WO2012017615A1

WO2012017615A1 - Aqueous gel composition of drug volatilization body

Info

Publication number: WO2012017615A1
Application number: PCT/JP2011/004191
Authority: WO
Inventors: Takashi Kawano; Kazuki Sugiyama; Sadahiko Yamazaki; Kunihide Hoshino
Original assignee: Takasago International Corporation
Priority date: 2010-08-05
Filing date: 2011-07-26
Publication date: 2012-02-09
Also published as: CN103068410A; KR20130095734A; JP2012034777A

Abstract

An aqueous gel composition of drug volatilization body comprising (A) an anionic oil dispersion polymer composition in which an anionic polymer is dispersed in an oil component, (B) a volatile drug such as a fragrance, a deodorant, an insect repellent, an insecticide, a bacteria eliminating agent and a repellent, (C) water and, if necessary, (D) other components such as solvents, colorants, antiseptic agents, salts, ultraviolet absorbers, surfactants, inorganic polymers, antioxidants, gelling agents, thickening agents, natural deodorants, synthetic deodorants, and stabilizers.

Description

AQUEOUS GEL COMPOSITION OF DRUG VOLATILIZATION BODY

The present invention relates to an aqueous gel composition, and more specifically the present invention relates to an aqueous gel composition of drug volatilization body that can gradually volatilize various volatile drugs such as a fragrance, a deodorant, an insect repellent, an insecticide, a bacteria eliminating agent and a repellent in the air.

In recent years, the air fresheners and deodorants have been widely used in living spaces so as to make living circumstances comfortable. The air fresheners/deodorants are roughly divided into three types such as aerosol types, liquid types and solid types. Above all, the solid types are widely utilized since they can provide fragrance or eliminate odor for a long time period by putting them in rooms, vehicles or the like. Known solid type fragrance and/or deodorants include hard solid types and aqueous gel types. The aqueous gel-type fragrance and/or deodorants can be produced more inexpensively than those of the aerosol types, liquid types such as aqueous types and solvent types, and solid types. Further, the aqueous gel types can give a clear contraction end point after volatilization of the volatile drug. When an insect repellent, an insecticide, a bacteria removing agent, a repellent or the like is used as the volatile drug other than the air fresheners and deodorants, inexpensive production and use for a long time period thereof can also be achieved and a clear contraction end point after volatilization of the volatile drug can also be given, like on the production and use of the air fresheners and deodorants.

As a gelling agent used for the preparation of an aqueous gel from which a drug volatilizes, carrageenan, gellan gum, gelatin and agar (see Patent Literatures 1 to 7 below), as well as acrylic polymers (see Patent Literature 8) have been known till now.

PTL 1: Japanese Patent Application Laid-Open No. 54-135229
PTL 2: Japanese Patent Application Laid-Open No. 60-135058
PTL 3: Japanese Patent Application Laid-Open No. 62-41661
PTL 4: Japanese Patent Application Laid-Open No. 64-40542
PTL 5: Japanese Patent Application Laid-Open No. 64-74239
PTL 6: Japanese Patent Application Laid-Open No. 2-144067
PTL 7: Japanese Patent Application Laid-Open No. 2000-300654
PTL 8: Japanese Patent Application Laid-Open No. 2005-87286

However, it was essential in producing the conventionally-proposed aqueous gel compositions of drug volatilization body, which use carrageenan, gellan gum, gelatin or agar as a gelling agent, to heat the aqueous gel composition for dissolving components such as the gelling agent or fragrance. During the heating, fragrance compounds constituting the low boiling point part of fragrance components are volatilized. Therefore, there occurs a problem that fragrances having a different fragrance component balance from that of the original fragrance are volatilized from the obtained aqueous gel composition, which gives a feeling of wrongness that is not preferable for fragrance note.

On the other hand, the aqueous gel composition of drug volatilization body which uses, as a gelling agent, an acrylic-based polymer described in PTL 8 has a problem that combination use of an inorganic polymer such as zeolite, scmetite-type clay minerals, talc, kaolin or silica gel is required for gellation. Unless the inorganic polymer is used, gellation does not occur. In addition, it is required to use an alkaline agent such as triethanolamine for accelerating gellation. The use of the alkaline agent, however, causes problems of a foul smell, safety and operatabilities such as pH control in production steps. Furthermore, there is another problem that fragrance components are deteriorated by incorporating the alkaline agent.

An object of the present invention, therefore, is to provide an aqueous gel composition of drug volatilization body that is suitable for processing and treatment at an room temperature, is safe in production steps, is able to operate easily, has a large content of the volatile drug, is excellent in stability of drug volatilization, and has long duration of drug volatilization.

As a result of intensive studies and investigations in order to solve the aforementioned problems, the present inventors have found that in the production of an aqueous gel composition of drug volatilization body, a dispersion processing of drugs such as fragrances in an aqueous gel can be achieved at an room temperature, gellation can be performed without utilizing an alkaline agent and an inorganic polymer, and a large amount of a volatile drug can be contained in the aqueous gel as well as an aqueous gel composition of drug volatilization body excellent in the stability of volatilization and a long duration of the drug volatilization can be obtained by use of an oil dispersion anionic polymer composition wherein an anionic polymer is dispersed in an oil component. The present invention has been completed based on these findings.

That is, the present invention relates to the aqueous gel compositions of drug volatilization body of the following items (1) to (5).

(1) An aqueous gel composition of drug volatilization body comprising;
(A) an anionic oil dispersion polymer composition in which an anionic polymer is dispersed in an oil component,
(B) a volatile drug, and
(C) water.

(2) The aqueous gel composition of drug volatilization body according to the item (1), which comprises the anionic oil dispersion polymer composition (A) by from 0.1 to 20.0% by weight, the volatile drug (B) by from 0.1 to 70.0% by weight and the water (C) by from 0.1 to 98.0% by weight on the basis of the whole amount of the composition.

(3) The aqueous gel composition of drug volatilization body according to the aforementioned item (1) or (2), which further comprises at least one or more kinds of substance selected from the group consisting of solvents, pigments and dyes, antiseptic agents, salts, ultraviolet absorbers, surfactants, inorganic polymers, antioxidants, gelling agents, thickening agents, natural deodorants, synthetic deodorants and stabilizers.

(4) The aqueous gel composition of drug volatilization body according to any one of the aforementioned items (1) to (3), wherein the polymer component in the oil dispersion anionic polymer composition (A) is a sodium acrylates copolymer, and the oil component therein is at least one kind selected from hydrocarbons such as paraffins, liquid paraffins, isoparaffins and hydrogenated polydecene, and/or at least one kind selected from ester oils.

(5) The aqueous gel composition of drug volatilization body according to any one of the aforementioned items (1) to (4), wherein the volatile drug (B) is at least one kind selected from a fragrance, an deodorant, an insect repellent, an insecticide, a bacteria eliminating agent and a repellent.

According to the present invention, by use of the anionic oil dispersion polymer, an aqueous gel composition containing a volatile drug (that is an aqueous gel composition of drug volatilization body) can be produced at a room temperature without use of an alkaline agent and an inorganic polymer. Therefore, as low boiling point substances contained in the volatile drug are not volatilized by the heat during production of the aqueous gel composition, the fragrance volatilized from the obtained fragrance aqueous gel composition has the same fragrance components and the same components ratio as those of the fragrance used as a raw material. This means that there occurs no problem of a feeling of wrongness of fragrance note, which is felt in a fragrance aqueous gel composition produced by dispersing a fragrance under heating. Furthermore, since it is not necessary to use an alkaline agent and an inorganic polymer in gellation, the aqueous gel composition can be produced inexpensively. In addition, there is no problem of a foul, safety and operatabilitys such as pH control in the production steps as well as deterioration of the fragrance components due to incorporation of an alkaline agent.

Furthermore, the aqueous gel composition of drug volatilization body of the present invention is excellent in stability and duration of drug volatilization and the incorporation percentage of the volatile drug can be increased as compared with that of conventional aqueous gel compositions. The drug, therefore, can be volatilized for a longer time than that of conventional ones, which enables use of a longer time period.

Mode of carrying out the Invention

Hereinafter, the present invention is explained in detail.
The aqueous gel composition of drug volatilization body of the present invention comprises;
(A) an anionic oil dispersion polymer composition in which an anionic polymer is dispersed in an oil component,
(B) a volatile drug,
(C) water, and
(D) other components, as necessary.

The anionic oil dispersion polymer used in the present invention is a hydrophilic anionic polymer, i.e., a polymer that does not dissolve but swells in water and is constituted by one or more kind of monoethylene unsaturated monomer that is an anionic monomer and one or more kind of nonionic monomer.

Examples of the anionic monomer include acrylic acid and/or methacrylic acid, and alkali metal salts thereof. Above all, there are exemplified, as preferred anionic monomers, those including carboxylic acid groups, of which preferably at least 50% and more preferably at least 65% have been converted to alkali metal salts. Furthermore, sodium salts are especially preferred as alkaline salts.

Examples of the nonionic monomer to be copolymerized with the anionic monomer include alkyl esters of acrylic acid or methacrylic acid and the like. In the case where the copolymer is a copolymer with acrylic acid or methacrylic acid, the alkyl esters of acrylic acid or methacrylic acid are preferred as the nonionic monomer, and more preferably alkyl esters of acrylic acid or methacrylic acid wherein the alkyl group has 1 to 4 carbons are. Furthermore, there may be used a small amount of crosslinkable monomer such as methylenebisacrylamide, ethylene glycol diacrylate, ethylene glycol dimethacrylate, diacrylamide, dimethacrylamide, vinyloxyethylene acrylate, and vinyloxyethylene methacrylate.

The anionic polymer used in the present invention can be produced by, for example, a conventionally-known method such as a polymerization method of monomers through a water droplets-in-oil type polymerization route. When polymerization is conducted via an oil droplets-in-water type polymerization route, the oil droplets-in-water polymer may be converted to a water droplets-in-oil type by a reverse phase emulsion procedure as necessary so as to form an oil dispersion type polymer. The thus-formed polymer particles are generally fine spherical microparticles, of which the particle size is typically in the range of from 0.1 to 2 mm and the average particle size thereof is from 0.5 to 1.0 mm. The oil dispersion type polymer is one obtained by dispersing the aforementioned polymer particles in an oil component. In order to obtain such polymer particles that are dispersed in the oil component, it is only necessary to remove the water which was included in the polymer composition on the synthesis.

An example of the anionic polymer preferably used in the present invention includes a sodium acrylates copolymer that is a sodium salt of a copolymer constituted by two or more monomers selected from C1-C4 alkyl acrylates, C1-C4 alkyl methacrylates, acrylic acid and methacrylic acid.

The oil component may be suitably selected from silicone polymers; hydrocarbons such as mineral oils, paraffins, liquid paraffins, isoparaffins, hydrogenated polydecene and isohexadecane; esters such as trimethyloylpropane tricaprylate/tricaprate, alkyl benzoates wherein the alkyl group has 12 to 15 carbon atoms, ethyl hexyl stearate, caprylic capric triglycerides, squalane, ethyl hexyl cocoate, decyl oleate, decyl cocoate, ethyl oleate, isopropyl myristate, ethyl hexyl perlagonate, pentaerythrityl tetracaprylate/tetracaprate, PPG-3 benzyl ether myristate, propylene glycol dicaprylate/dicaprate, ethyl hexyl isostearate and ethyl hexyl palmitate; and natural oils such as soybean oil, sunflower seed oil, jojoba oil, safflower oil, evening primrose oil and rapeseed oil; as well as derivatives thereof. These oil components may be used solely or as a mixture of two or more kinds thereof. The oil component is preferably selected from hydrocarbons such as mineral oils, paraffins, liquid paraffins, isoparaffins and hydrogenated polydecene, and ester oils including natural oils.

Furthermore, the anionic oil dispersion polymer composition contains surfactants, one being a surfactant that was used in the production of the aforementioned polymer particles and other being a surfactant that was used in dispersing the polymer particles in the oil component to form a thickened emulsion. The amount of the surfactant used for forming the thickened emulsion is generally from 1.0 to 10.0% by weight, preferably from 2.0 to 8.0% by weight to the weight of the aforementioned anionic oil dispersion polymer. As the surfactant, a nonionic oil-in-water type emulsifier having an HLB of more than 7 is generally preferred. Preferred examples thereof include ethoxylated alcohols and a specifically preferred example is PPG1-Trideceth 6. In some cases, there may be included an emulsifier that is used for converting an oil droplets-in-water type polymerization composition to a water droplets-in-oil type by a reverse phase emulsion procedure, for example, sorbitan esters such as sorbitan monooleate, ethoxylated sorbitan esters such as Tween81 manufactured by ICI, and the like.

The anionic oil dispersion polymer composition generally comprises (a) 35 to 65% by weight of the polymer, (b) 20 to 50% by weight of the oil component and (c) 5 to 25% by weight of the surfactant or surfactant mixture. In addition, it may further comprise inorganic compounds such as water, organic acids, salts thereof and the like, as necessary.

The anionic oil dispersion polymer composition of the present invention can be obtained by suitably mixing the polymer particles, the oil component, the surfactant and the like so that they fall within the aforementioned ranges. Commercially available products, however, may be used as the anionic oil dispersion polymer composition.

Examples of commercially available anionic oil dispersion polymer compositions include Salcare and Tinovis series available from Ciba Specialty Chemicals. 'Salcare' and 'Tinovis' both are registered trademarks.

Preferred examples of commercially available anionic oil dispersion polymer compositions include the followings:

As the amount of the anionic oil dispersion polymer composition (A) of the present invention depends on the desired state of a gel, the kind of the volatile drug to be used and the like, it cannot be generalized. However, it is made generally within the range of from 0.1 to 20.0% by weight on the basis of the whole amount of the aqueous gel composition of drug volatilization body.

The volatile drug that is the component (B) of the present invention is selected on the basis of the usage of the aqueous gel composition of drug volatilization body. Examples thereof include one kind or two or more kinds of natural aroma chemicals such as anis oil, bergamot oil, citronella oil, lemon oil, eucalyptus oil, geranium oil, lavender oil, rose oil, jasmine oil, lilac oil, orange oil, neroli oil and rosemary oil; synthetic aroma chemicals; formulated fragrances of two or more of those aroma chemicals; and, as needed, one kind or two or more kinds of additive components such as deodorants, insect repellents, insecticides, bacteria removing agents, repellents and the like, which have volatility. As the amount thereof varies depending on the kind of the volatile drug to be used, it is not specifically limited. However, the amount is made generally 0.1% by weight or more, preferably 1.0% by weight or more on the basis of the whole amount of the aqueous gel composition of drug volatilization body. When the amount is less than 1.0% by weight, the effect of the drug may not be exhibited sufficiently in some cases.

As the water that is the component (C) of the present invention, purified waters such as deionized water, distilled water and ion exchanged water are preferably used. Although the water is fundamentally a remnant, the amount of the water may be generally exemplified as from 0.1 to 99.0% by weight on the basis of the whole amount of the aqueous gel composition of drug volatilization body.

Besides the aforementioned components (A) to (C), components that are generally used for the known aqueous gel drug volatilization bodies may be incorporated in the aqueous gel composition of drug volatilization body of the present invention. Examples of such components include additives that improve appearance, stability and functions of the composition, for example, solvents such as alcohols, glycols, glycol ethers, polyols, substituted alcohols, hydrocarbons, esters and silicones; colorants such as water-soluble dyes, fluorescent dyes, natural colorants and inorganic pigments; antiseptic agents such as parabens such as methylparaben and benzoates; salts such as calcium chloride, calcium lactate and potassium chloride; ultraviolet absorbers; surfactants such as nonionic surfactants, anionic surfactants, cationic surfactants and amphoteric surfactants; inorganic polymers such as silica, calcium silicate, zeolite, scmetite-type clay minerals, talc, kaolin and vermiculite; antioxidants; gelling agents and thickening agents such as polyacrylic polymers; naturally-derived gelling agents and thickening agents such as carrageenan; natural deodorants; synthetic deodorants; stabilizers; and the like.

The aqueous gel composition of drug volatilization body of the present invention can be produced by easy operations, for example, as mentioned below. Namely, a desired aqueous gel composition of drug volatilization body is prepared by incorporating and dispersing the volatile drug (B) and other components (D) in the water (C) at a room temperature, followed by adding and dispersing the anionic oil dispersion polymer composition (A) thereto.

Hereinafter, the present invention will be specifically explained with reference to Examples and Comparative Examples. The present invention, however, is not limited at all by the exemplification of the following Examples and Comparative Examples.

20.0 g of a fragrance (a peach-based formulated fragrance manufactured by Takasago International Corporation) was added into 77.5 g of deionized water, followed by adding 2.5 g of Tinovis ADM (manufactured by Ciba Specialty Chemicals) thereto at a room temperature under stirring. It was dispersed homogeneously by further stirring to give an aqueous gel composition of drug volatilization body of Example 1.

20.0 g of a fragrance (a peach-based formulated fragrance manufactured by Takasago International Corporation) was added into 77.5 g of deionized water, followed by adding 2.5 g of Tinovis ADE (manufactured by Ciba Specialty Chemicals) thereto at a room temperature under stirring. It was dispersed homogeneously by further stirring to give an aqueous gel composition of drug volatilization body of Example 2.

Comparative Example 1

20.0 g of a fragrance (a peach-based formulated fragrance manufactured by Takasago International Corporation) was added into 75.2 g of deionized water, followed by dissolving 2.5 g of Salcare SC-80 (trade name; manufactured by Ciba Specialty Chemicals and comprising a crosslinked terpolymer of methacrylic acid, ethyl acrylate and polyethylene glycol (10EO) stearyl alcohol ether) therein at a room temperature under stirring to give a homogeneous dispersion.

Comparative Example 2

20.0 g of a fragrance (a peach-based formulated fragrance manufactured by Takasago International Corporation) was added into 75.2 g of deionized water, followed by dissolving 2.5 g of Acusol 820 (trade name; manufactured by Rohm & Haas and comprising a crosslinked terpolymer of methacrylic acid, ethyl acrylate and polyethylene glycol (10EO) stearyl methacrylate) therein at a room temperature under stirring to give a homogeneous dispersion.

Comparative Example 3

20.0 g of a fragrance (a peach-based formulated fragrance manufactured by Takasago International Corporation) was added into 75.2 g of deionized water, followed by dissolving 2.5 g of Salcare SC-80 therein at a room temperature under stirring. 0.3 g of triethanolamine was further added thereto for the pH adjustment to prepare an aqueous gel composition of drug volatilization body.

Comparative Example 4

20.0 g of a fragrance (a peach-based formulated fragrance manufactured by Takasago International Corporation) was added into 75.2 g of deionized water, followed by dissolving 2.5 g of Acusol therein at a room temperature under stirring. 0.3 g of triethanolamine was further added thereto for the pH adjustment to prepare an aqueous gel composition of drug volatilization body.

The compounding formulations of the aqueous gel compositions of drug volatilization body of Examples 1 and 2 and Comparative Examples 1 to 4 are shown in the following Table 1 together. In Table 1, the unit is % by weight.

Test for evaluating appearance

The appearances of the compositions obtained in Examples 1 and 2 and Comparative Examples 1 to 4 were observed by eye and evaluated based on the following criteria. The results are shown in Table 2.

Evaluation Criteria
Good: A preferable gel that is wholly uniform is produced.
Moderate: A gel from which a little amount of liquid is separated is produced.
No good: A gel in the form of a liquid or a significantly separated (that is, liquid separation) gel is produced.

As shown in Table 2, the aqueous gel compositions of drug volatilization body of Examples 1 and 2 formed preferable gels, whereas the aqueous gel compositions of drug volatilization body of Comparative Examples 1 to 4 did not form a gel or partially formed a gel wherein separation of water was observed. Those of the comparative examples, therefore, could not be utilized as drug volatilization body gels.

Claims

An aqueous gel composition of drug volatilization body comprising;
(A) an anionic oil dispersion polymer composition in which an anionic polymer is dispersed in an oil component,
(B) a volatile drug, and
(C) water.
The aqueous gel composition of drug volatilization body according to claim 1, which comprises the anionic oil dispersion polymer composition (A) by from 0.1 to 20.0% by weight, the volatile drug (B) by from 0.1 to 70.0% by weight and the water (C) by from 0.1 to 98.0% by weight, on the basis of the whole amount of the composition.
The aqueous gel composition of drug volatilization body according to claim 1 or 2, which further comprises at least one or more kinds of substance selected from the group consisting of solvents, pigments and dyes, antiseptic agents, salts, ultraviolet absorbers, surfactants, inorganic polymers, antioxidants, gelling agents, thickening agents, natural deodorants, synthetic deodorants and stabilizers.
The aqueous gel composition of drug volatilization body according to claim 1 or 2, wherein the polymer component in the oil dispersion anionic polymer composition (A) is a sodium acrylates copolymer, and the oil component is at least one kind selected from hydrocarbons such as paraffins, liquid paraffins, isoparaffins and hydrogenated polydecene, and/or at least one kind selected from ester oils,.
The aqueous gel composition of drug volatilization body according to claim 1 or 2, wherein the volatile drug (B) is at least one kind selected from a fragrance, a deodorant, an insect repellent, an insecticide, a bacteria eliminating agent and a repellent.