WO2012031329A1 - Analyse destinée à la détection et à la surveillance du cancer - Google Patents

Analyse destinée à la détection et à la surveillance du cancer Download PDF

Info

Publication number
WO2012031329A1
WO2012031329A1 PCT/AU2011/001161 AU2011001161W WO2012031329A1 WO 2012031329 A1 WO2012031329 A1 WO 2012031329A1 AU 2011001161 W AU2011001161 W AU 2011001161W WO 2012031329 A1 WO2012031329 A1 WO 2012031329A1
Authority
WO
WIPO (PCT)
Prior art keywords
methylation
loci
leukemia
geneid
dna
Prior art date
Application number
PCT/AU2011/001161
Other languages
English (en)
Inventor
Nicholas Chau Lun Wong
Jeffrey Mark Craig
Richard Eric Saffery
David Ashley
Justin Bedo
Adam Kowalczyk
Qiao WANG
Original Assignee
Murdoch Childrens Research Institute
National Ict Australia (Nicta)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2010904085A external-priority patent/AU2010904085A0/en
Application filed by Murdoch Childrens Research Institute, National Ict Australia (Nicta) filed Critical Murdoch Childrens Research Institute
Publication of WO2012031329A1 publication Critical patent/WO2012031329A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La présente invention concerne généralement une analyse destinée à la détermination de profils épigénétiques, y compris de profils épigénétiques associés à une condition pathologique. La présente invention concerne une analyse destinée à détecter des profils épigénétiques associés au cancer, y compris sa forme ou son type, son état et le statut de la maladie résiduelle imperceptible. L'analyse de l'invention permet en outre l'identification et la surveillance des formes et des sous-types de leucémie et autres malignités hématologiques. La présente invention concerne en outre des kits et des dosages de médicaments ainsi que des procédés de criblage d'agents qui modulent la méthylation.
PCT/AU2011/001161 2010-09-10 2011-09-08 Analyse destinée à la détection et à la surveillance du cancer WO2012031329A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU2010904085A AU2010904085A0 (en) 2010-09-10 Assay for detection and monitoring of cancer
AU2010904085 2010-09-10

Publications (1)

Publication Number Publication Date
WO2012031329A1 true WO2012031329A1 (fr) 2012-03-15

Family

ID=45810023

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/AU2011/001161 WO2012031329A1 (fr) 2010-09-10 2011-09-08 Analyse destinée à la détection et à la surveillance du cancer

Country Status (1)

Country Link
WO (1) WO2012031329A1 (fr)

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014056986A1 (fr) 2012-10-11 2014-04-17 Universitat De Barcelona Procédé de prédiction de l'évolution clinique d'un patient souffrant d'une leucémie lymphoïde chronique (cll)
EP2848697A1 (fr) * 2012-05-11 2015-03-18 National Cancer Center Procédé pour la prédiction du pronostic d'un néphrocarcinome
JP2015526096A (ja) * 2012-08-31 2015-09-10 国防医学院Ｎａｔｉｏｎａｌ Ｄｅｆｅｎｓｅ Ｍｅｄｉｃａｌ Ｃｅｎｔｅｒ 癌のスクリーニング方法
WO2016115530A1 (fr) * 2015-01-18 2016-07-21 The Regents Of The University Of California Procédé et système pour déterminer l'état d'un cancer
EP2898100B1 (fr) 2012-09-20 2017-11-22 The Chinese University Of Hong Kong Détermination non invasive d'un méthylome du foetus ou d'une tumeur à partir du plasma
WO2018009707A1 (fr) * 2016-07-06 2018-01-11 Youhealth Biotech, Limited Marqueurs de méthylation spécifiques d'une tumeur solide et utilisations de ces marqueurs
JP2018138036A (ja) * 2018-04-17 2018-09-06 国防医学院Ｎａｔｉｏｎａｌ Ｄｅｆｅｎｓｅ Ｍｅｄｉｃａｌ Ｃｅｎｔｅｒ 癌のスクリーニング方法
CN109456968A (zh) * 2018-12-29 2019-03-12 上海奕谱生物科技有限公司 基于甲基化修饰的肿瘤标记物stamp-ep5
US10392666B2 (en) 2012-09-20 2019-08-27 The Chinese University Of Hong Kong Non-invasive determination of methylome of tumor from plasma
US10513739B2 (en) 2017-03-02 2019-12-24 Youhealth Oncotech, Limited Methylation markers for diagnosing hepatocellular carcinoma and lung cancer
CN111088350A (zh) * 2020-02-24 2020-05-01 内蒙古医科大学 Mt2基因启动子区甲基化用检测引物与检测方法以及应用
US10706957B2 (en) 2012-09-20 2020-07-07 The Chinese University Of Hong Kong Non-invasive determination of methylome of tumor from plasma
US11062789B2 (en) 2014-07-18 2021-07-13 The Chinese University Of Hong Kong Methylation pattern analysis of tissues in a DNA mixture
WO2022040306A1 (fr) * 2020-08-19 2022-02-24 Mayo Foundation For Medical Education And Research Détection de lymphome non hodgkinien
US11410750B2 (en) 2018-09-27 2022-08-09 Grail, Llc Methylation markers and targeted methylation probe panel
US11435339B2 (en) 2016-11-30 2022-09-06 The Chinese University Of Hong Kong Analysis of cell-free DNA in urine
US11514289B1 (en) 2016-03-09 2022-11-29 Freenome Holdings, Inc. Generating machine learning models using genetic data
US11984195B2 (en) 2018-10-15 2024-05-14 The Chinese University Of Hong Kong Methylation pattern analysis of tissues in a DNA mixture

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090005268A1 (en) * 2005-07-18 2009-01-01 Epigenomics Ag Compositions and Methods for Cancer Diagnostics Comprising Pan-Cancer Markers
WO2010086389A1 (fr) * 2009-01-28 2010-08-05 Ait Austrian Institute Of Technology Gmbh Essai de méthylation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090005268A1 (en) * 2005-07-18 2009-01-01 Epigenomics Ag Compositions and Methods for Cancer Diagnostics Comprising Pan-Cancer Markers
WO2010086389A1 (fr) * 2009-01-28 2010-08-05 Ait Austrian Institute Of Technology Gmbh Essai de méthylation
WO2010086388A1 (fr) * 2009-01-28 2010-08-05 Ait Austrian Institute Of Technology Gmbh Marqueurs de méthylation pour le cancer du poumon

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ADORJAN, P. ET AL.: "Tumour class prediction and discovery by microarray-based DNA methylation analysis", NUCLEIC ACID RESEARCH, vol. 30, 2002, pages E21 *
MILANI, L. ET AL.: "DNA methylation for subtype classification and prediction of treatment outcome in patients with childhood acute lymphoblastic leukemia", BLOOD, vol. 115, 2010, pages 1214 - 1225, XP002731851, DOI: doi:10.1182/BLOOD-2009-04-214668 *

Cited By (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105408494B (zh) * 2012-05-11 2018-10-16 独立行政法人国立癌症研究中心 预测肾细胞癌的预后的方法
CN105408494A (zh) * 2012-05-11 2016-03-16 独立行政法人国立癌症研究中心 预测肾细胞癌的预后的方法
EP2848697A4 (fr) * 2012-05-11 2016-05-04 Nat Cancer Ct Procédé pour la prédiction du pronostic d'un néphrocarcinome
EP2848697A1 (fr) * 2012-05-11 2015-03-18 National Cancer Center Procédé pour la prédiction du pronostic d'un néphrocarcinome
JP2015526096A (ja) * 2012-08-31 2015-09-10 国防医学院Ｎａｔｉｏｎａｌ Ｄｅｆｅｎｓｅ Ｍｅｄｉｃａｌ Ｃｅｎｔｅｒ 癌のスクリーニング方法
US10221458B2 (en) 2012-08-31 2019-03-05 National Defense Medical Center Method for screening cancer
EP2891720A4 (fr) * 2012-08-31 2016-11-09 Nat Defense Medical Ct Méthode de dépistage du cancer
EP3536807B1 (fr) * 2012-09-20 2023-11-29 The Chinese University of Hong Kong Détermination non invasive d'un méthylome d'une tumeur à partir du plasma
EP2898100B1 (fr) 2012-09-20 2017-11-22 The Chinese University Of Hong Kong Détermination non invasive d'un méthylome du foetus ou d'une tumeur à partir du plasma
EP3354747B1 (fr) 2012-09-20 2021-02-17 The Chinese University Of Hong Kong Détermination non invasive d'un méthylome d'une tumeur à partir du plasma
US11274347B2 (en) 2012-09-20 2022-03-15 The Chinese University Of Hong Kong Non-invasive determination of type of cancer
US10706957B2 (en) 2012-09-20 2020-07-07 The Chinese University Of Hong Kong Non-invasive determination of methylome of tumor from plasma
IL268512B2 (en) * 2012-09-20 2023-06-01 Univ Hong Kong Chinese Non-invasive determination of fetal or tumor methylation from plasma
JP2022031753A (ja) * 2012-09-20 2022-02-22 ザ チャイニーズ ユニバーシティ オブ ホンコン 血漿による胎児または腫瘍のメチロームの非侵襲的決定
US10392666B2 (en) 2012-09-20 2019-08-27 The Chinese University Of Hong Kong Non-invasive determination of methylome of tumor from plasma
AU2020200128B2 (en) * 2012-09-20 2021-11-18 The Chinese University Of Hong Kong Non-invasive determination of methylome of fetus or tumor from plasma
EP2898100B2 (fr) † 2012-09-20 2023-05-10 The Chinese University Of Hong Kong Détermination non invasive d'un méthylome du foetus ou d'une tumeur à partir du plasma
WO2014056986A1 (fr) 2012-10-11 2014-04-17 Universitat De Barcelona Procédé de prédiction de l'évolution clinique d'un patient souffrant d'une leucémie lymphoïde chronique (cll)
US11062789B2 (en) 2014-07-18 2021-07-13 The Chinese University Of Hong Kong Methylation pattern analysis of tissues in a DNA mixture
US9984201B2 (en) 2015-01-18 2018-05-29 Youhealth Biotech, Limited Method and system for determining cancer status
EA036566B1 (ru) * 2015-01-18 2020-11-24 Зе Реджентс Оф Зе Юниверсити Оф Калифорния Способ и система определения статуса злокачественной опухоли
WO2016115530A1 (fr) * 2015-01-18 2016-07-21 The Regents Of The University Of California Procédé et système pour déterminer l'état d'un cancer
US11514289B1 (en) 2016-03-09 2022-11-29 Freenome Holdings, Inc. Generating machine learning models using genetic data
US10544467B2 (en) 2016-07-06 2020-01-28 Youhealth Oncotech, Limited Solid tumor methylation markers and uses thereof
WO2018009707A1 (fr) * 2016-07-06 2018-01-11 Youhealth Biotech, Limited Marqueurs de méthylation spécifiques d'une tumeur solide et utilisations de ces marqueurs
CN107847515A (zh) * 2016-07-06 2018-03-27 优美佳生物技术有限公司 实体瘤甲基化标志物及其用途
US11435339B2 (en) 2016-11-30 2022-09-06 The Chinese University Of Hong Kong Analysis of cell-free DNA in urine
US10513739B2 (en) 2017-03-02 2019-12-24 Youhealth Oncotech, Limited Methylation markers for diagnosing hepatocellular carcinoma and lung cancer
JP2018138036A (ja) * 2018-04-17 2018-09-06 国防医学院Ｎａｔｉｏｎａｌ Ｄｅｆｅｎｓｅ Ｍｅｄｉｃａｌ Ｃｅｎｔｅｒ 癌のスクリーニング方法
US11685958B2 (en) 2018-09-27 2023-06-27 Grail, Llc Methylation markers and targeted methylation probe panel
US11410750B2 (en) 2018-09-27 2022-08-09 Grail, Llc Methylation markers and targeted methylation probe panel
US11725251B2 (en) 2018-09-27 2023-08-15 Grail, Llc Methylation markers and targeted methylation probe panel
US11795513B2 (en) 2018-09-27 2023-10-24 Grail, Llc Methylation markers and targeted methylation probe panel
US11984195B2 (en) 2018-10-15 2024-05-14 The Chinese University Of Hong Kong Methylation pattern analysis of tissues in a DNA mixture
CN109456968B (zh) * 2018-12-29 2022-10-04 上海奕谱生物科技有限公司 基于甲基化修饰的肿瘤标记物
CN109456968A (zh) * 2018-12-29 2019-03-12 上海奕谱生物科技有限公司 基于甲基化修饰的肿瘤标记物stamp-ep5
JP2022515666A (ja) * 2018-12-29 2022-02-21 上▲海▼奕▲譜▼生物科技有限公司 メチル化修飾に基づく腫瘍マーカーｓｔａｍｐ－ｅｐ５
WO2020135862A1 (fr) * 2018-12-29 2020-07-02 上海奕谱生物科技有限公司 Marqueur tumoral stamp-ep5 basé sur une modification méthylée
JP7407824B2 (ja) 2018-12-29 2024-01-04 上▲海▼奕▲譜▼生物科技有限公司 メチル化修飾に基づく腫瘍マーカーｓｔａｍｐ－ｅｐ５
CN111088350A (zh) * 2020-02-24 2020-05-01 内蒙古医科大学 Mt2基因启动子区甲基化用检测引物与检测方法以及应用
WO2022040306A1 (fr) * 2020-08-19 2022-02-24 Mayo Foundation For Medical Education And Research Détection de lymphome non hodgkinien

Similar Documents

Publication Publication Date Title
WO2012031329A1 (fr) Analyse destinée à la détection et à la surveillance du cancer
Bibikova et al. Genome-wide DNA methylation profiling using Infinium® assay
AU2017251832B2 (en) Non-invasive determination of methylome of fetus or tumor from plasma
Kit et al. DNA methylation based biomarkers: practical considerations and applications
Toiyama et al. DNA methylation and microRNA biomarkers for noninvasive detection of gastric and colorectal cancer
Dedeurwaerder et al. Evaluation of the Infinium Methylation 450K technology
Sandoval et al. Validation of a DNA methylation microarray for 450,000 CpG sites in the human genome
Søes et al. Hypomethylation and increased expression of the putative oncogene ELMO3 are associated with lung cancer development and metastases formation
US9957570B2 (en) DNA hypermethylation diagnostic biomarkers for colorectal cancer
Dehan et al. DNA methylation and cancer diagnosis: new methods and applications
Kron et al. Discovery of novel hypermethylated genes in prostate cancer using genomic CpG island microarrays
US20090005268A1 (en) Compositions and Methods for Cancer Diagnostics Comprising Pan-Cancer Markers
Sapre et al. Gene-based urinary biomarkers for bladder cancer: an unfulfilled promise?
JP2021503943A (ja) 乳癌の検出
US11384401B2 (en) Detecting gastrointestinal neoplasms
WO2009108917A2 (fr) Marqueurs pour la détection améliorée du cancer du sein
US20230242995A1 (en) Method for detecting colorectal cancer
US20220220560A1 (en) Tumor marker stamp-ep3 based on methylation modification
US11702704B2 (en) Detecting ovarian cancer
EP2707506A2 (fr) Procédé de détection d'un cancer par l'intermédiaire d'une perte généralisée de stabilité de domaines épigénétiques, et compositions associées
US20220195528A1 (en) Tumor marker stamp-ep5 based on methylated modification
JP2024020392A (ja) 特定の遺伝子のｃｐｇメチル化変化を利用した肝癌診断用組成物およびその使用
Novak et al. Cell-type specific DNA methylation patterns define human breast cellular identity
Marsit et al. Blood-derived DNA methylation markers of cancer risk
US20220177973A1 (en) Methylation modification-based tumor marker stamp-ep6

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 11822937

Country of ref document: EP

Kind code of ref document: A1

DPE1 Request for preliminary examination filed after expiration of 19th month from priority date (pct application filed from 20040101)
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 11822937

Country of ref document: EP

Kind code of ref document: A1