applied to the same extracted tooth. It is a photograph shown. As shown in FIG. 5, as demonstrated in the same tooth, neutral 10% H 2 O 2 and 10% ultraphosphoric acid containing polymer (left half) is 10% H 2 O 2 containing polymer (right half) A higher bleaching effect was confirmed.
- 6A and 6B show photographs of teeth left for 20 hours at 42 ° C. under 20% H 2 O 2 (pH 10).
- 7A and 7B show photographs of teeth left at 42 ° C. for each time under 20% H 2 O 2 and 10% ultraphosphoric acid (pH 7).
- a semiconductor laser was irradiated to the coated part for 30 seconds to 5 minutes.
- a semiconductor laser a semiconductor laser ez laser (registered trademark) manufactured by Water Rays Japan Co., Ltd. was used.
- the output wavelength of this laser was 940 nm, and the output intensity was 7 W.
- the bleaching effect of the teeth was remarkably increased only by irradiating the semiconductor laser for about 1 minute. This is probably because the energy of the semiconductor laser dramatically improved the bleaching effect of the peroxide.
- the composition obtained by adding 1 to 10% by weight of black to the oral composition was applied to the teeth and irradiated with a semiconductor laser. Then, a high bleaching effect was confirmed.
- the present invention can be used in the industry related to oral compositions.
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Abstract
Description
ハイドロキシアパタイト(Biogel-HTP, BioRad社)1~2gを 50mL チューブにとり,タンパク質溶液(1% イクオスSCP5000,新田ゼラチン)20mLを加え,10~15分放置後,遠心分離(3000
x g, 2分)を行い,上清を除去した。次に遠心分離後沈殿したアパタイトに茶渋液(水110mLにインスタントコーヒー5g,紅茶ティーバック2個,緑茶ティーバック2個を入れ,電子レンジで2分加熱した。その後,室温で振りながら3時間から一晩放熱させた。その後,200メッシュの濾紙でろ過した。このようにして得られた液が茶渋液である)20mLを加え,10~15分放置後,遠心分離(2500rpm, 2分)を行い,上清を除去した。最後に遠心分離後沈殿したアパタイトに人口唾液(20mM HEPES-KOH pH7.0, 1.5mM CaCl2, 0.9mM KH2PO4)20mLを加え,10~15分放置後遠心分離(2500rpm, 2分)を行い,上清を除去して沈殿したアパタイトを乾燥させた。
乾燥茶渋アパタイトを20mg秤量し,各種濃度のH2O2と必要に応じて各種縮合リン酸塩,NaOH,その他の物質混合した溶液を
0.3mL 入れて一定時間一定温度で放置した。遠心分離(3000 x g, 15秒)によりアパタイトを沈殿させ,上清を除去後,水1mL入れてよく混和しアパタイトを洗浄した。さらに遠心分離(3000
x g, 15秒)し,上清を除去する操作を4回繰り返した。その後アパタイトを200μLの水に懸濁し,その懸濁液を96穴マイクロタイタープレートの1ウェルに移した。96穴マイクロタイタープレートをその底部よりスキャナー(エプソンGT8300)でスキャンし,得られた像を諧調反転し,イメージJ(imageJ)(フリーソフトウェア)にて光度を測定しステイン残存率を算出した。
表1に各種縮合リン酸による過酸化水素の漂白効果の向上に関する結果をまとめた。
各種濃度のウルトラリン酸ナトリウムを用いて,3.5%の過酸化水素におけるアパタイトの漂白効果に関して比較した。このときpHは7.5,温度を42℃の一定条件にし,10分,30分,1時間,及び3時間で漂白効果を比較した。その結果を表2に示す。
各種過酸化水素濃度(3.5~10%)における漂白効果に関して以下の条件で評価した。(i)ウルトラリン酸:5,10,20%,(ii)処理時間:10分,20分,30分,(iii)処理温度:45℃,(iv)pH
7.0。また,比較群として,アルカリ条件下(pH9.5~11.6)における過酸化水素単独での漂白効果及び,ウルトラリン酸単独での漂白作用に関しても評価しその結果を表3に示した。
漂白作用をもつラジカルを発生させる過酸化物をして,過酸化水素ではなく,過酸化尿素を使用した場合の漂白効果に関して,ウルトラリン酸との組み合わせの効果を評価し,表4にその結果を示した。
温度による漂白効果の違いを評価する目的で,37℃,42℃,及び45℃のそれぞれの温度での漂白効果を比較した。その結果を表5に示す。
過酸化水素とウルトラリン酸の混合系に各種分子量(分子量200,1000,4000,6000および20000)のポリエチレングリコールを終濃度1%となるように添加した場合の漂白効果に関して以下の条件で評価した。(i)ウルトラリン酸:10%,(ii)過酸化水素:0または5%,(iii)処理時間:10分,(iv)処理温度:45℃,(v)pH
7.0。また,比較群として,ウルトラリン酸単独での漂白効果及び,ウルトラリン酸と過酸化水素のみを組み合わせた場合の漂白作用に関しても評価し,その結果を合わせて表6に示した。
過酸化水素とウルトラリン酸の混合系に各濃度(0~15%)のポリエチレングリコール(分子量6000)を添加した場合の漂白効果に関して以下の条件で評価した結果を表7に示した。(i)ウルトラリン酸:10%,(ii)過酸化水素:5%,(iii)処理時間:10分,(iv)処理温度:42℃,(v)pH
7.0。また,同条件で各種分子量のポリエチレングリコールを各種濃度(0~1%)となるように添加した場合の漂白効果を比較した結果を表8に示した。
また表8より,1%未満の低濃度で各種ポリエチレングリコールを添加した場合の漂白効果を比較したところ,分子量6000および20000のポリエチレングリコールでは濃度の増加に従ってステイン残存率が低下し,漂白効果への濃度依存性が示されたが,分子量4000についてはいずれの濃度でもポリエチレングリコールを添加しなかった場合とほぼ同程度のステイン残存率(約30%)となり,漂白効果の濃度依存性はみられなかった。
過酸化水素とウルトラリン酸の混合系に分子量6000のポリエチレングリコールを終濃度が1%となるように添加した場合の漂白効果について,以下の条件で評価した結果を表9に示した。(i)ウルトラリン酸:0~20%,(ii)過酸化水素:5%,(iii)処理時間:10分,(iv)処理温度:42℃,(v)pH
7.0。また同様の条件において,ウルトラリン酸濃度を10%に固定し,各種分子量のポリエチレングリコールを終濃度1%で添加した場合の漂白効果について評価した結果を表10に示した。
以上の結果を踏まえ,確認のためウルトラリン酸の濃度を10%に固定し,各種分子量のポリエチレングリコールを濃度1%で添加した場合の漂白効果を比較したところ,表10のとおり分子量の増加に従って漂白促進効果が増大し,その効果が分子量6000で最大となった。以上の結果から,中性条件,処理温度42℃においては10%ウルトラリン酸,5%過酸化水素の混合系に分子量6000のポリエチレングリコールを1%濃度で添加することで顕著な漂白促進効果が得られることがわかった。
抜去歯を30% 過酸化水素溶液に12時間以上浸し脱色した後,(i)タンパク溶液(1時間以上),(ii)茶渋(12時間以上),(iii)人口唾液(1時間以上)の順に浸漬しステインを付着させた。タンパク質溶液としては新田ゼラチンSPC-5000(コラーゲンペプチド)を1w/v%で溶解したものを用いた。また,茶渋液としてはインスタントコーヒー5g,リプトンティーバッグ2袋,おーいお茶(登録商標)ティーバッグ 2 袋に蒸留水 110mLを加え,家庭用電子レンジで約2分加熱し,自然放熱後ろ過したものを用いた。人口唾液は20mM HEPES-KOH
pH7.0, 1.5mM CaCl2, 0.9mM KH2PO4の組成のものを用いた。上記の方法でステインを付着させた抜去歯を各種濃度の過酸化水素条件下で一方はpH10(対照実験),もう一方は10%
網目状ポリリン酸を加えpH 7に調製したものを塗付し(実施例1),42℃で最長30分放置し着色除去効果を調べた。
%H2O2及び10%ウルトラリン酸(pH7)下に於いて42℃で各時間放置した歯の写真である(実施例1)。図1A及び図1Bと,図2A及び図2Bを比較すると,中性条件下での10%ウルトラリン酸と過酸化水素水の併用の方がアルカリ条件下の過酸化水素水に比べて漂白効果が高いことがわかる。
5%H2O2条件下で一方はpH10のものを抜去歯に塗布し,もう一方は5%H2O2に10%ウルトラリン酸を加えpH7に調製したものを抜去歯に塗付し,42℃で最長30分放置した。
下に於いて42℃で各時間放置した歯の写真を示す。
同一歯を用いてその半分を10%H2O2条件下で一方はpH10,もう半分を10%ウルトラリン酸を加えpH
7に調製したジェルを塗付し,42℃で最長30分放置した。尚歯を処理する溶液をジェルするために,それぞれの処理液に最終濃度0.7%になるようにカルボキシビニルポリマーを加えた。
20%H2O2条件下で一方はpH10のものを抜去歯に塗布し,もう一方は20%H2O2に10%ウルトラリン酸を加えpH7に調製したものを抜去歯に塗付し,42℃で最長30分放置した。
上記の実施例における口腔内組成物を歯牙に塗布した後,半導体レーザを塗布部分に30秒から5分照射した。半導体レーザとして,ウォーターレーズジャパン社製半導体レーザezレーズ(登録商標)を用いた。このレーザの出力波長は940nmであり,出力強度は7Wであった。その結果,半導体レーザを1分程度照射しただけで,歯牙の漂白効果が飛躍的に高まることがわかった。これは,半導体レーザのエネルギーが,過酸化物の漂白効果を飛躍的に高めたためと考えられる。また,口腔内組成物に1重量%~10重量%の墨を添加したものについても同様にして,歯牙に塗布し,半導体レーザを照射した。すると,高い漂白効果が確認された。
Claims (13)
- 3.5重量%以上30重量%以下の過酸化物と,5重量%以上20重量%以下の縮合リン酸又はその塩とを含む,歯の汚れを除去するための口腔内組成物。
- 前記縮合リン酸がウルトラリン酸である,請求項1に記載の口腔内組成物。
- 前記ウルトラリン酸の平均リン酸重合度が10以上30以下である,請求項2に記載の口腔内組成物。
- 前記過酸化物が過酸化水素水,過酸化尿素又は過酸化カルシウムである請求項1に記載の口腔内組成物。
- 酸性度が6.5以上8以下である請求項1に記載の口腔内組成物。
- 酸性度が6.9以上7.5以下である請求項1に記載の口腔内組成物。
- 赤外線発熱物質を更に含み,使用時に赤外線が照射される,請求項1に記載の口腔内組成物。
- 前記赤外線発熱物質が,墨である,請求項7に記載の口腔内組成物。
- 37℃以上50℃以下で使用される請求項1に記載の口腔内組成物。
- 請求項1に記載の口腔内組成物であって,前記縮合リン酸又はその塩の濃度が7.5重量%以上12.5重量%以下である口腔内組成物。
- 請求項1に記載の口腔内組成物であって,ポリエチレングリコールをさらに含む口腔内組成物。
- 前記ポリエチレングリコールの平均分子量が4000以上10000以下である請求項11に記載の口腔内組成物。
- 請求項11に記載の口腔内組成物であって,前記ポリエチレングリコールの濃度が0.25重量%以上2重量%以下である口腔内組成物。
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JP2012535067A JP5511971B2 (ja) | 2010-09-23 | 2011-09-22 | 歯の汚れを除去するための口腔用組成物 |
CN201180045924.8A CN103153268B (zh) | 2010-09-23 | 2011-09-22 | 用于去除牙渍的口腔用组合物 |
SG2013021266A SG188631A1 (en) | 2010-09-23 | 2011-09-22 | Oral composition for removing tooth stain |
US13/825,555 US20130189200A1 (en) | 2010-09-23 | 2011-09-22 | Oral Composition For Removing Tooth Stain |
KR1020137010313A KR101537309B1 (ko) | 2010-09-23 | 2011-09-22 | 치아의 오염을 제거하기 위한 구강용 조성물 |
HK13107954.4A HK1180600A1 (zh) | 2010-09-23 | 2013-07-08 | 用於去除牙漬的口腔用組合物 |
US14/455,937 US9138387B2 (en) | 2010-09-23 | 2014-08-10 | Oral composition for removing tooth stain |
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US14/455,937 Division US9138387B2 (en) | 2010-09-23 | 2014-08-10 | Oral composition for removing tooth stain |
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Cited By (3)
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JP2014189540A (ja) * | 2013-03-28 | 2014-10-06 | Masaharu Kato | 象牙細管封鎖材キット |
WO2017109889A1 (ja) * | 2015-12-24 | 2017-06-29 | リジェンティス株式会社 | 歯牙漂白用組成物及び歯牙の漂白方法 |
JP2019535458A (ja) * | 2016-10-26 | 2019-12-12 | ザ プロクター アンド ギャンブルカンパニーThe Procter & Gamble Company | 口腔ケアにおける使用のための電磁放射線源及び多相口腔用組成物 |
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ITMI20131151A1 (it) * | 2013-07-09 | 2015-01-10 | Gianluigi Caccianiga | Composizione e relativo kit di trattamento parodontale, implantologico e endodontico ad azione antisettica e rigenerativa ottimizzata |
CN106998693A (zh) * | 2014-12-01 | 2017-08-01 | 高露洁-棕榄公司 | 使用臭氧控制沉淀碳酸钙浆料(pcc)中的生物负载的用途 |
WO2017079963A1 (en) * | 2015-11-13 | 2017-05-18 | The Procter & Gamble Company | Dentifrice compositions with whitening benefits |
US10744226B2 (en) | 2017-12-08 | 2020-08-18 | Johnson & Johnson Consumer Inc. | High-throughput method for detecting tooth stain prevention and removal |
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US20130189200A1 (en) | 2013-07-25 |
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US20140349253A1 (en) | 2014-11-27 |
MY157551A (en) | 2016-06-30 |
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