JP2012034777A - Water gel medicament volatilizing body composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a water gel medicament volatilizing body composition which can gel without blending an alkali agent and a mineral polymer, and can contain a lot of volatile chemicals, and is excellent in volatilization stability and persistence of a medicine.SOLUTION: The water gel medicament volatilizing body composition includes: (A) an anion in-oil distributed polymer composition in which an anion polymer is distributed by an oily component; (B) a volatile chemical; (C) water; (D) and if necessary, solvents, pigments, a preservative, salts, an ultraviolet absorber, surfactants, a mineral polymer, an antioxidant, a gelling agent, a thickener, a natural deodorant, a synthetic deodorant, and other components such as stabilizer. As the volatile chemical of the component (B), a perfume, deodorant, moth-repellent, insecticide, bacteria elimination agent, repellent or the like is mentioned.

Description

  The present invention can gradually volatilize an aqueous gel composition, more specifically, various volatile agents such as a fragrance, a deodorant, an insecticide, an insecticide, a disinfectant, and a repellent into the atmosphere. The present invention relates to an aqueous gel drug volatilizer composition.

  In recent years, in order to make a living environment comfortable, it is widely performed to use a fragrance or a deodorant in a living space. Such fragrances and deodorants can be broadly classified into aerosol type, liquid type, and solid type. Among them, the solid type should be fragranced and deodorized for a long time by placing it indoors or inside a car. Because it is possible, it is widely used. Solid type fragrance deodorants are known as solid type and aqueous gel type, but water gel type fragrance deodorants are generally compared to aerosol type, aqueous or solvent type liquid type and solid type. It can be manufactured at low cost and can have a clear shrinkage end point after volatilization of the volatile drug. In addition to fragrances and deodorants, when using insect repellents, insecticides, disinfectants, repellents, etc. as volatile chemicals, the same purpose as fragrance deodorants should be achieved at a low cost for a long time. It is possible to have a clear contraction end point after volatilization of the volatile drug.

  Conventionally, carrageenan, gellan gum, gelatin, agar (see, for example, Patent Documents 1 to 7), acrylic polymers (for example, see Patent Document 8), and the like have been proposed as gelling agents for producing drug volatilized water gels. ing.

JP 54-135229 A JP-A-60-135058 JP-A-62-41661 Japanese Patent Application Laid-Open No. 64-40542 JP-A 64-74239 Japanese Patent Laid-Open No. 2-144067 JP 2000-300654 A JP-A-2005-87286

  However, the conventionally proposed aqueous gel chemical volatilization composition using carrageenan, gellan gum, gelatin, and agar dissolves components such as a gelling agent or a fragrance, and thus heating during the production process is essential. ing. In this heating step, since the fragrance compound in the low boiling point portion in the fragrance component is volatilized, the fragrance is volatilized from the obtained aqueous gel composition with a different fragrance balance from the original fragrance component. There was a problem that an uncomfortable feeling was generated in the tone.

  On the other hand, a water gel chemical volatilization body using an acrylic polymer (for example, the above-mentioned Patent Document 8) requires the use of an inorganic polymer such as zeolite, sukumite-type clay mineral, talc, kaolin, or silica gel for gelation. When this is not used, there is a problem that gelation does not occur. Moreover, in order to accelerate | stimulate gelatinization, it is required to use alkaline agents, such as a triethanolamine, and there existed a problem in workability | operativity, such as a bad smell in a manufacturing process, safety | security, and pH control. Furthermore, there is also a problem that the fragrance component deteriorates due to the blending of the alkaline agent.

  Accordingly, the object of the present invention is an aqueous gel drug that is suitable for processing at room temperature, is safe in the manufacturing process, can be easily operated, has a large content of volatile chemicals, and has excellent chemical volatilization stability and sustainability. It is to provide a volatilizer composition.

  As a result of intensive studies to solve the problems as described above, the present inventors have now used an anionic oil-dispersed polymer composition in which an anionic polymer is dispersed in an oil component, and thereby a fragrance and the like. Can be dispersed and processed at room temperature, can be gelled without the addition of alkaline agents and inorganic polymers, can contain a large amount of volatile chemicals, and can be volatilized and stable. It discovered that the aqueous | water-based gel chemical volatilization body composition excellent in property was obtained, and completed this invention based on this knowledge.

  That is, the present invention relates to the following aqueous gel drug volatilizer compositions (1) to (5).

(1) An aqueous gel drug volatilization product comprising (A) an anionic polymer-dispersed polymer composition in which an anionic polymer is dispersed in an oil component, (B) a volatilizing drug, and (C) water. Composition.

(2) In the aqueous gel chemical volatilization composition according to (1) above, 0.1 to 20.0% by weight, volatility of the anionic oil-dispersed polymer composition (A) based on the total amount of the composition. An aqueous gel chemical volatilization composition comprising 0.1 to 70.0% by weight of drug (B) and 0.1 to 98.0% by weight of water (C).

(3) In the aqueous gel chemical volatilization composition according to the above (1) or (2), further, solvents, pigments, preservatives, salts, ultraviolet absorbers, surfactants, inorganic polymers, oxidation An aqueous gel chemical volatilization composition comprising at least one substance selected from an inhibitor, a gelling agent, a thickener, a natural deodorant, a synthetic deodorant, and a stabilizer.

(4) In the aqueous gel chemical volatilization composition according to any one of (1) to (3), the polymer component in the anionic oil-dispersed polymer composition (A) is acrylate salt sodium, Aqueous gel drug characterized in that the component is at least one selected from hydrocarbons such as paraffin, liquid paraffin, isoparaffin, hydrogenated polydecene and / or at least one selected from ester oils Volatilizer composition.

(5) In the aqueous gel chemical volatile composition according to any one of (1) to (4), the volatile chemical (B) is a fragrance, a deodorant, an insecticide, an insecticide, a disinfectant. And an aqueous gel drug volatilizer composition, which is at least one selected from repellents.

  According to the present invention, by using an anionic oil-dispersed polymer, an aqueous gel composition containing a volatile drug at room temperature and without using an alkaline agent and an inorganic polymer (aqueous gel drug volatilizer). Composition) can be produced. For this reason, since the low boiling point substance in a volatile chemical | medical agent does not volatilize by heating when manufacturing an aqueous gel composition, the fragrance | flavor volatilized from the obtained aromatic aqueous gel composition was used as a raw material. It is the same as the fragrance component of the fragrance, and there is no problem of an uncomfortable feeling of the fragrance that is felt in the aromatic aqueous gel composition obtained by dispersing the fragrance in a heated state. Furthermore, since it is not necessary to use an alkali agent and an inorganic polymer during gelation, it can be manufactured at a low cost, and there are problems of workability such as off-flavor, safety, and pH control during the manufacturing process. Moreover, there is no problem of deterioration of the fragrance component due to the blending of the alkali agent.

  Furthermore, the aqueous gel drug volatilizer composition of the present invention is excellent in drug volatilization stability and sustainability, and it is possible to increase the blending ratio of the volatile drug compared to the conventional aqueous gel composition, Compared with the conventional one, it becomes possible to volatilize the medicine for a longer period of time, and this enables a longer period of use.

Hereinafter, the present invention will be specifically described.
The aqueous gel chemical volatilization composition of the present invention comprises (A) an anionic oil-dispersed polymer composition in which an anionic polymer is dispersed in an oil component, (B) a volatilizing chemical and (C) water, and further required. According to (D), it consists of other components.

  The oil-dispersed anionic polymer used in the present invention is a hydrophilic anionic polymer, ie, a polymer that does not dissolve in water but swells, and is one or more monoethylenically unsaturated monomers that are anionic monomers It is composed of a monomer and a nonionic monomer.

  Examples of the anionic monomer include acrylic acid and / or methacrylic acid and alkali metal salts thereof. Preferably, the carboxylic acid group is at least 50%, more preferably at least 65% is an alkali metal salt. Is preferable, and a sodium salt is more preferable.

  Examples of the nonionic monomer copolymerized with the anionic monomer include acrylic acid or methacrylic acid alkyl ester. In the case of a copolymer with acrylic acid or methacrylic acid, acrylic acid or methacrylic acid alkyl ester is preferable, more preferably acrylic acid or methacrylic acid having an alkyl group having 1 to 4 carbon atoms. Examples include acid alkyl esters. A small amount of a crosslinkable monomer such as methylene bisacrylamide, ethylene glycol diacrylate (methacrylate), diacrylamide (methacrylamide), vinyloxyethylene acrylate, or methacrylate may be used.

  The anionic polymer used in the present invention can be produced by a conventionally known method such as polymerization using a water-in-oil type polymerization route. Further, when passing through an oil-in-water type polymerization route, a water-in-oil type may be formed by a reverse phase emulsion procedure as necessary in order to form a polymer dispersed in oil. The polymer particles formed are generally microspherical microparticles, typically having a particle size in the range of 0.1 to 2 μm and an average particle size of 0.5 to 1.0 μm. Have. The oil-dispersed polymer is obtained by dispersing the polymer particles in an oil component. In order to obtain polymer particles dispersed in such an oil component, water contained in the polymer composition may be removed during synthesis.

  Examples of the anionic polymer used in the present invention include a copolymer sodium composed of two or more monomers of alkyl acrylate (C1-C4), alkyl methacrylate (C1-C4), acrylic acid or methacrylic acid. The salt acrylate salt sodium is preferred.

  Oil components include silicone polymers, mineral oil, paraffin, liquid paraffin, isoparaffin, hydrogenated polydecene, hydrocarbons such as isohexadecane, trimethyloylpropane tricaprylate / tricaprylate, alkyl benzoate having 12 to 15 carbon atoms. , Ethylhexyl stearate, caprylcap print triglyceride, squalane, ethylhexyl cocoate, decyl oleate, decyl cocoate, ethyl oleate, isopropyl myristate, ethyl hexyl perlagonate, pentaerythrityl, tetracaprylate / tetracap Plate, PPG-3 benzyl ether myristate, propylene glycol dicaprylate / dicaplate, ethylhexyl Sosuteareto, esters such as ethylhexyl palmitate and soybean oil, sunflower oil, jojoba oil, safflower oil, further natural oils such as Akahana oil and rapeseed oil may be appropriately selected from these derivatives. These oil components may be used singly or as a mixture of two or more. The oily component is preferably selected from mineral oils, paraffins, liquid paraffins, isoparaffins, hydrocarbons such as hydrogenated polydecene, and ester oils including natural oils.

  The anionic oil-in-dispersion polymer composition contains a surfactant used in the production of the polymer particles. In addition, the polymer particles are dispersed in an oil component to form a thickened emulsion. Also included are surfactants used to do so. The surfactant used for forming the thickened emulsion is generally used in an amount of 1.0 to 10.0% by weight of the anionic oil-dispersed polymer, preferably 2.0 to 8%. Used at 0.0 wt%. As this surfactant, a nonionic oil-in-water emulsifier having an HLB of more than 7 is usually preferred, and for example, ethoxylated alcohol is preferred, and PPG1-trideceth 6 is particularly preferred. Also included are emulsifiers used to make oil-in-water polymerization compositions into water-in-oil by reverse phase emulsion procedures, such as sorbitan esters such as sorbitan monooleate and ethoxylated sorbitan esters such as Tween 81 from ICI May be.

  An anionic oil-in-dispersion polymer composition generally comprises (a) 35-65 wt% polymer, (b) 20-50 wt% oil component, (c) 5-25 wt% surface activity. Or an inorganic compound such as water, an organic acid and a salt thereof, and the like.

  The anionic oil-dispersed polymer composition of the present invention can be obtained by appropriately mixing polymer particles, an oil component, a surfactant and the like so as to be in the above range, but a commercially available product can also be used.

  Commercially available anionic oil-dispersed polymer compositions include the Salcere and Tinobis series available from Ciba Specialty Chemicals (Salcele and Tinovis are registered trademarks).

  Preferred commercially available anionic oil-dispersed polymer compositions include the following.

Salcere SC91 (trade name; manufactured by Ciba Specialty Chemicals)
・ Acrylates copolymer Na (CAS No. 9033-79-8) 50% by weight
・ Liquid paraffin 27% by weight
・ PPG-1 Trideceth-6 8% by weight
・ Other ingredients 15% by weight

TINOVIS ADM (trade name; manufactured by Ciba Specialty Chemicals)
・ Acrylates copolymer Na (CAS No. 9033-79-8) 54% by weight
・ 34% mineral oil
・ PPG-1 Trideceth-6 6% by weight
・ Sorbitan trioleate 4% by weight
・ Water 2% by weight
・ Bentetic acid 5Na less than 0.1%

TINOVIS ADE (trade name; manufactured by Ciba Specialty Chemicals)
・ Acrylates copolymer Na (CAS No. 9033-79-8) 54% by weight
・ Hydrogenated polydecene 34% by weight
・ PPG-1 Trideceth-6 6% by weight
・ Sorbitan trioleate 4% by weight
・ Water 2% by weight
・ Bentetic acid 5Na less than 0.1%

  The amount of the (A) anionic oil-dispersed polymer composition of the present invention varies depending on the desired gel state, the type of volatilizing agent used, etc. It is in the range of 0.1 to 20.0% by weight based on the total amount of the composition.

  The volatilizing agent which is the component (B) of the present invention is selected based on the use of the aqueous gel chemical volatilization composition, anise oil, bergamot oil, citronella oil, lemon oil, eucalyptus oil, geranium oil, lavender oil. , Rose oil, jasmine oil, lilac oil, orange oil, neroli oil, rosemary oil and other natural fragrances, synthetic fragrances, and two or more kinds of these fragrances, as well as various deodorants and insect repellents with volatility , And one or more additive components such as insecticides, disinfectants, and repellents. The amount used is not particularly limited and varies depending on the type of volatilizing agent used, but is usually 0.1% by weight or more, preferably 1.0% based on the total amount of the aqueous gel chemical volatilizing agent composition. % Or more. If the amount is less than 1.0% by weight, the effect of the drug may not be sufficiently exerted.

  As water which is (C) component of this invention, it is preferable to use purified water, such as deionized water, distilled water, and ion exchange water. Water is basically the balance, but the amount of water used is typically 0.1 to 99.0% by weight based on the total amount of the aqueous gel chemical volatilization composition.

  In addition to the above-described components (A) to (C), the aqueous gel drug volatilizer composition of the present invention can be blended with components usually used in water gel drug volatilizers. Examples of such components include alcohols, glycols, glycol ethers, polyols, substituted alcohols, hydrocarbons, esters, silicones, and other solvents; water-soluble dyes, fluorescent dyes, natural dyes, Dyes such as inorganic pigments; Parabens such as methylparaben; Preservatives such as benzoates; Salts such as calcium chloride, calcium lactate and potassium chloride; UV absorbers; Nonionic surfactants, anionic surfactants, cations Surface active agents, surfactants such as amphoteric surfactants; silica, calcium silicate, zeolite, squemite type viscosity minerals, inorganic polymers such as talc, kaolin, vermiculite; antioxidants; gels such as polyacrylic polymers Agent, thickener; naturally derived gelling agent such as carrageenan, thickener; natural deodorant; Forming deodorant; like appearance and stability stabilizer, and the like additives to improve functionality.

  The aqueous gel chemical volatilization body composition of this invention can be manufactured by the following easy operations, for example. That is, by mixing and dispersing the volatile drug (B) and other components (D) in water (C) at room temperature, and then adding / dispersing the anionic oil-dispersed polymer composition (A), the desired composition is obtained. A water gel volatilizer composition is prepared.

  Hereinafter, the present invention will be described by way of specific examples by way of examples and comparative examples. However, the present invention is not limited to the following examples and comparative examples.

[Example 1]
77.5g of deionized water was mixed with 20.0g of fragrance (peach-based fragrance made by Takasago International Corporation), and while stirring, 2.5g of TINOBIS ADM (manufactured by Ciba Specialty) was added at room temperature. The aqueous gel chemical volatilization composition of Example 1 was obtained by mixing and adjusting the dispersion uniformly.

[Example 2]
27.5 g of fragrance (peach blended fragrance made by Takasago International Corporation) was mixed with 77.5 g of deionized water, and 2.5 g of TINOBIS ADE (manufactured by Ciba Specialty) was added at room temperature while stirring. The aqueous gel chemical volatilization composition of Example 2 was obtained by mix | blending and carrying out uniform dispersion adjustment.

[Comparative Example 1]
20.0 g of a fragrance (peach blended fragrance made by Takasago International Corporation) was added to 75.2 g of deionized water, and further stirred with SALCARE SC-80 (methacrylic acid, ethyl acrylate and polyethylene glycol (10EO) 2.5 g of a stearyl alcohol ether crosslinked terpolymer (trade name: manufactured by Ciba Specialty) was dissolved at room temperature to prepare a uniform dispersion.

[Comparative Example 2]
20.0 g of a fragrance (peach blended fragrance made by Takasago International Corporation) is mixed with 75.2 g of deionized water, and further, Acusol 820 (methacrylic acid, ethyl acrylate and polyethylene glycol (10EO) stearyl methacrylate is stirred. 2.5 g of a crosslinked terpolymer (trade name; manufactured by Rohm and Haas) was dissolved at room temperature to prepare a uniform dispersion.

[Comparative Example 3]
20.0 g of a fragrance (peach-based fragrance made by Takasago International Corporation) was mixed with 75.2 g of deionized water, and 2.5 g of SALCARE SC-80 was dissolved at room temperature while stirring. Thereafter, 0.3 g of triethanolamine was added, and the pH of the dispersion was adjusted to prepare an aqueous gel chemical volatilization composition.

[Comparative Example 4]
20.0 g of a fragrance (peach-based blended fragrance made by Takasago International Corporation) was mixed with 75.2 g of deionized water, and 2.5 g of Acusol was dissolved at room temperature while stirring. Thereafter, 0.3 g of triethanolamine was added, and the pH of the dispersion was adjusted to prepare an aqueous gel chemical volatilization composition.

  Table 1 below collectively shows the formulation of the aqueous gel drug volatilizer compositions of Examples 1 and 2 and Comparative Examples 1 to 4 (unit:% by weight).

[Appearance evaluation test]
The appearance of the compositions obtained in Examples 1 and 2 and Comparative Examples 1 to 4 was visually observed. The results are shown in Table 2.

The symbols indicating the evaluation results from the tests were in accordance with the following criteria.
◯: A preferable gel-like body is uniform throughout.
(Triangle | delta): It shows the state which has carried out some liquid separation from the gel.
X: The gel is in a liquid state or is severely separated (separated).

  As shown in Table 2, the aqueous gel drug volatilizer compositions of Examples 1 and 2 formed good gels, whereas the aqueous gel drug volatilizer compositions of Comparative Examples 1 to 4 formed gels. However, although some gel formation was observed, water separation and the like were observed, and the gel could not be used as a chemical volatilization gel.

Claims (5)

An aqueous gel drug volatilization composition comprising (A) an anionic polymer-dispersed polymer composition in which an anionic polymer is dispersed in an oil component, (B) a volatilizing drug, and (C) water.   The aqueous gel chemical volatilizer composition according to claim 1, wherein 0.1 to 20.0% by weight of the anionic oil-dispersed polymer composition (A) is 0.1 to 20.0% by weight, based on the total amount of the composition. 0.1 to 70.0% by weight and water (C) in the range of 0.1 to 98.0% by weight.   The aqueous gel chemical volatilization composition according to claim 1 or 2, further comprising a solvent, a dye, a preservative, a salt, an ultraviolet absorber, a surfactant, an inorganic polymer, an antioxidant, and a gelling agent. An aqueous gel chemical volatilization composition comprising at least one substance selected from a thickener, a natural deodorant, a synthetic deodorant, and a stabilizer.   The aqueous gel chemical volatilization composition according to any one of claims 1 to 3, wherein the polymer component in the anionic oil-dispersed polymer composition (A) is sodium acrylate copolymer, and the oil component is paraffin. An aqueous gel chemical volatilization composition comprising at least one selected from hydrocarbons such as liquid paraffin, isoparaffin, hydrogenated polydecene, and / or at least one selected from ester oils .   The aqueous gel chemical volatilization composition according to any one of claims 1 to 4, wherein the volatile chemical (B) is a fragrance, a deodorant, an insecticide, an insecticide, a disinfectant, and a repellent. An aqueous gel chemical volatilization composition comprising at least one selected from the group consisting of: