WO2012017166A3 - Traitement d'une pathologie liee a un effet excessif du tnf par un compose de benzene sulfonamide - Google Patents
Traitement d'une pathologie liee a un effet excessif du tnf par un compose de benzene sulfonamide Download PDFInfo
- Publication number
- WO2012017166A3 WO2012017166A3 PCT/FR2011/051742 FR2011051742W WO2012017166A3 WO 2012017166 A3 WO2012017166 A3 WO 2012017166A3 FR 2011051742 W FR2011051742 W FR 2011051742W WO 2012017166 A3 WO2012017166 A3 WO 2012017166A3
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- WO
- WIPO (PCT)
- Prior art keywords
- tnf
- pathological condition
- benzenesulfonamide
- compound treatment
- excessive effect
- Prior art date
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- A—HUMAN NECESSITIES
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A—HUMAN NECESSITIES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
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- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
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- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
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- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
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- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
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Abstract
ou l'un de ses sels d'addition avec les acides pharmaceutiquement acceptables, pour son utilisation dans une méthode de traitement d'une pathologie lie un effet excessif du TNF-alpha et pour son utilisation dans une méthode de traitement du corps humain ou animal comme inhibiteur direct du TNF alpha.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2805206A CA2805206A1 (fr) | 2010-07-19 | 2011-07-19 | Traitement d'une pathologie liee a un effet excessif du tnf par un compose de benzene sulfonamide |
US13/811,144 US8975399B2 (en) | 2010-07-19 | 2011-07-19 | Benzenesulfon amide-compound treatment of a pathological condition linked to an excessive effect of TNF |
EP11754705.9A EP2595620A2 (fr) | 2010-07-19 | 2011-07-19 | Traitement d'une pathologie liee a un effet excessif du tnf par un compose de benzene sulfonamide |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1055867 | 2010-07-19 | ||
FR1055867A FR2962649A1 (fr) | 2010-07-19 | 2010-07-19 | Traitement d'une pathologie liee a un effet excessif du tnf par un compose de benzene sulfonamide |
US201161443132P | 2011-02-15 | 2011-02-15 | |
US61/443,132 | 2011-02-15 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2012017166A2 WO2012017166A2 (fr) | 2012-02-09 |
WO2012017166A3 true WO2012017166A3 (fr) | 2012-07-19 |
Family
ID=43566620
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PCT/FR2011/051742 WO2012017166A2 (fr) | 2010-07-19 | 2011-07-19 | Traitement d'une pathologie liee a un effet excessif du tnf par un compose de benzene sulfonamide |
Country Status (5)
Country | Link |
---|---|
US (1) | US8975399B2 (fr) |
EP (1) | EP2595620A2 (fr) |
CA (1) | CA2805206A1 (fr) |
FR (1) | FR2962649A1 (fr) |
WO (1) | WO2012017166A2 (fr) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103491956A (zh) | 2010-09-13 | 2014-01-01 | 麦克罗拜奥提斯公司 | 病毒进入哺乳动物细胞的抑制剂 |
ES2796850T3 (es) * | 2013-07-18 | 2020-11-30 | Baylor College Medicine | Composiciones para la prevención de una reacción alérgica |
US10112933B2 (en) | 2013-07-18 | 2018-10-30 | Baylor College Of Medicine | Methods and compositions for treatment of fibrosis |
EP3021841B1 (fr) | 2013-07-18 | 2022-11-16 | Baylor College Of Medicine | Méthodes et compositions de traitement de l'atrophie musculaire, de la faiblesse musculaire, et/ou de la cachexie |
WO2015130947A1 (fr) * | 2014-02-26 | 2015-09-03 | Howard University | Utilisation de dérivés benzène-sulfonamides comme inhibiteurs de l'intégrase du vih |
WO2016073897A1 (fr) | 2014-11-06 | 2016-05-12 | Northwestern University | Inhibition de la motilité de cellules cancéreuses |
CA2990477A1 (fr) * | 2015-08-12 | 2017-02-16 | Memorial Sloan-Kettering Cancer Center | Derives de phenylsulfonamido-benzofurane et leurs utilisations dans le traitement de maladies proliferatives |
CN105085450A (zh) * | 2015-09-14 | 2015-11-25 | 中国药科大学 | 苯并呋喃类衍生物、其制备方法及其治疗作用 |
WO2018086531A1 (fr) * | 2016-11-08 | 2018-05-17 | 正大天晴药业集团股份有限公司 | Composé de sulfonamides en tant qu'inhibiteur d'adnccc |
US10494334B2 (en) * | 2018-03-28 | 2019-12-03 | Academia Sinica | Compounds to inhibit calcium/calmodulin dependent protein kinase II and applications thereof |
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EP4093377A1 (fr) | 2020-01-24 | 2022-11-30 | Tvardi Therapeutics, Inc. | Composés thérapeutiques, formulations et leurs utilisations |
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Also Published As
Publication number | Publication date |
---|---|
US8975399B2 (en) | 2015-03-10 |
EP2595620A2 (fr) | 2013-05-29 |
CA2805206A1 (fr) | 2012-02-09 |
FR2962649A1 (fr) | 2012-01-20 |
US20130123266A1 (en) | 2013-05-16 |
WO2012017166A2 (fr) | 2012-02-09 |
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