JP2000300654A - Water gel medicine volatilizer - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a water gel medicine volatilizer which is capable of constantly volatilizing a medicine with good balance from the start of volatilization to the end of the volatilization and is capable of preventing the degradation in medicine effects, such as the intensity of the medicine with lapse of time, diffusivity, persistence, etc. SOLUTION: The water gel medicine volatilizer is prepared by compounding an acrylic acid-alkyl methacrylate (10C-30C) copolymer and a gelatinizing agent. The medicine is at least one kind selected from perfumes, deodorants, insectifuges, insecticides, sterilizing agents and repellents.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a water gel drug volatile containing a fragrance, a deodorant, an insect repellent, an insecticide, a disinfectant, a repellent, and the like.

[0002]

2. Description of the Related Art Pharmaceutical vaporizers have been used as fragrances and deodorants for use indoors, in automobiles, and the like. Water gel drug volatiles can be generally manufactured at a lower cost than aqueous liquid type, oily liquid type, solid type, etc. types of drug volatiles, and can have a clear contraction end point after volatilization. , Has been attracting attention recently. As such a water gel drug volatile, for example, those using carrageenan, gellan gum, and agar as gelling agents have been proposed (Japanese Patent Application Laid-Open Nos. 54-135229 and 60).
JP-A-135058, JP-A-62-41661, JP-A-64-40542, JP-A-1-742
39, JP-A-2-140407). However, in conventional water-gel drug volatilizers, the volatilization amount of water, which is a volatile medium substance, tends to decrease over time during volatilization. In addition, there is a problem in that the effect of the drug such as sustainability is reduced.

[0003]

SUMMARY OF THE INVENTION Accordingly, an object of the present invention is to provide a medicine capable of volatilizing the medicine in a well-balanced manner from the start of volatilization to the end of the volatilization, and to improve the strength, diffusibility, sustainability and the like of the medicine over time. It is an object of the present invention to provide a water gel drug volatilizer capable of preventing the effect from decreasing.

[0004]

SUMMARY OF THE INVENTION In order to solve the above-mentioned problems, the present invention provides a water-gel drug volatile by blending an acrylic acid / alkyl methacrylate (C10-C30) copolymer and a gelling agent. I do. In addition, medicine is fragrance, deodorant,
At least one selected from insect repellents, insecticides, disinfectants and repellents.

[0005]

BEST MODE FOR CARRYING OUT THE INVENTION The present inventors have conducted intensive studies on the conventional water gel drug volatiles as described above in order to solve the drawbacks. As a result, when producing a water gel drug volatile, an acrylic acid / alkyl methacrylate (C
10-C30) By adding and preparing a copolymer and a gelling agent, the drug can be volatilized constantly from the start of volatilization to the end of volatilization, and the volatilization strength, diffusivity, durability and the like of the drug over time can be improved. The inventors have found that a reduction in drug effect can be prevented, and have completed the present invention.

[0006] The acrylic acid / alkyl methacrylate (C10 to C3) used in the water gel drug vaporizer of the present invention.
0) Copolymers are high molecular emulsifiers, and have been applied to face care products such as creams and emulsions, as well as hand care products, hair care products, body care products, and sunscreen preparations. (Fragrance Journal, Vol. 26, No. 8, P. 79-83,
1998), the present inventors are the first to apply to a water gel drug vaporizer.

[0007] The copolymer of acrylic acid and alkyl methacrylate (C10 to C30) used in the water gel drug vaporizer of the present invention has an emulsifying action, so that the surfactant used in the conventional water gel drug vaporizer is used. No agent is used, or the amount of surfactant used can be reduced, and it is possible to cope with global environmental problems caused by surfactants. In addition, the volatilized water gel agent of the present invention has a constant water volatilization amount, so the residue shape and amount at the end of volatilization are smaller than conventional products, and the end point of the volatilized body can be easily determined visually. Thus, there is provided a water gel drug vaporizer having an effect of being able to do so.

Hereinafter, each component of the water gel drug volatile of the present invention will be described. The drug in the water gel drug vaporizer of the present invention is selected based on the use of the water gel drug vaporizer. For example, one or more additional components such as a fragrance, a deodorant, an insect repellent, an insecticide, a disinfectant, and a repellent can be used, and the amount of use is not particularly limited. About 0.01% based on the whole water gel
To 15% by weight, preferably about 0.1 to 10% by weight. If the amount is less than 0.01% by weight, the effect of the drug cannot be sufficiently exerted. If the amount is more than 15% by weight, the cost is increased and the stability of the water gel cannot be maintained.

The copolymer of acrylic acid and alkyl methacrylate (C10 to C30) used in the water gel drug volatile of the present invention comprises acrylic acid and alkyl methacrylate (C10
To C30) can be obtained by polymerizing benzoyl peroxide or the like as a polymerization initiator. By changing the ratio of acrylic acid to alkyl methacrylate, copolymers having various balances of hydrophilicity and lipophilicity can be obtained. Instead of manufacturing as described above, commercially available products can also be used. Examples of such commercially available products include Pemulen TR-1 and Pemulen TR-2 manufactured by Goodrich.

The amount of the acrylic acid / alkyl methacrylate (C10 to C30) copolymer used in the water gel drug vaporizer of the present invention is not particularly limited. About 0.01 to 10% by weight, preferably about 0.1 to 5% by weight.
If the amount is less than 0.01% by weight, the effect of the drug cannot be sufficiently exerted. If the amount is more than 10% by weight, the cost is increased, and the viscosity becomes high, so that it is difficult to prepare a water gel.

As the gelling agent used in the water gel chemical vaporizer of the present invention, those generally used in water gel chemical vaporizers can be used. For example, natural gelling agents such as carrageenan, gellan gum, agar and gelatin can be used. Synthetic gelling agents such as isobutylene-maleic anhydride copolymer and the like. The use amount of the gelling agent is not particularly limited, but may be, for example, about 0.1 to 15% by weight based on the whole water gel drug volatile. 0.
If it is less than 1% by weight, gelation is not sufficient, and 15% by weight
If the amount is larger, the viscosity becomes high and the preparation of the water gel becomes difficult.

As the water used for the water gel drug volatile of the present invention, it is preferable to use purified water such as deionized water, distilled water and ion-exchanged water. Water is basically the balance, but the amount of water used is usually about 40 to 95% by weight, assuming that the total amount of the obtained water gel drug volatiles is 100% by weight.

[0013] In addition to the above-mentioned components, components usually used for water gel drug volatiles can be blended into the water gel drug volatile of the present invention. Examples of such components include solvents such as alcohols, glycols, glycol ethers, polyols, and substituted alcohols; natural polymer substances such as locust bean gum and xanthan gum; and synthetic polymers such as cellulose and polyvinyl alcohol. Gel reinforcing agents such as molecular substances; anionic surfactants such as fatty acid soaps and alkyl sulfates; POE alkyl ethers;
Surfactants such as nonionic surfactants such as OE alkylphenol and POE sorbitan alkylate, and cationic surfactants such as quaternary ammonium salts; pigments such as water-soluble dyes, fluorescent dyes, natural pigments, and inorganic pigments; Preservatives such as parapenes such as methyl parapen and benzoates; inorganic alkalis such as sodium hydroxide and potassium hydroxide; triethanolamine; 2-amino-2-methyl-1,3-
Neutralizing agents such as organic alkalis such as propanediol; salts such as calcium chloride, calcium lactate and potassium chloride; and ultraviolet absorbers.

The water gel drug volatile of the present invention is preferably produced, for example, as follows. That is, first, a gelling agent is added to water and dissolved by heating generally at room temperature to 100 ° C., and then a drug and an acrylic acid / alkyl methacrylate (C10 to C30) copolymer are added and mixed. , To obtain a dispersion. Next, the dispersion is filled in a volatilization container, and solidified by cooling or cooling.

[0015]

Next, the present invention will be described more specifically with reference to examples and comparative examples. [Example 1] Mud on water 91.475g carrageenan: X-5189 dissolved by heating in addition to 90 ° C. The (manufactured by Nitta Gelatin Inc.) 2 g and methylparaben 0.2 g, osmanthus fragrance: No. 669 of 2569 (manufactured by Hasegawa Koryo Co., Ltd.) and alkyl acrylate / alkyl methacrylate (C10
To C30) Copolymer: 0.225 g of Pemulen TR-1 (manufactured by Goodrich) and 2-amino-2-methyl-
A mixture obtained by mixing 0.1 g of 1,3-propanediol (AMPD) is added to the above heated solution, and the mixture is stirred and mixed. Thereafter, the mixture was filled in a fragrance container, allowed to cool in air, and solidified, thereby producing the water gel drug volatile of the present invention.

Example 2 In Example 1, 91.475 g of deionized water was changed to 91.175 g, and a surfactant: Tween 60 (ICI SURFACTANTS) was used.
(Manufactured by K.K .: polyoxyethylene sorbitan monostearate) except that 0.3 g was added to produce a water gel drug vaporizer of the present invention.

Example 3 Example 1 was the same as Example 1 except that the perfume flavor was changed to 2 g of octyl crotonate-containing deodorant and deionized water, Pemulen TR-1, and AMPD were changed to the amounts shown in Table 1. In the same manner as in the above, a water gel drug volatile of the present invention was produced.

[Comparative Example 1] In Example 1, 91.475 g of deionized water was used as 91.2 g, and Pemulen TR was used.
Same as Example 1 except that 0.6 g of Tween 60 (supra) was used instead of 0.225 g of -1 (supra) and 0.1 g of 2-amino-2-methyl-1,3-propanediol. To produce a water gel drug vaporizer. Table 1 shows the components of Examples 1 to 3 and Comparative Example 1.

[0019]

[Table 1]

With respect to the obtained water gel drug volatiles, the change in the amount of volatilization per day per week and the evaluation by a sensory test (excluding Example 3) were performed. The test method is as follows, and the results are shown in Tables 2 and 3. Change in volatilization amount (g / day) The opening of the water gel drug volatilizer container is constantly opened, and the sample is volatilized at room temperature. The amount of volatilization every day was measured, and the amount of volatilization per day was averaged for each week. The unit is g / day. In addition, the ratio of the remaining volume of the volatilized body after the lapse of 5 weeks was calculated as (remaining volume of the volatile body / volume of the volatilized body immediately after preparation × 10
0). Sensory evaluation The water gel drug volatiles were subjected to sensory evaluation by 15 well-trained panels regarding the intensity of aroma over time. Each person evaluated using the 5-point method, and the average was taken as the strength of each water gel drug vaporizer on that day. The higher the value, the stronger the aroma.

[0021]

[Table 2]

[0022]

[Table 3]

As is clear from Table 2, in the example of the present invention, the amount of volatilization per day up to the fourth week is constant, while in Comparative Example 1, the amount of volatilization per day is from the second week. Volatilization was reduced. On the other hand, the amount of volatilization per day in the fifth week was extremely smaller in the example of the present invention than in the fourth week, indicating that the end point was almost reached. In Example 1, the end point was not clear because the volatilization gradually occurred even in the fifth week. As is evident from Table 3, the water gel drug volatile of the present invention has a strong aroma from the start to the fourth week, compared to the comparative example.
The aroma was constantly evaporating.

[0024]

EFFECTS OF THE INVENTION The water gel chemical vaporizer of the present invention can volatilize chemicals such as fragrances, deodorants and insect repellents in a well-balanced manner from the start to the end of volatilization. In addition, it is possible to prevent a decrease in drug effects such as sustainability. In addition, the acrylic acid / alkyl methacrylate (C10 to C10) used in the water gel drug volatile of the present invention.
C30) Since the copolymer has an emulsifying effect, it is possible to use no surfactant used in conventional water gel drug volatiles or to reduce the amount of surfactant used,
Can respond to global environmental problems with surfactants.
Since the volatilized water gel of the present invention has a constant water volatilization amount, the residual shape at the end of volatilization is smaller than conventional products, and the end point of the volatilized body can be easily determined visually. Has an effect.

Continuation of the front page (72) Inventor Toshihachi Kitamura 4-4-1, Nihonbashi-Honcho, Chuo-ku, Tokyo Fragrance Research Laboratories, Inc. Fragrance Research Laboratories, Hasegawa Inc. 4C080 AA03 BB02 BB03 BB05 BB07 BB08 BB10 CC01 HH06 JJ03 KK03 LL06 LL09 MM31 NN23 NN26 4H011 AA02 AC01 AC06 BA01 BB22 BC18 BC19 DA17 DF03 DG03 DH02 DH10 DH20

Claims (2)

[Claims] 1. An alkyl acrylate / alkyl methacrylate (C1
0-C30) A water gel drug volatile containing a copolymer and a gelling agent. 2. The water gel drug vaporizer according to claim 1, wherein the drug is at least one selected from fragrances, deodorants, insect repellents, insecticides, disinfectants and repellents.