WO2012019789A1 - Préparations à base de chlorure de benzethonium et de citrate d'argent - Google Patents

Préparations à base de chlorure de benzethonium et de citrate d'argent Download PDF

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Publication number
WO2012019789A1
WO2012019789A1 PCT/EP2011/054430 EP2011054430W WO2012019789A1 WO 2012019789 A1 WO2012019789 A1 WO 2012019789A1 EP 2011054430 W EP2011054430 W EP 2011054430W WO 2012019789 A1 WO2012019789 A1 WO 2012019789A1
Authority
WO
WIPO (PCT)
Prior art keywords
benzethonium chloride
emulsion
preparations
silver citrate
preservation
Prior art date
Application number
PCT/EP2011/054430
Other languages
German (de)
English (en)
Inventor
Bernd Traupe
Manuela Köhler
Gitta Neufang
Antonia Wagner
Andreas Firyn
Original Assignee
Beiersdorf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beiersdorf Ag filed Critical Beiersdorf Ag
Priority to DE112011102427T priority Critical patent/DE112011102427A5/de
Publication of WO2012019789A1 publication Critical patent/WO2012019789A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41—Amines
    • A61K8/416—Quaternary ammonium compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00—Anti-perspirants or body deodorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/002—Aftershave preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52—Stabilizers
    • A61K2800/524—Preservatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/58—Metal complex; Coordination compounds

Definitions

  • the invention relates to a preparation containing a combination of quaternary ammonium salt and silver citrate. All quantities are - unless otherwise stated - percentages by weight based on the total mass of the preparation.
  • Silver SDC for the purposes of the present specification is Tinosan SDC from CIBA and consists chemically of Citric Acid + Silver Citrate.
  • Benzethonium chloride is. It is thereby achieved that it is possible to use a quaternary ammonium salt which is already effective at low levels per se even at lower levels. This not only reduces the possibility of discomfort but also offers benefits in terms of formula stability. It is particularly preferred if the preparation is in the form of a w / o emulsion, o / w emulsion, w / o / w emulsion, high internal phase emulsion, w / si emulsion, si / w emulsion, a hydrogel, a gel cream, a Gels or as a solid formulation such as a bar of soap or lipstick is present. Due to the reduced use concentration of the quaternary ammonium salt is achieved that any formula instabilities that are observed by adding cationic substances from time to time are observed even less frequently. Further, it is preferable if
  • Benzethonium chloride is present in a concentration of 0.001 to 0.1%. This ensures that the likelihood of a malady is significantly reduced. It is very particularly preferred if silver citrate is present in a concentration of 1 to 20 ppm. This ensures that the synergistic effect and thus the possibility of
  • Benzethonium chloride and silver citrate for improving the preservation of cosmetic preparations, more preferably in a concentration of 0.001 to 0.1%.
  • the invention also encompasses the use of preparations according to the invention for the production of deodorant preparations and after-save products.
  • Such preparations may additionally comprise 2'-methylene-bis- (6- (2H-benzotriazol-2-yl) -4- (1,1,3,3-tetramethylbutyl) -phenol); Titanium dioxide, zinc oxide, 2,4,6-tris- (biphenyl) -1, 3,5-triazine, (2- ⁇ 4- [2- (4-diethylamino-2-hydroxybenzoyl) benzoyl] -piperazine- 1-carbonyl ⁇ -phenyl) - (4-diethylamino-2-hydroxy-phenyl) -methanone.
  • B. jojoba oil Dialkyl ethers and dialkyl carbonates in particular. Dicaprylyl ether and / or di-caprylylcarbona, soicosane, neopentyl glycol diheptanoate, propylene glycol dicaprylate / dicaprate, caprylic / capric / diglyceryl succinate, butylene glycol dicaprylate / dicaprate, Ci 2 -13-alkyl lactate, di-Ci 2 -13-alkyl tartrate, triisostearin, dipentaerythrityl hexacaprylate / hexacaprate,
  • Polyglyceryl-3 polydimethylsiloxyethyl dimethicone, acrylates / C 10-30 alkyl acrylates
  • the bacterium S. aureus was from a according to EN 12353
  • the reduction factor is the factor by which the cell number (CFU) of the test substance is reduced compared to the control.
  • This effect can even be repeated at 8 ppm (see table), so it can not be a randomly observed effect.
  • Carbomer (Carbopol 981) 0.2 0.3 0.2 0.4 0.15
  • Carrageenan (Chondrus Crispus) (Gelcarin) - - - - - 2
  • Hamamelis extract Hamamelis (extract PG) 0, 1 0.2 0.3 0.4 -
  • Xanthan Gum (Xanthan gum E 415 food 0.2 0.2 grade)
  • Panthenol 1 50 - - 0.70 - 0.00
  • Polyglyceryl-10 Stearate 0.70 - 1, 80 1, 00 - 1, 00
  • Titanium dioxide + trimethoxycaprylylsilane (Tego Sun T 805) 0.3600
  • Triglycerol diisostearate 1 0 0.5 0.25 2.0 3.0
  • Paraffin oil (Shell Ondina 917) 12.5 10.0 8.0 5.0 1 1, 5
  • Vaseline (Pioneer 6787) 8.0 6.0 5.0 12.0 2.5
  • Dicaprylyl carbonate 0, 1 0.05 0, 15 0.5 1, 0 hydrogenated castor oil 0.5 0.75 1, 0 2.5 5.0

Abstract

L'invention concerne une préparation cosmétique contenant une combinaison de sel d'ammonium quaternaire et de citrate d'argent. L'invention est caractérisée en ce que la conservation présente une synergie qui permet de réduire la concentration utilisée nécessaire à la conservation.
PCT/EP2011/054430 2010-07-19 2011-03-23 Préparations à base de chlorure de benzethonium et de citrate d'argent WO2012019789A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE112011102427T DE112011102427A5 (de) 2010-07-19 2011-03-23 Zubereitungen mit Benzethoniumchlorid und Silbercitrat

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102010027627.8 2010-07-19
DE201010027627 DE102010027627A1 (de) 2010-07-19 2010-07-19 Zubereitungen mit Benzethoniumchlorid und Silber

Publications (1)

Publication Number Publication Date
WO2012019789A1 true WO2012019789A1 (fr) 2012-02-16

Family

ID=44122052

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2011/054430 WO2012019789A1 (fr) 2010-07-19 2011-03-23 Préparations à base de chlorure de benzethonium et de citrate d'argent

Country Status (2)

Country Link
DE (2) DE102010027627A1 (fr)
WO (1) WO2012019789A1 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012167905A3 (fr) * 2011-06-07 2014-01-30 Beiersdorf Ag Compositions cosmétiques ou dermatologiques exemptes de polyéthylène glycol
WO2012167906A3 (fr) * 2011-06-07 2014-01-30 Beiersdorf Ag Compositions cosmétiques ou dermatologiques aux propriétés rhéologiques améliorées
WO2012167900A3 (fr) * 2011-06-07 2014-01-30 Beiersdorf Ag Compositions cosmétiques ou dermatologiques sous forme d'émulsions et ayant une libération de parfum améliorée
WO2012167902A3 (fr) * 2011-06-07 2014-01-30 Beiersdorf Ag Compositions cosmétiques ou dermatologiques ayant une stabilité microbiologique améliorée
DE102016000277A1 (de) * 2016-01-15 2017-07-20 Beiersdorf Ag Kosmetische Zubereitungen enthaltend Benzethonium Chlorid und Diole

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001041573A1 (fr) 1999-12-13 2001-06-14 Ethicon, Inc. Compositions therapeutiques antimicrobiennes
WO2005020915A2 (fr) * 2003-08-28 2005-03-10 Pure Bioscience Compositions de citrate de dihydrogene d'argent contenant un second agent antimicrobien
WO2005102046A1 (fr) 2004-04-20 2005-11-03 William H. Harvey Company Composition de traitement cutane antimicrobienne et procedes pour produire et utiliser une composition de traitement cutane antimicrobienne
US20060115440A1 (en) * 2004-09-07 2006-06-01 Arata Andrew B Silver dihydrogen citrate compositions
US20060254988A1 (en) * 2005-05-10 2006-11-16 Confirm Monitoring Systems, Inc. Methods and compositions for the treatment of water
JP2007284412A (ja) 2006-04-12 2007-11-01 I-Nage:Kk 殺菌消毒クリーム
JP2008110999A (ja) 2008-02-04 2008-05-15 Mandom Corp 抗菌性組成物及びデオドラント剤
EP1964543A1 (fr) 2007-03-02 2008-09-03 Takasago International Corporation Compositions de conservation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060210500A1 (en) * 2003-04-18 2006-09-21 Merck Patent Gmbh Formulations
WO2004092283A2 (fr) * 2003-04-18 2004-10-28 Merck Patent Gmbh Pigments antimicrobiens

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001041573A1 (fr) 1999-12-13 2001-06-14 Ethicon, Inc. Compositions therapeutiques antimicrobiennes
WO2005020915A2 (fr) * 2003-08-28 2005-03-10 Pure Bioscience Compositions de citrate de dihydrogene d'argent contenant un second agent antimicrobien
WO2005102046A1 (fr) 2004-04-20 2005-11-03 William H. Harvey Company Composition de traitement cutane antimicrobienne et procedes pour produire et utiliser une composition de traitement cutane antimicrobienne
US20060115440A1 (en) * 2004-09-07 2006-06-01 Arata Andrew B Silver dihydrogen citrate compositions
US20060254988A1 (en) * 2005-05-10 2006-11-16 Confirm Monitoring Systems, Inc. Methods and compositions for the treatment of water
JP2007284412A (ja) 2006-04-12 2007-11-01 I-Nage:Kk 殺菌消毒クリーム
EP1964543A1 (fr) 2007-03-02 2008-09-03 Takasago International Corporation Compositions de conservation
JP2008110999A (ja) 2008-02-04 2008-05-15 Mandom Corp 抗菌性組成物及びデオドラント剤

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012167905A3 (fr) * 2011-06-07 2014-01-30 Beiersdorf Ag Compositions cosmétiques ou dermatologiques exemptes de polyéthylène glycol
WO2012167906A3 (fr) * 2011-06-07 2014-01-30 Beiersdorf Ag Compositions cosmétiques ou dermatologiques aux propriétés rhéologiques améliorées
WO2012167900A3 (fr) * 2011-06-07 2014-01-30 Beiersdorf Ag Compositions cosmétiques ou dermatologiques sous forme d'émulsions et ayant une libération de parfum améliorée
WO2012167902A3 (fr) * 2011-06-07 2014-01-30 Beiersdorf Ag Compositions cosmétiques ou dermatologiques ayant une stabilité microbiologique améliorée
DE102016000277A1 (de) * 2016-01-15 2017-07-20 Beiersdorf Ag Kosmetische Zubereitungen enthaltend Benzethonium Chlorid und Diole
WO2017121538A1 (fr) * 2016-01-15 2017-07-20 Beiersdorf Ag Préparations cosmétiques contenant du chlorure de benzéthonium et des diols
EP3402455B1 (fr) 2016-01-15 2021-01-20 Beiersdorf AG Compositions cosmetique contenant chlorure de benzéthonium et un diol

Also Published As

Publication number Publication date
DE112011102427A5 (de) 2013-05-02
DE102010027627A1 (de) 2012-01-19

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